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目的评价含泊马度胺全口服治疗方案二线治疗多发性骨髓瘤的疗效与安全性。方法回顾性分析2020年3月至2023年12月在我中心接受含泊马度胺全口服方案作为二线治疗的多发性骨髓瘤患者共22例，评价其疗效与安全性。结果22例患中位年龄为71.5岁，含泊马度胺的全口服二线治疗方案包括IPD 7例，PCD 11例， XPD 2例，PD 2例，中位治疗周期数为14，二线治疗ORR为63.64%，VGPR以上疗效为 36.36%。有来那度胺暴露史的13例患者中，ORR为53.85%， VGPR以上疗效为23.08%；无来那度胺暴露史的9例患者中， ORR为77.78%，VGPR以上疗效为55.56%；两组ORR比较，差异无统计学意义（P=0.38）。伴遗传学高危的患者12例，ORR为50%，VGPR以上疗效为16.67%。整体中位随访时间10.6（2.0，39.3）个月，10例出现疾病进展，其中6例因原发病进展死亡，中位无进展生存期（PFS）尚未达到；其中来那度胺暴露的13例患者，中位PFS为10.6个月；非来那度胺暴露的9例患者，中位PFS未达到。≥3级不良事件占18.18%，包括粒细胞缺乏、血小板减少及肺部感染。没有导致死亡的治疗相关不良事件的发生。结论含泊马度胺全口服方案二线治疗多发性骨髓瘤具有较好的疗效及安全性，对有居家治疗意愿的老年多发性骨髓瘤患者具有积极的意义。

This article used Fu tea as raw material to compare the physical properties, micro-structure, active ingredient content and in vitro antioxidant, hypoglycemic and hypolipidemic activities of Fu tea powder with different particle sizes after micro-crushing to determine the optimal grinding degree of Fu tea powder. The results showed that the particle size D50 of 200 mesh Fu tea powder was 76.45±4.32 µm, the angle of repose was 50.3°, the slip angle was 47.0°, the water holding capacity was 2. 477 g/g, the oil holding capacity was 1.934 g/g, and the polysaccharide content was 11.9%, the polyphenol content was 37.1%, the DPPH clearance rate was 80.4%, the a-glucosidase inhibition rate was 72.7%, the cholate binding rate was 71.6%, and 200 mesh is the optimal crushing size of Fu tea powder. This study will provide a theoretical reference for raw material processing of Fu tea powder hypoglycemic and hypolipidemic functional food. [ABSTRACT FROM AUTHOR]

BACKGROUND: There is an internal relationship between hyperhomocysteinemia and vascular calcification. However, the pathogenesis of hyperhomocysteinemia promoting vascular calcification is still unclear. OBJECTIVE: To investigate the role of bone morphogenetic protein-2 in hyperhomocysteinemia-induced vascular calcification. METHODS: Human carotid wax samples were divided into a calcified group (n=29) and a non-calcified group (n=13) according to the presence or absence of calcified plaque. Sixteen ApoE-/- mice were randomly divided into a control group and a hyperhomocysteinemia group, with 8 mice in each group. Bone morphogenetic protein-2 vector was used to transfect rat thoracic artery smooth muscle A7r5 cells, and gradient concentration of homocysteine (50, 100, 200, and 400 μmol/L) was utilized to treat A7r5 cells. Calcification was detected by alizarin red staining and hematoxylin-eosin staining. The interaction of bone morphogenetic protein 2 with Runt-related transcription factor 2 was detected by immunofluorescence, and the expressions of bone morphogenetic protein 2, Runt-related transcription factor 2, and α-smooth muscle actin were detected by immunohistochemistry and western blot assay. RESULTS AND CONCLUSION: (1) Human carotid artery tissue staining revealed that compared with the non-calcification group, inflammatory cells increased and calcification positive rate increased in the calcification group (P < 0.05). Compared with the non-calcification group, the expressions of bone morphogenetic protein-2 and Runt-related transcription factor 2 were up-regulated, and the expression of α-smooth muscle actin was decreased in the calcification group (all P < 0.05). (2) The staining of mouse arterial specimens exhibited that, the positive rate of calcified area in the hyperhomocysteinemia group was significantly higher than that in the control group (P < 0.05); serum homocysteine level in the hyperhomocysteinemia group was significantly higher than that in the control group (P < 0.05). Compared with the control group, the expressions of bone morphogenetic protein-2 and Runt-related transcription factor 2 were up-regulated, and the expression of α-smooth muscle actin was decreased in the hyperhomocysteinemia group (all P < 0.05). (3) A7r5 cell culture analysis demonstrated that with the increase of homocysteine concentration gradient, the degree of calcification, the content of bone morphogenetic protein-2 and Runt-related transcription factor 2 protein in A7r5 cells increased (P < 0.05), and the content of α-smooth muscle actin protein decreased (P < 0.05). (4) The A7r5 cell culture analysis of overexpressed bone morphogenetic protein 2 showed that the calcification degree of the overexpressed bone morphogenetic protein 2 group was increased compared with the corresponding control group, the β-sodium glycerophosphate group, and the homocysteine group. RUNtrelated transcription factor 2 expression up-regulated (P < 0.05) and α-smooth muscle actin expression down-regulated (P < 0.05). (5) The expression of bone morphogenetic protein 2 increased in A7r5 cells cultured with homocysteine in calcified medium, and the expression of Runt-related transcription factor 2 increased with the increase of bone morphogenetic protein 2 expression. (6) The results confirm that bone morphogenetic protein-2 is a key target gene in the regulation of smooth muscle cell phenotypic transformation resulting in vascular calcification by hyperhomocysteinemia. Targeted regulation of bone morphogenetic protein-2 reduces hyperhomocysteinemia-induced vascular calcification. [ABSTRACT FROM AUTHOR]

Copyright of Industrial Minerals & Processing / Huagong Kuangwu yu Jiagong is the property of Industrial Minerals & Processing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi is the property of Editorial Board of Journal of Clinical Neurosurgery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shaanxi University of Science & Technology is the property of Journal of Shaanxi University of Science & Technology Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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The application of Internet technology in daily life is becoming increasingly widespread, which not only affects the way the government interacts with society, but also brings new social issues and governance challenges. Among them, the political trust issues related to social stability require particular attention. Previous studies on the political impact of Internet use in China have largely failed to distinguish between different ways of Internet use, and there is also a lack of classification and comparison of research on the intermediary mechanisms of Internet impact on political trust. This article selects rational choice and social capital as research perspectives from two major sources of political trust: institutionalism and culturalism. Using JSNET 2014 survey data, it explores the direct and intermediary effects of Internet use on political trust, and compares the differences in effects brought about by different Internet use methods. By analyzing the logical relationship between the vertical and horizontal information dissemination mechanism in the Internet era through the government performance evaluation and social capital construction; the Internet usage can be divided into four types: collective intervention-social orientation, collective intervention-entertainment orientation, individual intervention-social orientation, and individual intervention-entertainment orientation. This paper explores the characteristic orientation and political impact of each type of behavior. Overall, Internet use negatively affects political trust, but the direct impact of different Internet use methods on political trust is different. It is also found that both government performance evaluation and social capital construction are the intermediary mechanisms for the indirect impact of the Internet on political trust, but they have the opposite effect. Specifically, government performance evaluation is the main intermediary path for the negative impact of the Internet on political trust, while social capital construction has, to some extent, suppressed the negative impact of the Internet on political trust. It is speculated that the information dissemination mechanism of the internet conforms to the logic of bottom-up social capital construction. Moreover, the direct and indirect effects of different internet usage on political trust are different, which may be due to the fact that the political relevance of different types of internet use is essentially different. Social orientation is a relatively stronger influencing factor, and the weakening effect of individual intervention on trust and participation does not offset the positive impact of social orientation. This research answers the question of “how Internet use affects political trust” from the perspectives of usage patterns and intermediary mechanisms, which helps to dialectically view the positive and negative effects of information technology. The research conclusions also have certain policy implications. Political trust is the embodiment of the tension between government and society. The government needs to implement effective policy measures to gather public opinion to ensure the legitimacy of governance, which is the embodiment of national governance ability. The institutionalist research path reflects this top-down power operation logic. People need to enhance trust through spontaneous political participation to maintain their political rights, which is a demand from society. The path of cultural research reflects this bottom-up social impact process. The Internet technology can be used not only as a tool for government empowerment by improving governance capabilities and upgrading governance models, but also as a channel for public empowerment by promoting citizens' political participation and driving political and social collaboration and co-governance, which further increases the complexity and uncertainty of the relationship between the government and the public, and has an inherent logical correspondence with the two types of research paths of political trust sources. [ABSTRACT FROM AUTHOR]

Copyright of Coal Geology & Exploration is the property of Xian Research Institute of China Coal Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：分析公共卫生护理在社区卫生机构中的作用。方法：选取2022年7月-2023年7月本院92例社区卫 生机构慢性病患者开展研究，随机平均分为对照组46例，行常规护理，观察组46例，联合公共卫生护理，比较两组 心理状态, 相应指标改善情况, 生活质量和治疗依从性。结果：观察组的SF-36评分, 定期检查, 规律用药, 调整饮 食, 坚持锻炼评分和HDL均明显高于对照组，SAS, SDS评分, 2hPG, 血压, HbA1c, LDL, TG, TC, BMI和FBG 均明显低于对照组（P ＜ 0.05）。结论：在社区卫生机构中实施公共卫生护理，能有效防控慢性病，提升身心健康水 平，患者依从性更高，具有推广价值。 [ABSTRACT FROM AUTHOR]

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Copyright of Plastics Science & Technology / Suliao Ke-Ji is the property of Plastics Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shaanxi University of Science & Technology is the property of Journal of Shaanxi University of Science & Technology Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Geology & Exploration is the property of Xian Research Institute of China Coal Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shaanxi University of Science & Technology is the property of Journal of Shaanxi University of Science & Technology Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evaluate the feasibility of secondary transplantation for patients with acute leukemia after failure of the first haploidentical hematopoietic stem cell transplantation. Methods Two acute leukemia patients underwent the first haploidentical hematopoietic stem cell transplantation from two donors with thalassemia, and the number of collected CD34+ cells was 2.57×106 /kg and 1.99×106 /kg per donor, respectively. The first haploidentical hematopoietic stem cell transplantation failed. Secondary transplantation was performed from two non-thalassemia donors, and the number of collected CD34+ cells was 4.28×106 /kg and 5.75×106 /kg per donor, respectively. A reducedintensity conditioning regimen consisting of fludarabine (Flu), busulfan (Bu) and antithymocyte globulin (ATG) was adopted for the secondary transplantation. Results For two recipients, the time of secondary transplantation of neutrophil and platelet was +12 d and +10 d, +10 d and +10 d, respectively. Up to the final follow-up (+1 062 d and +265 d after secondary transplantation), the primary diseases of both two recipients have been completely relieved without evident post-transplantation complications. Conclusions Secondary transplantation with reduced-intensity conditioning regimen may successfully treat acute leukemia after failure of the first haploidentical hematopoietic stem cell transplantation. [ABSTRACT FROM AUTHOR]