Search

Your search keyword '"Bashiri Dezfouli, Ali"' showing total 15 results
Start Over Author "Bashiri Dezfouli, Ali" Publication Year Range Last 3 years
15 results on '"Bashiri Dezfouli, Ali"'

7. Crosstalk Between NK Cell Receptors and Tumor Membrane Hsp70‐Derived Peptide: A Combined Computational and Experimental Study

Author

Yazdi, Mina, primary, Hasanzadeh Kafshgari, Morteza, additional, Khademi Moghadam, Fatemeh, additional, Zarezade, Vahid, additional, Oellinger, Rupert, additional, Khosravi, Mohammad, additional, Haas, Stefan, additional, Hoch, Cosima C., additional, Pockley, Alan Graham, additional, Wagner, Ernst, additional, Wollenberg, Barbara, additional, Multhoff, Gabriele, additional, and Bashiri Dezfouli, Ali, additional

Published
2024
Full Text
View/download PDF

8. Biomarkers in Adult-Type Diffuse Gliomas: Elevated Levels of Circulating Vesicular Heat Shock Protein 70 Serve as a Biomarker in Grade 4 Glioblastoma and Increase NK Cell Frequencies in Grade 3 Glioma

Author

Lennartz, Philipp, primary, Thölke, Dennis, additional, Bashiri Dezfouli, Ali, additional, Pilz, Mathias, additional, Lobinger, Dominik, additional, Messner, Verena, additional, Zanth, Hannah, additional, Ainslie, Karen, additional, Kafshgari, Morteza Hasanzadeh, additional, Rammes, Gerhard, additional, Ballmann, Markus, additional, Schlegel, Martin, additional, Foulds, Gemma Ann, additional, Pockley, Alan Graham, additional, Schmidt-Graf, Friederike, additional, and Multhoff, Gabriele, additional

Published
2023
Full Text
View/download PDF

10. Elevated circulating Hsp70 levels are correlative for malignancies in different mammalian species

Author

Salvermoser, Lukas, Flisikowski, Krzysztof, Dressel-Böhm, Susann, Nytko, Katarzyna J, Rohrer Bley, Carla, Schnieke, Angelika, Samt, Ann-Kathrin, Thölke, Dennis, Lennartz, Philipp, Schwab, Melissa, Wang, Fei, Bashiri Dezfouli, Ali, Multhoff, Gabriele, University of Zurich, and Salvermoser, Lukas

Subjects
1307 Cell Biology, 10253 Department of Small Animals, 1303 Biochemistry, 630 Agriculture, 570 Life sciences, biology, Cell Biology, Biochemistry
Abstract

Circulating Hsp70 levels were determined in feline and porcine cohorts using two different ELISA systems. These comparative animal models of larger organisms often reflect diseases, and especially malignant tumors, better than conventional rodent models. It is therefore essential to investigate the biology and utility of tumor biomarkers in animals such as cats and pigs. In this study, levels of free Hsp70 in the blood of cats with spontaneously occurring tumors were detected using a commercial Hsp70 ELISA (R&D Systems). Sub-analysis of different tumor groups revealed that animals with tumors of epithelial origin presented with significantly elevated circulating Hsp70 concentrations. In addition to free Hsp70 levels measured with the R&D Systems Hsp70 ELISA, levels of exosomal Hsp70 were determined using the compHsp70 ELISA in pigs. Both ELISA systems detected significantly elevated Hsp70 levels (R&D Systems: median 24.9 ng/mL; compHsp70: median 44.2 ng/mL) in the blood of a cohort of APC1311/+ pigs diagnosed with high-grade adenoma polyps, and the R&D Systems Hsp70 ELISA detected also elevated Hsp70 levels in animals with low-grade polyps. In contrast, in flTP53R167H pigs, suffering from malignant osteosarcoma, the compHsp70 ELISA (median 674.32 ng/mL), but not the R&D Systems Hsp70 ELISA (median 4.78 ng/mL), determined significantly elevated Hsp70 concentrations, indicating that in tumor-bearing animals, the dominant form of Hsp70 is of exosomal origin. Our data suggest that both ELISA systems are suitable for detecting free circulating Hsp70 levels in pigs with high-grade adenoma, but only the compHsp70 ELISA can measure elevated, tumor-derived exosomal Hsp70 levels in tumor-bearing animals.

Published
2022

13. CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells

Author

Bashiri Dezfouli, Ali, primary, Yazdi, Mina, additional, Benmebarek, Mohamed-Reda, additional, Schwab, Melissa, additional, Michaelides, Stefanos, additional, Miccichè, Arianna, additional, Geerts, Dirk, additional, Stangl, Stefan, additional, Klapproth, Sarah, additional, Wagner, Ernst, additional, Kobold, Sebastian, additional, and Multhoff, Gabriele, additional

Published
2022
Full Text
View/download PDF

15. In Vivo Endothelial Cell Gene Silencing by siRNA-LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting.

Author

Yazdi M, Pöhmerer J, Hasanzadeh Kafshgari M, Seidl J, Grau M, Höhn M, Vetter V, Hoch CC, Wollenberg B, Multhoff G, Bashiri Dezfouli A, and Wagner E

Abstract

Although small-interfering RNAs (siRNAs) are specific silencers for numerous disease-related genes, their clinical applications still require safe and effective means of delivery into target cells. Highly efficient lipid nanoparticles (LNPs) are developed for siRNA delivery, showcasing the advantages of novel pH-responsive lipoamino xenopeptide (XP) carriers. These sequence-defined XPs are assembled by branched lysine linkages between cationizable polar succinoyl tetraethylene pentamine (Stp) units and apolar lipoamino fatty acids (LAFs) at various ratios into bundle or U-shape topologies. Formulation of siRNA-LNPs using LAF 4 -Stp 1 XPs as ionizable compounds led to robust cellular uptake, high endosomal escape, and successful in vitro gene silencing activity at an extremely low (150 picogram) siRNA dose. Of significance is the functional in vivo endothelium tropism of siRNA-LNPs with bundle LAF 4 -Stp 1 XP after intravenous injection into mice, demonstrated by superior knockdown of liver sinusoidal endothelial cell (LSEC)-derived factor VIII (FVIII) and moderate silencing of hepatocyte-derived FVII compared to DLin-MC3-DMA-based LNPs. Optimizing lipid composition following click-modification of siRNA-LNPs with ligand c(RGDfK) efficiently silenced vascular endothelial growth factor receptor-2 (VEGFR-2) in tumor endothelial cells (TECs). The findings shed light on the role of ionizable XPs in the LNP in vivo cell-type functional targeting, laying the groundwork for future therapeutic applications., (© 2024 The Author(s). Small published by Wiley‐VCH GmbH.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results