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1,930 results on '"Dong, Wen"'

256. Ontogenetic trait variation and metacommunity effects influence species relative abundances during tree community assembly

Author

Yun-Yun He, Kwansupa Srisombut, Ding-Liang Xing, Nanthan G. Swenson, Mengesha Asefa, Min Cao, Xiao-Yang Song, Han-Dong Wen, and Jie Yang

Subjects
Metacommunity, Maximum entropy, Ontogenetic trait variation, Community assembly, Trait-selected process, Biology (General), QH301-705.5, Botany, QK1-989
Abstract

Predicting species abundance is one of the most fundamental pursuits of ecology. Combining the information encoded in functional traits and metacommunities provides a new perspective to predict the abundance of species in communities. We applied a community assembly via trait selection model to predict quadrat-scale species abundances using functional trait variation on ontogenetic stages and metacommunity information for over 490 plant species in a subtropical forest and a lowland tropical forest in Yunnan, China. The relative importance of trait-based selection, mass effects, and stochasticity in shaping local species abundances is evaluated using different null models. We found both mass effects and trait selection contribute to local abundance patterns. Trait selection was detectable at all studied spatial scales (0.04–1 ha), with its strength stronger at larger scales and in the subtropical forest. In contrast, the importance of stochasticity decreased with spatial scale. A significant mass effect of the metacommunity was observed at small spatial scales. Our results indicate that tree community assembly is primarily driven by ontogenetic traits and metacommunity effects. Our findings also demonstrate that including ontogenetic trait variation into predictive frameworks allows ecologists to infer ecological mechanisms operating in community assembly at the individual level.

Published
2022
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276. MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

Author

Chao Chen, Yuan-jie Xu, Shang-rong Zhang, Xiao-hui Wang, Yuan Hu, Dai-hong Guo, Xiao-jiang Zhou, Wei-yu Zhu, Ai-Dong Wen, Qing-Rong Tan, Xian-Zhe Dong, and Ping Liu

Subjects
Depression, Kai-Xin-San, miR-1281, ADCY1, DVL1, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.

Published
2023
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293. What Happens to the Preserved Renal Parenchyma After Clamped Partial Nephrectomy?

Author

Xiong, Longbin, Nguyen, Jane K., Peng, Yulu, Zhou, Zhaohui, Ning, Kang, Jia, Nan, Nie, Jing, Wen, Dongxiang, Wu, Zeshen, Roversi, Gustavo, Palacios, Diego Aguilar, Abramczyk, Emily, Munoz-Lopez, Carlos, Campbell, Jack A., Cao, Yun, Li, Wencai, Zhang, Xuepei, He, Zhisong, Li, Xiang, Huang, Jiwei, Shou, Jianzhong, Wu, Jitao, Chen, Minfeng, Chen, Xiaofeng, Zheng, Jiaxuan, Xu, Congjie, Zhong, Wen, Li, Zaishang, Dong, Wen, Zhao, Juping, Zhang, Hailang, Luo, Junhang, Liu, Jianye, Sun, Fanghu, Han, Hui, Guo, Shengjie, Dong, Pei, Zhou, Fangjian, Yu, Chunping, Campbell, Steven C., and Zhang, Zhiling

Published
2022
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