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为积极响应国家走绿色可持续发展道路的号召，北京冬奥会采用了大量支承架体用于临时看台或舞台的搭建。为研究赛后的临时看台支承架体能否安全合理地被再次使用，以索氏不锈钢插销式节点临时看台支承架体为研究对象，设计并制作了一个横纵均为2跨且跨度为2 m的足尺模型试件，共进行了两次试验，即在首次水平加载试验结束后，将该试验架体搭建在室外，经历长时间严寒风雪后再重复做一次试验，重点对比分析了其在4种不同恒载与水平荷载组合作用下的整体结构变形模式、力学性能及典型位置峰值应变等。研究结果表明：在恒载为0.0 kN∙m-2、0.5 kN∙m-2、2.0 kN∙m-2和3.5 kN∙m-2的工况下，两次试验中架体结构的试验现象及变形模式基本相同，力学性能差值在5%以内，典型位置处峰值应变差值在10%以内，累计损伤较小。两次试验结束后结构均未出现明显损伤，仍具有较大安全储备，所以在经历长时间的严寒风雪后，临时看台支承架体仍可以被重复使用。研究结果可为北京冬奥会临时设施架体的赛后利用等研究提供参考。

为解决刚接柱脚自复位装配式钢框架结构在中震或大震下底层柱可能发生较大的塑性变形的问题，设计一种半刚接柱脚自复位装配式钢框架结构。对其子结构进行拟动力试验，对比框架在Taft地震波、LOS000地震波和El-Centro地震波输入及不同等级地震下的节点开口、耗能能力、刚度退化、预应力损失和应变变化。试验结果表明，钢框架在大震作用下具有良好的自复位功能和耗能能力。钢绞线平均预应力损失最多仅为1.58%，说明施加预应力的方法是可靠的。钢框架柱脚能够始终保持弹性状态，因此震后仅需修复钢梁，大大降低了修复成本。

为解决钢管混凝土柱与柱连接节点现场焊接带来的污染严重、建设效率低等问题，融合十字形芯筒方便加工和施工的优点，在课题组提出的自攻螺栓芯筒式柱节点基础上，提出一种新型连接节点，即内置十字形芯筒方钢管混凝土柱全螺栓装配式连接节点。基于该连接节点拟静力试验结果，利用ABAQUS软件建立数值分析模型，验证模拟方法的可靠性，并针对自攻螺栓、加劲肋和十字形芯筒不同构造组合开展参数化分析。研究结果表明：数值分析结果与试验结果吻合较好，验证了数值分析方法的可靠性；自攻螺栓有效抑制了法兰板的翘曲变形和相对开口，使节点抗弯承载力平均提高19.94%，延缓了节点的刚度退化；加劲肋抑制了法兰板变形，使节点抗弯承载力平均提高3.70%，但增大了法兰板发生相对开口的可能；十字形芯筒有效抑制了法兰板的翘曲变形和柱壁局部鼓曲，提高了节点承载力和刚度，延缓刚度退化。总体来说，加劲肋对该节点抗弯承载力影响不大，且增大上下法兰板的相对开口。因此可将方钢管混凝土柱全螺栓装配节点优化为芯筒和自攻螺栓的组合形式，十字形芯筒与自攻螺栓和混凝土之间具有良好的协同工作机制，优化前后的节点均能实现“强节点、弱构件”的性能化设计目标，在工程应用中值得推荐使用。

为了适应装配式自复位空间钢框架的节点开口和框架整体膨胀效应，提出一种带滑动次梁构造的装配式自复位空间钢框架。采用ABAQUS软件对装配式自复位空间钢框架进行有限元数值模拟对比分析，并在数值模拟基础上完成了新型滑动次梁的可行性分析。结果表明：数值模拟结果在节点开口、滞回曲线、索力变化和应变等方面均与试验结果吻合良好，验证了采用有限元方法研究的可行性；新型滑动次梁的设计有效地放松了楼板对装配式自复位空间钢框架的约束作用，达到了新型滑动次梁与自复位节点同步开口的目标，顺利实现了开口-闭合机制。

