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13 results on '"Adam, Jonathan"'

1. Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study

Author

Sharma, Sapna, Dong, Qiuling, Haid, Mark, Adam, Jonathan, Bizzotto, Roberto, Fernandez-Tajes, Juan J., Jones, Angus G., Tura, Andrea, Artati, Anna, Prehn, Cornelia, Kastenmüller, Gabi, Koivula, Robert W., Franks, Paul W., Walker, Mark, Forgie, Ian M., Giordano, Giuseppe, Pavo, Imre, Ruetten, Hartmut, Dermitzakis, Manolis, McCarthy, Mark I., Pedersen, Oluf, Schwenk, Jochen M., Tsirigos, Konstantinos D., De Masi, Federico, Brunak, Soren, Viñuela, Ana, Mari, Andrea, McDonald, Timothy J., Kokkola, Tarja, Adamski, Jerzy, Pearson, Ewan R., and Grallert, Harald

Published
2024
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2. Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i

Author

Harada, Makoto, Adam, Jonathan, Covic, Marcela, Ge, Jianhong, Brandmaier, Stefan, Muschet, Caroline, Huang, Jialing, Han, Siyu, Rommel, Martina, Rotter, Markus, Heier, Margit, Mohney, Robert P., Krumsiek, Jan, Kastenmüller, Gabi, Rathmann, Wolfgang, Zou, Zhongmei, Zukunft, Sven, Scheerer, Markus F., Neschen, Susanne, Adamski, Jerzy, Gieger, Christian, Peters, Annette, Ankerst, Donna P., Meitinger, Thomas, Alderete, Tanya L., de Angelis, Martin Hrabe, Suhre, Karsten, and Wang-Sattler, Rui

Published
2024
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4. Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Author

Brown, Andrew A., Fernandez-Tajes, Juan J., Hong, Mun-gwan, Brorsson, Caroline A., Koivula, Robert W., Davtian, David, Dupuis, Théo, Sartori, Ambra, Michalettou, Theodora-Dafni, Forgie, Ian M., Adam, Jonathan, Allin, Kristine H., Caiazzo, Robert, Cederberg, Henna, De Masi, Federico, Elders, Petra J. M., Giordano, Giuseppe N., Haid, Mark, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew T., Heggie, Alison J., Howald, Cédric, Jones, Angus G., Kokkola, Tarja, Laakso, Markku, Mahajan, Anubha, Mari, Andrea, McDonald, Timothy J., McEvoy, Donna, Mourby, Miranda, Musholt, Petra B., Nilsson, Birgitte, Pattou, Francois, Penet, Deborah, Raverdy, Violeta, Ridderstråle, Martin, Romano, Luciana, Rutters, Femke, Sharma, Sapna, Teare, Harriet, ‘t Hart, Leen, Tsirigos, Konstantinos D., Vangipurapu, Jagadish, Vestergaard, Henrik, Brunak, Søren, Franks, Paul W., Frost, Gary, Grallert, Harald, Jablonka, Bernd, McCarthy, Mark I., Pavo, Imre, Pedersen, Oluf, Ruetten, Hartmut, Walker, Mark, Adamski, Jerzy, Schwenk, Jochen M., Pearson, Ewan R., Dermitzakis, Emmanouil T., and Viñuela, Ana

Published
2023
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5. Moral distress among intensive care unit professions in the UK: a mixed-methods study

Author

Joyce Yeung, Christopher Bassford, Anne-Marie Slowther, and Adam Jonathan Boulton

Subjects
Medicine
Abstract

Objective To assess the experience of moral distress among intensive care unit (ICU) professionals in the UK.Design Mixed methods: validated quantitative measure of moral distress followed by purposive sample of respondents who underwent semistructured interviews.Setting Four ICUs of varying sizes and specialty facilities.Participants Healthcare professionals working in ICU.Results 227 questionnaires were returned and 15 interviews performed. Moral distress occurred across all ICUs and professional demographics. It was most commonly related to providing care perceived as futile or against the patient’s wishes/interests, followed by resource constraints compromising care. Moral distress score was independently influenced by profession (p=0.02) (nurses 117.0 vs doctors 78.0). A lack of agency was central to moral distress and its negative experience could lead to withdrawal from engaging with patients/families. One-third indicated their intention to leave their current post due to moral distress and this was greater among nurses than doctors (37.0% vs 15.0%). Moral distress was independently associated with an intention to leave their current post (p

