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Objective To investigate ẞ2-adrenergic receptor (ADRB2) rs1042713, immunoglobulin E high affinity receptor 2 (FCER2) rs28364072, interleukin-13 (IL-13) rs20541 and interleukin-4 (IL-4) rs2243250 gene polymorphisms, environmental factors and their interactions on the incidence of childhood asthma in Chongqing, aiming to provide scientific basis for the early diagnosis and effective prevention and treatment of childhood asthma. Methods A total of 88 children with asthma who visited the pediatric asthma clinic of the hospital from November 2020 to September 2022 were selected as the case group, and 80 non- asthmatic healthy children who underwent physical examination in the children's health care department of the hospital during the same period were selected as the control group. The demographic data of the two groups were collected, and the target genes were detected by multiplex polymerase chain reaction (PCR) combined with high-throughput sequencing technology. Logistic regression was used to analyze the effect of environmental factors on childhood asthma, and generalized multifactor dimensionality reduction (GMDR) was used to deeply explore the interaction between genes and environment. Results Cockroach exposure (OR = 2.791,95%CI 1.353-5. 353-5.757,P=0.005) and pet exposure (OR=3.055,95% CI 1.453-6.423,P=0.003) were significant risk factors for asthma in children, and the differences were statistically significant. There were significant differences in the genotype distribution of rs1042713, rs28364072 and rs20541 between the two groups (P<0.05). There was no significant difference in the genotype distribution of rs2243250 between the two groups (P>0.05). There was no significant difference in the genotype distribution of rs2243250 between the two groups (P<0.05). Conclusion Cockroach and pet exposure are important factors that increase the risk of childhood asthma in Chongqing, and the rs1042713, rs2836072 and rs20541 gene polymorphisms are closely related to the susceptibility to childhood asthma. The interaction of these gene polymorphisms and environmental factors affects the risk of childhood asthma. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Irrigation & Drainage is the property of Journal of Irrigation & Drainage Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to deepen the recognition of the trend of synergistic evolution of water resources, energy, food and ecosystem in China, a water-energy-food-ecology multi-dimensional system index system was constructed, and the coupling coordination degree model was applied to evaluate the coupling coordination degree of water resources-energy-food-ecology from 2005 to 2020 in China, and the driving force analysis was conducted by using multi-factor attribution analysis. The results show that the coupling degree of water resources-energy-food-ecosystems in China has increased from 0.55 in 2005 to 0.84 in 2020, and the coupling degree of each region has transitioned from a barely coordinated development level to an intermediate coordinated development level, and the driving force for the increase of the coupling degree of the each subsystem has gone through the process of being dominated by food subsystem, ecological subsystem and the water resources subsystem; although the contribution of the energy subsystem is relatively smaller, it may be a breakthrough for the regions to improve the coordinated development level of the multidimensional system of water resources-energy-food-ecosystem in the future. [ABSTRACT FROM AUTHOR]

Refractory asthma in children seriously affects their lung function and quality of life. There are no guidelines for the diagnosis and treatment of refractory asthma in children in China. This article reviews the research progress on childhood refractory asthma in terms of genetic, environmental, socio-psychological factors. Through genetic testing and biological indicators, early identification of refractory asthma in children and individualized treatment based on molecular level, combined with the control of environmental factors and psychosocial factors, provide new ideas for the prevention and control of refractory asthma in children. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nanjing Medical University: Natural Sciences is the property of Journal of Nanjing Medicial University (NMU) Medical Publications Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Biomass Chemical Engineering is the property of Editorial Office of Biomass Chemical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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