Search

Your search keyword '"Arhin, Francis"' showing total 20 results
Start Over Author "Arhin, Francis" Publication Year Range Last 3 years
20 results on '"Arhin, Francis"'

9. Critical Factors of Digital Supply Chains for Organizational Performance Improvement

Author

Khan, Sharfuddin Ahmed, Kusi-Sarpong, Simonov, Gupta, Himanshu, Arhin, Francis Kow, Lawal, Jennifer Nguseer, and Hassan, Syed Mehmood

Abstract

Technological advancement is redefining supply chains (SCs) processes and soon traditional ways of managing SCs will no more be feasible and effective. Due to recent advancement in technology, digitalization has become an emerging topic among decision-makers and researchers. To cope-up with this emerging trend in customer behavior and remain competitive, organizations must move from their traditional ways of managing their SCs to digital supply chains (DSCs) for improved organizational performance. Therefore, the purpose of this article is in two folds: First, to identify critical factors of DSCs that are essential for transitioning traditional SCs to DSCs to improve organizational performance. Second, interpretive structural modeling is used to establish the relationship among critical factors and (matriced’ impacts croise´s multiplication applique´e a´un classement used to identify the driving and dependency power of the critical factors. Thus, this article identified fifteen DSC critical factors and established their direct and indirect effect on DSCs. The results show that “SC resilience”, and “proactive prevention” have the highest dependency power factors whilst “integration” and “advanced operational models” have the highest driving power factors. This article can help SC managers and decision-makers to understand the critical factors essential in adopting DSCs for improving organizational performance.

Published
2024
Full Text
View/download PDF

20. Investigation of mechanisms responsible for decreased susceptibility of aztreonam/avibactam activity in clinical isolates of Enterobacterales collected in Europe, Asia and Latin America in 2019.

Author

Mendes, Rodrigo E, Doyle, Timothy B, Streit, Jennifer M, Arhin, Francis F, Sader, Helio S, and Castanheira, Mariana

Subjects
AZTREONAM, PENICILLIN-binding proteins, ENTEROBACTER cloacae, GRAM-negative bacteria, KLEBSIELLA pneumoniae, SEQUENCE analysis, ANTIBIOTICS, ESCHERICHIA coli, KLEBSIELLA, CEFTAZIDIME, RESEARCH, COMBINATION drug therapy, RESEARCH methodology, ORGANIC compounds, MEDICAL cooperation, EVALUATION research, HYDROLASES, COMPARATIVE studies, RESEARCH funding, MICROBIAL sensitivity tests, PHARMACODYNAMICS
Abstract

Background: The combination aztreonam/avibactam is currently under Phase 3 trials for the treatment of serious infections caused by Gram-negative bacteria including those with MBLs.Objectives: To investigate the resistance mechanisms in Enterobacterales exhibiting aztreonam/avibactam MICs of ≥4 mg/L.Methods: Among 8787 Enterobacterales, 17 (0.2%) isolates exhibited an aztreonam/avibactam MIC of ≥4 mg/L. Isolates were sequenced and screened for β-lactamases. Sequences of porins, penicillin-binding protein 3 (PBP3) and expression levels of AmpC and AcrA were evaluated.Results: Eleven (11/4154 isolates; 0.26%) Escherichia coli, three (3/1981; 0.15%) Klebsiella pneumoniae and three (3/628; 0.5%) Enterobacter cloacae were identified. All E. coli showed either an 'YRIK' or 'YRIN' insertion in PBP3. In general, these isolates carried blaCMY and/or blaCTX-M variants, except for one isolate from Korea that also produced NDM-5 and one isolate from Turkey that produced OXA-48. Two DHA-1-producing K. pneumoniae overexpressed acrA and had a premature stop codon in either OmpK35 or OmpK36, whereas a third K. pneumoniae carried blaPER-2 and had a premature stop codon in OmpK35. All three E. cloacae expressed AmpC at levels ≥570-fold, but sequence analysis did not reveal known amino acid alterations associated with decreased avibactam binding or increased hydrolysis of β-lactams. Minor amino acid polymorphisms within OmpC, OmpF and PBP3 were noted among the E. cloacae.Conclusions: A small number of isolates (0.2%) met the inclusion criteria. E. coli showed altered PBP3 as the most relevant resistance mechanism, whereas K. pneumoniae had multiple resistance mechanisms. Further investigations are needed to clarify resistance in E. cloacae. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results