Search

Your search keyword '"Anderson, Kyle"' showing total 121 results
Start Over Author "Anderson, Kyle" Publication Year Range Last 3 years
121 results on '"Anderson, Kyle"'

2. Thermalization and Criticality on an Analog-Digital Quantum Simulator

Author

Andersen, Trond I., Astrakhantsev, Nikita, Karamlou, Amir H., Berndtsson, Julia, Motruk, Johannes, Szasz, Aaron, Gross, Jonathan A., Schuckert, Alexander, Westerhout, Tom, Zhang, Yaxing, Forati, Ebrahim, Rossi, Dario, Kobrin, Bryce, Di Paolo, Agustin, Klots, Andrey R., Drozdov, Ilya, Kurilovich, Vladislav D., Petukhov, Andre, Ioffe, Lev B., Elben, Andreas, Rath, Aniket, Vitale, Vittorio, Vermersch, Benoit, Acharya, Rajeev, Beni, Laleh Aghababaie, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Atalaya, Juan, Ballard, Brian, Bardin, Joseph C., Bengtsson, Andreas, Bilmes, Alexander, Bortoli, Gina, Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Broughton, Michael, Browne, David A., Buchea, Brett, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Cabrera, Anthony, Campero, Juan, Chang, Hung-Shen, Chen, Zijun, Chiaro, Ben, Claes, Jahan, Cleland, Agnetta Y., Cogan, Josh, Collins, Roberto, Conner, Paul, Courtney, William, Crook, Alexander L., Das, Sayan, Debroy, Dripto M., De Lorenzo, Laura, Barba, Alexander Del Toro, Demura, Sean, Donohoe, Paul, Dunsworth, Andrew, Earle, Clint, Eickbusch, Alec, Elbag, Aviv Moshe, Elzouka, Mahmoud, Erickson, Catherine, Faoro, Lara, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Fowler, Austin G., Foxen, Brooks, Ganjam, Suhas, Gasca, Robert, Giang, William, Gidney, Craig, Gilboa, Dar, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Graumann, Dietrich, Greene, Alex, Habegger, Steve, Hamilton, Michael C., Hansen, Monica, Harrigan, Matthew P., Harrington, Sean D., Heslin, Stephen, Heu, Paula, Hill, Gordon, Hoffmann, Markus R., Huang, Hsin-Yuan, Huang, Trent, Huff, Ashley, Huggins, William J., Isakov, Sergei V., Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Jordan, Stephen, Joshi, Chaitali, Juhas, Pavol, Kafri, Dvir, Kang, Hui, Kechedzhi, Kostyantyn, Khaire, Trupti, Khattar, Tanuj, Khezri, Mostafa, Kieferová, Mária, Kim, Seon, Kitaev, Alexei, Klimov, Paul V., Korotkov, Alexander N., Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Langley, Brandon W., Laptev, Pavel, Lau, Kim-Ming, Guevel, Loïck Le, Ledford, Justin, Lee, Joonho, Lee, Kenny, Lensky, Yuri D., Lester, Brian J., Li, Wing Yan, Lill, Alexander T., Liu, Wayne, Livingston, William P., Locharla, Aditya, Lundahl, Daniel, Lunt, Aaron, Madhuk, Sid, Maloney, Ashley, Mandrà, Salvatore, Martin, Leigh S., Martin, Orion, Martin, Steven, Maxfield, Cameron, McClean, Jarrod R., McEwen, Matt, Meeks, Seneca, Miao, Kevin C., Mieszala, Amanda, Molina, Sebastian, Montazeri, Shirin, Morvan, Alexis, Movassagh, Ramis, Neill, Charles, Nersisyan, Ani, Newman, Michael, Nguyen, Anthony, Nguyen, Murray, Ni, Chia-Hung, Niu, Murphy Yuezhen, Oliver, William D., Ottosson, Kristoffer, Pizzuto, Alex, Potter, Rebecca, Pritchard, Orion, Pryadko, Leonid P., Quintana, Chris, Reagor, Matthew J., Rhodes, David M., Roberts, Gabrielle, Rocque, Charles, Rosenberg, Eliott, Rubin, Nicholas C., Saei, Negar, Sankaragomathi, Kannan, Satzinger, Kevin J., Schurkus, Henry F., Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Sivak, Volodymyr, Skruzny, Jindra, Small, Spencer, Smith, W. Clarke, Springer, Sofia, Sterling, George, Suchard, Jordan, Szalay, Marco, Sztein, Alex, Thor, Douglas, Torres, Alfredo, Torunbalci, M. Mert, Vaishnav, Abeer, Vdovichev, Sergey, Villalonga, Benjamin, Heidweiller, Catherine Vollgraff, Waltman, Steven, Wang, Shannon X., White, Theodore, Wong, Kristi, Woo, Bryan W., Xing, Cheng, Yao, Z. Jamie, Yeh, Ping, Ying, Bicheng, Yoo, Juhwan, Yosri, Noureldin, Young, Grayson, Zalcman, Adam, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Babbush, Ryan, Boixo, Sergio, Hilton, Jeremy, Lucero, Erik, Megrant, Anthony, Kelly, Julian, Chen, Yu, Smelyanskiy, Vadim, Vidal, Guifre, Roushan, Pedram, Lauchli, Andreas M., Abanin, Dmitry A., and Mi, Xiao

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract

Understanding how interacting particles approach thermal equilibrium is a major challenge of quantum simulators. Unlocking the full potential of such systems toward this goal requires flexible initial state preparation, precise time evolution, and extensive probes for final state characterization. We present a quantum simulator comprising 69 superconducting qubits which supports both universal quantum gates and high-fidelity analog evolution, with performance beyond the reach of classical simulation in cross-entropy benchmarking experiments. Emulating a two-dimensional (2D) XY quantum magnet, we leverage a wide range of measurement techniques to study quantum states after ramps from an antiferromagnetic initial state. We observe signatures of the classical Kosterlitz-Thouless phase transition, as well as strong deviations from Kibble-Zurek scaling predictions attributed to the interplay between quantum and classical coarsening of the correlated domains. This interpretation is corroborated by injecting variable energy density into the initial state, which enables studying the effects of the eigenstate thermalization hypothesis (ETH) in targeted parts of the eigenspectrum. Finally, we digitally prepare the system in pairwise-entangled dimer states and image the transport of energy and vorticity during thermalization. These results establish the efficacy of superconducting analog-digital quantum processors for preparing states across many-body spectra and unveiling their thermalization dynamics.