实效性临床试验（pragmatic clinical trials，PCT）作为真实世界研究的重要构成，在临床研究设计中越来越受到关注和重视。然而，目前对PCT的理解和应用仍存在的一些误区。因此，本文首先从PCT的概念、研究策划与设计、研究目的、常见的设计类型和核心特征等方面进行阐述，使读者全面和正确地认识PCT。其次，本文详述了PCT的使用范围、基本的统计分析原则与各类型试验设计的分析要求。最后，本文明确了此类研究的报告规范。 Abstract: Pragmatic clinical trials (PCT), as a important component of real-world research, attracted more and more attention in clinical study design. However, there exists some confusions in understanding and application of PCT. Therefore, this article provided technical specifications of PCT in terms of the concept, study planning and design, purpose, design types and core features, to make readers have a comprehensive and correct understanding of PCT; in addition, the application scope, basic statistical analysis principles, analysis requirements for various types of study design, and the report standards of PCT were also elaborated.

This paper summarized the nursing management of a patient with chronic obstructive pulmonary disease (COPD)complicated with acute respiratory failure and plaque psoriasis. Comprehensive nursing interventions such as airway clearance techniques, facial skin care, psoriasis skin care, psychological care and discharge preparation services were carried out to relieve the symptoms, prevent the complications and improve the quality of life of the patient (本文总结1例慢性阻塞性肺疾病(COPD)合并急性呼吸衰竭伴斑块状银屑病患者的护理经验。通过综合护理干预, 如气道廓清技术、面部皮肤护理、银屑病皮肤护理、心理护理及出院准备服务等措施, 预防并发症, 改善患者症状, 有效提高患者生活质量。)

随着诊疗技术的发展，脑血管病的诊疗越来越多地需要其他相关学科的参与和合作，既往基于卒中单元为基础的合作模式需要更多的科室加入和更深入的合作方式。例如：缺血性卒中超急性期的再灌注治疗需要神经内科、神经外科、急诊科、神经重症监护科、神经介入科、放射科和康复科的配合；在卒中二级预防阶段，急性和亚急性期的卒中患者更强调营养支持和康复锻炼。融合性卒中单元作为卒中单元的升级模式，旨在促进神经病学、神经外科、康复部门的深入合作，以不同的合作模式，抓住分秒必争的契机，实施最佳临床实践，为患者争取更好的临床结果。探索脑血管病融合病房的初衷就是为了探索深入合作的融合病房模式，进一步加强再灌注治疗、二级预防、围手术期管理等卒中诊疗多环节的多科室协作，为构建适合不同医疗机构的卒中诊疗多科室联合模式提供参考。 Abstract: The development of cerebrovascular disease diagnosis and treatment technology facilitated more and more relevant disciplines mutual cooperation. Moreover, the stroke unit-based cooperation model requires further collaboration between more disciplines. For example, the reperfusion treatment in superacute stage of stroke requires the collaboration of neurology, neurosurgery, emergency, neurointensive care unit, neurointervention, radiology and rehabilitation disciplines. On the stage of stroke secondary prevention, it is emphasized on nutrition support and rehabilitation exercise in acute and subacute stroke patients. As the upgraded model of stroke unit, syncretic stroke unit is aimed to promote the in-depth cooperation of neurology, neurosurgery, rehabilitation departments with different cooperation patterns in multiple links of stroke diagnosis and treatment, to take any chance and carry out best clinical practice for better outcomes, so as to provide reference for multi-disciplines collaboration of stroke care in different medical institutions.

