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Your search keyword '"André Felipe Leal Bernardes"' showing total 4 results
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4 results on '"André Felipe Leal Bernardes"'

1. Retrospective Analysis of Omicron in Minas Gerais, Brazil: Emergence, Dissemination, and Diversification

Author

Paula Luize Camargos Fonseca, Isabela Braga-Paz, Luiza Campos Guerra de Araújo e Santos, Rillery Calixto Dias, Carolina Senra Alves de Souza, Nara Oliveira Carvalho, Daniel Costa Queiroz, Hugo José Alves, João Locke Ferreira de Araújo, Filipe Romero Rebello Moreira, Mariane Talon Menezes, Diego Menezes, Aryel Beatriz Paz e Silva, Jorge Gomes Goulart Ferreira, Talita Emile Ribeiro Adelino, André Felipe Leal Bernardes, Natália Virtude Carobin, Renée Silva Carvalho, Carolina Zaniboni Ferrari, Natália Rocha Guimarães, Ludmila Oliveira Lamounier, Fernanda Gil Souza, Luisa Aimeé Vargas, Marisa de Oliveira Ribeiro, Monica Barcellos Arruda, Patricia Alvarez, Rennan Garcias Moreira, Eneida Santos de Oliveira, Adriano de Paula Sabino, Jaqueline Silva de Oliveira, José Nélio Januário, Felipe Campos de Melo Iani, Renan Pedra de Souza, and Renato Santana Aguiar

Subjects
VOC Omicron, SARS-CoV-2, subvariants, epidemiological scenario, genomic surveillance, Biology (General), QH301-705.5
Abstract

Brazil is one of the countries most affected by COVID-19, with the highest number of deaths recorded. Brazilian Health Institutions have reported four main peaks of positive COVID-19 cases. The last two waves were characterized by the emergence of the VOC Omicron and its sublineages. This study aimed to conduct a retrospective surveillance study illustrating the emergence, dissemination, and diversification of the VOC Omicron in 15 regional health units (RHUs) in MG, the second most populous state in Brazil, by combining epidemiological and genomic data. A total of 5643 confirmed positive COVID-19 samples were genotyped using the panels TaqMan SARS-CoV-2 Mutation and 4Plex SC2/VOC Bio-Manguinhos to define mutations classifying the BA.1, BA.2, BA.4, and BA.5 sublineages. While sublineages BA.1 and BA.2 were more prevalent during the third wave, BA.4 and BA.5 dominated the fourth wave in the state. Epidemiological and viral genome data suggest that age and vaccination with booster doses were the main factors related to clinical outcomes, reducing the number of deaths, irrespective of the Omicron sublineages. Complete genome sequencing of 253 positive samples confirmed the circulation of the BA.1, BA.2, BA.4, and BA.5 subvariants, and phylogenomic analysis demonstrated that the VOC Omicron was introduced through multiple international events, followed by transmission within the state of MG. In addition to the four subvariants, other lineages have been identified at low frequency, including BQ.1.1 and XAG. This integrative study reinforces that the evolution of Omicron sublineages was the most significant factor driving the highest peaks of positive COVID-19 cases without an increase in more severe cases, prevented by vaccination boosters.

Published
2024
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2. Potential use of high-resolution melting analyses for SARS-CoV-2 genomic surveillance

Author

Adriana de Souza Andrade, Eduarda Fernandes Freitas, Emerson de Castro Barbosa, Natália Rocha Guimarães, Felipe Campos de Melo Iani, Alana Vitor Barbosa da Costa, André Felipe Leal Bernardes, Talita Emile Ribeiro Adelino, Ana Caroline Zampiroli Ataide, Tatiana Schäffer Gregianini, Jônathas Dias Nunes, Lorenzzo Lyrio Stringari, Irina Nastassja Riediger, Sandra Bianchini Fernandes, Ronaldo de Jesus, Vagner Fonseca, and Sérgio Caldas

Subjects
Virology
Published
2023

3. Identification of a novel SARS-CoV-2 P.1 sub-lineage in Brazil provides new insights about the mechanisms of emergence of variants of concern

Author

Tiago Gräf, Gonzalo Bello, Taina Moreira Martins Venas, Elisa Cavalcante Pereira, Anna Carolina Dias Paixão, Luciana Reis Appolinario, Renata Serrano Lopes, Ana Carolina Da Fonseca Mendonça, Alice Sampaio Barreto da Rocha, Fernando Couto Motta, Tatiana Schäffer Gregianini, Richard Steiner Salvato, Sandra Bianchini Fernandes, Darcita Buerger Rovaris, Andrea Cony Cavalcanti, Anderson Brandão Leite, Irina Riediger, Maria do Carmo Debur, André Felipe Leal Bernardes, Rodrigo Ribeiro-Rodrigues, Beatriz Grinsztejn, Valdinete Alves do Nascimento, Victor Costa de Souza, Luciana Gonçalves, Cristiano Fernandes da Costa, Tirza Mattos, Filipe Zimmer Dezordi, Gabriel Luz Wallau, Felipe Gomes Naveca, Edson Delatorre, Marilda Mendonça Siqueira, and Paola Cristina Resende

