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Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including The use of digitalization and precision medicine in the IVF clinic, The environment and reproduction, The use of gonadotropin-releasing hormone agonists and the efficiency of IVF, Controlled ovarian stimulation for freeze-all cycles, Immunology in ART, Home monitoring of ART cycles, Luteal-phase support in ART, The POSEIDON stratification of ‘low prognosis'patients in ART, Controlled ovarian stimulation for low responder patients, Adjuvants for poor responders, Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients, and Fertility options for transgender and nonbinary individuals. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

The Infertility Manual has offered an accurate and hands on practical guide for the management of infertility while also serving as a reference manual for students; clinicians and embryologists. The authors contributing to The Infertility Manual were all selected for their special expertise in their subject and their ability to explain its significance in an effective and lucid way. In this fifth Edition; the authors have done a meticulous survey of the current literature and have amalgamated it with their rich experience to bring out this comprehensive textbook.

As the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms. Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes. This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis.

This atlas is the first reference covering exclusively all aspects of sciatic pain. It is designed to serve as a brief and easy-to-comprehend review of the knowledge of spinal sciatica, with emphasis on classification, epidemiology, clinical presentations, neuroimaging, and treatment options. Sections on extraspinal sciatica and differential diagnosis of this multifaceted topic are also included. This atlas delivers more information in less space than traditional texts, allowing for a quick review of the essential facts of this clinical entity through plentiful images and tables. Pertinent imaging is combined with intraoperative photographs and hand-drawn illustrations to help readers visualize variable presentations and enhance their management. The comprehensive content of this richly-illustrated book covers different etiologies of sciatic pain seen in spinal, neurosurgical, neurologic, rheumatologic and emergency practices, divided into five thematic sections. After general considerations about sciatica and their differential diagnosis, the second section focuses on lumbosacral discogenic sciatica. The third section includes spinal non-discogenic sciatica. The fourth section focuses on extraspinal intrapelvic sciatica, and the fifth provides a description of the most important etiologies of extraspinal extrapelvic sciatica. Comprehensive and unique, Atlas of Sciatica is an excellent pictorial resource for neurosurgeons, spinal surgeons, neurologists, rheumatologists, and many other clinicians worldwide. It is a “one of a kind” book that stands head and shoulders above any other book on this subject (from the foreword of Professor Edward C. Benzel, MD, Founder of the World Spinal Column Society).

The book provides a comprehensive overview of the use of non-invasive prenatal screening (NIPS) in clinical practice. It covers advanced genomic approaches and operational strategies related to NIPS. It aims to fill a gap by offering a thorough historical background and genesis of NIPS technology, including its methodology, clinical utility, challenges, and future directions. The book is divided into three sections: Section I discusses the advent of NIPS, Section II addresses detection strategies and clinical implementation, and Section III explores the challenges and prospects of NIPS technology. The book benefits specialists who practice prenatal medicine as well as reproductive specialists, genetic councilors, research scholars and postgraduate medical students of obstetrics and gynecology.

The readers of this text will encounter a comprehensive and perspicacious view of the discipline of reproductive medicine as revealed by practicing fertility specialists of the day. The book has been designed to keep a balance of text and algorithms, flowcharts, diagrams, to provide comprehensive information in a concise and easy-to-understand format. Also, the memory for such diagrammatic presentation is long-lasting and it acts as a ready reckoner for clinicians in practice and students for their examinations. The contents are mainly practical problems faced by clinicians in day-to-day practice and the chapters have been contributed by experienced doctors working in the field of infertility and reproductive medicine incorporating their vast practical experience. The information provided in the textbook is based on evidence-based guidelines and clinical experience.

Pelvic Floor, Perineal, and Anal Sphincter Trauma During Childbirth is a comprehensive text that focuses on the maternal morbidity associated with childbirth. The book is edited by a reputable international team of obstetricians and urogynaecologists who have an in-depth knowledge of the subject and are actively involved in training and research. In recognition of the longstanding global diversity in obstetric practice and the management of its sequelae, the authors have compiled the ultimate evidence-based textbook that examines the diagnosis, pathophysiology, management, and prevention of obstetric trauma. It is known that the majority of doctors and midwives have suboptimal training in the anatomy and repair of perineal and anal sphincter trauma. This book aims to address these deficiencies by providing a comprehensive approach in the understanding of this anatomy and provides tips on making an accurate diagnosis and classification of perineal trauma. The dilemmas surrounding repair techniques and management of subsequent pregnancies are fully debated and preventative strategies are highlighted. Chapters on female genital mutilation, the management of faecal incontinence, caesarean section, pre-existing bowel conditions, sexual dysfunction and litigation are also Included. This book is essential reading for all who are involved in obstetric care both in the labour ward and even years after parturition; obstetricians, midwives, family practitioners, colorectal surgeons, gastroenterologists, physiotherapists, continence advisors and lawyers can all glean knowledge applicable to their own specialty. In everyday practice, the text can also serve as a handbook for quick reference and should therefore be easily accessible in all antenatal clinics labour ward rooms and perineal/pelvic floor clinics.

