1. Exploration of thyroglobulin as a biomarker of iodine status in iodine-sufficient and mildly iodine-deficient pregnant women.
- Author
-
Dineva, Mariana, Rayman, Margaret P., Levie, Deborah, Hunziker, Sandra, Guxens, Mònica, Peeters, Robin P., Murcia, Mario, Rebagliato, Marisa, Irizar, Amaia, Jimeno-Romero, Alba, Sunyer, Jordi, Korevaar, Tim I. M., and Bath, Sarah C.
- Subjects
- *
THERAPEUTIC use of iodine , *BIOMARKERS , *KRUSKAL-Wallis Test , *STATISTICS , *MULTIPLE regression analysis , *MATHEMATICAL models , *MULTIVARIATE analysis , *PREGNANT women , *DIET , *MANN Whitney U Test , *PREGNANCY complications , *THEORY , *CHI-squared test , *DESCRIPTIVE statistics , *RESEARCH funding , *GLOBULINS , *SOCIODEMOGRAPHIC factors , *SMOKING , *DATA analysis , *DATA analysis software , *IODINE deficiency , *IODINE , *NUTRITIONAL status , *PREGNANCY - Abstract
Purpose: Urinary iodine-to-creatinine ratio (UI/Creat) reflects recent iodine intake but has limitations for assessing habitual intake. Thyroglobulin (Tg) concentration, which increases with thyroid size, appears to be an indicator of longer-term iodine status in children and adults, however, less is known in pregnancy. This study investigated the determinants of serum-Tg in pregnancy and its use as an iodine-status biomarker in settings of iodine-sufficiency and mild-to-moderate deficiency. Methods: Stored blood samples and existing data from pregnant women from the Netherlands-based Generation R (iodine-sufficient) and the Spain-based INMA (mildly-to-moderately iodine-deficient) cohorts were used. Serum-Tg and iodine status (as spot-urine UI/Creat) were measured at median 13 gestational weeks. Using regression models, maternal socio-demographics, diet and iodine-supplement use were investigated as determinants of serum-Tg, as well as the association between UI/Creat and serum-Tg. Results: Median serum-Tg was 11.1 ng/ml in Generation R (n = 3548) and 11.5 ng/ml in INMA (n = 1168). When using 150 µg/g threshold for iodine deficiency, serum-Tg was higher in women with UI/Creat < 150 vs ≥ 150 µg/g (Generation R, 12.0 vs 10.4 ng/ml, P = 0.010; INMA, 12.8 vs 10.4 ng/ml, P < 0.001); after confounder adjustment, serum-Tg was still higher when UI/Creat < 150 µg/g (regression coefficients: Generation R, B = 0.111, P = 0.050; INMA, B = 0.157, P = 0.010). Iodine-supplement use and milk intake were negatively associated with serum-Tg, whereas smoking was positively associated. Conclusion: The association between iodine status and serum-Tg was stronger in the iodine-deficient cohort, than in the iodine-sufficient cohort. Serum-Tg might be a complementary (to UI/Creat) biomarker of iodine status in pregnancy but further evidence is needed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF