13 results on '"Alborzinia, Hamed"'
Search Results
2. Ferroptosis in health and disease.
- Author
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Berndt, Carsten, Alborzinia, Hamed, Amen, Vera, Ayton, Scott, Barayeu, Uladzimir, Bartelt, Alexander, Bayir, Hülya, Bebber, Christina, Birsoy, Kivanc, Böttcher, Jan, Brabletz, Simone, Brabletz, Thomas, Brown, Ashley, Brüne, Bernhard, Bulli, Giorgia, Bruneau, Alix, Chen, Quan, DeNicola, Gina, Dick, Tobias, Distéfano, Ayelén, Dixon, Scott, Engler, Jan, Esser-von Bieren, Julia, Fedorova, Maria, Friedmann Angeli, José, Friese, Manuel, Fuhrmann, Dominic, García-Sáez, Ana, Garbowicz, Karolina, Götz, Magdalena, Gu, Wei, Hammerich, Linda, Hassannia, Behrouz, Jiang, Xuejun, Jeridi, Aicha, Kang, Yun, Kagan, Valerian, Konrad, David, Kotschi, Stefan, Lei, Peng, Le Tertre, Marlène, Lev, Sima, Liang, Deguang, Linkermann, Andreas, Lohr, Carolin, Lorenz, Svenja, Luedde, Tom, Methner, Axel, Michalke, Bernhard, Milton, Anna, Min, Junxia, Mishima, Eikan, Müller, Sebastian, Motohashi, Hozumi, Muckenthaler, Martina, Murakami, Shohei, Olzmann, James, Pagnussat, Gabriela, Pan, Zijan, Papagiannakopoulos, Thales, Pedrera Puentes, Lohans, Pratt, Derek, Proneth, Bettina, Ramsauer, Lukas, Rodriguez, Raphael, Saito, Yoshiro, Schmidt, Felix, Schmitt, Carina, Schulze, Almut, Schwab, Annemarie, Schwantes, Anna, Soula, Mariluz, Spitzlberger, Benedikt, Stockwell, Brent, Thewes, Leonie, Thorn-Seshold, Oliver, Toyokuni, Shinya, Tonnus, Wulf, Trumpp, Andreas, Vandenabeele, Peter, Vanden Berghe, Tom, Venkataramani, Vivek, Vogel, Felix, von Karstedt, Silvia, Wang, Fudi, Westermann, Frank, Wientjens, Chantal, Wilhelm, Christoph, Wölk, Michele, Wu, Katherine, Yang, Xin, Yu, Fan, Zou, Yilong, and Conrad, Marcus
- Subjects
Cancer ,Cell death ,Iron ,Ischemia/reperfusion ,Lipid peroxidation ,Neurodegeneration - Abstract
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, in vivo relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with - or caused by - ferroptosis.
