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OBJECTIVE: To elicit symptoms, risk factors, and habits existing before or right after blood pressure elevation in newly diagnosed patients with hypertension from the traditional Persian medicine perspective. METHODOLOGY: This was a concurrent nested mixed-method study conducted in 2018. We included newly diagnosed cases of hypertension (BP≥140/90 mmHg in two consecutive screenings) in the study. In contrast, those who had a history of hypertension or used anti-hypertension medication were excluded. The participants were surveyed and interviewed to identify their temperament and extract their recent experiences with hypertension. The sampling followed the criterion-based purposive technique, and the sample size was defined based on qualitative data saturation. The recorded interviews were transcribed and coded according to Persian medicine until no new code emerged. RESULTS: Twenty participants were interviewed, and two themes were extracted: (i) primary or predisposing factors, such as warm temperament, change of residence, improper eating habits, abrupt cessation of exercise, psychological factors, and irregular sleep patterns, and (ii) early symptoms that occur at the first sign of rising blood pressure, including digestive complaints and changes in body excretion, psychological manifestations, and unclassifiable general symptoms. CONCLUSION: Physicians are advised to pay attention to these items when taking a history from patients to prevent hypertension and treat it at its early stages.

Abstract Human milk feeding can support premature infants to thrive. Yet those with premature infants can be challenged in human milk production. Considering this, and the use of potentially harmful human milk enhancers, the present study was conducted with the aim of determining the effect of orally consumed Lactuca sativa (L. sativa) syrup (lettuce extract) on human milk volume and subsequent weight gain in the preterm infant. Extracts from lettuce and other plants such as silymarin are already evidenced to be safe for use during lactation and have other therapeutic effects in humans. Yet this is the first study of its kind. This parallel randomized clinical trial included lactating participants with their preterm infants who were born at

Abstract Background and aims Human milk supports pre-term infants to thrive. Yet human milk production can be inhibited when infants are born prematurely. Pimpinella Anisum has been evidenced to increase milk production and infant weight gain in previous animal studies. The present study aimed to determine the effect of Pimpinella Anisum herbal tea on human milk volume and preterm infant weight in human populations for the first time. Methods Human milk supports pre-term infants to thrive. Yet human milk production can be inhibited when infants are born prematurely. Pimpinella Anisum has been evidenced to increase milk production and infant weight gain in previous animal studies. The present study aimed to determine the effect of Pimpinella Anisum herbal tea on human milk volume and preterm infant weight in human populations for the first time. Results There was a statistically significant difference in terms of milk volume in the first, third, fourth, fifth, sixth and seventh days between the three groups of intervention, placebo, and control (p