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the active components and potential molecular mechanism of Triphala (composed of Phyllanthi Fructus, Terminaliae Belliricae Fructus and Chebulae Fructus, THL) in regulating the function of pancreatic islet β by using the network pharmacology method and animal experiment verification. Methods The active constituents and predicted targets of THL were obtained by Traditional Chinese Medicine Database and Analysis Platform (TCMSP) combined with literature search and SwissADME. The main targets of diabetes were obtained from Drugbank, Genecards, OMIM and TTD databases. Venn diagram was used to analyze the common genes of drugs and disease, and STRING database and CytoScape 3.8.0 software was used to construct the protein-protein interaction (PPI) network of the common targets of “THL- compositions- targets- genes- disease.” The potential targets and their enrichment pathways were visualized using ClueGO and CytoHubba. Wistar male rats were randomly divided into normal group, model group and low-, medium- and high- dose (0.43, 0.86, 1.72 g·kg-1) THL groups. The diabetic model was replicated by introperitoneally injecting streptozotocin (STZ). The followup experiment was carried out with corresponding drug. Pancreatic islet function index calculation, pathological section staining, and PCR detection were then carried out. Results There were 23 active ingredients in THL, 434 predicted targets, 1 200 disease genes. A total of 146 common genes in THL and diabetes were obtained by Venn analysis. It was found that THL in the treatment of diabetes was mainly related to regulating insulin secretion, glucose transmembrane transport, activation of protein kinase, promoting vascular growth and MAPK cascade reaction, which were involved seven core targets including protein kinase B alpha (AKT1), glyceraldehyde -3- phosphate glyceraldehyde dehydrogenase (GAPDH), vascular endothelial growth factor A (VEGFA), mitogen activated protein kinase 1 (MAPK1), prostaglandin endoperoxide synthase (PTGS2), signal transduction and transcription activating factor 3 (STAT3), and Toll-like receptor 4 (TLR4) . Animal validation results showed that THL could increase HOMA- β index (P＜0.01), promote recovery of pancreatic islet volume and β cell function, decrease the number of α cell, and significantly up-regulate the expression of AKT1 and GAPDH genes in rat pancreatic tissue (P＜0.001), as well as down-regulate the expression of VEGFA, MAPK1, PTGS2, STAT3, and TLR4 genes (P＜0.001, P＜0.0001). The partial prediction of network pharmacology results were validated with the experimental results. Conclusion THL can treat diabetes through multiple targets and pathways. It is confirmed that THL could achieve the effect of treating diabetes by regulating seven key target genes including AKT1, GAPDH, VEGFA, MAPK1, PTGS2, STAT3 and TLR4 to regulate the function of pancreatic islet β cells. This study can provide a reliable basis for the clinical use and basic research of THL in antidiabetes. [ABSTRACT FROM AUTHOR]

To improve the picking efficiency of AGVs in intelligent warehouse systems, aiming at two sub-problems of AGVshelf task allocation and multi-AGV conflict-free path planning, this paper introduced order splitting strategy according to the order characteristics and built a mathematical model with the objective of minimizing the total time for AGVs to complete all orders. Firstly, it designed the ASTA to solve the matching problem by determining the shelf priority. Secondly, it proposed an improved Q-Learning algorithm with a greedy parameter and embedded conflict elimination strategy to obtain the optimal conflict-free picking path scheme under the splitting strategy. Finally, through experimental comparative analysis of order set values in the 40 m × 40 m warehouse layout, the proposed algorithm was compared with the two existing algorithms. The results indicate that the proposed algorithm reduced the total time for AGVs to complete the all orders by an average of 11.63% and 26.74% respectively, which verified the effectiveness of the splitting strategy. And it was verified that the splitting strategy and the proposed algorithm can effectively alleviate the congestion, reduce the length of traveling paths and improve the picking efficiency, through the comparison of three indexes of the number of AGVs used, the time of complete orders and the percentage of waiting time for path conflict. Furthermore, for the sensitivity on the number of AGVs, it tested the influence of different numbers of AGVs on the travel time and path conflict waiting time. It was found that the number of 19 AGVs is the optimal configuration. These results verify the feasibility of the model and the effectiveness of the proposed algorithm. [ABSTRACT FROM AUTHOR]

Copyright of Acta Scientiarum Naturalium Universitatis Sunyatseni / Zhongshan Daxue Xuebao is the property of Sun-Yat-Sen University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To conduct a deep-level analysis of the causes of civil aviation accidents for the purpose of preventing accidents, addressing the current incompleteness of accident data statistics, and ensuring the credibility and depth of accident causation analysis, accident report data from global civil aviation accidents in the year 2000 were collected as samples and subjected to structured processing. The accident data were categorized based on stages, types, and other fields, and statistical analysis was conducted. Utilizing the K-means algorithm, civil aviation safety risk factors were clustered from multiple perspectives, comparing the differences between structured and unstructured processing results. Various risk factors' combined impact on accidents was comprehensively considered. Key risky factors from the word cloud diagram and latent topic distribution in text data identified through LDA( latent dirichlet allocation) topic modeling were used to analyze accident causation. This study provides valuable reference information and safety recommendations for future civil aviation safety from multiple aspects. [ABSTRACT FROM AUTHOR]