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- 2024
3. 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
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Freitas, Florencio Porto, Alborzinia, Hamed, dos Santos, Ancély Ferreira, Nepachalovich, Palina, Pedrera, Lohans, Zilka, Omkar, Inague, Alex, Klein, Corinna, Aroua, Nesrine, Kaushal, Kamini, Kast, Bettina, Lorenz, Svenja M., Kunz, Viktoria, Nehring, Helene, Xavier da Silva, Thamara N., Chen, Zhiyi, Atici, Sena, Doll, Sebastian G., Schaefer, Emily L., Ekpo, Ifedapo, Schmitz, Werner, Horling, Aline, Imming, Peter, Miyamoto, Sayuri, Wehman, Ann M., Genaro-Mattos, Thiago C., Mirnics, Karoly, Kumar, Lokender, Klein-Seetharaman, Judith, Meierjohann, Svenja, Weigand, Isabel, Kroiss, Matthias, Bornkamm, Georg W., Gomes, Fernando, Netto, Luis Eduardo Soares, Sathian, Manjima B., Konrad, David B., Covey, Douglas F., Michalke, Bernhard, Bommert, Kurt, Bargou, Ralf C., Garcia-Saez, Ana, Pratt, Derek A., Fedorova, Maria, Trumpp, Andreas, Conrad, Marcus, and Friedmann Angeli, José Pedro
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- 2024
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4. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance
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Chen, Zhiyi, Inague, Alex, Kaushal, Kamini, Fazeli, Gholamreza, Schilling, Danny, Xavier da Silva, Thamara N., dos Santos, Ancely Ferreira, Cheytan, Tasneem, Freitas, Florencio Porto, Yildiz, Umut, Viviani, Lucas Gasparello, Lima, Rodrigo Santiago, Pinz, Mikaela Peglow, Medeiros, Isadora, Iijima, Thais Satie, Alegria, Thiago Geronimo Pires, Pereira da Silva, Railmara, Diniz, Larissa Regina, Weinzweig, Simon, Klein-Seetharaman, Judith, Trumpp, Andreas, Mañas, Adriana, Hondal, Robert, Bartenhagen, Christoph, Fischer, Matthias, Shimada, Briana K., Seale, Lucia A., Chillon, Thilo Samson, Fabiano, Marietta, Schomburg, Lutz, Schweizer, Ulrich, Netto, Luis E., Meotti, Flavia C., Dick, Tobias P., Alborzinia, Hamed, Miyamoto, Sayuri, and Friedmann Angeli, José Pedro
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- 2024
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5. LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma
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Alborzinia, Hamed, Chen, Zhiyi, Yildiz, Umut, Freitas, Florencio Porto, Vogel, Felix C E, Varga, Julianna Patricia, Batani, Jasmin, Bartenhagen, Christoph, Schmitz, Werner, Büchel, Gabriele, Michalke, Bernhard, Zheng, Jashuo, Meierjohann, Svenja, Girardi, Enrico, Espinet, Elisa, Flórez, Andrés F, dos Santos, Ancely Ferreira, Aroua, Nesrine, Cheytan, Tasneem, Haenlin, Julie, Schlicker, Lisa, Xavier da Silva, Thamara N, Przybylla, Adriana, Zeisberger, Petra, Superti‐Furga, Giulio, Eilers, Martin, Conrad, Marcus, Fabiano, Marietta, Schweizer, Ulrich, Fischer, Matthias, Schulze, Almut, Trumpp, Andreas, and Friedmann Angeli, José Pedro
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- 2023
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6. Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs
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Samarin, Jana, Fabrowski, Piotr, Kurilov, Roman, Nuskova, Hana, Hummel-Eisenbeiss, Johanna, Pink, Hannelore, Li, Nan, Weru, Vivienn, Alborzinia, Hamed, Yildiz, Umut, Grob, Laura, Taubert, Minerva, Czech, Marie, Morgen, Michael, Brandstädter, Christina, Becker, Katja, Mao, Lianghao, Jayavelu, Ashok Kumar, Goncalves, Angela, Uhrig, Ulrike, Seiler, Jeanette, Lyu, Yanhong, Diederichs, Sven, Klingmüller, Ursula, Muckenthaler, Martina, Kopp-Schneider, Annette, Teleman, Aurelio, Miller, Aubry K., and Gunkel, Nikolas
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- 2023
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7. MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
