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Your search keyword '"Arya, Akanksha"' showing total 5 results
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5 results on '"Arya, Akanksha"'

1. COVID-19 in solid organ transplant: A multi-center cohort study

Author

Kates, Olivia S, Haydel, Brandy M, Florman, Sander S, Rana, Meenakshi M, Chaudhry, Zohra S, Ramesh, Mayur S, Safa, Kassem, Kotton, Camille Nelson, Blumberg, Emily A, Besharatian, Behdad D, Tanna, Sajal D, Ison, Michael G, Malinis, Maricar, Azar, Marwan M, Rakita, Robert M, Morilla, Jose A, Majeed, Aneela, Sait, Afrah S, Spaggiari, Mario, Hemmige, Vagish, Mehta, Sapna A, Neumann, Henry, Badami, Abbasali, Goldman, Jason D, Lala, Anuradha, Hemmersbach-Miller, Marion, McCort, Margaret E, Bajrovic, Valida, Ortiz-Bautista, Carlos, Friedman-Moraco, Rachel, Sehgal, Sameep, Lease, Erika D, Fisher, Cynthia E, Limaye, Ajit P, Arya, Akanksha, Jeng, Amy, Kuo, Alexander, Luk, Alfred, Puing, Alfredo G, Rossi, Ana P, Brueckner, Andrew J, Multani, Ashrit, Keller, Brian C, Derringer, Darby, Florescu, Diana F, Dominguez, Edward A, Sandoval, Elena, Bilgili, Erin P, Hashim, Faris, Silveira, Fernanda P, Haidar, Ghady, Joharji, Hala G, Murad, Haris F, Gani, Imran Yaseen, el-amm, Jose-Marie, Kahwaji, Joseph, Popoola, Joyce, Yabu, Julie M, Hughes, Kailey, Saharia, Kapil K, Gajurel, Kiran, Bowman, Lyndsey J, Veroux, Massimiliano, Morales, Megan K, Fung, Monica, Theodoropoulos, Nicole M, de la Cruz, Oveimar, Kapoor, Rajan, La Hoz, Ricardo M, Allam, Sridhar R, Vora, Surabhi B, McCarty, Todd P, Anderson-Haag, Tracy, Malhotra, Uma, Kelly, Ursula M, Bhandaram, Vidya, Bennett, William M, and Lominadze, Zurabi

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Clinical Trials and Supportive Activities, Organ Transplantation, Transplantation, Clinical Research, Good Health and Well Being, COVID-19, Cohort Studies, Humans, Male, Middle Aged, SARS-CoV-2, Transplant Recipients, UW COVID-19 SOT Study Team, coronavirus, solid organ transplantation, transplantation, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has led to significant reductions in transplantation, motivated in part by concerns of disproportionately more severe disease among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors of mortality in SOT recipients are not well described.MethodsWe performed a multicenter cohort study of SOT recipients with laboratory-confirmed COVID-19. Data were collected using standardized intake and 28-day follow-up electronic case report forms. Multivariable logistic regression was used to identify risk factors for the primary endpoint, 28-day mortality, among hospitalized patients.ResultsFour hundred eighty-two SOT recipients from >50 transplant centers were included: 318 (66%) kidney or kidney/pancreas, 73 (15.1%) liver, 57 (11.8%) heart, and 30 (6.2%) lung. Median age was 58 (interquartile range [IQR] 46-57), median time post-transplant was 5 years (IQR 2-10), 61% were male, and 92% had ≥1 underlying comorbidity. Among those hospitalized (376 [78%]), 117 (31%) required mechanical ventilation, and 77 (20.5%) died by 28 days after diagnosis. Specific underlying comorbidities (age >65 [adjusted odds ratio [aOR] 3.0, 95% confidence interval [CI] 1.7-5.5, P

Published
2021

4. Changing trends in mortality among solid organ transplant recipients hospitalized for COVID‐19 during the course of the pandemic

Author

Heldman, Madeleine R., Kates, Olivia S., Safa, Kassem, Kotton, Camille N., Georgia, Sarah J., Steinbrink, Julie M., Alexander, Barbara D., Hemmersbach‐Miller, Marion, Blumberg, Emily A., Multani, Ashrit, Haydel, Brandy, La Hoz, Ricardo M., Moni, Lisset, Condor, Yesabeli, Flores, Sandra, Munoz, Carlos G., Guitierrez, Juan, Diaz, Esther I., Diaz, Daniela, Vianna, Rodrigo, Guerra, Giselle, Loebe, Matthias, Rakita, Robert M., Malinis, Maricar, Azar, Marwan M., Hemmige, Vagish, McCort, Margaret E., Chaudhry, Zohra S., Singh, Pooja P., Hughes Kramer, Kailey, Velioglu, Arzu, Yabu, Julie M., Morillis, Jose A., Mehta, Sapna A., Tanna, Sajal D., Ison, Michael G., Derenge, Ariella C., Duin, David, Maximin, Adrienne, Gilbert, Carlene, Goldman, Jason D., Lease, Erika D., Fisher, Cynthia E., Limaye, Ajit P., De la Cruz, Oveimar, Besharatian, Behdad D., Crespo, Maria, Tomic, Rade, Sehgal, Sameep, Weisshaar, Dana, Girgis, Reda, Lawrence, Cameron, Nelson, Joanna, Bennett, William, Leandro, Jennifer, Sait, Afrah, Rumore, Amy, West, Patricia, Jeng, Amy, Bajrovic, Valida, Bilgili, Erin P., Anderson‐Haag, Tracy, Nastase, Abigail, Badami, Abbas, Alvarez‐Garcia, Jesus, Bowman‐Anger, Lyndsey, Julien, Lovelyn, Ortiz‐Bautista, Carlos, Friedman‐Morocco, Rachel, Gajurel, Kiran, Cahuayme‐Zuniga, Lizbeth, Wakefield, Mark, Fung, Monica, Theodoropoulos, Nicole, Chuang, Sally T., Bhandaram, Srividya, Veroux, Massimiliano, Chopra, Bhavna, Florescu, Diana, Witteck, Danielle, Diaz, Daniela, Ripley, Kathryn, Saharia, Kapil, Akkina, Sanjeev, McCarty, Todd P., Webb, Ally, Arya, Akanksha, Vedula, Giridhar, El‐Amm, Jose‐Marie, Katherine Dokus, M., Narayanan, Arun, Cilene Leon Bueno de Camargo, Priscila, Ouseph, Rosemary, Breuckner, Andrew, Luk, Alfred, Aujayeb, Avinash, Ganger, Daniel, Keith, Douglas S., Meloni, Federica, Haidar, Ghady, Zapernick, Lori, Moraels, Megan, Goyal, Nitender, Sharma, Tanvi, Malhotra, Uma, Kuo, Alexander, Rossi, Ana P., Edwards, Angelina, Keller, Brian, Beneri, Christy, Derringer, Darby, Dominguez, Edward, Carlson, Elise, Hashim, Faris, Murad, Haris, Wilkens, Heinrike, Neumann, Henry, Gani, Imran, Kahwaji, Joseph, Popoola, Joyce, Michaels, Marian, Jakharia, Niyati, Puing, Alfredo, Motallebzadeh, Reza, Velagapudi, Ravi, Kapoor, Rajan, Allam, Sridhar, Silveira, Fernanda, Vora, Surabhi, Kelly, Ursala M., Reddy, Uttam, Dharnidharka, Vikas, Wadei, Hani, and Zurabi, Lominadze

Abstract

Mortality among patients hospitalized for COVID‐19 has declined over the course of the pandemic. Mortality trends specifically in solid organ transplant recipients (SOTR) are unknown. Using data from a multicenter registry of SOTR hospitalized for COVID‐19, we compared 28‐day mortality between early 2020 (March 1, 2020–June 19, 2020) and late 2020 (June 20, 2020–December 31, 2020). Multivariable logistic regression was used to assess comorbidity‐adjusted mortality. Time period of diagnosis was available for 1435/1616 (88.8%) SOTR and 971/1435 (67.7%) were hospitalized: 571/753 (75.8%) in early 2020 and 402/682 (58.9%) in late 2020 (p < .001). Crude 28‐day mortality decreased between the early and late periods (112/571 [19.6%] vs. 55/402 [13.7%]) and remained lower in the late period even after adjusting for baseline comorbidities (aOR 0.67, 95% CI 0.46–0.98, p = .016). Between the early and late periods, the use of corticosteroids (≥6 mg dexamethasone/day) and remdesivir increased (62/571 [10.9%] vs. 243/402 [61.5%], p< .001 and 50/571 [8.8%] vs. 213/402 [52.2%], p < .001, respectively), and the use of hydroxychloroquine and IL‐6/IL‐6 receptor inhibitor decreased (329/571 [60.0%] vs. 4/492 [1.0%], p< .001 and 73/571 [12.8%] vs. 5/402 [1.2%], p< .001, respectively). Mortality among SOTR hospitalized for COVID‐19 declined between early and late 2020, consistent with trends reported in the general population. The mechanism(s) underlying improved survival require further study. Data from the pre‐vaccine era show declining mortality among solid organ transplant recipients hospitalized for COVID‐19 over the course of the pandemic. Kalil comments on page 12.

Published
2022
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5. Fever in a returning traveler: A case and literature review of melioidosis.

Author

Arya A, Shaikh H, Weber D, Pettengill M, and Moss S

Abstract

Burkholderia pseudomallei is an aerobic, motile, non-spore-forming gram-negative bacillus found in tropical endemic environments that causes the disease melioidosis. Melioidosis displays a diversity of clinical presentations ranging from septic shock to chronic latent infection, often with characteristic abscesses in multiple organs. Melioidosis is an opportunistic infection, with risk factors, including diabetes, alcohol use, chronic lung disease, and chronic renal disease, and these risk factors increase the severity of disease (Wiersinga et al., 2006) [1]. In this case report, we illustrate a case of a 32 year old man with several risk factors and recent travel to an endemic region presenting with melioidosis. Our case demonstrates the challenges in obtaining a diagnosis in a non-endemic location, highlights a complex presentation of this disease, and describes the multifaceted clinical management required to care for this patient. As global travel increases, there is an increased need for clinician awareness of this disease in non-endemic regions., Competing Interests: No conflicts of interest., (© 2021 The Authors.)

Published
2021
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