Published
2023
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6. Stensikker Biodiversitet: Et studie i biodiversitetseffekterne ved udlægning af sten

Author

Jørgensen, Erik Røj, Gøricke, Adam Jonathan, Jørgensen, Erik Røj, and Gøricke, Adam Jonathan

Abstract

Dansk natur er i en dårlig tilstand, og naturgenopretning er derfor på dagsordenen. En metode til at genoprette natur er genudlægning af store sten. Følgende opgave undersøger behovet for stenudlægning, ved at analyse arter og artsgruppers tilknytning til sten. Det foregår ved en analyse af den danske rødliste, der sammenligner stenlevende arters risiko for at uddø. Desuden indhentes og analyseres videnskabelige artikler i et litteraturstudie, der baserer sig på metoden ”Systematisk litteraturstudie”. Til slut undersøges en naturlig forekomst af sten på øen Hornfiskrøn, med baggrund i rewilding-teorien. Opgavens finder, at mange arter er tilknyttet sten, men at størrelsen, placeringen og typen har betydning for hvilke økologiske nicher, der genskabes ved udlægning. Opgaven afsluttes derfor med en guide, der indeholder konkrete anbefalinger til udlægning af sten. Her anbefales blandt andet prioritering af lokalitet, hvor stenene med fordel kan placeres, stenenes størrelse og mængden af sten pr. hektar., Danish nature is in poor condition, and nature restoration is therefore on the agenda. One method of restoring nature is the placement of large stones. The following bachelorproject examines the need for stone placement by analyzing species and species groups' association with stones. This is done through an analysis of the Danish “Rødliste”, comparing the extinction risk of stone-dwelling species. Additionally, scientific articles are collected and analyzed in a literature study based on the method "Systematic Literature Review." Finally, a natural occurrence of stones on the island of Hornfiskrøn is examined, based on rewilding-theory. The bachelorproject finds that many species are associated with stones, but the size, location, and type are important for the ecological niches recreated by the stone. The task concludes with a guide containing specific recommendations for stone placement. It recommends prioritizing the location where stones can be advantageously placed, the size of the stones, and the number of stones per hectare.

Published
2024

8. Metabolomics reveals reasons for the efficacy of acupuncture in migraine patients: The role of anaerobic glycolysis and mitochondrial citrate in migraine relief

Author

Gao, Zishan, primary, Yan, Xian-Zhong, additional, Wang-Sattler, Rui, additional, Covic, Marcela, additional, Yu, Guang, additional, Ge, Feifei, additional, Lin, Jia, additional, Chen, Qin, additional, Liu, Juan, additional, Sharma, Sapna, additional, Molnos, Sophie, additional, Kuehnel, Brigitte, additional, Wilson, Rory, additional, Adam, Jonathan, additional, Brandmaier, Stefan, additional, Yu, Shuguang, additional, Mansmann, Ulrich, additional, Liang, Fanrong, additional, and Gieger, Christian, additional

Published
2023
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10. Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Author

Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B., de Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E. Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T., ‘t Hart, Leen M., Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, McCarthy, Mark I., Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, S. ren, Froguel, Philippe, Thomas, Cecilia Engel, Haussler, Ragna, Beulens, Joline, Rutters, Femke, Nijpels, Giel, van Oort, Sabine, Groeneveld, Lenka, Elders, Petra, Giorgino, Toni, Rodriquez, Marianne, Nice, Rachel, Perry, Mandy, Bianzano, Susanna, Graefe-Mody, Ulrike, Hennige, Anita, Grempler, Rolf, Baum, Patrick, Stærfeldt, Hans-Henrik, Shah, Nisha, Teare, Harriet, Ehrhardt, Beate, Tillner, Joachim, Dings, Christiane, Lehr, Thorsten, Scherer, Nina, Sihinevich, Iryna, Cabrelli, Louise, Loftus, Heather, Bizzotto, Roberto, Tura, Andrea, Dekkers, Koen, van Leeuwen, Nienke, Groop, Leif, Slieker, Roderick, Ramisch, Anna, Jennison, Christopher, McVittie, Ian, Frau, Francesca, Steckel-Hamann, Birgit, Adragni, Kofi, Thomas, Melissa, Pasdar, Naeimeh Atabaki, Fitipaldi, Hugo, Kurbasic, Azra, Mutie, Pascal, Pomares-Millan, Hugo, Bonnefond, Amelie, Canouil, Mickael, Caiazzo, Robert, Verkindt, Helene, Holl, Reinhard, Kuulasmaa, Teemu, Deshmukh, Harshal, Cederberg, Henna, Laakso, Markku, Vangipurapu, Jagadish, Dale, Matilda, Thorand, Barbara, Nicolay, Claudia, Fritsche, Andreas, Hill, Anita, Hudson, Michelle, Thorne, Claire, Allin, Kristine, Arumugam, Manimozhiyan, Jonsson, Anna, Engelbrechtsen, Line, Forman, Annemette, Dutta, Avirup, Sondertoft, Nadja, Fan, Yong, Gough, Stephen, Robertson, Neil, McRobert, Nicky, Wesolowska-Andersen, Agata, Brown, Andrew, Davtian, David, Dawed, Adem, Donnelly, Louise, Palmer, Colin, White, Margaret, Ferrer, Jorge, Whitcher, Brandon, Artati, Anna, Prehn, Cornelia, Adam, Jonathan, Grallert, Harald, Gupta, Ramneek, Sackett, Peter Wad, Nilsson, Birgitte, Tsirigos, Konstantinos, Eriksen, Rebeca, Jablonka, Bernd, Uhlen, Mathias, Gassenhuber, Johann, Baltauss, Tania, de Preville, Nathalie, Klintenberg, Maria, Abdalla, Moustafa, Lundgaard, Agnete Troen [0000-0001-7447-6560], Hernández Medina, Ricardo [0000-0001-6373-2362], Johansen, Joachim [0000-0001-7052-1870], Niu, Lili [0000-0003-4571-4368], Biel, Jorge Hernansanz [0000-0002-3125-2951], Benros, Michael Eriksen [0000-0003-4939-9465], Pedersen, Anders Gorm [0000-0001-9650-8965], Jacobsen, Ulrik Plesner [0000-0001-9181-6854], Koivula, Robert [0000-0002-1646-4163], Vinuela, Ana [0000-0003-3771-8537], Haid, Mark [0000-0001-6118-1333], Hong, Mun-Gwan [0000-0001-8603-8293], Kennedy, Gwen [0000-0002-9856-3236], Thomas, E Louise [0000-0003-4235-4694], Frost, Gary [0000-0003-0529-6325], Hansen, Tue Haldor [0000-0001-5948-8993], Kaye, Jane [0000-0002-7311-4725], Hattersley, Andrew [0000-0001-5620-473X], Ridderstråle, Martin [0000-0002-3270-9167], Pedersen, Oluf [0000-0002-3321-3972], Hansen, Torben [0000-0001-8748-3831], Schwenk, Jochen M [0000-0001-8141-8449], Rasmussen, Simon [0000-0001-6323-9041], Brunak, Søren [0000-0003-0316-5866], Apollo - University of Cambridge Repository, Epidemiology and Data Science, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, General practice, ACS - Heart failure & arrhythmias, APH - Aging & Later Life, Graduate School, and APH - Methodology

Subjects
Biomedical Engineering, Type 2 diabetes, Bioengineering, Applied Microbiology and Biotechnology, Deep Learning, SDG 3 - Good Health and Well-being, Diabetes Mellitus, Type 2, Machine learning, Molecular Medicine, Humans, Data integration, IMI DIRECT Consortium, Systems biology, Algorithms, Biotechnology
Abstract

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate such data and applied it to a cohort of 789 people with newly diagnosed type 2 diabetes with deep multi-omics phenotyping from the DIRECT consortium. Using in silico perturbations, we identified drug–omics associations across the multi-modal datasets for the 20 most prevalent drugs given to people with type 2 diabetes with substantially higher sensitivity than univariate statistical tests. From these, we among others, identified novel associations between metformin and the gut microbiota as well as opposite molecular responses for the two statins, simvastatin and atorvastatin. We used the associations to quantify drug–drug similarities, assess the degree of polypharmacy and conclude that drug effects are distributed across the multi-omics modalities.