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective] The aims of this study are to determine the distribution pattern of soil water in desert dunes, to clarify the relationship between soil water and various terrain and vegetation factors, so as to provide scientific and reasonable suggestions for the protection and reconstruction of vegetation in desert areas. [Methods] There were four different micro-landforms, including windward slope, leeward slope, hill top and bottom. The soil moisture was divided into surface (0-40 cm), middle (40-200 cm) and deep (200-300 cm) layers. The distribution characteristics of soil water on different micro-landforms and depths in Gurbantunggut Desert were studied on the small scale. Generalized linear model, generalized additive model and random forest were used to study the relationship between soil moisture and topographic- vegetation factors. [Results] (1) The soil moisture on the windward slope and the bottom of the hill was higher than that on the lee slope and the top of the hill at different depths. There were significant differences of surface soil moisture between the lee slope (including the top and bottom of the hill) and the windward slope. (2) The effect of topographic factors on soil moisture was greater than that of vegetation factors. The main factors affecting surface soil water were slope and slope direction. The main factors affecting middle and deep soil water was shrub cover. (3) The fitting effect of the random forest was significantly higher than that of the generalized linear model and generalized additive model. [Conclusion] As for soil moisture on different micro-landforms, topographic factors have a greater impact on mobile dunes in Gurbantunggut Desert than vegetation factors. Slope and slope direction have the important influence on surface soil moisture. Shrub cover has a major effect on middle and deep soil moisture. [ABSTRACT FROM AUTHOR]

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of South China Fisheries Science is the property of South China Fisheries Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the gradual improvement of the understanding of sleep disorders and sleep diseases in modern medicine, actigraphy as an objective sleep monitoring device has been paid more and more attention by scholars. In this study, the consistency of actigraphy and polysomnography in sleep monitoring was reviewed in order to provide reference for future research on sleep quality monitoring and management. (随着现代医学对睡眠障碍和睡眠疾病的认识逐渐提高, 体动记录仪作为客观睡眠监测设备越来越受到学者们的关注。本文对体动记录仪与多导睡眠监测仪在睡眠监测应用中一致性研究进行综述, 以期为未来研究睡眠质量监测和管理提供参考。)

This paper reviewed the nursing experience of an elderly patient with ischemic cerebrovascular disease complicated with pulmonary infection. On the basis of routine treatment and nursing intervention of pulmonary infection, the traditional Chinese medicine aerosol inhalation nursing was given. The implementation of atomized inhalation of traditional Chinese medicine can obviously reduce the viscosity of sputum of patients, and reduce the number of times of daily sputum aspiration. (本文回顾1例缺血性脑卒中并发肺部感染老年患者的护理经验。在常规肺部感染治疗、护理干预的基础上, 给予中药雾化吸入。中药雾化吸入能够有效降低患者痰液的黏稠度, 减少患者每日吸痰次数。)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Oilfield Chemistry is the property of Sichuan University, Oilfield Chemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The intensification of agriculture has led to the loss of non-crop habitats, resulting in a sharp decline in farmland biodiversity and weakening the control of agricultural pests by their natural enemies. The resurgence of pests and the serious threat of pesticide residue contamination pose significant risks to food security. Conservation of farmland biodiversity through farmland habitat management and the utilization of ecological control of crop pests based on the balance among organisms are crucial for addressing the ecological and environmental issues in intensified farmland. It represents the fundamental approach to promoting green and sustainable agricultural development. This paper briefly outlines the development of ecological pest control in agriculture, systematically summarizes the concepts, principles, techniques, and advancements in farmland habitat management. It focuses on prospects for theoretical research, methodological advancements, and organizational practices in non-crop habitat management, aiming to provide insights for theoretical research and practical applications in ecological pest control of agricultural crops [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Publishing Journal is the property of Wuhan University, School of Information Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Resources & Environment / Nongye Ziyuan yu Huanjing Xuebao is the property of Journal of Agricultural Resources & Environment Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Resources & Environment / Nongye Ziyuan yu Huanjing Xuebao is the property of Journal of Agricultural Resources & Environment Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the inhibitory effects of human fetal dermal mesenchymal stem cells (FDMSCs) on proliferation, migration, and invasion of human melanoma cells (A375 cells). Methods FDMSCs were extracted by en zyme digestion method from the back skin of healthy fetuses at 16-20 weeks of gestation and identified. A375 cells were se lected and divided into three groups. FDMSCs conditional medium was added to the F-CM group, adult dermal fibroblasts conditional medium was added to the A-CM group, and DMEM low-glycemic blank medium was added to the Control group. CCK-8 cell proliferation assay, wound healing assay and cell invasion assay were used to measure the relative cell vitality, cell migration rate and the number of invasive cells in each group. Results FDMSCs could be successfully extracted from human fetal skin with positive expression of MSCs specific markers like CD44, CD90, CD105 and embryonic specific markers like SSEA-4 and OCT-4. Furthermore, FDMSCs had the ability of multidirectional differentiation into lipid, bone and cartilage. Compared with Control group, the relative cell viability, cell mobility and the number of invasive cells in the F-CM group decreased (all P<0. 05). Conclusion FDMSCs can inhibit proliferation, migration, and invasion of A375 cells. [ABSTRACT FROM AUTHOR]

