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Severe air pollution in China and India threatens the health of over one-third of the global population. When it comes to air pollution governance, the two countries have vastly different approaches. China's approach features centralized target-setting and implementation, with policies enforced primarily through top-down administrative lines. While India's approach reflects the division of power among central and state governments and relies substantially on legislative and judiciary systems for accountability. We conduct a detailed review of the trends and sources of six air pollutants in China and India, and make a structured comparison of China and India's air pollution policy frameworks. An extensive literature review is conducted to evaluate the effectiveness of policies in each country. The studies show that China's policy efforts have achieved significant improvements in air quality, while India's policies have been largely ineffective. Nevertheless, both approaches have the potential to lead to effective air pollution governance, if a country can build strong political will and clearly defined accountability systems. We further identify key lessons learned from the two countries for air pollution policymaking in developing countries, including taking good advantage of "post-crisis policy window", and targeting "low-hanging fruits" to make incremental improvements in a cost-effective way. • We systematically reviewed and compared air pollution governance in China and India. • China and India have similar policy frameworks but different implementation approaches. • Strong political will and clearly defined accountability systems are key to success. • We provide insights into effective air pollution control in developing countries. [ABSTRACT FROM AUTHOR]

Estuaries usually experience the most intense anthropogenic influences among coastal areas due to their geographical and physical attributes, and they represent important parts of marine eco-civilization construction in China. Although assessments of the eco-civilization performance in estuaries are important, few methodologies or case studies related to marine eco-civilization assessments are available. This study aimed to formulate both an index system and an evaluation model for assessing the eco-civilization performance of the Oujiang Estuary. The index system consisted of six subsystems, including society, economy, resources, ecology, culture, and governance, based on the requirements of "marine eco-civilization construction" and the attributes of the estuary area. The evaluation model was developed based on a 3-D space state model. The results showed that the overall performance of marine eco-civilization construction in the Oujiang Estuary was good but that the development of the six subsystems was not balanced. The performance of the culture and ecology subsystems was relatively lower than that of the other four subsystems, indicating that the local government could focus more on developing marine culture and restoring the marine ecological environment in the future. [ABSTRACT FROM AUTHOR]

Seneca Valley virus (SVV), also known as Senecavirus A (SVA), is a non-enveloped and single-strand positive-sense RNA virus, which belongs to the genus of Senecavirus within the family Picornaviridae. Porcine idiopathic vesicular disease (PIVD) caused by SVV has frequently been prevalent in America and Southeast Asia (especially in China) since the end of 2014, and has caused continuing issues. In this study, an SVV strain isolated in China, named SVV LNSY01-2017 (MH064435), was used as the stock virus for the preparation of an SVV-inactivated vaccine. The SVV culture was directly inactivated using binary ethyleneimine (BEI) and β-propiolactone (BPL). BPL showed a better effect as an SVV inactivator, according to the results of pH variation, inactivation kinetics, and the detection of VP1 content during inactivation. Then, SVV inactivated by BPL was subsequently emulsified using different adjuvants, including MONTANIDETM ISA 201 VG (ISA 201) and MONTANIDETM IMG 1313 VG N (IMS 1313). The immunoreactivity and protection efficacy of the inactivated vaccines were then evaluated in finishing pigs. SVV-BPL-1313 showed a better humoral response post-immunization and further challenge tests post-immunization showed that both the SVV-BPL-201 and SVV-BPL-1313 combinations could resist challenge from a virulent SVV strain. The SVV LNSY01-2017-inactivated vaccine candidate developed here represents a promising alternative to prevent and control SVV infection in swine. [ABSTRACT FROM AUTHOR]