Subjects
genomic surveillance, SARS-CoV-2, variant of concern Gamma, Virology, AcademicSubjects/SCI01130, AcademicSubjects/SCI02285, AcademicSubjects/MED00860, lineage P.1, Microbiology, Brazil, Research Article
Abstract

One of the most remarkable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) features is the significant number of mutations they acquired. However, the specific factors that drove the emergence of such variants since the second half of 2020 are not fully resolved. In this study, we describe a new SARS-CoV-2 P.1 sub-lineage circulating in Brazil, denoted here as Gamma-like-II, that as well as the previously described lineage Gamma-like-I shares several lineage-defining mutations with the VOC Gamma. Reconstructions of ancestor sequences support that most lineage-defining mutations of the Spike (S) protein, including those at the receptor-binding domain (RBD), accumulated at the first P.1 ancestor. In contrast, mutations outside the S protein were mostly fixed at subsequent steps. Our evolutionary analyses estimate that P.1-ancestral strains carrying RBD mutations of concern probably circulated cryptically in the Amazonas for several months before the emergence of the VOC Gamma. Unlike the VOC Gamma, the other P.1 sub-lineages displayed a much more restricted dissemination and accounted for a low fraction (

Published
2021

4. Phylogenetic-based inference reveals distinct transmission dynamics of SARS-CoV-2 lineages Gamma and P.2 in Brazil

Author

Tiago Gräf, Gonzalo Bello, Felipe Gomes Naveca, Marcelo Gomes, Vanessa Leiko Oikawa Cardoso, Alexandre Freitas da Silva, Filipe Zimmer Dezordi, Mirleide Cordeiro dos Santos, Katia Correa de Oliveira Santos, Érika Lopes Rocha Batista, Alessandro Leonardo Álvares Magalhães, Fernando Vinhal, Fábio Miyajima, Helisson Faoro, Ricardo Khouri, Gabriel Luz Wallau, Edson Delatorre, Marilda Mendonça Siqueira, Paola Cristina Resende, Tirza Peixoto Mattos, Valdinete Alves Nascimento, Victor Souza, André de Lima Guerra Corado, Fernanda Nascimento, George Silva, Matilde Mejía, Maria Júlia Brandão, Ágatha Costa, Karina Pessoa, Michele Jesus, Luciana Fé Gonçalves, Cristiano Fernandes, Valnete Andrade, Luana Barbagelata, Ana Cecília Ribeiro Cruz, Andrea Costa, Lindomar dos Anjos Silva, Jucimária Dantas Galvão, Anderson Brandao Leite, Felicidade Mota Pereira, Thais Oliveira Costa, Joaquim Cesar Sousa, Lidio Gonçalves Lima Neto, Haline Barroso, Dalane Loudal Florentino Teixeira, Joao Felipe Bezerra, Cássia Docena, Raul Emídio de Lima, Lilian Caroliny Amorim Silva, Gustavo Barbosa de Lima, Laís Ceschini Machado, Matheus Filgueira Bezerra, Marcelo Henrique Santos Paiva, Maria Eduarda Pessoa Lopes Dantas, Raíssa Liane Do Nascimento Pereira, Josélio Araújo, Cliomar A. Santos, Rodrigo Ribeiro-Rodrigues, André Felipe Leal Bernardes, Felipe Campos de Melo Iani, Beatriz Grinsztejn, Valdiléa G. Veloso, Patricia Brasil, Anna Carolina Dias da Paixão, Luciana Reis Appolinario, Renata Serrano Lopes, Fernando do Couto Motta, Alice Sampaio Rocha, Taina Moreira Martins Venas, Elisa Cavalcante Pereira, Andrea Cony Cavalcanti, Leonardo Soares Bastos, Luis Fernando de Macedo Brigido, Mauro de Medeiros Oliveira, Michelle Orane Schemberger, Andreia Akemi Suzukawa, Irina Riediger, Maria do Carmo Debur, Richard Steiner Salvato, Tatiana Schäffer Gregianini, Darcita Buerger Rovaris, and Sandra Bianchini Fernandes

Subjects
Multidisciplinary
Abstract

The COVID-19 epidemic in Brazil experienced two major lineage replacements until mid-2021. The first was driven by lineage P.2, in late 2020, and the second by lineage Gamma, in early 2021. To understand how these SARS-CoV-2 lineages spread in Brazil, we analyzed 11,724 genomes collected throughout the country between September 2020 and April 2021. Our findings indicate that lineage P.2 probably emerged in July 2020 in the Rio de Janeiro state and Gamma in November 2020 in the Amazonas state. Both states were the main hubs of viral disseminations to other Brazilian locations. We estimate that Gamma was 1.56-3.06 times more transmissible than P.2 in Rio de Janeiro and that the median effective reproductive number (Re) of Gamma varied according to the geographic context (Re = 1.59-3.55). In summary, our findings support that lineage Gamma was more transmissible and spread faster than P.2 in Brazil.

Published
2022

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