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基于无源物联网的定位系统具有低成本、可标记的特点，适用于需要对大量目标进行定位的场景。传统无源物联网定位多应用于资产管理、物料跟踪等室内场景，随着蜂窝无源物联网的兴起，无源物联网定位技术将拥有更广阔的应用空间。基于此背景，在分析不同定位技术的原理及特点的基础上，介绍了无源物联网定位的最新研究进展，并根据实现原理将无源物联网定位技术总结为基于几何测量、基于指纹特征和基于成像技术的3类定位方法。鉴于当前研究大多采用在传统无源物联网架构和协议下获取的数据进行定位，从架构、协议、数据3个层面分析无源物联网定位技术的未来发展方向，以期为无源物联网定位技术研究提供新的思路。

Objective To explore the efficacy of combination therapy of Ginkgo biloba injection and donepezil in the treatment of Alzheimer's disease (AD) based on cerebral hemodynamics and inflammatory factors. Methods A total of 90 patients with AD in Zhangjiakou Shalingzi Hospital from March 2020 to January 2022 were randomly divided into a control group ( 45 cases) and a study group (45 cases) . Both groups received the conventional symptomatic treatment. On this basis, the control group was given donepezil treatment, and the study group was given ginkgo leaf injection combined with donepezil treatment. The therapeutic effects, cerebral hemodynamic parameters [mean flow velocity (MFV) and pulsatility index (PI) of bilateral middle cerebral arteries (bilateral MCA) and basilar arteries (BA)], inflammatory factors [interleukin-6 (IL-6), tumor necrosis factorα (TNF-α), IL-1β], s100β protein, Aβ-amyloid 1-42 ( Aβ1-42), bradykinin (BK), cognitive function, activities of daily living, and adverse reactions were compared between the two groups. Results Compared with the control group (77.78%), the total effective rate of the study group (93.33%) was significantly improved (P < 0.05); 1, 3, and 6 months after the treatment, the MFV of BA and bilateral MCA in the study group was higher than that in the control group, while the PI of BA and bilateral MCA was lower than that in the control group (P < 0.05); The levels of serum TNF-α, IL-6, and IL-1β in the study group were lower than those in the control group 1, 3, and 6 months after the treatment (P < 0.05); 1, 3, and 6 months after the treatment, the levels of serum s100β protein, Aβ1-42, and BK in the study group were lower than those in the control group（P< 0.05); 1, 3, and 6 months after the treatment, the score of the mini-mental state examination scale (MMSE) in the study group was higher than that in the control group, while the scores of the AD assessment subscale cognitive scale (ADAS-cog) and activities of daily living scale (ADL) were lower than those in the control group (P < 0.05); The incidence of adverse reactions in the study group (13.33%) was not significantly different from that in the control group (8.89%) (P > 0.05). Conclusion The efficacy of ginkgo biloba injection combined with donepezil in the treatment of AD is significant, which may be achieved by improving cerebral hemodynamics, downregulating inflammatory factors, and regulating the levels of serum s100β protein, Aβ1-42, and BK. [ABSTRACT FROM AUTHOR]

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