Search

Risperidone microspheres for injection, as the first long-acting injection of the second generation antipsychotic drugs in China, combines the advantages of long-acting dosage forms and atypical antipsychotics, and had accumulated rich clinical application experience for more than ten years, bringing significant clinical benefits to schizophrenia patients. On the basis of the Expert Opinions on Clinical Application of Atypical Long-acting Injection (Risperidone Microspheres for Injection) in 2012, experts organized by Schizophrenia Collaboration Group of the Chinese Psychiatry Society systematically summarized the latest guidelines and evidence-based evidence at home and abroad, and combined with the clinical practice in China, formulated the Expert Consensus on Clinical Application of Risperidone Microspheres for Injection, aiming at improving the scientific and normative clinical use of risperidone microspheres for injection and providing better clinical medication guidance for clinicians. [ABSTRACT FROM AUTHOR]

Lurasidone is a second-generation anti psychotic drug which has a high affinity for dopamine D2, serotonin 5-HT2A and 5-HT7 receptors. Several clinical trials in patients with schizophrenia indicated lurasidone' s effect on improving psychotic symptoms, affective symptoms and cognitive symptoms, and it also manifested fewer side effects on metabolic indicators. Based on the evidence from previous studies on lurasidone and clinical experiences of experts from China Mainland and Taiwan, this experts' advice has been formed with an aim to provide guidance on the use of lurasidone in clinical practice. [ABSTRACT FROM AUTHOR]

Blonanserin is a second-generation atypical antipsychotic agent with potent affinity to dopamine D2 and D3 receptors and serotonin 5-HT2 A receptor,and with low or negligible affinity for adrenergic α1,serotonin5-HT2 C,histamine H1,and muscarinic M1 and M3 receptors.It is effective in both positive and negative symptoms of schizophrenia,and improves some domain of the cognitive symptoms and social functions of patients.Based on the evidences and clinical experiences of several Chinese and Japanese experts,the article aimed to provide a comprehensive,objective,and reasonable medication recommendation for clinical psychiatrists and help patients with schizophrenia to recover and return to society at the earliest. [ABSTRACT FROM AUTHOR]

Eating disorders (EDs) are a kind of chronic disease with high relapse rate and heavy disease burden. Patients with EDS have neurocognitive deficits related to executive function, among which the main manifestations are abnormal attentional bias and inhibitory control. Event-related potential studies are being undertaken to explore the underlying neural mechanism of cognitive abnormalities in EDS. This paper reviews the research of event-related potentials in EDs from the aspect of attentional bias and inhibition control. Suggestions for the future diagnosis and treatment programs based on neurocognitive mechanism are provided. [ABSTRACT FROM AUTHOR]

Objective: To explore the characteristic of cognitive flexibility in young female patients with eating disorders (EDs）,including anorexia nervosa (AN) and bulimia nervosa (BN）,and its relationship with the clinical features of ED. Methods : Ninety-two young female patients with EDs, including 28 patients with AN and 64 patients with BN, and 38 normal controls were enrolled.Cognitive flexibility was assessed with percentage of persistent errors (PPE) and percentage of persistent responses (PPR) of the Wisconsin Card Sorting Test (WCST）,and clinical features of ED by using the Eating Disorder Inventory-1 (EDI-1）.Results:The PPE[ (5.0±4.7) % vs. (2.8±2.8) %,P <0.01] and PPR[ (11.7±7.8) % vs. (6.4±5.9) %,P <0.001] were higher in ED group than in normal control group, but the differences on PPE[ (5.5±5.4) % vs. (5.0±4.5) %,P> 0.05] and PPR[ (11.2±7.8) % vs. (11.1±7.3）%,P> 0.05] between AN and BN groups were not statistically significant. The PPE (r=0.21,P <0.05) and PPR (r=0.27,P <0.01) were positively correlated with the EDI-1 total scores.PPR was positively correlated with the frequency of appetite suppressant use (r=0.28,P <0.05) and skipping several meals (r=0.30,P <0.01) in the ED group. Conclusion: The presence of cognitive flexibility deficits in young female patients with eating disorders, and their correlation with clinical features of eating disorders further support the possibility of being an endophenotype of eating disorders. [ABSTRACT FROM AUTHOR]