1. A novel clinical signature predicts the survival of elderly patients with oral squamous cell carcinoma.
- Author
-
Zhou, Wenkai, Peng, Canbang, Liu, Zheqi, and Cao, Wei
- Subjects
- *
OLDER patients , *SQUAMOUS cell carcinoma , *OVERALL survival , *PROGRESSION-free survival , *NEUTROPHIL lymphocyte ratio - Abstract
Background: The risk factors for the survival of elderly patients with oral squamous cell carcinoma (OSCC) are multifarious. Here, we developed a novel clinical signature to serve as an indicator of prognosis in these patients. Materials and methods: Clinicopathological data were collected for 554 patients aged ≥ 60 years who were treated for primary OSCC. Overall survival (OS), disease-specific survival, and disease-free survival were the primary outcomes. Results: Multivariate cox regression analysis showed that high N stage, low hemoglobin level, low body mass index (BMI), and high neutrophil-to-lymphocyte ratio (NLR) showed a poor survival (P < 0.05). A nomogram was constructed with a c-index of 0.702. Conclusion: A novel clinical signature including hemoglobin level, BMI, and NLR, which are obtained through noninvasive examinations can be used as prognostic indicators in clinical practice for elderly patients with OSCC. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF