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Your search keyword '"Alfredo Molteni"' showing total 9 results
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9 results on '"Alfredo Molteni"'

1. PB2672: EXPLORING UNMET NEEDS OF PATIENTS WITH MYELODYSPLASTIC NEOPLASMS AND CAREGIVERS IN A NATIONAL ITALIAN SURVEY

Author

Elena Crisà, Annamaria Nosari, Daniela Cilloni, Sam Salek, Tatyana Ionova, Matteo Giovanni Della Porta, Maria Teresa Voso, Luca Maurillo, Carlo Finelli, Valeria Santini, Enrico Balleari, Federica Pilo, Giuseppe Palumbo, Alfredo Molteni, Marta Riva, and Esther Oliva

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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2. PB2670: EQOL-MDS TRIAL: PATIENT-REPORTED OUTCOMES IN PATIENTS WITH LOWER RISK MYELODYSPLASTIC SYNDROMES WITH SEVERE THROMBOCYTOPENIA.

Author

Esther Oliva, Giuseppe Iannì, Marta Riva, Pasquale Niscola, Valeria Santini, Massimo Breccia, Valentina Gaidano, Antonella Poloni, Andrea Patriarca, Elena Crisà, Isabella Capodanno, Prassede Salutari, Gianluigi Reda, Grazia Sanpaolo, Dario Ferrero, Attilio Guarini, Giovanni Tripepi, Andrea Castelli, Bruno Fattizzo, Germana Beltrami, Monica Bocchia, Alfredo Molteni, Pierre Fenaux, Ulrich Germing, Alessandra Ricco, Giuseppe A. Palumbo, Stefana Impera, Nicola DI Renzo, Francesco Buccisano, Aspasia Stamatoullas, Anna Marina Liberati, Anna Candoni, Ilaria Maria Delfino, Patrizia Cufari, Lorenzo Rizzo, and Roberto Latagliata

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2023
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3. Adapting the Fitness Criteria for Non-Intensive Treatments in Older Patients with Acute Myeloid Leukemia to the Use of Venetoclax-Hypomethylating Agents Combination—Practical Considerations from the Real-Life Experience of the Hematologists of the Rete Ematologica Lombarda

Author

Giuseppe Rossi, Erika Borlenghi, Patrizia Zappasodi, Federico Lussana, Massimo Bernardi, Claudia Basilico, Alfredo Molteni, Ivana Lotesoriere, Mauro Turrini, Marco Frigeni, Monica Fumagalli, Paola Cozzi, Federica Gigli, Chiara Cattaneo, Nicola Stefano Fracchiolla, Marta Riva, Gianluca Martini, Valentina Mancini, Roberto Cairoli, and Elisabetta Todisco

Subjects
fitness, elderly, acute myeloid leukemia, treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

A retrospective survey was conducted in hematologic centres of the Rete Ematologica Lombarda (REL) on 529 older AML patients seen between 2020–2022. Compared to 2008–2016, the use of intensive chemotherapy (ICT) decreased from 40% to 18.1% and of hypomethylating agents (HMAs) from 19.5% to 13%, whereas the combination of Venetoclax/HMA, initially not available, increased from 0% to 36.7%. Objective treatment-specific fitness criteria proposed by SIE/SIES/GITMO in 2013 allow an appropriate choice between ICT and HMAs by balancing their efficacy and toxicity. Venetoclax/HMA, registered for patients unfit to ICT, has a unique toxicity profile because of prolonged granulocytopenia and increased infectious risk. Aiming at defining specific fitness criteria for the safe use of Venetoclax/HMA, a preliminary investigation was conducted among expert REL hematologists, asking for modifications of SIE/SIES/GITMO criteria they used to select candidates for Venetoclax/HMA. While opinions among experts varied, a general consensus emerged on restricting SIE/SIES/GITMO criteria for ICT-unfit patients to an age limit of 80–85, cardiac function > 40%, and absence of recurrent lung infections, bronchiectasis, or exacerbating COPD. Also, the presence of an adequate caregiver was considered mandatory. Such expert opinions may be clinically useful and may be considered when treatment-specific fitness criteria are updated to include Venetoclax/HMA.

Published
2024
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5. Efficacy and Safety of Luspatercept in Adult Patients with Transfusion-Dependent Anemia Due to Very Low, Low and Intermediate Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts, Who Had an Unsatisfactory Response to or Are Ineligible for Erythropoietin-Based Therapy: A Retrospective Multicenter Study By Fondazione Italiana Sindromi Mielodisplastiche (FiSiM ETS)

