1. Association between IL-6, miRNA-146a, MALAT1 genetic polymorphisms and risk of rheumatoid arthritis.
- Author
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Ali YB, Hasan NM, El-Maadawy EA, Bassyouni IH, El-Shahat M, and Talaat RM
- Subjects
- Humans, Female, Male, Middle Aged, Adult, Case-Control Studies, Egypt, Genotype, Risk Factors, Arthritis, Rheumatoid genetics, Polymorphism, Single Nucleotide genetics, MicroRNAs genetics, RNA, Long Noncoding genetics, Interleukin-6 genetics, Genetic Predisposition to Disease genetics, Alleles
- Abstract
Aim: This study aimed to investigate the associations between single nucleotide polymorphisms (SNPs) of IL-6 (-174G/C), microRNA146a (rs2910164C/G) and MALAT1 (rs619586A/G) and susceptibility to rheumatoid arthritis (RA) in Egyptians. Methods: SNPs were genotyped in 101 RA patients and 104 controls. Expression levels were evaluated either by Enzyme-linked immunosorbent assay (ELISA) for IL-6 or quantitative real-time PCR (qRT-PCR) for miR-146a and MALAT1. Results: IL-6-174 GC (OR = 3.422) genotype, IL-6-174 C allele (OR = 2.565), miR-146a (rs2910164) CG (OR = 2.190) and MALAT1 (rs619586) AA (OR = 4.125) genotypes and A allele (OR = 6.122) could be considered as risk factors for RA. An increase in the expression of IL-6, miR-146a and MALAT1 was detected in RA patients, which was independent of any SNP. Conclusion: SNPs of IL-6, miR-146a and MALAT1were linked to RA predisposition in Egyptians.
- Published
- 2024
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