Published
2023
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11. Moral distress among intensive care unit professions in the UK: a mixed-methods study

Author

Adam Jonathan Boulton, Anne-Marie Slowther, Joyce Yeung, and Christopher Bassford

Subjects
General Medicine
Abstract

ObjectiveTo assess the experience of moral distress among intensive care unit (ICU) professionals in the UK.DesignMixed methods: validated quantitative measure of moral distress followed by purposive sample of respondents who underwent semistructured interviews.SettingFour ICUs of varying sizes and specialty facilities.ParticipantsHealthcare professionals working in ICU.Results227 questionnaires were returned and 15 interviews performed. Moral distress occurred across all ICUs and professional demographics. It was most commonly related to providing care perceived as futile or against the patient’s wishes/interests, followed by resource constraints compromising care. Moral distress score was independently influenced by profession (p=0.02) (nurses 117.0 vs doctors 78.0). A lack of agency was central to moral distress and its negative experience could lead to withdrawal from engaging with patients/families. One-third indicated their intention to leave their current post due to moral distress and this was greater among nurses than doctors (37.0% vs 15.0%). Moral distress was independently associated with an intention to leave their current post (pConclusionsMoral distress is widespread among UK ICU professionals and can have an important negative impact on patient care, professional wellbeing and staff retention, a particularly concerning finding as this study was performed prior to the COVID-19 pandemic. Moral distress due to resource-related issues is more severe than comparable studies in North America. Interventions to support professionals should recognise the individualistic nature of coping with moral distress. The value of close-knit teams and supportive environments has implications for how intensive care services are organised.

Published
2023
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13. Usability of Avionic Touchscreens Under Vibration: Supported versus Freehand Target Selection in Cockpit Conditions

Author

Schachner, Adam Jonathan and Schachner, Adam Jonathan

Abstract

RÉSUMÉ: (Problème) Dans le poste de pilotage, les écrans tactiles peuvent être éloignés du pilote et utilisés dans des conditions de vibration ou de turbulence. Des travaux précédents ont trouvé que les écrans tactiles offrent un débit (throughput; une métrique de performance capturant à la fois la vitesse et la précision) plus élevé dans des conditions statiques par rapport à d'autres dispositifs testés, mais que leur performance et leur taux d'erreur a dégradé plus rapidement sous l'effet des vibrations. L'utilisation d'un support manuel pour atténuer cet effet a été suggérée par la norme SAE ARP60494. Il est nécessaire de quantifier l'impact des vibrations sur la sélection des cibles à l'écran tactile dans le poste de pilotage, ainsi que de mesurer l'utilité du support manuel, en utilisant une méthodologie normalisée. (Objectif) Nous avons mesuré les effets de la vibration sur la sélection des cibles de l'écran tactile à l'aide d'une méthode normalisée, ce qui permet de comparer nos résultats avec ceux d'autres études, et comparé le support manuel (utilisant le pouce, en tenant le bord de l'écran, versus utilisant l'index, avec main libre), les écrans tactiles avioniques et commerciaux, et les positions de l'écran tactile. (Méthode) 24 participants ont effectué une tâche de sélection multidirectionnelle ISO 9241-411 (une tâche de sélection standardisée de Fitts). Nous avons bâti une plateforme d'essai réglable qui vibre, avec des écrans tactiles positionnés dans une géométrie représentative du poste de pilotage. Les participants ont été exposés à des niveaux de vibration représentatifs du vol en hélicoptère. Nous avons testé quatre écrans tactiles, deux positions d'écran, deux méthodes de support manuel et deux niveaux de vibration. Nous avons mesuré le débit de sélection des cibles, le taux d'erreur et la préférence subjective. (Résultats et discussion) Nous avons trouvé des valeurs moyennes de débit de 6,5 bits/sec sans vibration, contre 5,7 bits/sec avec vibra

Published
2022

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