28 results on '"Bianchi, Giampaolo"'
Search Results
2. Pre-operative geriatric screening and assessment as predictors of postoperative complications in older adults with gynecologic cancer: A pilot cohort study on a neglected issue
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Cioli Puviani, Filippo, Calogero, Pietro, Bianchi, Giampaolo, De Benedetti, Pierandrea, Boussedra, Safia, Dondi, Giulia, Perrone, Anna Myriam, De Iaco, Pierandrea, and Galetti, Caterina
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- 2023
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3. CT-guided cryoablation for management of bone metastases: a single center experience and review of the literature
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Arrigoni, Francesco, Bianchi, Giampaolo, Formiconi, Francesco, Palumbo, Pierpaolo, Zugaro, Luigi, Gravina, Giovanni Luca, Barile, Antonio, and Masciocchi, Carlo
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- 2022
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4. Prognostic Value of Stress Hyperglycemia in Patients Admitted to Medical/Geriatric Departments for Acute Medical Illness
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Di Luzio, Raffaella, Dusi, Rachele, Barbanti, Francesca Alessandra, Calogero, Pietro, Marchesini, Giulio, and Bianchi, Giampaolo
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- 2022
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5. Initial Experience and Evaluation of a Nomogram for Outcome Prediction in Management of Medium-sized (1–2 cm) Kidney Stones
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Micali, Salvatore, Sighinolfi, Maria Chiara, Iseppi, Andrea, Morini, Elena, Calcagnile, Tommaso, Benedetti, Mattia, Ticonosco, Marco, Kaleci, Shaniko, Bevilacqua, Luigi, Puliatti, Stefano, De Nunzio, Cosimo, Arada, Raphael, Chiancone, Francesco, Campobasso, Davide, Eissa, Ahmed, Bonfante, Giulia, Simonetti, Elisa, Cotugno, Michele, Galli, Riccardo, Curti, Pierpaolo, Schips, Luigi, Ditonno, Pasquale, Villa, Luca, Ferretti, Stefania, Bergamaschi, Franco, Bozzini, Giorgio, Zoeir, Ahmed, Sherbiny, Ahmed El, Frattini, Antonio, Fedelini, Paolo, Okhunov, Zhamshid, Tubaro, Andrea, Landman, Jaime, Bianchi, Giampaolo, and Rocco, Bernardo
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- 2022
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6. Feasibility of a telementoring approach as a practical training for transurethral enucleation of the benign prostatic hyperplasia using bipolar energy: a pilot study
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Amato, Marco, Eissa, Ahmed, Puliatti, Stefano, Secchi, Cristian, Ferraguti, Federica, Minelli, Marco, Meneghini, Agostino, Landi, Isotta, Guarino, Giulio, Sighinolfi, Maria Chiara, Rocco, Bernardo, Bianchi, Giampaolo, and Micali, Salvatore
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- 2021
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7. Digital Biopsy with Fluorescence Confocal Microscope for Effective Real-time Diagnosis of Prostate Cancer: A Prospective, Comparative Study
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Rocco, Bernardo, Sighinolfi, Maria Chiara, Sandri, Marco, Spandri, Valentina, Cimadamore, Alessia, Volavsek, Metka, Mazzucchelli, Roberta, Lopez-Beltran, Antonio, Eissa, Ahmed, Bertoni, Laura, Azzoni, Paola, Reggiani Bonetti, Luca, Maiorana, Antonino, Puliatti, Stefano, Micali, Salvatore, Paterlini, Maurizio, Iseppi, Andrea, Rocco, Francesco, Pellacani, Giovanni, Chester, Johanna, Bianchi, Giampaolo, and Montironi, Rodolfo
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- 2021
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8. Fluorescence laser confocal microscopy: a glimpse from the future
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PULIATTI, Stefano, primary, EISSA, Ahmed, additional, FERRETTI, Stefania, additional, MICALI, Salvatore, additional, and BIANCHI, Giampaolo, additional
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- 2023
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9. Artificial Intelligence in Surgical Training for Kidney Cancer: A Systematic Review of the Literature
