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Backgroud and Purpose: Despite advances in surgical technique, excess bleeding remains a major complication associated with surgery and contributes to poor clinical outcomes. A haemostatic agent with broad applicability and minimal adverse effects such as TXA is attractive as a way to control pathologic haemorrhage. Data for its use in L.C is limited. A study to review the use of TXA in controlling bleeding in uncomplicated L.C, measured in terms of drain output, preoperative and postoperative hemoglobin and hematocrit and hospital stay related to bleeding. Materials and Method: Patients were randomly divided into 4 groups of 25 patients each by Group A: receiving 10 ml I/v TXA, 30 min prior to surgery and 10ml Topical NS, Group B: receiving I.v dose of 10ml of NS, 30 min prior to surgery and 10ml TXA topically, Group C: receiving 10 ml i.v TXA, 30 min prior to surgery and 10mlof topical TXA intraoperatively, Group D: receiving 10 ml i.v NS, 30min. prior to surgery and 10ml topical NS intraoperatively. Results:The drain output and the hospital stay of the patients has significantly reduced. Group C (34.8 as compared to other TXA groups. Whereas in group-D: drain output was found to be significantly higher (81.08 and the hospital stay of the patient prolonged for a day as well. Thus use of TXA in uncomplicated L.C is recommended. Conclusion: We concluded from our study that the groups where TXA was used in either intravenous or topical or in both the forms. [ABSTRACT FROM AUTHOR]

Introduction: Successful treatment in the endodontics and periodontics depends on the periapical status. Hence, in the present meta-analysis, we evaluate the various bone regenerative materials in the periapical surgeries. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were bone regenerative, bone grafts, bio materials, periapical surgery, and endodontic surgery. Based on the PRISMA guidelines, the meta-analysis was performed. The studies for the past 10 years were considered that included at least 10 patients. The translatable articles were included that had the human studies that were clinical studies and/or trials and also had the bone regenerative materials used in the procedure. Results: A total of 475 articles were selected, of which 30 were selected based on the criteria. Of these, after the removal of the 21 duplicate articles, 9 articles were finalized. The meta-analysis showed that when the bone graft materials are used along with the barriers for the regeneration, there were observed higher success rates. Conclusions: The bone regenerative materials can be used for the successful outcome for the periapical surgeries. The guided tissue regeneration along with the bone regenerative materials may aid in the good prognosis of the endodontic and periodontal cases. [ABSTRACT FROM AUTHOR]