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Hepatitis B (HB) vaccination is recommended for people with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). We aimed to assess the immune response to the HB vaccine and associated factors using the standard vaccination schedule among people with HIV (PWH) in China. A prospective study was carried out from 2016 to 2020 in Beijing, China. PWH were given three 20 μg doses of recombinant HB vaccine at 0, 1, and 6 months. Blood samples were taken within 4–6 weeks after each dose to evaluate the anti-HBs levels. A total of 312 participants completed vaccination and serologic testing. The seroconversion (anti-HBs ≥ 10 IU/L) rates following the first, second, and third doses of the vaccine were 35.6% (95% CI: 30.3–40.9%), 55.1% (95% CI: 49.6–60.7%), and 86.5% (95% CI: 82.8–90.3%), respectively, and the geometric means of the anti-HBs titers were 0.8 IU/L (95% CI: 0.5–1.6 IU/L), 15.7 IU/L (95% CI: 9.4–26.3 IU/L), and 241.0 IU/L (95% CI: 170.3–341.1 IU/L), respectively. In multivariate analysis, after three doses of vaccination, age, CD4 cell count, and HIV-RNA viral load were significantly associated with strong, moderate, and weak response, respectively. These findings confirm that these personal health conditions are related to the HB response. HB vaccination in PWH using the standard schedule was still highly effective in the context of early treatment initiation, especially among participants aged 30 years and younger. [ABSTRACT FROM AUTHOR]

This qualitative case study explores the Chinese school principals' experiences in building a learning community through the Fifth Discipline (shared vision, personal mastery, mental models, team learning, and system thinking) in helping them embrace student engagement, teacher commitment, and parents' involvement for school improvement and student achievement. Findings show that principals face three challenges, including (1) testing score limits to create a learning community; (2) saving cost causes difficulty to hire a highly professional teacher; (3) high expectations cause the high rate of dropout. This study also finds three ways in using the Fifth Discipline for student engagement, teacher commitment, and parent involvement which are (1) communication, (2) self-improvement, and (3) self-reflection. Findings show that principals use three strategies of nurturing school capacity, including (1) visibility, (2) educational core values, and (3) lifelong learning. The future qualitative grounded theory research design of using the Fifth Discipline was suggested by interviewing principals, teachers, parents, and students to create a leadership framework in leading the school change in the 21st century. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the response and safety of an inactivated vaccine (Sinovac Life Sciences Co., Ltd., Beijing, China) for coronavirus disease 2019 (COVID-19) in liver transplant (LTx) recipients from China. Patients and Methods: Thirty-five recipients post LTx from the First Affiliated Hospital of Zhejiang University School of Medicine who received inactivated vaccine from June to October 2021 were screened. Information regarding vaccine side effects and clinical data were collected. Results: Thirty-five LTx recipients were enrolled, with a mean age of 46 years, and most patients were male (30, 85.71%). All the participants had a negative history of COVID-19 infection. Predictors for negative response in the recipients were interleukin-2 receptor (IL-2R) induction during LTx, shorter time post LTx and application of a derivative from mycophenolate acid (MPA). No serious adverse events were observed during the progress of vaccination or after the vaccination. Conclusion: LTx recipients have a substantially partial immunological response to the inactivated vaccine for COVID-19. IL-2R induction during LTx, a shorter time post LTx and the application of a derivative from MPA seem to be predictors for a negative serological immunoglobulin G (IgG) antibody response in recipients. The findings require booster vaccination in these LTx recipients. [ABSTRACT FROM AUTHOR]

Root rot is a major disease of strawberry (Fragaria × ananassa cv. Duchesne) worldwide affecting production and leading to huge economic losses. In 2018 and 2019, strawberry plants displaying root rot symptoms accompanied by plant wilting were observed on commercial farms in Beijing, China. A fungus with the general morphological characters of Neopestalotiopsis was consistently isolated from necrotic lesions in symptomatic roots. Eight representative isolates were selected for further studies. Based on morphological characters and phylogenetic analyses of the combined internal transcribed spacer (ITS) region, partial sequences of the β-tubulin gene (tub2) and the transcription elongation factor 1-α (tef1), all isolates were identified as Neopestalotiopsis rosae. Pathogenicity test showed that N. rosae can produce wilt and root rot symptoms on strawberry plants. Therefore, N. rosae was recognized as the causal agent of root rot of strawberry. This is the first report that discusses the role of N. rosae in causing root rot disease on strawberries in China. 1. Root rot symptoms accompany with plant wilt were observed on strawberry in Beijing, China. 2. Neopestalotiopsis rosae was identified based on morphological characteristics and multilocus phylogenetic analyses. 3. The isolates fulfilled Koch's postulate. 4. This is the first report of N. rosae causing root rot of strawberry in China. [ABSTRACT FROM AUTHOR]

• Proposed a technical framework for ecological restoration zoning from the hydro-ecological perspective. • Proposed an zoning method which embedding landscape pattern models and hydrological models. • Emphasis on dynamic evolution process of hydro-ecology. • There is significant improvement of hydro-ecology and the regional differentiation was enlarged during 2000–2022. To prevent the degradation and destruction of ecosystems, ecological restoration has become a worldwide issue. In recent years, China has been comprehensively carrying out relevant work on national spatial ecological restoration planning, among which the work on ecological restoration zoning can provide strong support for the implementation of ecological restoration strategies. We propose a theoretical framework and technical route for ecological restoration zoning from the hydro-ecological perspective, and suggest forming a regional ecological restoration zoning system based on the watershed as the basic unit and the dynamic evolution process of hydro-ecology as the core. We conduct an empirical study in Yanqing District, Beijing. The results show that: (i) From 2000 to 2022, the hydro-ecological comprehensive index of Yanqing District shows an upward trend. In terms of spatial pattern changes, it roughly shows a rising trend in the northeastern and southern mountainous areas, and a downward trend in the central-western and southwestern basins. (ii) Six types of ecological restoration zones are formed with the watershed as the basic unit. Zone Ⅰ accounts for the largest area (26.87%), and Zone Ⅵ accounts for the smallest proportion (7.14%). (iii) The proportion of areas with good or superior hydro-ecology in the Ecological Policy Zone of Yanqing District increased by 15.89% from 2000 to 2022, which is significantly higher than the average level, confirming the effectiveness of ecological policies such as nature reserves. This study provides a paradigm for ecological restoration zoning from the hydro-ecological perspective, and provides assistance for regional ecological restoration and sustainable development in China and even globally. [ABSTRACT FROM AUTHOR]