Published
2024

3. Triggering the 2022 eruption of Mauna Loa

Author

Lynn, Kendra J., Downs, Drew T., Trusdell, Frank A., Wieser, Penny E., Rangel, Berenise, McDade, Baylee, Hotovec-Ellis, Alicia J., Bennington, Ninfa, Anderson, Kyle R., Ruth, Dawn C. S., DeVitre, Charlotte L., Ellis, Andria P., Nadeau, Patricia A., Clor, Laura, Kelly, Peter, Dotray, Peter J., and Chang, Jefferson C.

Published
2024
Full Text
View/download PDF

5. Dynamics of magnetization at infinite temperature in a Heisenberg spin chain

Author

Rosenberg, Eliott, Andersen, Trond, Samajdar, Rhine, Petukhov, Andre, Hoke, Jesse, Abanin, Dmitry, Bengtsson, Andreas, Drozdov, Ilya, Erickson, Catherine, Klimov, Paul, Mi, Xiao, Morvan, Alexis, Neeley, Matthew, Neill, Charles, Acharya, Rajeev, Allen, Richard, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Atalaya, Juan, Bardin, Joseph, Bilmes, A., Bortoli, Gina, Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Broughton, Michael, Buckley, Bob B., Buell, David, Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chang, Hung-Shen, Chen, Zijun, Chiaro, Benjamin, Chik, Desmond, Cogan, Josh, Collins, Roberto, Conner, Paul, Courtney, William, Crook, Alexander, Curtin, Ben, Debroy, Dripto, Barba, Alexander Del Toro, Demura, Sean, Di Paolo, Agustin, Dunsworth, Andrew, Earle, Clint, Farhi, E., Fatemi, Reza, Ferreira, Vinicius, Flores, Leslie, Forati, Ebrahim, Fowler, Austin, Foxen, Brooks, Garcia, Gonzalo, Genois, Élie, Giang, William, Gidney, Craig, Gilboa, Dar, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Gross, Jonathan, Habegger, Steve, Hamilton, Michael, Hansen, Monica, Harrigan, Matthew, Harrington, Sean, Heu, Paula, Hill, Gordon, Hoffmann, Markus, Hong, Sabrina, Huang, Trent, Huff, Ashley, Huggins, William, Ioffe, Lev, Isakov, Sergei, Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Juhas, Pavol, Kafri, D., Khattar, Tanuj, Khezri, Mostafa, Kieferová, Mária, Kim, Seon, Kitaev, Alexei, Klots, Andrey, Korotkov, Alexander, Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Lau, Kim Ming, Laws, Lily, Lee, Joonho, Lee, Kenneth, Lensky, Yuri, Lester, Brian, Lill, Alexander, Liu, Wayne, Livingston, William P., Locharla, A., Mandrà, Salvatore, Martin, Orion, Martin, Steven, McClean, Jarrod, McEwen, Matthew, Meeks, Seneca, Miao, Kevin, Mieszala, Amanda, Montazeri, Shirin, Movassagh, Ramis, Mruczkiewicz, Wojciech, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Niu, M., O'Brien, Thomas, Omonije, Seun, Opremcak, Alex, Potter, Rebecca, Pryadko, Leonid, Quintana, Chris, Rhodes, David, Rocque, Charles, Rubin, N., Saei, Negar, Sank, Daniel, Sankaragomathi, Kannan, Satzinger, Kevin, Schurkus, Henry, Schuster, Christopher, Shearn, Michael, Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Sivak, Volodymyr, Skruzny, Jindra, Smith, Clarke, Somma, Rolando, Sterling, George, Strain, Doug, Szalay, Marco, Thor, Douglas, Torres, Alfredo, Vidal, Guifre, Villalonga, Benjamin, Heidweiller, Catherine Vollgraff, White, Theodore, Woo, Bryan, Xing, Cheng, Yao, Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhang, Yaxing, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Babbush, Ryan, Bacon, Dave, Boixo, Sergio, Hilton, Jeremy, Lucero, Erik, Megrant, Anthony, Kelly, Julian, Chen, Yu, Smelyanskiy, Vadim, Khemani, Vedika, Gopalakrishnan, Sarang, Prosen, Tomaž, and Roushan, Pedram

Subjects
Quantum Physics
Abstract

Understanding universal aspects of quantum dynamics is an unresolved problem in statistical mechanics. In particular, the spin dynamics of the 1D Heisenberg model were conjectured to belong to the Kardar-Parisi-Zhang (KPZ) universality class based on the scaling of the infinite-temperature spin-spin correlation function. In a chain of 46 superconducting qubits, we study the probability distribution, $P(\mathcal{M})$, of the magnetization transferred across the chain's center. The first two moments of $P(\mathcal{M})$ show superdiffusive behavior, a hallmark of KPZ universality. However, the third and fourth moments rule out the KPZ conjecture and allow for evaluating other theories. Our results highlight the importance of studying higher moments in determining dynamic universality classes and provide key insights into universal behavior in quantum systems.

