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2,220 results on '"Wang, Wenjie"'

167. Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene

Author

Wang, Wenjie, Min, Qing, Lai, Nannan, Csomos, Krisztian, Wang, Ying, Liu, Luyao, Meng, Xin, Sun, Jinqiao, Hou, Jia, Ying, Wenjing, Zhou, Qinhua, Sun, Bijun, Hui, Xiaoying, Ujhazi, Boglarka, Gordon, Sumai, Buchbinder, David, Schuetz, Catharina, Butte, Manish, Walter, Jolan E, Wang, Xiaochuan, and Wang, Ji-Yang

Subjects
Biomedical and Clinical Sciences, Immunology, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Class I Phosphatidylinositol 3-Kinases, Gain of Function Mutation, Immunoglobulin M, Mutation, Phosphatidylinositol 3-Kinases, activated PI3K delta syndrome, B cell survival and activation, CD27(-)IgD(-) double-negative B cells, Ig gene class switch recombination, plasma cell differentiation, CD27-IgD- double-negative B cells, activated PI3Kδ syndrome, Medical Microbiology, Biochemistry and cell biology
Abstract

BackgroundActivated phosphoinositide 3 kinase (PI3K) -delta syndrome (APDS) is an inborn error of immunity with variable clinical phenotype of immunodeficiency and immune dysregulation and caused by gain-of-function mutations in PIK3CD. The hallmark of immune phenotype is increased proportions of transitional B cells and plasmablasts (PB), progressive B cell loss, and elevated levels of serum IgM.ObjectiveTo explore unique B cell subsets and the pathomechanisms driving B cell dysregulation beyond the transitional B cell stage in APDS.MethodsClinical and immunological data was collected from 24 patients with APDS. In five cases, we performed an in-depth analysis of B cell phenotypes and cultured purified naïve B cells to evaluate their survival, activation, Ig gene class switch recombination (CSR), PB differentiation and antibody secretion. We also analyzed PB differentiation capacity of sorted CD27-IgD- double-negative B (DNB) cells.ResultsThe patients had increased B cell sizes and higher proportions of IgM+ DNB cells than healthy controls (HC). Their naïve B cells exhibited increased death, impaired CSR but relatively normal PB differentiation. Upon stimulation, patient's DNB cells secreted a similar level of IgG but a higher level of IgM than DNB cells from HC. Targeted therapy of PI3K inhibition partially restored B cell phenotypes.ConclusionsThe present study suggests additional mechanistic insight into B cell pathology of APDS: (1) decreased peripheral B cell numbers may be due to the increased death of naïve B cells; (2) larger B cell sizes and expanded DNB population suggest enhanced activation and differentiation of naïve B cells into DNB cells; (3) the impaired CSR yet normal PB differentiation can predominantly generate IgM-secreting cells, resulting in elevated IgM levels.

Published
2022

169. Multimodal Software Defect Severity Prediction Based on Sentiment Probability

Author

Li, Ying, Lin, Yuhao, Zhong, Yongchao, Yue, Qiuling, Hu, Jinglu, Wang, Wenjie, Shi, Huiyang, Zhang, Yuqing, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Meng, Weizhi, editor, Yan, Zheng, editor, and Piuri, Vincenzo, editor

Published
2023
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170. Pricing Strategy of Apparel Supply Chain Considering Traceability Awareness of Consumers Driven by Blockchain

Author

Wang, Wenjie, Zheng, Jinxia, Liu, Yazhou, Xie, Lei, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Goedicke, Michael, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Stettner, Lukasz, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Rettberg, Achim, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Alfnes, Erlend, editor, Romsdal, Anita, editor, Strandhagen, Jan Ola, editor, von Cieminski, Gregor, editor, and Romero, David, editor

Published
2023
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172. Role of Prostasome-derived miRNA-146a in Regulating TLR-4/NF-κB Pathway and Mechanism of Action of Anemone Tomentosa in Treating Chronic Inflammation in a Rat Model of Experimental Autoimmune Prostatitis

Author

LU Liangxi, SHI Hong, HUANG Zhimin, WANG Wenjie, ZOU Han, ZHANG Zhiying, WU Jinyu

Subjects
chronic prostatitis, prostasome, mirna-146a, tlr-4, nf-κb, rats, znflammation, Medicine
Abstract