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Alborzinia, Hamed, Flórez, Andrés F., Kreth, Sina, Brückner, Lena M., Yildiz, Umut, Gartlgruber, Moritz, Odoni, Dorett I., Poschet, Gernot, Garbowicz, Karolina, Shao, Chunxuan, Klein, Corinna, Meier, Jasmin, Zeisberger, Petra, Nadler-Holly, Michal, Ziehm, Matthias, Paul, Franziska, Burhenne, Jürgen, Bell, Emma, Shaikhkarami, Marjan, Würth, Roberto, Stainczyk, Sabine A., Wecht, Elisa M., Kreth, Jochen, Büttner, Michael, Ishaque, Naveed, Schlesner, Matthias, Nicke, Barbara, Stresemann, Carlo, Llamazares-Prada, María, Reiling, Jan H., Fischer, Matthias, Amit, Ido, Selbach, Matthias, Herrmann, Carl, Wölfl, Stefan, Henrich, Kai-Oliver, Höfer, Thomas, Trumpp, Andreas, and Westermann, Frank
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- 2022
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8. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance
- Author
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Chen, Zhiyi, primary, Inague, Alex, additional, Kaushal, Kamini, additional, Fazeli, Gholamreza, additional, N Xavier da Silva, Thamara, additional, Ferreira dos Santos, Ancely, additional, Cheytan, Tasneem, additional, Porto Freitas, Florencio, additional, Yildiz, Umut, additional, Gasparello Viviani, Lucas, additional, Santiago Lima, Rodrigo, additional, Peglow Pinz, Mikaela, additional, Medeiros, Isadora, additional, Geronimo Pires Alegria, Thiago, additional, Pereira da Silva, Railmara, additional, Regina Diniz, Larissa, additional, Weinzweig, Simon, additional, Klein-Seetharaman, Judith, additional, Trumpp, Andreas, additional, Manas, Adriana, additional, Hondal, Robert, additional, Fischer, Matthias, additional, Bartenhagen, Christoph, additional, Shimada, Briana K., additional, Seale, Lucia A., additional, Fabiano, Marietta, additional, Schweizer, Ulrich, additional, Netto, Luis E., additional, Meotti, Flavia Carla, additional, Alborzinia, Hamed, additional, Miyamoto, Sayuri, additional, and Friedmann Angeli, Jose Pedro, additional
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- 2024
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9. Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs
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Samarin, Jana, primary, Fabrowski, Piotr, additional, Kurilov, Roman, additional, Nuskova, Hana, additional, Hummel-Eisenbeiss, Johanna, additional, Pink, Hannelore, additional, Li, Nan, additional, Weru, Vivienn, additional, Alborzinia, Hamed, additional, Yildiz, Umut, additional, Grob, Laura, additional, Taubert, Minerva, additional, Czech, Marie, additional, Morgen, Michael, additional, Brandstädter, Christina, additional, Becker, Katja, additional, Mao, Lianghao, additional, Jayavelu, Ashok Kumar, additional, Goncalves, Angela, additional, Uhrig, Ulrike, additional, Seiler, Jeanette, additional, Lyu, Yanhong, additional, Diederichs, Sven, additional, Klingmüller, Ursula, additional, Muckenthaler, Martina, additional, Kopp-Schneider, Annette, additional, Teleman, Aurelio, additional, Miller, Aubry K, additional, and Gunkel, Nikolas, additional
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- 2023
- Full Text
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10. LRP8-Mediated Selenocysteine Uptake is a Targetable Vulnerability in MYCN-Amplified Cancers
- Author
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Alborzinia, Hamed, primary, Chen, Zhiyi, additional, Yildiz, Umut, additional, Freitas, Florencio P., additional, Vogel, Felix CE, additional, Varga, Julianna Patricia, additional, Batani, Jasmin, additional, Bartenhagen, Christoph, additional, Schmitz, Werner, additional, Büchel, Gabriele, additional, Michalke, Bernhard, additional, Zheng, Jashuo, additional, Meierjohann, Svenja, additional, Girardi, Enrico, additional, Espinet, Elisa, additional, Florez, Andres F., additional, dos Santos, Ancely Ferreira, additional, Aroua, Nesrine, additional, Cheytan, Tasneem, additional, Haenlin, Julie, additional, Schlicker, Lisa, additional, Xavier da Silva, Thamara Nishida, additional, Przybylla, Adriana, additional, Zeisberger, Petra, additional, Superti-Furga, Giulio, additional, Eilers, Martin, additional, Conrad, Marcus, additional, Fabiano, Marietta, additional, Schweizer, Ulrich, additional, Fischer, Matthias, additional, Schulze, Almut, additional, Trumpp, Andreas, additional, and Friedmann Angeli, Jose Pedro, additional
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- 2023