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Rodriguez Peñaranda, Natali, primary, Eissa, Ahmed, additional, Ferretti, Stefania, additional, Bianchi, Giampaolo, additional, Di Bari, Stefano, additional, Farinha, Rui, additional, Piazza, Pietro, additional, Checcucci, Enrico, additional, Belenchón, Inés Rivero, additional, Veccia, Alessandro, additional, Gomez Rivas, Juan, additional, Taratkin, Mark, additional, Kowalewski, Karl-Friedrich, additional, Rodler, Severin, additional, De Backer, Pieter, additional, Cacciamani, Giovanni Enrico, additional, De Groote, Ruben, additional, Gallagher, Anthony G., additional, Mottrie, Alexandre, additional, Micali, Salvatore, additional, and Puliatti, Stefano, additional
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- 2023
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10. Artificial intelligence evaluation of confocal microscope prostate images: our preliminary experience
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BIANCHI, Giampaolo, primary, PULIATTI, Stefano, additional, RODRIGUEZ, Natalia, additional, MICALI, Salvatore, additional, BERTONI, Laura, additional, REGGIANI BONETTI, Luca, additional, CARAMASCHI, Stefania, additional, BOLELLI, Federico, additional, PINAMONTI, Maurizio, additional, ROZZE, Davide, additional, and GRANA, Costantino, additional
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- 2023
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11. Current applications of ex-vivo fluorescent confocal microscope in urological practice: a systematic review of literature
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Eissa, Ahmed, primary, Puliatti, Stefano, additional, Rodriguez Peñaranda, Natali, additional, Resca, Stefano, additional, Di Bari, Stefano, additional, Vella, Jessica, additional, Maggiorelli, Sofia, additional, Bertoni, Laura, additional, Azzoni, Paola, additional, Reggiani Bonetti, Luca, additional, Campobasso, Davide, additional, Ferretti, Stefania, additional, Micali, Salvatore, additional, and Bianchi, Giampaolo, additional
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- 2023
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12. Pre-operative geriatric screening and assessment as predictors of postoperative complications in older adults with gynecologic cancer: A pilot cohort study on a neglected issue
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Filippo, Cioli Puviani, primary, Calogero, Pietro, additional, Bianchi, Giampaolo, additional, De Benedetti, Pierandrea, additional, Boussedra, Safia, additional, Dondi, Giulia, additional, Perrone, Anna Myriam, additional, De Iaco, Pierandrea, additional, and Galetti, Caterina, additional
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- 2023
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13. Interventional Radiology’s Osteoid Osteoma Management: Percutaneous Thermal Ablation
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Bianchi, Giampaolo, primary, Zugaro, Luigi, additional, Palumbo, Pierpaolo, additional, Candelari, Roberto, additional, Paci, Enrico, additional, Floridi, Chiara, additional, and Giovagnoni, Andrea, additional
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- 2022
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14. CT-guided cryoablation for management of bone metastases: a single center experience and review of the literature
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Arrigoni, Francesco, primary, Bianchi, Giampaolo, additional, Formiconi, Francesco, additional, Palumbo, Pierpaolo, additional, Zugaro, Luigi, additional, Gravina, Giovanni Luca, additional, Barile, Antonio, additional, and Masciocchi, Carlo, additional
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- 2021
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15. Prognostic Value of Stress Hyperglycemia in Patients Admitted to Medical/Geriatric Departments for Acute Medical Illness
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Di Luzio, Raffaella, primary, Dusi, Rachele, additional, Barbanti, Francesca Alessandra, additional, Calogero, Pietro, additional, Marchesini, Giulio, additional, and Bianchi, Giampaolo, additional
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- 2021
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16. Digital Frozen Sections with Fluorescence Confocal Microscopy During Robot-assisted Radical Prostatectomy: Surgical Technique