Background: Pseudorabies virus (PRV) causes Aujeszky's disease or pseudorabies (PR) in pigs worldwide, which leads to heavy economic losses to the swine industry. Pigs are the natural host, meanwhile, animals such as dogs, cats, foxes, rabbits, cattle and sheep are susceptible to infection. In 2011, the emerging PRV variant led to the outbreak of PR in Bartha-K61 vaccinated pigs. The PR outbreaks demonstrated that the Bartha-K61 vaccine did not provide full protection against the emerging PRV variant. It is widely believed that PRV live attenuated vaccine could control PRV infection. Methods: In this study, we developed a novel PRV live attenuated vaccine by deleting its gI, gE, US9, and US2 genes through CRISPR/Cas9, which was named PRV GDFS-delgI/gE/US9/US2. Results: Safety experiments confirmed that PRV GDFS-delgI/gE/US9/US2 was safe for 5- to 7-day-old suckling piglets. Piglets immunized with the PRV GDFS-delgI/gE/US9/US2 vaccine did not produce PRV gE-specific antibodies but could generate PRV gB-specific antibodies and high neutralizing titers against the PRV GDFS strain (variant PRV strain) or PRV Ea strain (older PRV strain). After challenge with the emerging PRV GDFS variant, none of the piglets immunized with the PRV GDFS-delgI/gE/US9/US2 vaccine showed any clinical signs, and their rectal temperatures were normal. Moreover, the autopsy and histopathological analyses revealed that the piglets in the PRV GDFS-delgI/gE/US9/US2 vaccine group did not show apparent gross or pathological lesions. Furthermore, the piglets in the PRV GDFS-delgI/gE/US9/US2 vaccine groups did not present weight loss. According to the criteria of the OIE terrestrial manual, the results of the experiment confirmed that the PRV GDFS-delgI/gE/US9/US2 vaccine could provide full protection against the emerging PRV variant strain in piglets. Conclusions: The PRV GDFS-delgI/gE/US9/US2 strain is a potential new live attenuated vaccine against emerging PRV variant strain infections in China. [ABSTRACT FROM AUTHOR]

Background: Chinese Herbal Medicines (CHMs), as an important and integral part of a larger system of medicine practiced in China, called Traditional Chinese Medicine (TCM), have been used in stroke therapy for centuries. A large body of studies suggest that some Chinese herbs can help reverse cognitive impairment in stroke patients, while whether these herbs also exert therapeutic benefits for Alzheimer's disease remains to be seen.Objective: To address this issue, we selected four types of CHMs that are commonly prescribed for stroke treatment in clinical practice, namely DengZhanXiXin (D1), TongLuoJiuNao (T2), QingKaiLing (Q3), and HuangQinGan (H4), and tested their effects on amyloid-β protein precursor (AβPP) processing in vitro.Methods: AβPP, β-secretase (BACE1), and 99-amino acid C-terminal fragment of AβPP (C99) stably transfected cells were used for the tests of AβPP processing. The production of Aβ, activity of BACE1, neprilysin (NEP), and γ-secretase were assessed by ELISA, RT-PCR, and western blot.Results: By upregulating BACE1 activity, D1 increased Aβ production whereas decreased the ratio of Aβ42/Aβ40; by downregulating BACE1 activity and modulating the expression of γ-secretase, T2 decreased Aβ production and the ratio of Aβ42/Aβ40; by downregulating BACE1 activity, Q3 decreased Aβ production; H4 did not change Aβ production due to the simultaneously downregulation of BACE1 and NEP activity.Conclusion: Our study indicates that these four anti-stroke CHMs regulate AβPP processing through different mechanisms. Particularly, T2 with relatively simple components and prominent effect on AβPP processing may be a promising candidate for the treatment of AD. [ABSTRACT FROM AUTHOR]

Co-abatement strategies that can reduce both CO 2 and air pollutants emissions are essential for the green and low-carbon transition of China's iron and steel industry. Most previous studies analyzed CO 2 and air pollutants reduction policies independently, but the synergies and tradeoffs between the two types of policies have rarely been investigated. By establishing a bottom-up simulation model that considers combinations of different policy objectives, crude steel demand and technology development options, this study couples air pollutants reduction into the carbon neutrality pathways to evaluate the synergistic effects of different abatement strategies in China's iron and steel industry. The study also incorporates the indirect CO 2 and air pollutants emissions from the upstream energy production sectors into pathway analysis, in order to avoid cross-sectoral carbon and air pollution leakages. The results show that the current emissions reduction policies in the iron and steel industry are far from achieving the carbon neutrality goals. To achieve synergistic reduction in CO 2 and air pollutants emissions, the short term policies should mainly rely on increasing the share of the scrap-electric arc furnace (EAF), while reducing crude steel demand and promoting breakthrough technologies, particularly hydrogen-based direct reduction, should play a major role in the long term. Meanwhile, China should promote the decarbonization of power generation and hydrogen production to reduce indirect CO 2 and air pollutants emissions from the upstream sectors. [Display omitted] • Explore pathways for CO 2 and air pollutants co-abatement in iron and steel industry. • Evaluate contributions and synergistic effects of different abatement strategies. • Stronger policy measures are needed to achieve carbon neutrality target. • Decarbonization of upstream energy sectors is critical to reduce indirect emissions. • Material efficiency and structural adjustment have greater synergistic effects. [ABSTRACT FROM AUTHOR]