Published
2023
Full Text
View/download PDF

7. Overcoming leakage in scalable quantum error correction

Author

Miao, Kevin C., McEwen, Matt, Atalaya, Juan, Kafri, Dvir, Pryadko, Leonid P., Bengtsson, Andreas, Opremcak, Alex, Satzinger, Kevin J., Chen, Zijun, Klimov, Paul V., Quintana, Chris, Acharya, Rajeev, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Bardin, Joseph C., Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chiaro, Ben, Collins, Roberto, Conner, Paul, Crook, Alexander L., Curtin, Ben, Debroy, Dripto M., Demura, Sean, Dunsworth, Andrew, Erickson, Catherine, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Fowler, Austin G., Foxen, Brooks, Garcia, Gonzalo, Giang, William, Gidney, Craig, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Gross, Jonathan A., Hamilton, Michael C., Harrington, Sean D., Heu, Paula, Hilton, Jeremy, Hoffmann, Markus R., Hong, Sabrina, Huang, Trent, Huff, Ashley, Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Kelly, Julian, Kim, Seon, Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Laws, Lily, Lee, Kenny, Lester, Brian J., Lill, Alexander T., Liu, Wayne, Locharla, Aditya, Lucero, Erik, Martin, Steven, Megrant, Anthony, Mi, Xiao, Montazeri, Shirin, Morvan, Alexis, Naaman, Ofer, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Potter, Rebecca, Rocque, Charles, Roushan, Pedram, Sankaragomathi, Kannan, Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Skruzny, Jindra, Smith, W. Clarke, Sterling, George, Szalay, Marco, Thor, Douglas, Torres, Alfredo, White, Theodore, Woo, Bryan W. K., Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Smelyanskiy, Vadim, Petukhov, Andre, Korotkov, Alexander N., Sank, Daniel, and Chen, Yu

Subjects
Quantum Physics
Abstract

Leakage of quantum information out of computational states into higher energy states represents a major challenge in the pursuit of quantum error correction (QEC). In a QEC circuit, leakage builds over time and spreads through multi-qubit interactions. This leads to correlated errors that degrade the exponential suppression of logical error with scale, challenging the feasibility of QEC as a path towards fault-tolerant quantum computation. Here, we demonstrate the execution of a distance-3 surface code and distance-21 bit-flip code on a Sycamore quantum processor where leakage is removed from all qubits in each cycle. This shortens the lifetime of leakage and curtails its ability to spread and induce correlated errors. We report a ten-fold reduction in steady-state leakage population on the data qubits encoding the logical state and an average leakage population of less than $1 \times 10^{-3}$ throughout the entire device. The leakage removal process itself efficiently returns leakage population back to the computational basis, and adding it to a code circuit prevents leakage from inducing correlated error across cycles, restoring a fundamental assumption of QEC. With this demonstration that leakage can be contained, we resolve a key challenge for practical QEC at scale., Comment: Main text: 7 pages, 5 figures

Published
2022
Full Text
View/download PDF

8. Coordinating science during an eruption: lessons from the 2020–2021 Kīlauea volcanic eruption

Author

Cooper, Kari M, Anderson, Kyle, Cashman, Kathy, Coombs, Michelle, Dietterich, Hannah, Fischer, Tobias, Houghton, Bruce, Johanson, Ingrid, Lynn, Kendra J, Manga, Michael, and Wauthier, Christelle

Subjects
Eruption response, Scientific coordination, Scientific advisory committee, Hawaii, CONVERSE, Geology, Geochemistry & Geophysics
Abstract

Data collected during well-observed eruptions can lead to dramatic increases in our understanding of volcanic processes. However, the necessary prioritization of public safety and hazard mitigation during a crisis means that scientific opportunities may be sacrificed. Thus, maximizing the scientific gains from eruptions requires improved planning and coordinating science activities among governmental organizations and academia before and during volcanic eruptions. One tool to facilitate this coordination is a Scientific Advisory Committee (SAC). In the USA, the Community Network for Volcanic Eruption Response (CONVERSE) has been developing and testing this concept during workshops and scenario-based activities. The December 2020 eruption of Kīlauea volcano, Hawaii, provided an opportunity to test and refine this model in real-time and in a real-world setting. We present here the working model of a SAC developed during this eruption. Successes of the Kīlauea SAC (K-SAC) included broadening the pool of scientists involved in eruption response and developing and codifying procedures that may form the basis of operation for future SACs. Challenges encountered by the K-SAC included a process of review and facilitation of research proposals that was too slow to include outside participation in the early parts of the eruption and a decision process that fell on a small number of individuals at the responding volcano observatory. Possible ways to address these challenges include (1) supporting community-building activities between eruptions that make connections among scientists within and outside formal observatories, (2) identifying key science questions and pre-planning science activities, which would facilitate more rapid implementation across a broader scientific group, and (3) continued dialog among observatory scientists, emergency responders, and non-observatory scientists about the role of SACs. The SAC model holds promise to become an integral part of future efforts, leading in the short and longer term to more effective hazard response and greater scientific discovery and understanding.

Published
2023

12. Understanding the drivers of volcano deformation through geodetic model verification and validation

Author

Crozier, Josh, Karlstrom, Leif, Montgomery-Brown, Emily, Angarita, Mario, Cayol, Valérie, Bato, Mary Grace, Wang, Taiyi A., Grapenthin, Ronni, Shreve, Tara, Anderson, Kyle, Astort, Ana, Bodart, Olivier, Cannavò, Flavio, Currenti, Gilda, Dabaghi, Farshid, Erickson, Brittany A., Garg, Deepak, Head, Matthew, Iozzia, Adriana, Kim, Young Cheol, Le Mével, Hélène, Novoa Lizama, Camila, Rucker, Cody, Silverii, Francesca, Trasatti, Elisa, and Zhan, Yan

Published
2023
Full Text
View/download PDF

19. Zucker Diabetic‐Sprague Dawley Rats Have Impaired Peri‐Implant Bone Formation, Matrix Composition, and Implant Fixation Strength

Author

Anderson, Kyle D, primary, Beckmann, Christian, additional, Heermant, Saskia, additional, Ko, Frank C, additional, Dulion, Bryan, additional, Tarhoni, Imad, additional, Borgia, Jeffrey A, additional, Virdi, Amarjit S, additional, Wimmer, Markus A, additional, Sumner, D Rick, additional, and Ross, Ryan D, additional

Published
2023
Full Text
View/download PDF

20. The 2018 Eruption of Kīlauea: Insights, Puzzles, and Opportunities for Volcano Science.

Author

Anderson, Kyle R., Shea, Thomas, Lynn, Kendra J., Montgomery-Brown, Emily K., Swanson, Donald A., Patrick, Matthew R., Shiro, Brian R., and Neal, Christina A.

