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Your search keyword '"Škrabić, Veselin"' showing total 4 results
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4 results on '"Škrabić, Veselin"'

1. Occupational Physical Activity and Regular Exercise Are Inversely Correlated with Thyroid Function in Patients with Hashimoto's Thyroiditis.

Author

Vuletić, Marko, Kaličanin, Dean, Barić Žižić, Ana, Cvek, Maja, Sladić, Sanda, Škrabić, Veselin, Punda, Ante, and Boraska Perica, Vesna

Subjects
AUTOIMMUNE thyroiditis, VITAMIN D, PHYSICAL activity, THYROID gland, AUTOIMMUNITY
Abstract

Objective: We evaluated correlations of occupational physical activity (OPA) and recreational exercise (RE), respectively, with thyroid function in patients with Hashimoto's thyroiditis (HT). Methods: We included 438 individuals with clinically diagnosed HT. Information on OPA and RE were collected through a self-report questionnaire. We assessed correlations between clinical phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume, vitamin D) and physical activities (OPA and RE) in all HT patients (ALL) and in two severity-based subgroups of patients (MILD and OVERT). Results: The main novel findings are significant correlations between increase in OPA and (i) a decrease in fT4 (OVERT, r = −0.265, p = 0.0002 and ALL, r = −0.138, p = 0.006); (ii) an increase in TSH (ALL, r = 0.124, p = 0.014 and OVERT, r = 0.183, p = 0.013) and (iii) an increase in TPOAb antibodies (ALL, r = 0.101, p = 0.045). In contrast, we observed correlations between increase in RE and: (i) a decrease in TSH (OVERT, r = −0.238, p = 0.001); (ii) a decrease in TgAb antibodies (OVERT, r = −0.194, p = 0.01) and (iii) an increase in vitamin D levels (ALL, r = 0.146, p = 0.005 and OVERT, r = 0.173, p = 0.023). Conclusions: Our results suggest that, unlike RE, OPA correlates with decreased thyroid function and increased thyroid autoimmunity. Our study proposes that the PA health paradox also applies for the thyroid health. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Catestatin and vitamin D in obesity and metabolic syndrome in children and adolescents

Author

Šimunović, Marko, Škrabić, Veselin, Krželj, Vjekoslav, Eterović, Davor, and Stipančić, Gordana

Subjects
Metabolic Syndrome, Pediatric Obesity, kromogranin A, metabolički sindrom, vitamin D, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Pedijatrija, udc:616(043.3), pedijatrijska pretilost, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Pediatrics, Chromogranin A, Pathology. Clinical medicine, Vitamin D, Patologija. Klinička medicina
Abstract

Pretilost u ranoj životnoj dobi je jedan od vodećih javno zdravstvenih problema u svijetu. Poznato je da pretilost u ranoj životnoj dobi većinom perzistira u odrasloj dobi, a što je važan čimbenik razvoja kardiovaskularnih komplikacija i metaboličkog sindroma (MS). Zbog svega navedenoga postoji stalna potreba za pronalaskom novih molekularnih biljega koji bi dodatno pomogli u praćenju napredovanja metaboličkog poremećaja. Katestatin je peptid koji proteolitičikim cijepanjem nastaje iz kromogranina A te ima široki spektar biološke aktivnosti, poput inhibicije otpuštanja katekolamina, smanjenja krvnog tlaka, poticanja oslobađanja histamina, smanjenja beta-adrenergičke stimulacije i regulacije oksidativnog stresa. Do sada je objavljeno nekoliko studija na odrasloj populaciji, a koje su pokazale da je katestatin značajan rizični faktor za hipertenziju, a koliko nam je poznato, ovo je prvo izvješće o serumskim koncentracijama katestatina u pretile djece i adolescenata. Također, manjkavost vitamina D povezana je s nizom različitih kronični bolesti uključujući pretilost. Uloga vitamina D u pretilosti nije u potpunosti razjašnjena, a potencijalni učinci uključuju regulaciju upalnog odgovora, ekspresiju gena koji reguliraju adipogenezu i adipocitnu apoptozu te utjecaj na lučenje leptina i adiponektina i regulaciju intenziteta metabolizma. Cilj ovoga istraživanja je bio usporediti serumske koncentracije katestatina i 25- hidroksi vitamin D (25(OH)D) s odrednicama MS-a i ostalim kardiovaskularnim rizičnim čimbenicima između pretilih ispitanika i odgovarajuće kontrolne skupine ispitanika. U studiju je uključeno 91 pretilo dijete i adolescent s ITM z vrijednosti >2 i kao kontrolna skupina 39 zdrave djece (ITM z vrijednosti, Childhood obesity is one of the leading public health problems in the world and it is well known that early childhood obesity persists most into adulthood, an important factor in the development of cardiovascular complications and metabolic syndrome (MS). There is a constant need for new molecular biomarkers that will help clinicians decipher the progression of the metabolic disorder. Catestatin is a peptide by proteolytic cleavage derived from chromogranin A and has a wide range of biological activities, such as inhibition of catecholamine release, reduction of blood pressure, stimulation of histamine release, reduction of beta-adrenergic stimulation and regulation of oxidative stress. So far, several studies have been published in the adult population that have shown that catestatin is a significant risk factor for hypertension, and to our knowledge, this is the first report of serum catestatin levels in obese children and adolescents. Also, vitamin D deficiency is associated with a number of different chronic diseases including obesity. The role of vitamin D in obese individuals has not been fully elucidated, but it is considered possible to regulate the inflammatory response, the expression of genes that regulate adipogenesis and adipocyte apoptosis and also affect leptin and adiponectin secretion and regulate energy metabolism. The aim of this study was to compare serum levels of catestatin and 25-hydroxy vitamin D (25 (OH) D) with components of MS and other cardiovascular risk factors among obese subjects, with control group. The study included 91 obese children and adolescents with BMI z score >2 and control group of 39 healthy children and adolescents (BMI z score

Published
2023

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