1. Histomorphological Pattern Analysis of Endometrial Carcinomas in a Tertiary Care Hospital
- Author
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Dr. Dharani V C, Dr. Manjunath H K, Dr. Akshatha Basavaraju, Dr. Bhargavi Mohan, Dr. Sushman T A, Dr. Hassan Sona Rai, Dr. Vineethra K, and Dr. Vishwas Suresh
- Subjects
prognosis Serous carcinoma ,carcinoscarcoma. Myometrial invasion ,Endometrioid carcinoma ,secretory carcinoma - Abstract
Background: Endometrial carcinoma which has various histological types is the commonest invasive cancer of female genital tract. Two general groups of endometrial cancer include Type 1 and Type 2. Type 1 tumors are related to prolonged estrogenic stimulation and include endometrioid type and type 2 includes serous carcinoma, clear cell carcinoma and carcinosarcoma. Materials and methods: The present study is a retrospective study conducted in the department of pathology at BGS GIMS from January 2018- January 2021. All the endometrial carcinoma specimens obtained from D&C and hysterectomy specimens were assessed on paraffin embedded sections stained with H&E stain and immunohistochemical study was done wherever required. Results : In the present study 33 cases of endometrial carcinoma cases were analyzed. Majority of them were >60years (36.5%) and most were post-menopausal females .Most common clinical presentation was abnormal uterine / post-menopausal bleeding seen in 100% of cases . The most common histological type observed was endometrioid type (81.8% )of endometrial carcinoma followed by serous carcinoma(6.4%)and carcinosarcoma(6.4%). One case of endometrioid carcinoma with secretory differentiation was reported. Most of endoemetrioid carcinomas belonged to FIGO histological grade 1(71.4%) and the most common TNM stage was Stage 1A (60%) with majority of them showing less than half of myometrial invasion(60%). Importance of IHC in differentiating variants of endometrial carcinoma found to be very significant. Conclusion: Endoemetrioid type of endometrial carcinoma was the most common histological type seen and generally present in early stage and carry good prognosis when compared to other variants like serous carcinoma, adenosarcoma which present in late stages and carry bad prognosis. Detailed study of histological appearance of endometrial carcinoma provides insight into prognosis and plays a role in determining therapy., {"references":["Brigitte M. Ronnett R. Blaustein's Pathology Of Female Genital Tract. 6th ed. Springer New York: Springer; 2022.","Stacey E Mills. Uterine corpus in Sternberg's diagnostic surgical pathology. 5th ed. Philadelphia: Wolters Kluwer; 2010: 2207-2248","Hussun saeed Jezan et.al. Histopathological variations of endometrial carcinomas. International Journal of science and healthcare Research. 2019;4(4):207-211.","Stacey E Mills Uterine corpus in Sternberg's diagnostic surgical pathology. 5th ed. Philadelphia: Wolters Kluwer; 2014: 2461-2496","WHO classification of tumors female genital system. 5th ed. France: LYON; 2020.","Alsharani S, Soliman AS,Hablas A, et al. \"Changes in Uterine cancer incidencerates in Egypt\" Obstetric and Gynaecology International , 2018, vol 18","Mitul modi, et al . Detailed Histopathological Study of Endometrial Carcinoma, and Importance of Immunohistochemistry . American Pathology Of Clinical Pathology. 2016,;146( Issue suppl_1): 74.","Deodhar KK, Rekhi B, Menon S, Ganesh B. An audit of histopathology reports of carcinoma endometrium: experience from a tertiary referral center. J Postgrad Med. 2015;61(2):84-87. doi:10.4103/0022-3859.150444","Florescu, M M et al. \"Histopathological Prognostic Factors for Endometrial Carcinoma.\" Current health sciences journal vol. 42,2 (2016): 139-144. doi:10.12865/CHSJ.42.02.04","Muhammad AA, Adekunle OO, Modupeola SO et al,… A diary of endometrial malignancies in zaria, Northern Nigeris.SubSaharan Afr J Med2017;4:43-46","Lee EJ1, Kim TJ, Choi CH,et al,. Uterine endometrial carcinoma: 10year's experience with long term follow up at a single Korean Institution. Gyecol Obstet Invest 2010;74(4)"]}
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- 2022
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