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1. Advancing Kawasaki Disease Research in the Arab World: Scoping Literature Review Analysis with Emphasis on Giant Coronary Aneurysms

Author

Mohamed, Mariam, Harahsheh, Ashraf, Choueiter, Nadine, Agha, Hala M., Alrabte, Hanifa, Abu Al-Saoud, Sima Y., Al-Saloos, Hesham, Al Senaidi, Khalfan, Alzyoud, Raed, Al Awadhi, Zainab, Belbouab, Reda, Bouayed, Kenza, Bouaziz, Asma, El Ganzoury, Mona, Fitouri, Zohra, Kotby, Alyaa, Ladj, Mohamed S., Bekkar, Mohammed Mokhtar, Rugige, Najat, Salih, Aso Faeq, Sulaiman, Mohamed, and Dahdah, Nagib

Published
2024
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3. Access to Care and Therapy for Kawasaki Disease in the Arab Countries: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey

Author

Alzyoud, Raed, El-Kholy, Nermeen, Arab, Yousra, Choueiter, Nadine, Harahsheh, Ashraf S., Aselan, Adnan Salem, Kotby, Alyaa, Bouaziz, Asma, Salih, Aso F., Abushhaiwia, Awatif, Alahmadi, Fahad, Agha, Hala M., Elmarsafawy, Hala M., Alrabte, Hanifa, Al-Saloos, Hesham, Boudiaf, Houda, Hijazi, Issa, Bouayed, Kenza, Al Senaidi, Khalfan Salim, Boughammoura, Lamia, Jalal, Maryam, Ladj, Mohamed S., Abu-Shukair, Mohammed E., ElGanzoury, Mona M., Hammadouche, Nacera, Elsamman, Nora, Mouawad, Pierre, Boukari, Rachida, Benalikhoudja, Nassiba, Jdour, Salima, Abu Al-Saoud, Sima Y., Touri, Soued Nabila, Kammoun, Thouraya, Fitouri, Zohra, and Dahdah, Nagib

Published
2023
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4. The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

Author

Baris, Safa, Abolhassani, Hassan, Massaad, Michel J., Al-Nesf, Maryam, Chavoshzadeh, Zahra, Keles, Sevgi, Reisli, Ismail, Tahiat, Azzeddine, Shendi, Hiba Mohammad, Elaziz, Dalia Abd, Belaid, Brahim, Al Dhaheri, Fatima, Haskologlu, Sule, Dogu, Figen, Ben-Mustapha, Imen, Sobh, Ali, Galal, Nermeen, Meshaal, Safa, Elhawary, Rabab, El-marsafy, Aisha, Alroqi, Fayhan J., Al-Saud, Bandar, Al-Ahmad, Mona, Al Farsi, Tariq, AL Sukaiti, Nashat, Al-Tamemi, Salem, Mehawej, Cybel, Dbaibo, Ghassan, ElGhazali, Gehad, Kilic, Sara Sebnem, Genel, Ferah, Kiykim, Ayca, Musabak, Ugur, Artac, Hasibe, Guner, Sukru Nail, Boukari, Rachida, Djidjik, Reda, Kechout, Nadia, Cagdas, Deniz, El-Sayed, Zeinab Awad, Karakoc-Aydiner, Elif, Alzyoud, Raed, Barbouche, Mohamed Ridha, Adeli, Mehdi, Wakim, Rima Hanna, Reda, Shereen M., Ikinciogullari, Aydan, Ozen, Ahmet, Bousfiha, Aziz, Al-Mousa, Hamoud, Rezaei, Nima, Al-Herz, Waleed, and Geha, Raif S.

Published
2023
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5. Kawasaki Disease Arab Initiative [Kawarabi]: Establishment and Results of a Multicenter Survey

Author

Arab, Yousra, Choueiter, Nadine, Dahdah, Nagib, El-Kholy, Nermeen, Abu Al-Saoud, Sima Y., Abu-Shukair, Mohammed E., Agha, Hala M., Al-Saloos, Hesham, Al Senaidi, Khalfan Salim, Alzyoud, Raed, Bouaziz, Asma, Boukari, Rachida, El Ganzoury, Mona M., Elmarsafawy, Hala M., ELrugige, Najat, Fitouri, Zohra, Ladj, Mohamed S., Mouawad, Pierre, Salih, Aso F., Rojas, Rocio G., and Harahsheh, Ashraf S.