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Rocco, Bernardo, primary, Sarchi, Luca, additional, Assumma, Simone, additional, Cimadamore, Alessia, additional, Montironi, Rodolfo, additional, Reggiani Bonetti, Luca, additional, Turri, Filippo, additional, De Carne, Cosimo, additional, Puliatti, Stefano, additional, Maiorana, Antonino, additional, Pellacani, Giovanni, additional, Micali, Salvatore, additional, Bianchi, Giampaolo, additional, and Sighinolfi, Maria Chiara, additional
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- 2021
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17. Outcomes of EAU-endorsed Live Surgical Events over a 5-year Period (2015–2020) and Updated Guidelines from the EAU Live Surgery Committee
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Somani, Bhaskar, primary, Liatsikos, Evangelos, additional, Mottrie, Alexandre, additional, Gözen, Ali S., additional, Breda, Alberto, additional, Knoll, Thomas, additional, Bianchi, Giampaolo, additional, Sarica, Kemal, additional, Bedke, Jens, additional, and Rassweiler, Jens, additional
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- 2021
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18. Psychological distress among patients awaiting histopathologic results after prostate biopsy: An unaddressed concern
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Sarchi, Luca, primary, Eissa, Ahmed, additional, Puliatti, Stefano, additional, Amato, Marco, additional, Assumma, Simone, additional, Calcagnile, Tommaso, additional, Ticonosco, Marco, additional, Iseppi, Andrea, additional, Toso, Stefano, additional, Sighinolfi, Maria Chiara, additional, Bianchi, Giampaolo, additional, Micali, Salvatore, additional, and Rocco, Bernardo, additional
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- 2021
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19. Psychological distress among patients awaiting histopathologic results after prostate biopsy: An unaddressed concern.
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Sarchi, Luca, Eissa, Ahmed, Puliatti, Stefano, Amato, Marco, Assumma, Simone, Calcagnile, Tommaso, Ticonosco, Marco, Iseppi, Andrea, Toso, Stefano, Sighinolfi, Maria Chiara, Bianchi, Giampaolo, Micali, Salvatore, and Rocco, Bernardo
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PSYCHOLOGICAL distress ,PROSTATE biopsy ,PSYCHOLOGICAL factors ,HOSPITAL patients ,PSYCHOMETRICS - Abstract
Background: Prostate cancer is the most commonly diagnosed neoplasm in men. From the introduction of PSA testing, an increasing number of men undergoes prostate biopsy (PBX). While the physical side effects of PBx have been well investigated, its psychological impact has been under-evaluated. Aim: The aim of our study is to investigate the presence of psychological distress (anxiety and depression) in patients waiting for histopathological results after prostate biopsy (PBx). Methods: From February to April 2019, 51 consecutive patients undergoing prostate biopsies at our institution were included. Age, PSA, DRE, familiarity for prostate cancer, number of previous biopsies, type of anesthesia, number of cores were recorded. All patients filled the Hospital Anxiety and Depression Scale (HADS), a psychometric Likert-scale questionnaire, before receiving the histopathological results of their PBx. Results: The prevalence of psychological distress among patients awaiting histopathologic results is 41% (21/51 patients), with anxiety being the main component of their distress. On multivariate analysis, PSA, family history, and repeat biopsy were significantly associated with anxiety and depression. Conclusion: Patients undergoing PBx experience a burden of psychological distress waiting for histopathologic results, especially anxiety. Appropriate counseling should be offered to patients at high risk of developing psychological distress after PBx. Future goals would include technological improvements to shorten the time between biopsy and definitive results. [ABSTRACT FROM AUTHOR]
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- 2022
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20. COVID-19 and slowdown of residents' activity: Feedback from a novel e-learning event and overview of the literature.