Subjects
*VOLCANOES, *EARTHQUAKES, *VOLCANIC eruptions, *VOLCANOLOGY, *LAVA flows, *CALDERAS
Abstract

The science of volcanology advances disproportionately during exceptionally large or well-observed eruptions. The 2018 eruption of Kīlauea Volcano (Hawai'i) was its most impactful in centuries, involving an outpouring of more than one cubic kilometer of basalt, a magnitude 7 flank earthquake, and the volcano's largest summit collapse since at least the nineteenth century. Eruptive activity was documented in detail, yielding new insights into large caldera-rift eruptions; the geometry of a shallow magma storage-transport system and its interaction with rift zone tectonics; mechanisms of basaltic tephra-producing explosions; caldera collapse mechanics; and the dynamics of fissure eruptions and high-volume lava flows. Insights are broadly applicable to a range of volcanic systems and should reduce risk from future eruptions. Multidisciplinary collaboration will be required to fully leverage the diversity of monitoring data to address many of the most important outstanding questions. Unprecedented observations of a caldera collapse and coupled rift zone eruption yield new opportunities for advancing volcano science. Magma flow to a low-elevation rift zone vent triggered quasi-periodic step-like collapse of a summit caldera, which pressurized the magma system and sustained the eruption. Kīlauea's magmatic-tectonic system is tightly interconnected over tens of kilometers, with complex feedback mechanisms and interrelated hazards over widely varying timescales. The eruption revealed magma stored in diverse locations, volumes, and compositions, not only beneath the summit but also within the volcano's most active rift zone. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Drivers of Volcano Deformation (DVD) validation and verification exercises: Phase 1

Author

Cayol, Valérie, Karlstrom, Leif, Crozier, Joshua, Montgomery-Brown, Emily, Bato, Mary-Grace, Vargas, Mario Angarita, Grapenthin, Ronni, Anderson, Kyle, Astort, Ana, Bodart, Olivier, Cannavo, Flavio, Currenti, Gilda, Dabaghi, Farshid, Garg, Deepak, Head, Matthew, Iozzia, Adriana, Le Mével, Hélène, McCluskey, Owen, Novoa, Camilla, Silverii, Francesca, Trasatti, Elisa, Shreve, Tara, Wang, Taiyi, and Zhan, Yan

Abstract

Volcano geodesy typically requires the synthesis of ground deformation models with observational data. A wide variety of volcano deformation models have been developed, from simple point source models to sophisticated numerical approaches that attempt to account for realistic topographies, complex source geometries and heterogeneous geologic structure. A wide variety of inverse methods are also combined with these models to characterize the volcanic sources from the observed data. However, to date there has been no comprehensive attempt to intercompare volcano deformation models and inversion results, or to establish baseline standards of reproducibility. The Drivers of Volcano Deformation (DVD) exercises provide a community-driven framework to accomplish these goals with a series of exercises for verification - quantitative comparison of forward model outputs, and validation - comparison of inversion results from synthetic data. The forward model exercises begin with a spherical reservoir in a homogeneous half-space, for which an exact solution exists, then introduce topography, more complex source geometries, and heterogeneous elastic properties. The inversion exercises provide synthetic GNSS and InSAR datasets for spherical reservoirs in elastic half-spaces with varying noise, and assess the consistency and uniqueness with which reservoir location, volume change, radius and pressurization can be inverted. The forward models comparison resulted in multiple bugs being fixed in commonly used solutions. The variability of inversion results emphasizes the importance of model choice, inverse methods, and uncertainty quantification. The Drivers of Volcano Deformation exercises are planned to evolve with additional phases that will test more complex forward models and inverse problems., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023

26. Decrease in volcano jet noise peak frequency as crater expands

Author

McKee, Kathleen F., primary, Snee, Eveanjelene, additional, Maher, Sean, additional, Smith, Cassandra, additional, Reath, Kevin, additional, Roman, Diana, additional, Matoza, Robin, additional, Carn, Simon, additional, Mastin, Larry, additional, Anderson, Kyle, additional, Damby, David, additional, Perttu, Anna, additional, Assink, Jelle D., additional, de Negri Leiva, Rodrigo, additional, Degterev, Artem, additional, Rybin, Alexander, additional, Chibisova, Marina, additional, Itikarai, Ima, additional, Mulina, Kila, additional, and Saunders, Steve, additional

Published
2023
Full Text
View/download PDF

28. Essay: I haven't even graduated yet, stop asking me for money

Author

Anderson, Kyle

Subjects
News, opinion and commentary, Sports and fitness
Abstract

Byline: Kyle Anderson Graduating college comes with a lot of extra expenses, and your cap and gown is just the start. Seniors shell out hundreds - sometimes thousands - of [...]