Published
2022
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6. Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry

Author

Rasouli, Seyed Erfan, Esmaeili, Marzie, Yazdani, Reza, Delavari, Samaneh, Tavakol, Marzieh, Sadri, Homa, Karimi, Abdollah, Shiari, Reza, Alavi, Samin, Babaie, Delara, Eshghi, Peyman, Armin, Shahnaz, Vosughimotlagh, Ahmad, Eltan, Sevgi Bilgic, Babayeva, Royala, Sefer, Asena Pinar, Kolukisa, Burcu, Gungoren, Ezgi Yalcin, Altunbas, Melek Yorgun, Mammadova, Vafa, Jamee, Mahnaz, Azizi, Gholamreza, Baris, Safa, Karakoc-Aydiner, Elif, Ozen, Ahmet, Kiliç, Sara Ş., Kose, Hulya, Chavoshzadeh, Zahra, Mahdaviani, Seyed Alireza, Momen, Tooba, Shamsian, Bibi Shahin, Fallahi, Mazdak, Sharafian, Samin, Gülez, Nesrin, Aygun, Ayşe, Karaca, Neslihan Edeer, Kutukculer, Necil, Al Sukait, Nashat, Al Farsi, Tariq, Al-Tamemi, Salem, Khalifa, Nisreen, Shereen, Reda, El-Ghoneimy, Dalia, El-Owaidy, Rasha, Radwan, Nesrine, Alzyoud, Raed, Barbouche, Mohamed-Ridha, Ben-Mustapha, Imen, Mekki, Najla, Rais, Afef, Boukari, Rachida, Belbouab, Reda, Djenouhat, Kamel, Tahiat, Azzeddine, Touri, Souad, Elghazali, Gehad, Al-Hammadi, Suleiman, Shendi, Hiba Mohammed, Alkuwaiti, Amna, Belaid, Brahim, Djidjik, Reda, Artac, Hasibe, Adeli, Mehdi, Sobh, Ali, Elnagdy, Marwa H., Bahgat, Sara A., Nasrullayeva, Gulnara, Chou, Janet, Rezaei, Nima, Al-Herz, Waleed, Geha, Raif S., and Abolhassani, Hassan

Published
2022
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7. Defining criteria for disease activity states in systemic juvenile idiopathic arthritis based on the systemic Juvenile Arthritis Disease Activity Score

Author

Rosina, Silvia, primary, Rebollo‐Gimenez, Ana I., additional, Tarantola, Letizia, additional, Pistorio, Angela, additional, Vyzhga, Yulia, additional, El Miedany, Yasser, additional, Lotfy, Hala M., additional, Abu‐Shady, Hend, additional, Eissa, Mervat, additional, Osman, Naglaa S., additional, Hassan, Waleed, additional, Mahgoub, Marwa Y., additional, Fouad, Nermeen A., additional, Mosa, Doaa M., additional, Adel, Yasmin, additional, Mohamed, Sheren E. M., additional, Radwan, Ahmed R., additional, Abu‐Zaid, Mohamed H., additional, Tabra, Samar A. A., additional, Shalaby, Radwa H., additional, Nasef, Samah I., additional, Khubchandani, Raju, additional, Khan, Archana, additional, Maldar, Naziya P., additional, Ozen, Seza, additional, Bayindir, Yagmur, additional, Alsuweiti, Motasem, additional, Alzyoud, Raed, additional, Almaaitah, Hiba, additional, Vilaiyuk, Soamarat, additional, Lerkvaleekul, Butsabong, additional, Alexeeva, Ekaterina, additional, Dvoryakovskaya, Tatyana, additional, Kriulin, Ivan, additional, Bracaglia, Claudia, additional, Pardeo, Manuela, additional, De Benedetti, Fabrizio, additional, Licciardi, Francesco, additional, Montin, Davide, additional, Robasto, Francesca, additional, Minoia, Francesca, additional, Filocamo, Giovanni, additional, Rossano, Martina, additional, Simonini, Gabriele, additional, Marrani, Edoardo, additional, Abu‐Rumeleih, Sarah, additional, Kostik, Mikhail M., additional, Belozerov, Konstantin E., additional, Pal, Priyankar, additional, Bathia, Jigna N., additional, Katsicas, María M., additional, Villarreal, Giselle, additional, Marino, Achille, additional, Costi, Stefania, additional, Sztajnbok, Flavio, additional, Silva, Rodrigo M., additional, Maggio, Maria C., additional, El‐Ghoneimy, Dalia H., additional, El Owaidy, Rasha, additional, Civino, Adele, additional, Diomeda, Federico, additional, Al‐Mayouf, Sulaiman M., additional, Al‐Sofyani, Fuad, additional, Dāvidsone, Zane, additional, Patrone, Elisa, additional, Saad‐Magalhães, Claudia, additional, Consolaro, Alessandro, additional, and Ravelli, Angelo, additional