Background It is urgently necessary to find new drugs for chronic prostatitis (CP) as desired treatment effect is still yet to be achieved. Our previous clinical study has found that Anemone tomentosa (Maxim.) Péi has a good effect on CP, but the specific mechanism of action remains to be further studied. Objective To investigate the role of prostasome-derived miRNA-146a in regulating toll-like receptor 4/nuclear factor-κB (TLR-4/NF-κB) pathway and the mechanism of action of Anemone tomentosa in treating chronic inflammation in experimental autoimmune prostatitis (EAP) rats. Methods This study was conducted between December 2021 and June 2022. Forty-two Wistar rats were equally divided into seven groups using a random number table, including normal group, model group, low-, medium- and high-dose Anemone tomentosa groups, miRNA-146a mimics and inhibitor groups. After drug intervention, miRNA-146a-5p mRNA in prostasome was detected by real-time polymerase chain reaction, and TLR-4, inhibitor of NF-κB (IκB), phosphorylation of IκB (p-IκB) and tumor necrosis factor receptor-associated factor 6 (TRAF6) protein were detected by western blot, and inflammatory cytokines were detected by enzyme-linked immunosorbent assay. Results Compared with normal group, the expression level of miRNA-146a-5p mRNA in prostasome was down-regulated in each of the other six groups (P

Published
2023
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193. Implementation of Global Hearts Hypertension Control Programs in 32 Low- and Middle-Income Countries: JACC International

