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Your search keyword '"Annicchiarico Petruzzelli, Luigi"' showing total 4 results
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4 results on '"Annicchiarico Petruzzelli, Luigi"'

2. Acute kidney injury in children hospitalised for febrile urinary tract infection.

Author

Marzuillo, Pierluigi, Guarino, Stefano, Alfiero, Salvatore, Annicchiarico Petruzzelli, Luigi, Arenella, Mattia, Baccelli, Francesco, Brugnara, Milena, Corrado, Ciro, Delcaro, Giulia, Di Sessa, Anna, Gallotta, Giulia, Lanari, Marcello, Lorenzi, Maya, Malgieri, Gabriele, Miraglia del Giudice, Emanuele, Pecoraro, Carmine, Pennesi, Marco, Picassi, Sara, Pierantoni, Luca, and Puccio, Giuseppe

Subjects
ACUTE kidney failure, URINARY organs, MULTIPLE regression analysis, URINARY tract infections, LOGISTIC regression analysis, CONGENITAL disorders
Abstract

Aim: To determine (i) prevalence and the risk factors for acute kidney injury (AKI) in children hospitalised for febrile urinary tract infection (fUTI) and (ii) role of AKI as indicator of an underlying VUR. AKI, in fact, is favoured by a reduced nephron mass, often associated to VUR. Methods: This retrospective Italian multicentre study enrolled children aged 18 years or younger (median age = 0.5 years) discharged with a primary diagnosis of fUTI. AKI was defined using Kidney Disease/Improving Global Outcomes serum creatinine criteria. Results: Of 849 children hospitalised for fUTI (44.2% females, median age 0.5 years; IQR = 1.8), 124 (14.6%) developed AKI. AKI prevalence rose to 30% in the presence of underlying congenital anomalies of the kidney and urinary tract (CAKUT). The strongest AKI predictors were presence of CAKUT (OR = 7.5; 95%CI: 3.8–15.2; p = 9.4e‐09) and neutrophils levels (OR = 1.13; 95%CI: 1.08–1.2; p = 6.8e‐07). At multiple logistic regression analysis, AKI during fUTI episode was a significant indicator of VUR (OR = 3.4; 95%CI: 1.7–6.9; p = 0.001) despite correction for the diagnostic covariates usually used to assess the risk of VUR after the first fUTI episode. Moreover, AKI showed the best positive likelihood ratio, positive predictive value, negative predictive value and specificity for VUR. Conclusion: AKI occurs in 14.6% of children hospitalised for fUTI and is a significant indicator of VUR. [ABSTRACT FROM AUTHOR]

Published
2024
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3. De Novo Large Deletions in the PHEX Gene Caused X-Linked Hypophosphataemic Rickets in Two Italian Female Infants Successfully Treated with Burosumab

Author

Pecoraro, Carmine, primary, Fioretti, Tiziana, additional, Perruno, Assunta, additional, Klain, Antonella, additional, Cioffi, Daniela, additional, Ambrosio, Adelaide, additional, Passaro, Diego, additional, Annicchiarico Petruzzelli, Luigi, additional, Di Domenico, Carmela, additional, de Girolamo, Domenico, additional, Vallone, Sabrina, additional, Cattaneo, Fabio, additional, Ammendola, Rosario, additional, and Esposito, Gabriella, additional

Published
2023
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4. Pediatric Minimal Change Disease and AKI following the Pfizer-BioNTech COVID-19 Vaccine: causal or incidental correlation?

Author

Annicchiarico Petruzzelli L, Minale B, Serio V, De Luca A, Marino Marsilia G, Campione S, Diomedi Camassei F, D'Arcangelo R, Luongo I, Lepore L, Giannattasio P, Molino D, Pirro L, Lonardo MC, Malgieri G, and Pecoraro C

Subjects
Adult, Child, Humans, Male, BNT162 Vaccine, Steroids, Vaccination, Acute Kidney Injury chemically induced, COVID-19 prevention & control, COVID-19 Vaccines adverse effects, Nephrosis, Lipoid chemically induced, Nephrotic Syndrome
Abstract

The global coronavirus 2019 (COVID-19) pandemic required vaccination even in children to reduce infection. We report on the development of acute kidney injury (AKI) and minimal change disease (MCD) nephrotic syndrome (NS), shortly after the first injection BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). A 12-year-old previously healthy boy was referred to our hospital with complaints of peripheral edema and nephrotic range proteinuria. Nine days earlier he had received his first injection BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). Seven days after injection, he developed leg edema, which rapidly progressed to anasarca with significant weight gain. On admission, serum creatinine was 1.3 mg/dL and 24-hour urinary protein excretion was 4 grams with fluid overload. As kidney function continued to decline over the next days, empirical steroid treatment and renal replacement therapy with ultrafiltration were started and kidney biopsy was performed. Seven days after steroid therapy, kidney function began to improve, gradually returning to normal. The association of MCD, nephrotic syndrome and AKI hasn't been previously described following the Pfizer-BioNTech COVID-19 vaccine in pediatric population, but this triad has been reported in adults. We need further similar case reports to establish the real incidence of this possible vaccine side effect., (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.)

Published
2022

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