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10 results on '"Berni Ebbs"'

1. Supplementary Figure S2 from Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

Author

Johann S. de Bono, Suzanne Carreira, Arul M. Chinnaiyan, Emma Hall, Christopher J. Lord, Alexa Gillman, Diletta Bianchini, Nina Tunariu, Adam Sharp, Zafeiris Zafeiriou, Pasquale Rescigno, Semini Sumanasuriya, Ruth Riisnaes, Ines Figueiredo, Mateus Crespo, Matthew Clarke, Mark Atkin, Claudia Bertan, Gunther Boysen, Daniel Nava Rodrigues, George Seed, Penny Flohr, Berni Ebbs, Gemma Fowler, Shahneen Sandhu, Dan R. Robinson, David Dolling, Raquel Perez-Lopez, Susana Miranda, Nuria Porta, Helen Mossop, Wei Yuan, Joaquin Mateo, and Jane Goodall

Abstract

Plots showing percentage changes in total cfDNA concentration for each patient at weeks 4 and 8 of treatment, compared to same-patient baseline value. The left plot includes non-responding patients and the right plot includes patients who responded to olaparib in the clinical trial. Below, Mann-Whitney test comparing these changes at each time point for responders and non-responder patients.

Published
2023
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2. Supplementary Figure S1 from Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

Author

Johann S. de Bono, Suzanne Carreira, Arul M. Chinnaiyan, Emma Hall, Christopher J. Lord, Alexa Gillman, Diletta Bianchini, Nina Tunariu, Adam Sharp, Zafeiris Zafeiriou, Pasquale Rescigno, Semini Sumanasuriya, Ruth Riisnaes, Ines Figueiredo, Mateus Crespo, Matthew Clarke, Mark Atkin, Claudia Bertan, Gunther Boysen, Daniel Nava Rodrigues, George Seed, Penny Flohr, Berni Ebbs, Gemma Fowler, Shahneen Sandhu, Dan R. Robinson, David Dolling, Raquel Perez-Lopez, Susana Miranda, Nuria Porta, Helen Mossop, Wei Yuan, Joaquin Mateo, and Jane Goodall

Abstract

Consort diagram describing samples disposition in the study.

Published
2023
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3. Figure S1 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Clinical data: a) Summary of prior treatments of all 14 patients prior to apheresis. b) A histogram presenting the lymphocyte and neutrophil counts (x109/L) in peripheral blood pre- and post-apheresis procedures.

Published
2023
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4. Table S1 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Baseline characteristics of study patients (n=14). *All values given are at time of apheresis unless otherwise specified. â^§The Eastern Cooperative Oncology Group (ECOG) performance status score ranges from 0 to 5, with 0 indicating no symptoms and higher scores indicating increasing disability.

Published
2023
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5. Figure S5 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Organoid cultures of CTCs acquired by apheresis from patient P05: a) Dendrogram and heat map of hierarchical clustering, based on Euclidean distance, for patient P05 evaluating CTC (green bars) and organoid CNAs (red). b) Micrographs of two organoids from P05 with scale bar in bottom left (100µm). c) Phylogenetic tree showing the cultured organoids have CNA that cluster with CTCs. d) Two organoids and 3 CTCs with truncal CNA including shared BRCA2 loss and AR amplification but sub-clonal chromosome 1 aberrations.

Published
2023
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6. Data from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Purpose: Circulating tumor cells (CTCs) have clinical relevance, but their study has been limited by their low frequency.Experimental Design: We evaluated liquid biopsies by apheresis to increase CTC yield from patients suffering from metastatic prostate cancer, allow precise gene copy-number calls, and study disease heterogeneity.Results: Apheresis was well tolerated and allowed the separation of large numbers of CTCs; the average CTC yield from 7.5 mL of peripheral blood was 167 CTCs, whereas the average CTC yield per apheresis (mean volume: 59.5 mL) was 12,546 CTCs. Purified single CTCs could be isolated from apheresis product by FACS sorting; copy-number aberration (CNA) profiles of 185 single CTCs from 14 patients revealed the genomic landscape of lethal prostate cancer and identified complex intrapatient, intercell, genomic heterogeneity missed on bulk biopsy analyses.Conclusions: Apheresis facilitated the capture of large numbers of CTCs noninvasively with minimal morbidity and allowed the deconvolution of intrapatient heterogeneity and clonal evolution. Clin Cancer Res; 24(22); 5635–44. ©2018 AACR.

Published
2023
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7. Table S3 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Summary of individual CTCs per patient with percentage of the genome covered by a copy number segment and percentage of genes that are altered.

Published
2023
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8. Table S2 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Summary of the CTC and WBC counts from both peripheral blood and apheresis product for all 14 patients, with additional clinical characteristics including sites of disease at apheresis and time to disease progression following apheresis procedure (when available). [ND = Not determined; WBC = White Blood Cells; CTC = Circulating Tumor Cells; PB = Peripheral Blood; Tot.Vol = Total Volume; Inc. = Increase]

Published
2023
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9. Figure S4 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Heatmaps presenting unsupervised hierarchical clustering based on CNA and Euclidean distance, of all the samples for each patient. Each individual patient is depicted by number from left to right, with chromosomal aberrations from top to bottom. Tumor biopsies are identified by black bars, and CTCs by green bars, at the bottom of the heatmap.

Published
2023
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10. Figure S2 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Johann S. de Bono, Leon W.M.M. Terstappen, Nikolas H. Stoecklein, Kiki Andree, Joost Swennenhuis, Rui P. Neves, Lucy Hamilton, Deirdre Moloney, Joanne Hunt, Zafeiris Zafeiriou, Pasquale Rescigno, Diletta Bianchini, Suzanne Carreira, Gunther Boysen, Jane Goodall, Adam Sharp, Daniel Nava Rodrigues, Ruth Riisnaes, Ines Figueiredo, Claudia Bertan, Rita Pereira, Ana Ferreira, Alan Mackay, Wei Yuan, Susana Miranda, Penny Flohr, Berni Ebbs, Gemma Fowler, Niven Mehra, Rob Chandler, Mariane Fontes, Mateus Crespo, Veronica Gil, Semini Sumanasuriya, George Seed, and Maryou B. Lambros

Abstract

Summary of the validation steps. a) Male vs female: Genome plot of amplified male DNA vs amplified female DNA using the Ampli 1 kit. b) WBC vs WBC: Genomic profile of Ampli1 amplified WBCs against another WBC. c) Dilution evaluation: Genomic aberrations of an mCRPC sample with known CNA diluted serially to 10ng/µL, 1ng/µL, 0.1ng/µL, and 0.03ng/µL with all dilutions generating similar profiles after Ampli1TM WGA and aCGH. Gains and amplification depicted in blue, and losses and homozygous/deep deletion in red.

Published
2023
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