Published
2024
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9. Quality indicators for care in juvenile idiopathic arthritis

Author

Alkwai, Hend, primary, Alshammari, Reem, additional, Abdwani, Reem, additional, Almutairi, Muna, additional, Alzyoud, Raed, additional, Arkachaisri, Thaschawee, additional, Farman, Sumaira, additional, Hashad, Soad, additional, James, Rebecca, additional, Khawaja, Khulood, additional, Lotfy, Hala, additional, Tang, Swee Ping, additional, Vilaiyuk, Soamarat, additional, and Al-Mayouf, Sulaiman M, additional

Published
2024
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14. Access to Care and Therapy for Kawasaki Disease in the Arab Countries: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey

Author

Alzyoud, Raed, primary, El-Kholy, Nermeen, additional, Arab, Yousra, additional, Choueiter, Nadine, additional, Harahsheh, Ashraf S., additional, Aselan, Adnan Salem, additional, Kotby, Alyaa, additional, Bouaziz, Asma, additional, Salih, Aso F., additional, Abushhaiwia, Awatif, additional, Alahmadi, Fahad, additional, Agha, Hala M., additional, Elmarsafawy, Hala M., additional, Alrabte, Hanifa, additional, Al-Saloos, Hesham, additional, Boudiaf, Houda, additional, Hijazi, Issa, additional, Bouayed, Kenza, additional, Senaidi, Khalfan Salim Al, additional, Boughammoura, Lamia, additional, Jalal, Maryam, additional, Ladj, Mohamed S., additional, Abu-Shukair, Mohammed E., additional, Ganzoury, Mona M. El, additional, Hammadouche, Nacera, additional, Elsamman, Nora, additional, Mouawad, Pierre, additional, Boukari, Rachida, additional, Benalikhoudja, Nassiba, additional, Jd, Salima, additional, Al-Saoud, Sima Y. Abu, additional, Touri, Soued Nabila, additional, Kammoun, Thouraya, additional, Fitouri, Zohra, additional, and Dahdah, Nagib, additional

Published
2023
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15. Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry

Author

Jamee, Mahnaz, primary, Azizi, Gholamreza, additional, Baris, Safa, additional, Karakoc-Aydiner, Elif, additional, Ozen, Ahmet, additional, Kiliç, Sara Ş., additional, Kose, Hulya, additional, Chavoshzadeh, Zahra, additional, Mahdaviani, Seyed Alireza, additional, Momen, Tooba, additional, Shamsian, Bibi Shahin, additional, Fallahi, Mazdak, additional, Sharafian, Samin, additional, Gülez, Nesrin, additional, Aygun, Ayşe, additional, Karaca, Neslihan Edeer, additional, Kutukculer, Necil, additional, Al Sukait, Nashat, additional, Al Farsi, Tariq, additional, Al-Tamemi, Salem, additional, Khalifa, Nisreen, additional, Shereen, Reda, additional, El-Ghoneimy, Dalia, additional, El-Owaidy, Rasha, additional, Radwan, Nesrine, additional, Alzyoud, Raed, additional, Barbouche, Mohamed-Ridha, additional, Ben-Mustapha, Imen, additional, Mekki, Najla, additional, Rais, Afef, additional, Boukari, Rachida, additional, Belbouab, Reda, additional, Djenouhat, Kamel, additional, Tahiat, Azzeddine, additional, Touri, Souad, additional, Elghazali, Gehad, additional, Al-Hammadi, Suleiman, additional, Shendi, Hiba Mohammed, additional, Alkuwaiti, Amna, additional, Belaid, Brahim, additional, Djidjik, Reda, additional, Artac, Hasibe, additional, Adeli, Mehdi, additional, Sobh, Ali, additional, Elnagdy, Marwa H., additional, Bahgat, Sara A., additional, Nasrullayeva, Gulnara, additional, Chou, Janet, additional, Rezaei, Nima, additional, Al-Herz, Waleed, additional, Geha, Raif S., additional, and Abolhassani, Hassan, additional

Published
2022
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19. Genetic causes of primary immunodeficiency in the Jordanian population.