Published
2023

30. Measurement-Induced State Transitions in a Superconducting Qubit: Within the Rotating Wave Approximation

Author

Khezri, Mostafa, Opremcak, Alex, Chen, Zijun, Bengtsson, Andreas, White, Theodore, Naaman, Ofer, Acharya, Rajeev, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Bardin, Joseph C., Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chiaro, Ben, Collins, Roberto, Crook, Alexander L., Curtin, Ben, Demura, Sean, Dunsworth, Andrew, Erickson, Catherine, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Foxen, Brooks, Garcia, Gonzalo, Giang, William, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Hamilton, Michael C., Harrington, Sean D., Heu, Paula, Hilton, Jeremy, Hoffmann, Markus R., Hong, Sabrina, Huang, Trent, Huff, Ashley, Iveland, Justin, Jeffrey, Evan, Kelly, Julian, Kim, Seon, Klimov, Paul V., Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Laws, Lily, Lee, Kenny, Lester, Brian J., Lill, Alexander T., Liu, Wayne, Locharla, Aditya, Lucero, Erik, Martin, Steven, McEwen, Matt, Megrant, Anthony, Mi, Xiao, Miao, Kevin C., Montazeri, Shirin, Morvan, Alexis, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Potter, Rebecca, Quintana, Chris, Rocque, Charles, Roushan, Pedram, Sankaragomathi, Kannan, Satzinger, Kevin J., Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shvarts, Vladimir, Skruzny, Jindra, Smith, W. Clarke, Sterling, George, Szalay, Marco, Thor, Douglas, Torres, Alfredo, Woo, Bryan W. K., Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zhu, Ningfeng, Zobrist, Nicholas, Sank, Daniel, Korotkov, Alexander, Chen, Yu, and Smelyanskiy, Vadim

Subjects
Quantum Physics, FOS: Physical sciences, Quantum Physics (quant-ph)
Abstract

Superconducting qubits typically use a dispersive readout scheme, where a resonator is coupled to a qubit such that its frequency is qubit-state dependent. Measurement is performed by driving the resonator, where the transmitted resonator field yields information about the resonator frequency and thus the qubit state. Ideally, we could use arbitrarily strong resonator drives to achieve a target signal-to-noise ratio in the shortest possible time. However, experiments have shown that when the average resonator photon number exceeds a certain threshold, the qubit is excited out of its computational subspace, which we refer to as a measurement-induced state transition. These transitions degrade readout fidelity, and constitute leakage which precludes further operation of the qubit in, for example, error correction. Here we study these transitions using a transmon qubit by experimentally measuring their dependence on qubit frequency, average photon number, and qubit state, in the regime where the resonator frequency is lower than the qubit frequency. We observe signatures of resonant transitions between levels in the coupled qubit-resonator system that exhibit noisy behavior when measured repeatedly in time. We provide a semi-classical model of these transitions based on the rotating wave approximation and use it to predict the onset of state transitions in our experiments. Our results suggest the transmon is excited to levels near the top of its cosine potential following a state transition, where the charge dispersion of higher transmon levels explains the observed noisy behavior of state transitions. Moreover, occupation in these higher energy levels poses a major challenge for fast qubit reset.

Published
2022

31. Ground Deformation and Gravity for Volcano Monitoring.

Author

Montgomery-Brown, Emily K., Anderson, Kyle R., Johanson, Ingrid A., Poland, Michael P., and Flinders, Ashton F.

Subjects
GLOBAL Positioning System, SYNTHETIC aperture radar, SLOW earthquakes, DEFORMATION potential, DEFORMATION of surfaces, VOLCANIC eruptions, DIKES (Geology)
Abstract

The document "Ground Deformation and Gravity for Volcano Monitoring" offers recommendations and tools for monitoring volcanic activity in the United States. It stresses the importance of detecting changes in surface deformation, identifying geodetic sources, and distinguishing between volcanic and nonvolcanic ground movements. The document suggests using a combination of instruments like GNSS stations, borehole tiltmeters, and InSAR for optimal geodetic observations. Recommendations vary depending on the volcano's threat level, with higher threat level volcanoes requiring more monitoring instrumentation. The document includes scientific research articles on various volcanic activities, such as ground deformation at Soufrière Hills Volcano, magma chamber geometry at Sierra Negra Volcano, and magma supply in the east central Aleutian arc, utilizing radar interferometry, GPS, and InSAR observations to study volcanic processes and magma dynamics. [Extracted from the article]

Published
2024
Full Text
View/download PDF

32. Host Defense Peptide Piscidin and Yeast-Derived Glycolipid Exhibit Synergistic Antimicrobial Action through Concerted Interactions with Membranes

Author

Liu, Fei, Greenwood, Alexander I., Xiong, Yawei, Miceli, Rebecca T., Fu, Riqiang, Anderson, Kyle W., McCallum, Scott A., Mihailescu, Mihaela, Gross, Richard, and Cotten, Myriam L.

Abstract

Developing new antimicrobials as alternatives to conventional antibiotics has become an urgent race to eradicate drug-resistant bacteria and to save human lives. Conventionally, antimicrobial molecules are studied independently even though they can be cosecreted in vivo. In this research, we investigate two classes of naturally derived antimicrobials: sophorolipid (SL) esters as modified yeast-derived glycolipid biosurfactants that feature high biocompatibility and low production cost; piscidins, which are host defense peptides (HDPs) from fish. While HDPs such as piscidins target the membrane of pathogens, and thus result in low incidence of resistance, SLs are not well understood on a mechanistic level. Here, we demonstrate that combining SL–hexyl ester (SL-HE) with subinhibitory concentration of piscidins 1 (P1) and 3 (P3) stimulates strong antimicrobial synergy, potentiating a promising therapeutic window. Permeabilization assays and biophysical studies employing circular dichroism, NMR, mass spectrometry, and X-ray diffraction are performed to investigate the mechanism underlying this powerful synergy. We reveal four key mechanistic features underlying the synergistic action: (1) P1/3 binds to SL-HE aggregates, becoming α-helical; (2) piscidin–glycolipid assemblies synergistically accumulate on membranes; (3) SL-HE used alone or bound to P1/3 associates with phospholipid bilayers where it induces defects; (4) piscidin–glycolipid complexes disrupt the bilayer structure more dramatically and differently than either compound alone, with phase separation occurring when both agents are present. Overall, dramatic enhancement in antimicrobial activity is associated with the use of two membrane-active agents, with the glycolipid playing the roles of prefolding the peptide, coordinating the delivery of both agents to bacterial surfaces, recruiting the peptide to the pathogenic membranes, and supporting membrane disruption by the peptide. Given that SLs are ubiquitously and safely used in consumer products, the SL/peptide formulation engineered and mechanistically characterized in this study could represent fertile ground to develop novel synergistic agents against drug-resistant bacteria.