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Calcagnile, Tommaso, Sighinolfi, Maria Chiara, Sarchi, Luca, Assumma, Simone, Filippi, Beatrice, Bonfante, Giulia, Cassani, Alessandra, Spandri, Valentina, Turri, Filippo, Puliatti, Stefano, Bozzini, Giorgio, Moschovas, Marcio, Bianchi, Giampaolo, Micali, Salvatore, and Rocco, Bernardo
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COVID-19 ,DIGITAL learning ,COVID-19 pandemic ,TRAINING of medical residents ,ONLINE education - Abstract
Objective: To evaluate the impact of an e-learning online event, created for supporting resident's training during the slowdown of surgical and clinical activities caused by COVID-19 pandemic. An overview of PubMed literature depicting the state of the art of urology residency in the COVID-19 era was performed as well, to contextualize the issue. Methods: An online learning event for residents was set up at the beginning of the pandemic; the faculty consisted of experts in urology who provided on-line lectures and videos on surgical anatomy, procedures, updates in guidelines, technology, training. The audience was composed of 30–500 attendees from Italy, USA, India and Belgium. A questionnaire to analyze relevance, satisfaction and popularity of the lessons was mailed to 30 local residents. Results and limitations: Almost all residents defined the web environment suitable to achieve the learning outcomes; the method, the number and the competence of the faculty were appropriate/excellent. Most of the younger residents (81.8%) stated their surgical knowledge would improve after the course; 72.7% declared they would take advantage into routine inpatients clinical activity. Nineteen more expert residents agreed that the course would improve their surgical knowledge and enhance their practical skills; almost all stated that the initiative would change their outpatients and inpatients practice. Overall, 44 articles available in PubMed have addressed the concern of urological learning and training during the pandemic from different standpoints; four of them considered residents' general perception towards web-based learning programs. Conclusions: The paper confirms residents' satisfaction with e-learning methods and, to our knowledge, is the first one focusing on a specific event promptly settled up at the beginning of the outbreak. Web-based educational experience developed during the pandemic may represent the very basis for the implementation of prospective on-site training and overall scientific update of future urologists. [ABSTRACT FROM AUTHOR]
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- 2021
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21. The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults.
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Muscari, Antonio, Bianchi, Giampaolo, Forti, Paola, Magalotti, Donatella, Pandolfi, Paolo, and Zoli, Marco
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CARDIOLOGICAL manifestations of general diseases ,PERIPHERAL vascular diseases ,AGE ,BLOOD sedimentation ,MORTALITY ,OLDER people ,ANXIETY - Abstract
NT-proB-type natriuretic peptide (NT-proBNP) serum concentration can be transformed by simple formulas into proBNPage, a surrogate of biological age strongly associated with chronological age, all-cause mortality, and disease count. This cross-sectional study aimed to assess whether proBNPage is also associated with other manifestations of the aging process in comparison with other variables. The study included 1117 noninstitutionalized older adults (73.1 ± 5.6 years, 537 men). Baseline measurements of serum NT-proBNP, erythrocyte sedimentation rate, hemoglobin, lymphocytes, and creatinine, which have previously been shown to be highly associated with both age and all-cause mortality, were performed. These variables were compared between subjects with and without manifestations of cardiovascular impairment (myocardial infarction (MI), stroke, peripheral artery disease (PAD), arterial revascularizations (AR)), physical impairment (long step test duration (LSTD), walking problems, falls, deficit in one or more activities of daily living), and psychological impairment (poor self-rating of health (PSRH), anxiety/depression, Mini Mental State Examination (MMSE) score < 24). ProBNPage (years) was independently associated (OR, 95% CI) with MI (1.08, 1.07–1.10), stroke (1.02, 1.00–1.05), PAD (1.04, 1.01–1.06), AR (1.06, 1.04–1.08), LSTD (1.03, 1.02–1.04), walking problems (1.02, 1.01–1.03), and PSRH (1.02, 1.01–1.02). For 5 of these 7 associations, the relationship was stronger than that of chronological age. In addition, proBNPage was univariately associated with MMSE score < 24, anxiety/depression, and falls. None of the other variables provided comparable performances. Thus, in addition to the known associations with mortality and disease count, proBNPage is also associated with cardiovascular manifestations as well as noncardiovascular manifestations of the aging process. [ABSTRACT FROM AUTHOR]
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- 2021
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22. a survey-based study on the spread of en-bloc resection of bladder tumors among IEA and ESUT members.
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BONFANTE, Giulia, PULIATTI, Stefano, SIGHINOLFI, Maria C., EISSA, Ahmed, CIARLARIELLO, Silvia, FERRARI, Riccardo, TICONOSCO, Marco, GOEZEN, Ali Serdar, GUVEN, Selcuk, RASSWEILER, Jens, BIANCHI, Giampaolo, ROCCO, Bernardo, and MICALI, Salvatore
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- 2021
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23. Diagnostic bias during the COVID-19 era: COVID-19 or renal abscess?