Author

Obeidat, Loiy, Abu-Halaweh, Marwan, Alzyoud, Raed, Albsoul, Eman, and Zaravinos, Apostolos

Subjects
CAPPING proteins, JAK-STAT pathway, PRIMARY immunodeficiency diseases, G proteins, COCAINE abuse
Abstract

Ιnborn errors of immunity (IEI) represents a heterogenous collection of >480 immune system anomalies, leading to severe infections, autoimmune disorders and malignancies. While these conditions are rare globally, their prevalence is notably higher in the Jordanian population, attributed to elevated rates of consanguinity. The intricate nature of IEI has driven the adoption of genomic technologies for the identification of associated genetic defects. In the present study, whole-exome sequencing was performed on nine Jordanian IEI patient samples, confirming germline single-nucleotide variations (SNVs) in 14 genes through Sanger sequencing. Of note, signal transducer and activator of transcription 1 (STAT1), elastase, neutrophil expressed (ELANE) and interferon induced with helicase c domain 1 (IFIH1) harbored mutations that were previously unreported in the Jordanian IEI population. In addition, mutations in capping protein regulator and myosin 1 linker 2 (c.3683C>T), TNFα-induced protein 3-interacting protein 1 (TNIP1) (c.460C>G) and STAT1 (c.1061T>C) were confirmed, marking their association with Jordanian IEI. For robustness, the genomic databases Ensemble, Genome AD and ClinVar were used to confirm the SNVs' associations with IEI. Kyoto Encyclopedia of Genes and Genomes pathway analysis also showed involvement of the IL-17 signaling pathway (including IL-17 receptor A), T-helper type 17 cell differentiation (including STAT1), the JAK-STAT signaling pathway (including STAT2 and tyrosine kinase 2), neutrophil extracellular trap formation (including ELANE), cocaine addiction [G protein signaling modulator 1 (GPSM1)] and cytokine-cytokine receptor interaction (IL-17 receptor C). In summary, exome sequencing identified a likely causative genetic defect in ELANE (PID-28), STAT1 (PID-30) and IFIH1 (PID-33). The present findings reveal the association of novel STAT1, ELANE mutations with the clinical phenotype of the patients, as well as known mutations in NLRP12, GPSM1 and TNIP1, in addition to novel ELANE, STAT1 and IFIH1 mutations associated in the context of Jordanian IEI. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Kawarabi: Administrative Structuring of a Multicenter Research Collaborative to Study Kawasaki Disease in the Arab Countries

Author

Arab, Yousra, Harahsheh, Ashraf S., Dahdah, Nagib, El-Kholy, Nermeen, Abed, Maysam Y., Abu Al-Saoud, Sima Y., Agha, Hala M., Alahmadi, Fahad, Alamer, Suad R., Awadhi, Zainab Al, Ali, Sulafa, Ali, Mohamed T., Alrabte, Hanifa, Al-Saloos, Hesham, Al-Senaidi, Khalfan S., Alzyoud, Raed, Awidat, Najat, Bouayed, Kenza, Bouaziz, Asma, Boukari, Rachida, El Ganzoury, Mona M., Elmarsafawy, Hala M., Elrugige, Najat, Fitouri, Zohra, Kotby, Alyaa, Ladj, Mohamed S., Bekkar, Mokhtar, Mouawad, Pierre, Salih, Aso F., Suleiman, Mohamed, and Choueiter, Nadine F.

Abstract

Kawasaki disease (KD), the leading cause of acquired heart disease in children in developed countries, merits conducting detailed studies in Arab countries. We introduce Kawarabi, as a multicenter research collaborative effort dedicated to improving diagnosis, care, and outcome of children and adults with KD in the Arab world. During the COVID-19 pandemic, there emerged a new multisystem inflammatory syndrome in children; a disease similar to KD. This highlighted the challenges that Arab physicians face in diagnosing and managing children with KD and KD-like illnesses. Kawarabi brings together experts in North America and Arab nations to study this family of diseases in a not-for-profit, voluntary scientific collaborative setting. Bylaws addressing the vision, objectives, structure, and governance of Kawarabi were established, and vetted by the 45 organizing members in 2021. An initial scientific publication showed evidence of a decreased level of awareness of the disease in the general population, as well as the lack of access to resources available for physicians caring for children with KD in Arab countries. Kawarabi has since held several educational webinars and an inaugural yearly meeting. The groundwork for future initiatives targeted at increasing awareness and understanding of the management and the long-term outcomes of children with KD in the region was established. Data on KD in the Arab world are lacking. Kawarabi is a multicenter research collaborative organization that has the unique resources, diversified ethnic makeup, and energy, to accomplish significant advances in our understanding and management of KD and its variants.

Published
2024
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