Published
2023
Full Text
View/download PDF

33. Purification-based quantum error mitigation of pair-correlated electron simulations

Author

O'Brien, Thomas, primary, Anselmetti, Gian-Luca, additional, Gkritsis, Fotios, additional, Elfving, Vincent, additional, Polla, Stefano, additional, Huggins, William, additional, Oumarou, Oumarou, additional, Kechedzhi, Kostyantyn, additional, Abanin, Dmitry, additional, Acharya, Rajeev, additional, Aleiner, Igor, additional, Allen, Richard, additional, Andersen, Trond, additional, Anderson, Kyle, additional, Ansmann, Markus, additional, Arute, Frank, additional, Arya, Kunal, additional, Asfaw, Abraham, additional, Atalaya, Juan, additional, Bacon, Dave, additional, Bardin, Joseph, additional, Bengtsson, Andreas, additional, Boixo, Sergio, additional, Bortoli, Gina, additional, Bourassa, Alexandre, additional, Bovaird, Jenna, additional, Brill, Leon, additional, Broughton, Michael, additional, Buckley, Bob, additional, Buell, David, additional, Burger, Tim, additional, Burkett, Brian, additional, Bushnell, Nicholas, additional, Campero, Juan, additional, Chen, Yu, additional, Chen, Zijun, additional, Chiaro, Ben, additional, Chik, Desmond, additional, Cogan, Josh, additional, Collins, Roberto, additional, Conner, Paul, additional, Courtney, William, additional, Crook, Alexander, additional, Curtin, Ben, additional, Debroy, Dripto, additional, Barba, Alexander Del Toro, additional, Demura, Sean, additional, Drozdov, Ilya, additional, Dunsworth, Andrew, additional, Eppens, Daniel, additional, Erickson, Catherine, additional, Faoro, Lara, additional, Farhi, Edward, additional, Fatemi, Reza, additional, Ferreira, Vinicius, additional, Burgos, Leslie Flores, additional, Forati, Ebrahim, additional, Fowler, Austin, additional, Foxen, Brooks, additional, Giang, William, additional, Gidney, Craig, additional, Gilboa, Dar, additional, Giustina, Marissa, additional, Gosula, Raja, additional, Dau, Alejandro Grajales, additional, Gross, Jonathan, additional, Habegger, Steve, additional, Hamilton, Michael, additional, Hansen, Monica, additional, Harrigan, Matthew, additional, Harrington, Sean, additional, Heu, Paula, additional, Hilton, Jeremy, additional, Hoffmann, Markus, additional, Hong, Sabrina, additional, Huang, Trent, additional, Huff, Ashley, additional, Ioffe, L. B., additional, Isakov, Sergei, additional, Iveland, Justin, additional, Jeffrey, E., additional, Jiang, Zhang, additional, Jones, Cody, additional, Juhas, Pavol, additional, Kafri, Dvir, additional, Kelly, Julian, additional, Khattar, Tanuj, additional, Khezri, Mostafa, additional, Kieferova, Marika, additional, Kim, Seon, additional, Klimov, Paul, additional, Klots, Andrey, additional, Korotkov, Alexander, additional, Kostritsa, Fedor, additional, Kreikebaum, John Mark, additional, Landhuis, David, additional, Laptev, Pavel, additional, Lau, Kim-Ming, additional, Laws, Lily, additional, Lee, Joonho, additional, Lee, Kenny, additional, Lester, Brian, additional, Lill, Alexander, additional, Liu, Wayne, additional, Livingston, William, additional, Locharla, Aditya, additional, Lucero, Erik, additional, Malone, Fionn, additional, Mandra, Salvatore, additional, Martin, Orion, additional, Martin, Steven, additional, McClean, Jarrod, additional, McCourt, Trevor, additional, McEwen, Matthew, additional, Megrant, Anthony, additional, Mi, Xiao, additional, Miao, Kevin, additional, Mieszala, Amanda, additional, Mohseni, Masoud, additional, Montazeri, Shirin, additional, Morvan, Alexis, additional, Movassagh, Ramis, additional, Mruczkiewicz, Wojciech, additional, Naaman, Ofer, additional, Neeley, Matthew, additional, Neill, Charles, additional, Nersisyan, Ani, additional, Neven, Hartmut, additional, Newman, Michael, additional, Ng, Jiun How, additional, Nguyen, Anthony, additional, Nguyen, Murray, additional, Niu, Murphy, additional, Omonije, Seun, additional, Opremcak, Alex, additional, Petukhov, Andre, additional, Potter, Rebecca, additional, Pryadko, Leonid, additional, Quintana, Chris, additional, Rocque, Charles, additional, Roushan, Pedram, additional, Saei, Negar, additional, Sank, Daniel, additional, Sankaragomathi, Kannan, additional, Satzinger, Kevin, additional, Schurkus, Henry, additional, Shearn, Michael, additional, Shorter, Aaron, additional, Shutty, Noah, additional, Vladimir, Shvarts, additional, Skruzny, Jindra, additional, Smelyanskiy, Vadim, additional, Smith, W. Clarke, additional, Somma, Rolando, additional, Sterling, George, additional, Strain, Doug, additional, Szalay, Marco, additional, Thor, Douglas, additional, Torres, Alfredo, additional, Vidal, Guifre, additional, Villalonga, Benjamin, additional, Heidweiller, Catherine Vollgraff, additional, White, Theodore, additional, Woo, Bryan, additional, Xing, Cheng, additional, Yao, Z. Jamie, additional, Yeh, Ping, additional, Yoo, Juhwan, additional, Young, Grayson, additional, Zalcman, Adam, additional, Zhang, Yaxing, additional, Zhu, Ningfeng, additional, Zobrist, Nicholas, additional, Gogolin, Christian, additional, Babbush, Ryan, additional, and Rubin, Nicholas, additional

Published
2022
Full Text
View/download PDF

34. Science Values and epistemic exclusion

Author

Flores-Robles, Grace, Milless, Katlyn, Myer, Annalisa, Franklin, Elissia, Fikslin, Rachel, Gomez, Bryant, and Anderson, Kyle

Subjects
FOS: Psychology, Social Psychology, Psychology, Social and Behavioral Sciences
Abstract

The goal of this project is to examine the relationship between science values, epistemic exclusion, and endorsement of academic meritocracy beliefs.