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Amato, Marco, Eissa, Ahmed, Rosiello, Giuseppe, Farinha, Rui, Piazza, Pietro, Sighinolfi, Maria Chiara, Rocco, Bernardo, Bianchi, Giampaolo, Micali, Salvatore, Mottrie, Alexandre, and Puliatti, Stefano
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COVID-19 ,COMPUTED tomography ,MEDICAL personnel ,SYMPTOMS ,DIAGNOSIS - Abstract
Introduction: The Coronavirus disease-2019 (COVID-19) has been declared as a pandemic in March 2020 by the World Health Organization (WHO). Since then, this pandemic has dramatically affected the entire world, even radically influencing the way patients are framed at triage. Symptoms and tests in most cases lead to a correct diagnosis; however, error may be around the corner. Case report: A 60 years old patient was referred with weight loss, fatigue and mild fever for 3 weeks as he was working in a COVID-19 ward. After a positive swab and chest CT scan, he was admitted in the hospital and treated as mild COVID-19 patient. A CT scan performed after the patient was discharged revealed a renal lesion misidentified as a tumor then clarified to be an abscess which retrospectively appears to be the main cause of his symptoms. Conclusion: Clinicians should consider other life-threatening disease in the differential diagnosis of patients presenting with similar symptoms to minimize mistakes and avoid further unnecessary investigations. [ABSTRACT FROM AUTHOR]
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- 2021
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24. A Prospective, Multicenter Evaluation of Predictive Factors for Positive Surgical Margins After Nephron-Sparing Surgery for Renal Cell Carcinoma: The RECORd1 Italian Project
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Schiavina, Riccardo, Serni, Sergio, Mari, Andrea, Antonelli, Alessandro, Bertolo, Riccardo, Bianchi, Giampaolo, Brunocilla, Eugenio, Borghesi, Marco, Carini, Marco, Longo, Nicola, Martorana, Giuseppe, Mirone, Vincenzo, Morgia, Giuseppe, Porpiglia, Francesco, Rocco, Bernardo, Rovereto, Bruno, Simeone, Claudio, Sodano, Mario, Terrone, Carlo, Ficarra, Vincenzo, and Minervini, Andrea
- Abstract
The early oncological goal of any partial nephrectomy (PN) is to achieve negative surgical margins (SMs). Several factors have been advocated as predictors of positive SMs (PSMs) after nephron-sparing surgery (NSS). In our study, age, upper pole tumor location, standard PN and Fuhrman 3/4 nuclear grade were found to be independent predictors of PSMs at multivariable analysis. Further evaluations are required to verify the oncological effect of the PSM on local and systemic recurrence.
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- 2024
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25. Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis
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Kastritis E., Palladini G., Minnema M. C., Wechalekar A. D., Jaccard A., Lee H. C., Sanchorawala V., Gibbs S., Mollee P., Venner C. P., Lu J., Schonland S., Gatt M. E., Suzuki K., Kim K., Cibeira M. T., Beksac M., Libby E., Valent J., Hungria V., Wong S. W., Rosenzweig M., Bumma N., Huart A., Dimopoulos M. A., Bhutani D., Waxman A. J., Goodman S. A., Zonder J. A., Lam S., Song K., Hansen T., Manier S., Roeloffzen W., Jamroziak K., Kwok F., Shimazaki C., Kim J. -S., Crusoe E., Ahmadi T., Tran N., Qin X., Vasey S. Y., Tromp B., Schecter J. M., Weiss B. M., Zhuang S. H., Vermeulen J., Merlini G., Comenzo R. L., Bradley Augustson, Fiona Kwok, Peter Mollee, Simon Gibbs, Chantal Doyen, Greet Bries, Isabelle Vande Broek, Ka Lung Wu, Koen Theunissen, Koen Van Eygen, Michel Delforge, Nathalie Meuleman, Philip Vlummens, Angelo Maiolino, Breno Moreno de Gusmão, Carlos Eduardo Miguel, Edvan Crusoe, Fernanda Moura, Fernanda Seguro, Jandey Bigonha, Juliane Musacchio, Karla Zanella, Laura Garcia, Marcelo Eduardo Zanella Capra, Reijane Alves de Assis, Rosane Bittencourt, Vania Hungria, Walter Braga, Wolney Barreto, Christopher Venner, Donna Reece, Emilie Lemieux-Blanchard, Kevin Song, Michael Sebag, Selay Lam, Victor Zepeda, Haitao Zhang, Jianda Hu, Jin Lu, Juan Li, Songfu Jiang, Ting Niu, Wenming Chen, Xiaonong Chen, Zhen Cai, Zhou Fude, Maja Oelholm Vase, Morten Salomo, Niels Abildgaard, Alain Fuzibet, Anne-Marie Stoppa, Arnaud Jaccard, Bertrand Arnulf, Bruno Moulin, Bruno Royer, David Ghez, Denis Caillot, Dominique Chauveau, Franck Bridoux, Lauriane Clement-Filliatre, Lionel Karlin, Lotfi Benboubker, Mamoun Dib, Margaret Macro, Mohamad Mohty, Olivier Decaux, Olivier Hermine, Olivier Tournilhac, Philippe Moreau, Salomon Manier, Sylvain Choquet, Véronique Dorvaux, Alexander Carpinteiro, Axel Nogai, Britta Besemer, Christoph Roellig, Roland Fenk, Stefan Knop, Stefan Schönland, Timon Hansen, Argiris Symeonidis, Efstathios Kastritis, Gabor Mikala, Tamás Masszi, Zsolt Nagy, Celia Suriu, Hila Magen, Iuliana Vaxman, Lev Shvidel, Meir Preis, Moshe Gatt, Noa Lavi, Osnat Jarchowsky, Tamar Tadmor, Yael Cohen, Angelo Vacca, Giovanni Palladini, Mario Boccadoro, Maurizio Martelli, Maurizio Musso, Michele Cavo, Chihiro Shimazaki, Hiroyuki Takamatsu, Kazutaka Sunami, Kenshi Suzuki, Nagaaki Katoh, Shinsuke Iida, Takayuki Ikezoe, Tomoaki Fujisaki, Yuta Katayama, Chang Ki Min, Ho-Jin Shin, Jin Seok Kim, Jung Yong Hong, Ki Hyun Kim, Sung-Soo Yoon, Aline Ramirez, Alvaro Cabrera, Christian Ramos, David Gomez Almaguer, Deborah Martinez, Guillermo Ruiz, Helen Dayani Caballero, Juan Antonio Flores Jimenez, Annemiek Broijl, Laurens Nieuwenhuizen, Monique Minnema, Paula Ypma, Wilfried Roeloffzen, Dominik Dytfeld, Grzegorz Charlinski, Grzegorz Helbig, Krzysztof Jamroziak, Sebastian Grosicki, Wieslaw Jedrzejczak, Albert Oriol Rocafiguera, Elham Askari, Fernando Escalante Barrigon, Isabel Krsnik Castello, Javier De la Rubia Comos, Jesus Martin Sanchez, Joaquin Martinez Lopez, Jose Angel Hernandez Rivas, Luis Felipe Casado Montero, Maria Jesus Blanchard Rodriguez, Maria Teresa Cibeira Lopez, Maria Victoria Mateos Manteca, Marta Sonia Gonzalez Perez, Mercedes Gironella Mesa, Rafael Rios Tamayo, Ramon Lecumberri Villamediana, Ricarda Garcia Sanchez, Sunil Lakhwani, Yolanda Gonzalez, Hareth Nahi, Kristina