Author

Luca Lanino, Prassede Salutari, Alessandra Perego, Bruno Fattizzo, Marta Riva, Marta Ubezio, Pellegrino Musto, Daniela Cilloni, Esther Natalie Oliva, Maria Teresa Voso, Anna Maria Pelizzari, Antonella Poloni, Isabella Capodanno, Chiara Elena, Claudio Fozza, Fabrizio Pane, Massimo Breccia, Marco De Gobbi, Francesco Di Bassiano, Daniela Barraco, Elena Crisà, Dario Ferrero, Chiara Frairia, Antonella Vaccarino, Davide Griguolo, Stefania Paolini, Martina Quintini, Mariarosaria Sessa, Mauro Turrini, Monica Bocchia, Nicola Di Renzo, Elisa Diral, Cristina Foli, Alfredo Molteni, Ubaldo Occhini, Giulia Rivoli, Carmine Selleri, Roberto Bono, Anna Calvisi, Andrea Castelli, Eros Di Bona, Ambra Di Veroli, Luana Fianchi, Sara Galimberti, Daniele Grimaldi, Monia Marchetti, Marianna Norata, Alessandro Rambaldi, Ilaria Tanasi, Patrizia Tosi, Ilaria Naldi, Valeria Santini, and Matteo G. Della Porta

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

6. Association of Hypometilating Agents (HMA) + Venetoclax (VEN) in the Treatment of Myeloproliferative Neoplasms in Blastic Phase (MPN-BP) and Acute Leukemias Evolved from Myelodysplastic Syndromes (AML-MDS) Already Treated with Azacytidine

Author

Roberto Latagliata, Gianluca Cristiano, Dorela Lama, Susanna Fenu, Lorenzo Rizzo, Benedetta Cambò, Simone Zoletto, Francesca Spirito, Fabrizio Cavalca, Daniele Cattaneo, Natalia Cenfra, Giulia De Luca, Beatrice Esposito Vangone, Ambra Di Veroli, Raffaele Palmieri, Mario Annunziata, Olga Mulas, Elisabetta Abruzzese, Alfredo Molteni, Monica Piedimonte, Ida Carmosino, Prassede Salutari, Annalisa Biagi, Monica Bocchia, Michelina Santopietro, Gianni Binotto, Alessandra Iurlo, Monica Crugnola, Marta Riva, Anna Lina Piccioni, Elena Maria Elli, Antonio Curti, and Antonella Poloni

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

8. Effects of Whole Pelvic Radiotherapy on the Distribution of Lymphocyte Subpopulations in Prostate Cancer Patients

Author

Giandomenico Roviello, Valerio Nardone, Alberto Bonetta, Pierpaolo Correale, Alfredo Molteni, Maria C. Lazzari, Daniele Generali, Roviello, G., Nardone, V., Bonetta, A., Correale, P., Molteni, A., Lazzari, M. C., and Generali, D.

Subjects
Male, change, lymphocyte, radiotherapy, subpopulations, Cancer Research, Prostatic Neoplasms, Lymphocyte Subsets, Pelvis, Oncology, Humans, Prospective Studies, Neoplasm Grading
Abstract

Introduction: In the current study, we have investigated the effects of the different modalities of treatment (volume of radiotherapy [RT], previous surgery) as well as the Gleason score of prostate cancer (PC) on the lymphocyte composition of PC patients undergoing RT. Methods: This is a monoinstitutional study that prospectively included PC patients that underwent RT from January 2016 until December 2017. To compare the different evaluations, the Wilcoxon signed-rank test was used among 2 times (Timepoint 0 to Timepoint 1). Percentage variation was calculated for all the lymphocyte subpopulation and was correlated with clinical parameters (previous surgery, Gleason score, and pelvic irradiation) with the χ2test. The statistical analysis was repeated also on the stratified dataset according to the above parameters (previous surgery, Gleason score, and whole pelvic radiotherapy [WPRT]). Results: One hundred and eleven patients were included in the present analysis. All the lymphocyte subpopulations resulted significantly lower after RT. The modifications of several lymphocyte subpopulations correlated with previous surgery, Gleason score, and WPRT, although stratified analysis demonstrated that WPRT showed the greatest correlation. Conclusion: Our results could be used to design a prospective trial in order to study the use of WPRT on the lymphocyte subpopulations.

Published
2022

9. Evolutionary Portrait of Adult Core-Binding Factor Leukemia Patients Treated with a Continuation Therapy with Midostaurin: Preliminary Results

Author

Roberto Cairoli, Arianna Gatti, Giovanni Grillo, Monica Fumagalli, Mauro Krampera, Patrizia Zappasodi, Erika Borlenghi, Elisabetta Todisco, Marta Ubezio, Massimo Bernardi, Alfredo Molteni, Claudia Basilico, Mauro Turrini, Rosa Greco, Valentina Mancini, Marta Riva, Beatrice De Marco, Marta Rachele Stefanucci, Bruno Brando, Silvio Marco Veronese, Alessandro Beghini, Cairoli, R, Gatti, A, Grillo, G, Fumagalli, M, Krampera, M, Zappasodi, P, Borlenghi, E, Todisco, E, Ubezio, M, Bernardi, M, Molteni, A, Basilico, C, Turrini, M, Greco, R, Mancini, V, Riva, M, De Marco, B, Stefanucci, M, Brando, B, Veronese, S, and Beghini, A

Subjects
MED/15 - MALATTIE DEL SANGUE, Immunology, Cell Biology, Hematology, CBFL, Midostaurin, Biochemistry
Published
2022

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