Published
2022
Full Text
View/download PDF

39. Interlaboratory Studies Using the NISTmAb to Advance Biopharmaceutical Structural Analytics

Author

Yandrofski, Katharina, primary, Mouchahoir, Trina, additional, De Leoz, M. Lorna, additional, Duewer, David, additional, Hudgens, Jeffrey W., additional, Anderson, Kyle W., additional, Arbogast, Luke, additional, Delaglio, Frank, additional, Brinson, Robert G., additional, Marino, John P., additional, Phinney, Karen, additional, Tarlov, Michael, additional, and Schiel, John E., additional

Published
2022
Full Text
View/download PDF

43. Author Correction: Triggering the 2022 eruption of Mauna Loa.

Author

Lynn, Kendra J., Downs, Drew T., Trusdell, Frank A., Wieser, Penny E., Rangel, Berenise, McDade, Baylee, Hotovec-Ellis, Alicia J., Bennington, Ninfa, Anderson, Kyle R., Ruth, Dawn C. S., DeVitre, Charlotte L., Ellis, Andria P., Nadeau, Patricia A., Clor, Laura, Kelly, Peter, Dotray, Peter J., and Chang, Jefferson C.

Subjects
INTERNET publishing, LIBRARIES
Abstract

The correction notice in Nature Communications addresses an error in the EarthChem Library doi listed in the original article "Triggering the 2022 eruption of Mauna Loa." The correction provides the accurate link to the EarthChem Library doi as https://doi.org/10.60520/IEDA/113447. The authors of the article are listed as Kendra J. Lynn, Drew T. Downs, Frank A. Trusdell, Penny E. Wieser, Berenise Rangel, Baylee McDade, Alicia J. Hotovec-Ellis, Ninfa Bennington, Kyle R. Anderson, Dawn C. S. Ruth, Charlotte L. DeVitre, Andria P. Ellis, Patricia A. Nadeau, Laura Clor, Peter Kelly, Peter J. Dotray, and Jefferson C. Chang. [Extracted from the article]

Published
2025
Full Text
View/download PDF

45. Effect of surface roughness on mixed salt crystallization fouling in pool boiling.

Author

Messer, Morgan, Anderson, Kyle, Xiang Zhang, and Abbasi, Bahman

Subjects
EBULLITION, SURFACE roughness, HEAT transfer coefficient, FOULING, CRYSTALLIZATION, ETHYLENE glycol
Abstract

Desalination technologies face fouling challenges (particularly on heat exchanger surfaces) which causes lower heat transfer and freshwater yield. Few studies have focused on multi-salt high salinity solutions (well above seawater) during pool boiling. This study investigates the effect of a heat exchanger's surface roughness on fouling resistance and heat transfer coefficient in a highly saline (20% by mass) pool boiling environment. The average surface roughness was tested at 0.35, 5, and a 10.5 µm (microchannel surface). The 0.35 µm surface had a 1.5 cm² K/W lower fouling resistance compared to the other tested surfaces. 5 and 10.5 µm heat exchange surfaces had nearly identical heat transfer performance with fouling resistances of 2.7 cm² K/W after 2 h. Decreasing the surface roughness reduced fouling for smooth surfaces (0.35 µm) but had minimal impact on sufficiently rough surfaces (5-10.5 µm). Additional tests determined the effect adding 3% ethylene glycol had on the fouling resistance, heat transfer coefficient, and salt composition for the 10.5 µm surface. Ethylene glycol had no effect on the fouling resistance or heat transfer coefficient; however, it effected the fouling composition. This study will help inform heat exchanger surface design for utilization with high salinity water. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

46. Overcoming leakage in quantum error correction

Author

Miao, Kevin C., McEwen, Matt, Atalaya, Juan, Kafri, Dvir, Pryadko, Leonid P., Bengtsson, Andreas, Opremcak, Alex, Satzinger, Kevin J., Chen, Zijun, Klimov, Paul V., Quintana, Chris, Acharya, Rajeev, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Bardin, Joseph C., Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chiaro, Ben, Collins, Roberto, Conner, Paul, Crook, Alexander L., Curtin, Ben, Debroy, Dripto M., Demura, Sean, Dunsworth, Andrew, Erickson, Catherine, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Fowler, Austin G., Foxen, Brooks, Garcia, Gonzalo, Giang, William, Gidney, Craig, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Gross, Jonathan A., Hamilton, Michael C., Harrington, Sean D., Heu, Paula, Hilton, Jeremy, Hoffmann, Markus R., Hong, Sabrina, Huang, Trent, Huff, Ashley, Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Kelly, Julian, Kim, Seon, Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Laws, Lily, Lee, Kenny, Lester, Brian J., Lill, Alexander T., Liu, Wayne, Locharla, Aditya, Lucero, Erik, Martin, Steven, Megrant, Anthony, Mi, Xiao, Montazeri, Shirin, Morvan, Alexis, Naaman, Ofer, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Potter, Rebecca, Rocque, Charles, Roushan, Pedram, Sankaragomathi, Kannan, Schurkus, Henry F., Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Skruzny, Jindra, Smith, W. Clarke, Sterling, George, Szalay, Marco, Thor, Douglas, Torres, Alfredo, White, Theodore, Woo, Bryan W. K., Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Smelyanskiy, Vadim, Petukhov, Andre, Korotkov, Alexander N., Sank, Daniel, and Chen, Yu