Carlsson, Markus Hansson, Ulf-Henrik Mellqvist, Ali Unal, Burhan Ferhanoglu, Hayri Ozsan, Levent Undar, Mehmet Turgut, Mehmet Yilmaz, Meral Beksac, Muhlis Cem Ar, Muzaffer Demir, Sevgi Besisik, Ashutosh Wechalekar, Jamie Cavenagh, Jim Cavet, Mark Cook, Rachel Hall, Adam Waxman, Anuj Mahindra, Cesar Rodriguez Valdes, Christine Ye, Craig Reeder, Daphne Friedman, David Siegel, Divaya Bhutani, Edward Libby, Eva Medvedova, Frank Passero, Giada Bianchi, Giampaolo Talamo, Guido Tricot, Hans Lee, Heather Landau, Jan Moreb, Jason Valent, Jeffrey Matous, Jeffrey A Zonder, Jesus Berdeja, Jonathan Kaufman, Keith Stockerl-Goldstein, Keren Osman, Ketan Doshi, Kevin Barton, Larry Anderson, Manisha Bhutani, Mehmet Kocoglu, Michael Rosenzweig, Michael Schuster, Michaela Liedtke, Morie Gertz, Naresh Bumma, Natalie Callander, Raymond Comenzo, Robert Vescio, Roger Pearse, Sandy W Wong, Stacey A Goodman, Stefano Tarantolo, Taimur Sher, Tibor Kovacsovics, Tomer Mark, Vaishali Sanchorawala, William Bensinger, Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias (CHELTER), Université Clermont Auvergne (UCA), Kastritis E., Palladini G., Minnema M.C., Wechalekar A.D., Jaccard A., Lee H.C., Sanchorawala V., Gibbs S., Mollee P., Venner C.P., Lu J., Schonland S., Gatt M.E., Suzuki K., Kim K., Cibeira M.T., Beksac M., Libby E., Valent J., Hungria V., Wong S.W., Rosenzweig M., Bumma N., Huart A., Dimopoulos M.A., Bhutani D., Waxman A.J., Goodman S.A., Zonder J.A., Lam S., Song K., Hansen T., Manier S., Roeloffzen W., Jamroziak K., Kwok F., Shimazaki C., Kim J.-S., Crusoe E., Ahmadi T., Tran N., Qin X., Vasey S.Y., Tromp B., Schecter J.M., Weiss B.M., Zhuang S.H., Vermeulen J., Merlini G., and Comenzo R.L., Bradley Augustson, Fiona Kwok, Peter Mollee, Simon Gibbs, Chantal Doyen, Greet Bries, Isabelle Vande Broek, Ka Lung Wu, Koen Theunissen, Koen Van Eygen, Michel Delforge, Nathalie Meuleman, Philip Vlummens, Angelo Maiolino, Breno Moreno de Gusmão, Carlos Eduardo Miguel, Edvan Crusoe, Fernanda Moura, Fernanda Seguro, Jandey Bigonha, Juliane Musacchio, Karla Zanella, Laura Garcia, Marcelo Eduardo Zanella Capra, Reijane Alves de Assis, Rosane Bittencourt, Vania Hungria, Walter Braga, Wolney Barreto, Christopher Venner, Donna Reece, Emilie Lemieux-Blanchard, Kevin Song, Michael Sebag, Selay Lam, Victor Zepeda, Haitao Zhang, Jianda Hu, Jin Lu, Juan Li, Songfu Jiang, Ting Niu, Wenming Chen, Xiaonong Chen, Zhen Cai, Zhou Fude, Maja Oelholm Vase, Morten Salomo, Niels Abildgaard, Alain Fuzibet, Anne-Marie Stoppa, Arnaud Jaccard, Bertrand Arnulf, Bruno Moulin, Bruno Royer, David Ghez, Denis Caillot, Dominique Chauveau, Franck Bridoux, Lauriane Clement-Filliatre, Lionel Karlin, Lotfi Benboubker, Mamoun Dib, Margaret Macro, Mohamad Mohty, Olivier Decaux, Olivier Hermine, Olivier Tournilhac, Philippe Moreau, Salomon Manier, Sylvain Choquet, Véronique Dorvaux, Alexander Carpinteiro, Axel Nogai, Britta Besemer, Christoph Roellig, Roland Fenk, Stefan Knop, Stefan Schönland, Timon Hansen, Argiris Symeonidis, Efstathios Kastritis, Gabor Mikala, Tamás Masszi, Zsolt Nagy, Celia Suriu, Hila Magen, Iuliana Vaxman, Lev