For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology. - Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro. - Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction. - Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. - Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams. - Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. - Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. - Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

GI and Liver Disease During Pregnancy: A Practical Approach by Drs. Kim Isaacs and Millie D. Long is a unique handbook focusing on common gastrointestinal symptoms and diseases seen in pregnant patients. Each chapter addresses the diseases or symptoms and focuses on key questions to ask the patient and key points regarding diagnosis and management.This handbook is organized to have each chapter focus on a common complaint or discrete disease, making it easy to find exact information in a ready reference. Also provided are tables of drug safety during pregnancy and breast feeding. Unique features also include a section on alternative therapies and a chapter on care in post bariatric surgery patients.Each Chapter Covers: Epidemiology Pathology Presentation and Evaluation Management Summary Key Points Pocket-sized and easy to read, GI and Liver Disease During Pregnancy: A Practical Approach is a convenient and accessible reference for gastroenterology fellows, OB/GYN fellows and residents, and practicing gastroenterologists.

This book aims to provide readers with the latest information on application of hysteroscopy in diagnosis and treatment of gynaecological diseases. The first chapters systematically review current status, equipment and instruments, applied anatomy, preoperative treatment and anesthesia for hysteroscopic surgery. In the following chapters, details in aspect of hysteroscopy from diagnostic to hysteroscopic surgery are explained with clinical cases. After that, advanced techniques in hysteroscopy combined with laparoscopy and ultrasound monitoring hysteroscopic surgery are introduced with high-resolution illustrations. Written by experts with wealthy experience in the field, this book will be a valuable reference for gynecologists at hysteroscopy units, reproductive units, gynecological and oncological units.

This is a practical guide to pediatric vascular access. It covers how to use ultrasound appropriately, how to prevent and manage early and late complications, and how to correctly place the catheter tip using ECG or radiology. It includes all the most modern approaches and devices. In particular, the best approach for some specific populations is covered, including neonates and infants, complex patients, and children with cancer or renal failure requiring long term treatments. A guide on how to establish a vascular access team in a pediatric hospital is included, including the costs and benefits of having this hospital-based team. Vascular Access in Neonates and Children is aimed at pediatric anesthesists and surgeons, and radiologists, pediatricians and other specialities may also find it of interest.

Training in obstetrics and gynaecology is based on clinical exposure and a strong foundation of knowledge. There are some immutable aspects related to basic sciences in every field, but knowledge is constantly evolving. There is a surfeit of information, and there is a felt-need to distill this into a practical and useful manner.

A unique textbook in laparoscopic surgery which deals with all essential aspects for surgeons, gynecologists, and urologists. Specifically address topics of fundamentals of laparoscopic surgery and operative steps of each procedure in detail. Aimed not only at the dedicated laparoscopic surgeons, but also at general surgeons, gynecologists, urologists, and surgical trainees. Aim of each chapter is to define, sharpen and emphasize issues of surgical steps, using the available evidence. Art and science of minimal access surgery is explained giving a true overall view as well as the recent technological advances made in this field. Intended for those who are conversant with operative surgical and gynecological procedures. Its scope is broad and deep. Illustrations and diagrams are provided to facilitate faster learning of minimal access surgery. Self-sufficient book which explains the concept of ergonomics, task analysis and practical, and practical problems encountered in laparoscopic operative surgery. An overall view of the latest instruments and techniques of their application is presented.

This book is a complete guide to the use of hysteroscopy in the investigation and diagnosis of gynaecological disorders and diseases. Beginning with an introduction to the technique, discussion on anatomy and physiology of the uterus, and descriptions of other imaging technologies, the book then explains the hysteroscope and procedural techniques. Each of the following chapters covers the diagnosis of different disorders using hysteroscopy, including polyps and fibroids, abnormal bleeding, infertility, intrauterine adhesions, and much more. The final sections discuss potential complications, medico-legal aspects and anaesthesia in hysteroscopy.