Abstract

The leakage of quantum information out of the two computational states of a qubit into other energy states represents a major challenge for quantum error correction. During the operation of an error-corrected algorithm, leakage builds over time and spreads through multi-qubit interactions. This leads to correlated errors that degrade the exponential suppression of the logical error with scale, thus challenging the feasibility of quantum error correction as a path towards fault-tolerant quantum computation. Here, we demonstrate a distance-3 surface code and distance-21 bit-flip code on a quantum processor for which leakage is removed from all qubits in each cycle. This shortens the lifetime of leakage and curtails its ability to spread and induce correlated errors. We report a tenfold reduction in the steady-state leakage population of the data qubits encoding the logical state and an average leakage population of less than 1 × 10−3throughout the entire device. Our leakage removal process efficiently returns the system back to the computational basis. Adding it to a code circuit would prevent leakage from inducing correlated error across cycles. With this demonstration that leakage can be contained, we have resolved a key challenge for practical quantum error correction at scale.

Published
2023
Full Text
View/download PDF

47. The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats.

Author

Anderson, Kyle D., Ko, Frank C., Fullam, Spencer, Virdi, Amarjit S., Wimmer, Markus A., Sumner, Dale R., and Ross, Ryan D.

Subjects
*COMPACT bone, *CANCELLOUS bone, *SPRAGUE Dawley rats, *RATS, *RAMAN spectroscopy, *OSSEOINTEGRATION
Abstract

Bone microarchitectural parameters significantly contribute to implant fixation strength but the role of bone matrix composition is not well understood. To determine the relative contribution of microarchitecture and bone matrix composition to implant fixation strength, we placed titanium implants in 12‐week‐old intact Sprague–Dawley rats, ovariectomized‐Sprague–Dawley rats, and Zucker diabetic fatty rats. We assessed bone microarchitecture by microcomputed tomography, bone matrix composition by Raman spectroscopy, and implant fixation strength at 2, 6, and 10 weeks postimplantation. A stepwise linear regression model accounted for 83.3% of the variance in implant fixation strength with osteointegration volume/total volume (50.4%), peri‐implant trabecular bone volume fraction (14.2%), cortical thickness (9.3%), peri‐implant trabecular crystallinity (6.7%), and cortical area (2.8%) as the independent variables. Group comparisons indicated that osseointegration volume/total volume was significantly reduced in the ovariectomy group at Week 2 (~28%) and Week 10 (~21%) as well as in the diabetic group at Week 10 (~34%) as compared with the age matched Sprague–Dawley group. The crystallinity of the trabecular bone was significantly elevated in the ovariectomy group at Week 2 (~4%) but decreased in the diabetic group at Week 10 (~3%) with respect to the Sprague–Dawley group. Our study is the first to show that bone microarchitecture explains most of the variance in implant fixation strength, but that matrix composition is also a contributing factor. Therefore, treatment strategies aimed at improving bone‐implant contact and peri‐implant bone volume without compromising matrix quality should be prioritized. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

48. Visioning Cass: A Roadmap for the Future

Author

Anderson, Kyle

Subjects
development, urban, Detroit, sustainability
Abstract

Dexter-Linwood is a neighborhood on the near west side of Detroit. In the heart of this neighborhood sits Cass Community Social Services (CCSS), a non profit organization pursuing a mission to “make a profound difference in the lives of the diverse populations it serves by providing for basic needs, including affordable housing, promoting self-reliance and encouraging community involvement.” CCSS works to serve residents both inside and outside its immediate campus, delivering meals, providing healthcare, and maintaining job programs. As CCSS continues to grow and plan for the future, they sought a partnership with the University of Michigan's School for Environment and Sustainability to help them explore opportunities to continue to sustainably redevelop the neighborhood they serve in proactive, rather than reactive ways. With the goal to expand CCSS’s reach and deliver more options and programming to help carry out their mission in service to the community, the team’s project entailed creating a vision plan and roadmap for future sustainable redevelopment opportunities on and around CCSS’s campus. The “Sustainability Roadmap” consists of projects under the interconnected themes of economic development, health, clean energy, ecological health, community vitality, and strong partnerships, largely inspired from the United Nations’ Sustainable Development Goals. Each theme includes goals for specific strategies CCSS could pursue to promote and enhance the theme and the overall mission of CCSS. Embedded in each goal are opportunities and best practices, informed through site visits, case studies, research, information gathering and project management, and include funding strategies, partnership opportunities, implementation plans, and design renderings in order to provide CCSS with a portfolio of potential plans to pursue. Additionally, in order to ensure that development and programming are in sync with the needs of the community, the team presents recommendations to CSSS for how to best deliver services based on community feedback and strategies for further participatory engagement. This document is intended to be a resource for CCSS, helping them sustainably expand their footprint, and leverage their position in the community in order to deliver greater benefits to the neighborhood and the populations they serve.

Published
2024

49. Assessment of Extracellular Vesicles Purity Using Proteomic Standards

Author

Wang, Tingting, Anderson, Kyle W., and Turko, Illarion V.

Abstract

The increasing interest in extracellular vesicles (EVs) research is fueled by reports indicating their unique role in intercellular communication and potential connection to the development of common human diseases. The unique role assumes unique protein and nucleic acid cargo. Unfortunately, accurate analysis of EVs cargo faces a challenge of EVs isolation. Generally used isolation techniques do not separate different subtypes of EVs and even more, poorly separate EVs from non-EVs contaminants. Further development of EVs isolation protocols urgently needs a quantitative method of EVs purity assessment. We report here that multiple reaction monitoring assay using internal standards carrying peptides for quantification of EVs and non-EVs proteins is a suitable approach to assess purity of EVs preparations. As a first step in potential standardization of EVs isolation, we have evaluated polymer-based precipitation techniques and compared them to traditional ultracentrifugation protocol.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results