Author

Pathni, Anupam, Osi, Kufor, Dessie, Girma, Zhang, Xiulei, Cazabon, Danielle, Banigbe, Bolanle, Farrell, Margaret, Erojikwe, Okeoma, Swahoo, Swagata, Krishna, Ashish, Yusuf, Abdikaid Ahmed, Kebede, Henok Gebreyohannes, Berhanu, Molla Gedefaw, Bezabih, Tilahun, Tegegn, Teshome Ayalew, Demissie, Workneh, Burka, Daniel, Tasmin, Misu, Ogbeide, Bolatito, Cheadle, Timothy, Odu, Joseph, Beyene, Meron Hailu, Borkhataria, Cecile, Elliott, Kate, Jaffe, Marc, Garg, Renu, Frieden, Thomas R., Khan, Taskeen, Slama, Slim, Mikkelson, Bente, Lai, Truong Duc, Santos, Rauell John, Aquino, Tyrone, Calla, Dofel Joseph, Kunwar, Abhishek, Durgad, Kiran, Bunluesin, Sushera, Dewan, Mary, Obagha, C.E., Msyamboza, Kelias, Das, Bidisha, Kishore, Navneet, Puthussery, Yannick Poulose, Sambandam, Gopinath Thirugnana, Immanuel, A Branch, Chandrakant Joshi, Chakshu, Bhardawaj, Rupali, Wankhede, Amol, Khedkar, Suhas Namdevrao, Bhardawaj, Vishwajit Washudeorao, Kumar Reddy, Thokala Sravan, Chavan, Tejpalsinh Anandrao, Chittimella, Raghavendra Patel, Bhandari, Subhasis, Shah, Urvin Kumar, Chandram, Deenadayalan, Wassey, Mohammed Abdul, Kadia, Abhinav, Sarode, Lalit Dinkar, Chauhan, Lalita, Ponna, Satyendra Nath, Babu, Suresh, Gupta, Piyush, Reddy, Thej Kiran, Sekhon, Hanspreet, Jeelani, Asif, Nath, Gunjan, Wankhede, Virendra, Jayaprasad, Niniya, Mohanty, Trishna, Kumar, Praveen, Khanna, Abhishek, Singh, Shweta, Bhat, Ashish, Thakkar, Jatin, Anitha Sreekumar, Aiswarya Lakshmi, Lakshmanasamy, Ravivarman, Rafique, Mohamed Essa, Dar, Sunil Kumar, Chintala, Sreedhar, Jagadeesh, Bharath, Patruni, Manoj, Raimule, Madhur, Prabhu Valawalkar, Shahanara S., Ordunez, Pedro, Giraldo, Gloria, Martinez, Ramon, Rosende, Andres, Rodriguez, Yenny, Lombardi, Cintia, Gamarra, Angelo, Rodriguez, Libardo, Parra, Natalia, Rodriguez, Gonzalo, Villalta, Noelia, Escobar, Maria C., Villacres, Nilda, Sorto, Carlos, Baca, Edith, Batista, Vhania, Perez, Vivian, Victoria, Jorge, Abaakouk, Zohra, Malcolm, Taraleen, Kostova, Deliana, Richter, Patricia, Whelton, Paul K., Lackland, Daniel, Weber, Michael, Pineiro, Daniel, Wood, David, Pinto, Fausto, Mwangi, Jeremiah, Perel, Pablo, Codato, Elisa, Eiselé, Jean-Luc, Kaur, Prabhdeep, Parashuraman, Ganeshkumar, Sharma, Meenakshi, Shivashankar, Roopa, Bangar, Sampada Dipak, Chakma, Tapas, Pragya, Pragati, Malik, Abdul, Awal, Khondker Abdul, Malik, Fazilatunnesa, Choudhury, Sohel Reza, Bhuiyan, Mahfuzur Rahman, Jubayer, Shamim, Al Mamun, Mohammad Abdullah, Ishraquzzaman, Mir, Abrar, Ahmed Khairul, Akhter, Jubaida, Sultana, Sarmin, Parvej, Aslam, Sayem Khandoker Ehsanul Amin, Noor Nabi, Islam, Md Shahinul, Dey Parag, Deb Dulal, Amin, Ruhul, Luna, Mahfuja, Ibn Karim, Md Abbas, Mahajabin, Progga, Khan, Iqbal Ahmed, Hossain, Sazzad, Ullah, Riasat Razi, Nahid, Muhtamim Fuwad, Zhang, Xinhua, Huang, Hongxia, Wang, Hao, Guan, Tingrui, Zhao, Haiying, Ojji, Dike, Shedul, Gabriel Lamkur, Shedul, Grace, Orji, Anthony, Asuku, Regina, Alo-Joseph, Confidence, Akor, Charity, Egenti, Nonye, Nwankwo, Ada, Omitiran, Kasarachi, Okoli, Rosemary, Ripiye, Nanna, Akor, Blessing, Cai, Jun, Wang, Lu, Wang, Wenjie, Fan, Luyun, Xu, Jianrong (Jenny), Tang, Shanshan, Wu, Guoli, Smith, Barbara, Kenyon, Thomas, Mandal, Sudarsan, Swarnakar, Sunny, Wickramasinghe, S.C., Herath, Amila Bandarra, Ratnayake, I.U., Samarasinghe, Kosala, Kumarasiri, K.H.N., Vensentini, Natalia, Mendieta, Daniel Palacios, Rivera, Marcela, Gonzalez, Yamile Valdez, Cevallos, Lucia, Villatoro, Matías Humberto, Gloria Hernandez, Laura Elena, Arenas, Elsa, Fernández, Daniel, De Oleo, Daniel Mola, Cyr, Shana, Mitchell, Roxanne, Hossain, AHM Enayet, Amin, Mohammad Robed, Alim, Abdul, Milon, Sarowar Uddin, Alex-Okoh, M.O., Odoh-Bako, D.O., Malau, M.T., Oshundele, B.R., Akinkoye, O.K., Abraham, E.A., Eze, S.V., Elemuwa, Chris, Lamorde, Suleiman, Oguntayo, E.A., Rajab, Ashiru, Ibrahim, Auwalu, Soyinka, Festus, Caluag, Maria Elizabeth, Uy, Maria Rosario, Adriano Subaan, Regional Director, Gayomali, Aimee Marie, Lapascua, John Richard, Taffese, Hiwot Solomon, Bac, Truong Dinh, Bao, Tran Quoc, Guo, Xiaolei, Xu, Chunxiao, Zhang, Bingyin, Thi Tho, Nguyen Thi, Van, Ngo Hai, Danh, Phan Cong, Tinh, Ho Huu, Hau, Tran Phuc, Appel, Lawrence J., Matsushita, Kunihiro, Andersen, Katye, Ayensu-Asiedu, Christabelle, Byiringiro, Samuel, Brady, Tammy, Charleston, Jeanne, Chen, Mengkun, Commodore–Mensah, Yvonne, Dalcin, Arlene, Dennison-Himmelfarb, Cheryl, Ding, Ning, Doyle, Christopher K., Edward, Anbrasi, de Souza Elias, Sabrina, Foti, Kathryn, Greer, Raquel, Henry, Megan, Hu, Xiao, Ishigami, Junichi, Kou, Minghao, Lord, Katherine, Lu, Yifei, Marklund, Matti, Amezcua, Pablo Martinez, Mattingly, Joey, McArthur, Kristin, Miller, Edgar R., III, Neupane, Dinesh, Ogungbe, Bunmi, Pariyo, George, Pathak, Priya, Pilla, Scott, Rao, Krishna, Resnick, Carol, Riekert, Kristin, Sakulsaengprapha, Tangkwa, Scheiber, Simona, Shilkofski, Nicole, Tamplin, Steve, Tang, Olive, Zhao, Di, Campbell, Norman, Ogedegbe, Olugbenga, Di Pette, Donald, Brettler, Jeffrey, Connell, Kenneth, Kishore, Sandeep P., Huffman, Mark, Hutchinson, Brian, Abdalla, Marwa, Moran, Andrew E., and Gupta, Reena

Published
2023
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