1. Met is required for oligodendrocyte progenitor cell migration in Danio rerio
- Author
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Leah Hogenmiller, Andrew J. Latimer, Laura Fontenas, Cecilia B. Moens, Adam J. Isabella, Maria F. Ali, Yinxue Wang, Guoqiang Yu, and Sarah Kucenas
- Subjects
AcademicSubjects/SCI01140 ,AcademicSubjects/SCI00010 ,Central nervous system ,Danio ,Oligodendrocyte progenitor ,Met receptor ,QH426-470 ,AcademicSubjects/SCI01180 ,Genetics ,medicine ,Animals ,Molecular Biology ,Zebrafish ,Genetics (clinical) ,Oligodendrocyte Precursor Cells ,Investigation ,glial migration ,biology ,oligodendrocyte progenitor cells ,Neural tube ,Cell Differentiation ,Cell migration ,zebrafish ,Spinal cord ,biology.organism_classification ,Cell biology ,Oligodendroglia ,stomatognathic diseases ,medicine.anatomical_structure ,Spinal Cord ,nervous system ,AcademicSubjects/SCI00960 ,spinal cord development ,Signal Transduction - Abstract
During vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivo, the role of Met signaling in OPC migration and provide new insight into how OPC migration is regulated during development.
- Published
- 2021