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With an in-depth understanding of noncoding ribonucleic acid (RNA), many studies have shown that microRNA (miRNA) plays an important role in human diseases. Because traditional biological experiments are time-consuming and laborious, new calculation methods have recently been developed to predict associations between miRNA and diseases. In this review, we collected various miRNA–disease association prediction models proposed in recent years and used two common data sets to evaluate the performance of the prediction models. First, we systematically summarized the commonly used databases and similarity data for predicting miRNA–disease associations, and then divided the various calculation models into four categories for summary and detailed introduction. In this study, two independent datasets (D 5430 and D 6088) were compiled to systematically evaluate 11 publicly available prediction tools for miRNA–disease associations. The experimental results indicate that the methods based on information dissemination and the method based on scoring function require shorter running time. The method based on matrix transformation often requires a longer running time, but the overall prediction result is better than the previous two methods. We hope that the summary of work related to miRNA and disease will provide comprehensive knowledge for predicting the relationship between miRNA and disease and contribute to advanced computation tools in the future. [ABSTRACT FROM AUTHOR]

Accurate prediction of drug-target interactions (DTIs) through biological data can reduce the time and economic cost of drug development. The prediction method of DTIs based on a similarity network is attracting increasing attention. Currently, many studies have focused on predicting DTIs. However, such approaches do not consider the features of drugs and targets in multiple networks or how to extract and merge them. In this study, we proposed a Network EmbeDding framework in mulTiPlex networks (NEDTP) to predict DTIs. NEDTP builds a similarity network of nodes based on 15 heterogeneous information networks. Next, we applied a random walk to extract the topology information of each node in the network and learn it as a low-dimensional vector. Finally, the Gradient Boosting Decision Tree model was constructed to complete the classification task. NEDTP achieved accurate results in DTI prediction, showing clear advantages over several state-of-the-art algorithms. The prediction of new DTIs was also verified from multiple perspectives. In addition, this study also proposes a reasonable model for the widespread negative sampling problem of DTI prediction, contributing new ideas to future research. Code and data are available at https://github.com/LiangYu-Xidian/NEDTP. [ABSTRACT FROM AUTHOR]

Therefore, the wording of the Methods, subsection "Construct drug similarity network based on side effects" closely resembles the method description in Reference 57 designed for symptom-based similarity detection, but this reference was not cited in this section. To construct drug similarity network based on side effects, the Authors used the data and the method reported by Zhou et al. whose paper is cited as Reference 57 in the Article. [Extracted from the article]

Accurate prediction of energy prices is crucial to the development of energy security and environmental policies in various countries. This paper proposes a novel multi-step prediction hybrid model with genetic algorithm for variational mode decomposition, improved complete ensemble empirical modal decomposition with adaptive noise, bidirectional gated recurrent unit, temporal convolutional network, and multi-layer perceptron (GVMD-ICEEMDAN-BIGRU-TCN-MLP) for predicting carbon and natural gas futures prices. First genetic algorithm (GA) is used to fix the parameters of VMD model, the carbon and natural gas prices are decomposed into subsequences. Then the difference between the original series and the VMD after decomposition is further decomposed into subseries using ICEEMDAN. Next, the highest frequency series is predicted using the MLP model, and other subsequences are predicted using the BIGRU-TCN model. Finally, each predicted value is added linearly to determine the final result of steps 1, 3, and 5 of the entire forecasting process. According to the experimental results, it is shown that the model has lower prediction errors than the comparison model under mean absolute error (MAE), root mean square error (RMSE), mean absolute percentage error (MAPE), coefficient of determination (R2), and modified Diebold-Mariano test (MDM). The good prediction results of the novel hybrid model are demonstrated in multi-step ahead integrated prediction experiments, especially in the experiments with 1-step ahead prediction, as well as in the experiments with varying training ratios. • GVMD-ICEEMDAN-BIGRU-TCN-MLP model is used to forecast energy prices. • ICEEMDAN is used to further decompose the residuals. • Hierarchical prediction based on subsequence features is better. • Multi-step forecasting integrated study of energy prices. [ABSTRACT FROM AUTHOR]

Accurate prediction of drug-target interactions (DTIs) can reduce the cost and time of drug repositioning and drug discovery. Many current methods integrate information from multiple data sources of drug and target to improve DTIs prediction accuracy. However, these methods do not consider the complex relationship between different data sources. In this study, we propose a novel computational framework, called MccDTI, to predict the potential DTIs by multiview network embedding, which can integrate the heterogenous information of drug and target. MccDTI learns high-quality low-dimensional representations of drug and target by preserving the consistent and complementary information between multiview networks. Then MccDTI adopts matrix completion scheme for DTIs prediction based on drug and target representations. Experimental results on two datasets show that the prediction accuracy of MccDTI outperforms four state-of-the-art methods for DTIs prediction. Moreover, literature verification for DTIs prediction shows that MccDTI can predict the reliable potential DTIs. These results indicate that MccDTI can provide a powerful tool to predict new DTIs and accelerate drug discovery. The code and data are available at: https://github.com/ShangCS/MccDTI. [ABSTRACT FROM AUTHOR]