Copyright of China Plastics / Zhongguo Suliao is the property of Journal Office of CHINA PLASTICS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Warm-needling moxibustion can effectively treat knee osteoarthritis. Degeneration, injury and fracture of the anterior cruciate ligament can affect the local stability of the knee joint, and then induce the formation of knee osteoarthritis. Whether warm-needling moxibustion can repair the injured cruciate ligament and the mechanism of action are still unclear. OBJECTIVE: To observe the effects of warm-needling moxibustion on the morphology of the anterior cruciate ligament and the expression of insulin growth factor-1 and transforming growth factor-β in rabbits with knee osteoarthritis and to clarify the mechanism of anterior cruciate ligament repair by warmneedling moxibustion. METHODS: Thirty New Zealand rabbits were randomly divided into blank group, model group and warm-needling moxibustion group, with 10 rabbits in each group. Knee osteoarthritis model was established by plaster cast immobilization. The blank group was not intervened. Rabbits in the model group rabbits were fixed in a rabbit holder for 15 minutes every day. The warm-needling moxibustion group was treated with warm acupuncture, once a day, 7 days as a course of treatment, a total of two courses. After treatment, the imaging changes of the anterior cruciate ligament were observed by MRI and MRI grading statistics were performed. Morphological changes of the anterior cruciate ligament were observed by transmission electron microscope and hematoxylin-eosin staining. mRNA and protein expressions of insulin growth factor-1 and transforming growth factor-β were detected by RT-PCR and western blot, respectively. RESULTS AND CONCLUSION: MRI examination: Compared with the blank control group, the anterior cruciate ligament in the model group was thickened, edematous, and partially torn, and the difference in grading statistics was statistically significant (P < 0.05). Compared with the model group, the anterior cruciate ligament in the warm-needling moxibustion group was slightly thickened, with mild edema and no tearing, and the difference in grading statistics was statistically significant (P < 0.05). General observation: In the model group, the surface of the anterior cruciate ligament was glossy and faded, with the edge being covered with flocculent periosteum and obvious tissue necrosis; in the warm-needling moxibustion group, the surface of the ligament was glossy, and the ligament was in a normal helical shape. Hematoxylin-eosin staining: In the model group, there was obvious tissue necrosis in the anterior cruciate ligament, a large number of new capillaries, loosely arranged fibroblasts and collagen fibers. In the warm-needling moxibustion group, there was a small amount of tissue necrosis and few new vessels in the anterior cruciate ligament, and the cells and collagen fibers were loosely and irregularly arranged. Transmission electron microscopy: In the model group, the fibers in the anterior cruciate ligament were arranged in a disordered way with uneven thickness and distribution, and there are more fibroblasts that were irregular in morphology; in the warm acupuncture group, the fibers were basically arranged longitudinally, with uneven thickness and distribution, and a small number of oval-shaped fibroblasts were observed. RT-PCR and western blot assay: mRNA and protein expressions of insulin growth factor-1 and transforming growth factor-β were significantly decreased in the model group compared with the blank control group (P < 0.05), but significant increased after treatment with warm-needling moxibustion (P < 0.05). To conclude, warm-needling moxibustion can alleviate anterior cruciate ligament injury and regulate the expression of insulin growth factor-1 and transforming growth factor-β to treat knee osteoarthritis. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Aesthetic & Plastic Surgery is the property of Chinese Journal of Aesthetic & Plastic Surgery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)