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In the paper, the effect of spontaneous Brillouin scattering (SpBS) is analyzed as a noise source in distributed acoustic sensors (DAS). The intensity of the SpBS wave fluctuates over time, and these fluctuations increase the noise power in DAS. Based on experimental data, the probability density function (PDF) of the spectrally selected SpBS Stokes wave intensity is negative exponential, which corresponds to the known theoretical conception. Based on this statement, an estimation of the average noise power induced by the SpBS wave is given. This noise power equals the square of the average power of the SpBS Stokes wave, which in turn is approximately 18 dB lower than the Rayleigh backscattering power. The noise composition in DAS is determined for two configurations, the first for the initial backscattering spectrum and the second for the spectrum in which the SpBS Stokes and anti-Stokes waves are rejected. It is established that in the analyzed particular case, the SpBS noise power is dominant and exceeds the powers of the thermal, shot, and phase noises in DAS. Accordingly, by rejecting the SpBS waves at the photodetector input, it is possible to reduce the noise power in DAS. In our case, this rejection is carried out by an asymmetric Mach-Zehnder interferometer (MZI). The rejection of the SpBS wave is most relevant for broadband photodetectors, which are associated with the use of short probing pulses to achieve short gauge lengths in DAS.

A simple and cost-effective architecture of a distributed acoustic sensor (DAS) or a phase-OTDR for engineering geology is proposed. The architecture is based on the dual-pulse acquisition principle, where the dual probing pulse is formed via an unbalanced Michelson interferometer (MI). The necessary phase shifts between the sub-pulses of the dual-pulse are introduced using a 3 × 3 coupler built into the MI. Laser pulses are generated by direct modulation of the injection current, which obtains optical pulses with a duration of 7 ns. The use of an unbalanced MI for the formation of a dual-pulse reduces the requirements for the coherence of the laser source, as the introduced delay between sub-pulses is compensated in the fiber under test (FUT). Therefore, a laser with a relatively broad spectral linewidth of about 1 GHz can be used. To overcome the fading problem, as well as to ensure the linearity of the DAS response, the averaging of over 16 optical frequencies is used. The performance of the DAS was tested by recording a strong vibration impact on a horizontally buried cable and by the recording of seismic waves in a borehole in the seabed.

A distributed acoustic sensor (a phase optical time-domain reflectometer) configuration with a low noise level in the hertz and sub-hertz frequency ranges is proposed. The sensor scheme uses a Mach-Zehnder interferometer to generate a dual-pulse probe signal and implements the frequency stabilization of a laser source using the same interferometer as a frequency etalon. The scheme simultaneously provides a low noise level owing to the compensation of the optical path difference of interfering backscattered fields and low drift of the output signal. It has been shown experimentally that the stabilization of the laser frequency provides up to 35 dB signal/noise gain in the sub-hertz frequencies, which are of interest for seismology. The applicability of the proposed scheme is demonstrated experimentally by teleseismic earthquakes recorded by a fiber-optic cable deployed on the seabed of the Black Sea.

Plasmalemmal ATP sensitive potassium (K ATP ) channels are recognized metabolic sensors, yet their cellular reach is less well understood. Here, transgenic Kir6.2 null hearts devoid of the K ATP channel pore underwent multiomics surveillance and systems interrogation versus wildtype counterparts. Despite maintained organ performance, the knockout proteome deviated beyond a discrete loss of constitutive K ATP channel subunits. Multidimensional nano-flow liquid chromatography tandem mass spectrometry resolved 111 differentially expressed proteins and their expanded network neighborhood, dominated by metabolic process engagement. Independent multimodal chemometric gas and liquid chromatography mass spectrometry unveiled differential expression of over one quarter of measured metabolites discriminating the Kir6.2 deficient heart metabolome. Supervised class analogy ranking and unsupervised enrichment analysis prioritized nicotinamide adenine dinucleotide (NAD + ), affirmed by extensive overrepresentation of NAD + associated circuitry. The remodeled metabolome and proteome revealed functional convergence and an integrated signature of disease susceptibility. Deciphered cardiac patterns were traceable in the corresponding plasma metabolome, with tissue concordant plasma changes offering surrogate metabolite markers of myocardial latent vulnerability. Thus, Kir6.2 deficit precipitates multiome reorganization, mapping a comprehensive atlas of the K ATP channel dependent landscape., (© 2022. The Author(s).)

In the paper, we present a qualitative analysis of the dual-pulse phase optical time domain reflectometry (phase-OTDR) response to uniform and nonuniform propagating fiber strain. It is found that on average over all realizations of scattering centers the response of the dual-pulse phase-OTDR is linear with respect to an external perturbation. Meanwhile, individual responses contain random phase jumps, which are an intrinsic property of phase-OTDR. These jumps are the result of nonlinear responses of the scattering fiber segments and arise due to interference of random backscattered fields varying in time. Two types of phase jumps are considered: π jumps and 2 π jumps; the first type is caused by the fading in phase-OTDR spatial channel, while the second type occurs when a nonuniform perturbation propagates along the fiber. The origin of the phase jumps is explained by considering the simulated response on the complex plane. It is shown that the distribution of 2 π jumps can be well described by the Gaussian probability mass function (PMF), provided the number of 2 π jumps is large. The conducted experiments on the registration of uniform and nonuniform fiber strain confirm the presence of the jumps in the phase-OTDR response.