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11. Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers
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Alborzinia, Hamed, primary, Chen, Zhiyi, additional, Yildiz, Umut, additional, Freitas, Florencio Porto, additional, Vogel, Felix C.E., additional, Varga, Julianna, additional, Batani, Jasmin, additional, Bartenhagen, Christoph, additional, Schmitz, Werner, additional, Büchel, Gabriele, additional, Michalke, Bernhard, additional, Zheng, Jashuo, additional, Meierjohann, Svenja, additional, Girardi, Enrico, additional, Espinet, Elisa, additional, Florez, Andres, additional, dos Santos, Ancely Ferreira, additional, Aroua, Nesrine, additional, Schlicker, Lisa, additional, Xavier da Silva, Thamara N., additional, Przybylla, Adriana, additional, Zeisberger, Petra, additional, Superti-Furga, Giulio, additional, Eilers, Martin, additional, Conrad, Marcus, additional, Fischer, Matthias, additional, Schulze, Almut, additional, Trumpp, Andreas, additional, and Friedmann Angeli, José Pedro, additional
- Published
- 2022
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12. Iron: The Secret Ingredient Breaking PARPi Resistance.
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Alborzinia H and Friedmann Angeli JP
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- Humans, Neoplasms drug therapy, Neoplasms genetics, Neoplasms metabolism, Poly(ADP-ribose) Polymerase Inhibitors therapeutic use, Poly(ADP-ribose) Polymerase Inhibitors pharmacology, Drug Resistance, Neoplasm, Ferroptosis drug effects, Iron metabolism
- Abstract
PARP inhibitors (PARPi) are used as a first-line treatment option for cancers with BRCA1/2 mutations, yet a significant number of patients show a limited response to these agents. In the present study, Lei and colleagues demonstrate that PARPi promote increased ferroptosis sensitivity and this can be exploited therapeutically to improve the response to PARPi, marking an important therapeutic concept to exploit ferroptosis-based strategies in clinical settings. See related article by Lei et al., p. 1476 (2)., (©2024 American Association for Cancer Research.)
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- 2024
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13. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance.
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Chen Z, Inague A, Kaushal K, Fazeli G, N Xavier da Silva T, Ferreira Dos Santos A, Cheytan T, Porto Freitas F, Yildiz U, Gasparello Viviani L, Santiago Lima R, Peglow Pinz M, Medeiros I, Geronimo Pires Alegria T, Pereira da Silva R, Regina Diniz L, Weinzweig S, Klein-Seetharaman J, Trumpp A, Manas A, Hondal R, Fischer M, Bartenhagen C, Shimada BK, Seale LA, Fabiano M, Schweizer U, Netto LE, Meotti FC, Alborzinia H, Miyamoto S, and Friedmann Angeli JP
- Abstract
Selenocysteine (Sec) metabolism is crucial for cellular function and ferroptosis prevention and has traditionally been thought to begin with the uptake of the Sec carrier selenoprotein P (SELENOP). Following uptake, Sec released from SELENOP undergoes metabolisation via selenocysteine lyase (SCLY), producing selenide, a substrate used by selenophosphate synthetase 2 (SEPHS2), which provides the essential selenium donor - selenophosphate - for the biosynthesis of the selenocysteine tRNA. Here, we report the discovery of an alternative pathway mediating Sec metabolisation that is independent of SCLY and mediated by peroxiredoxin 6 (PRDX6). Mechanistically, we demonstrate that PRDX6 can readily react with selenide and interact with SEPHS2, potentially acting as a selenium delivery system. Moreover, we demonstrate the presence and functional significance of this alternative route in cancer cells where we reveal a notable association between elevated expression of PRDX6 with a highly aggressive neuroblastoma subtype. Altogether, our study sheds light on a previously unrecognized aspect of Sec metabolism and its implications in ferroptosis, offering new avenues for therapeutic exploitation.
- Published
- 2024
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