Shvidel, Meir Preis, Moshe Gatt, Noa Lavi, Osnat Jarchowsky, Tamar Tadmor, Yael Cohen, Angelo Vacca, Giovanni Palladini, Mario Boccadoro, Maurizio Martelli, Maurizio Musso, Michele Cavo, Chihiro Shimazaki, Hiroyuki Takamatsu, Kazutaka Sunami, Kenshi Suzuki, Nagaaki Katoh, Shinsuke Iida, Takayuki Ikezoe, Tomoaki Fujisaki, Yuta Katayama, Chang Ki Min, Ho-Jin Shin, Jin Seok Kim, Jung Yong Hong, Ki Hyun Kim, Sung-Soo Yoon, Aline Ramirez, Alvaro Cabrera, Christian Ramos, David Gomez Almaguer, Deborah Martinez, Guillermo Ruiz, Helen Dayani Caballero, Juan Antonio Flores Jimenez, Annemiek Broijl, Laurens Nieuwenhuizen, Monique Minnema, Paula Ypma, Wilfried Roeloffzen, Dominik Dytfeld, Grzegorz Charlinski, Grzegorz Helbig, Krzysztof Jamroziak, Sebastian Grosicki, Wieslaw Jedrzejczak, Albert Oriol Rocafiguera, Elham Askari, Fernando Escalante Barrigon, Isabel Krsnik Castello, Javier De la Rubia Comos, Jesus Martin Sanchez, Joaquin Martinez Lopez, Jose Angel Hernandez Rivas, Luis Felipe Casado Montero, Maria Jesus Blanchard Rodriguez, Maria Teresa Cibeira Lopez, Maria Victoria Mateos Manteca, Marta Sonia Gonzalez Perez, Mercedes Gironella Mesa, Rafael Rios Tamayo, Ramon Lecumberri Villamediana, Ricarda Garcia Sanchez, Sunil Lakhwani, Yolanda Gonzalez, Hareth Nahi, Kristina Carlsson, Markus Hansson, Ulf-Henrik Mellqvist, Ali Unal, Burhan Ferhanoglu, Hayri Ozsan, Levent Undar, Mehmet Turgut, Mehmet Yilmaz, Meral Beksac, Muhlis Cem Ar, Muzaffer Demir, Sevgi Besisik, Ashutosh Wechalekar, Jamie Cavenagh, Jim Cavet, Mark Cook, Rachel Hall, Adam Waxman, Anuj Mahindra, Cesar Rodriguez Valdes, Christine Ye, Craig Reeder, Daphne Friedman, David Siegel, Divaya Bhutani, Edward Libby, Eva Medvedova, Frank Passero, Giada Bianchi, Giampaolo Talamo, Guido Tricot, Hans Lee, Heather Landau, Jan Moreb, Jason Valent, Jeffrey Matous, Jeffrey A Zonder, Jesus Berdeja, Jonathan Kaufman, Keith Stockerl-Goldstein, Keren Osman, Ketan Doshi, Kevin Barton, Larry Anderson, Manisha Bhutani, Mehmet Kocoglu, Michael Rosenzweig, Michael Schuster, Michaela Liedtke, Morie Gertz, Naresh Bumma, Natalie Callander, Raymond Comenzo, Robert Vescio, Roger Pearse, Sandy W Wong, Stacey A Goodman, Stefano Tarantolo, Taimur Sher, Tibor Kovacsovics, Tomer Mark, Vaishali Sanchorawala, William Bensinger
- Subjects
Male ,Treatment outcome ,Immunoglobulin Light-chain Amyloidosis/drug therapy ,CD38 ,Dexamethasone ,Cyclophosphamide/administration & dosage ,Bortezomib ,0302 clinical medicine ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,CRITERIA ,Immunoglobulin Light-chain Amyloidosis ,ComputingMilieux_MISCELLANEOUS ,Aged, 80 and over ,biology ,Amyloidosis ,Antibodies, Monoclonal ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,General Medicine ,Middle Aged ,3. Good health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Female ,Antibody ,Human ,Adult ,Dexamethasone/administration & dosage ,ANTIBODY DARATUMUMAB ,Immunoglobulin light chain ,DIAGNOSIS ,Antibodies, Monoclonal/administration & dosage ,Disease-Free Survival ,03 medical and health sciences ,Humans ,Cyclophosphamide ,Aged ,Antineoplastic Combined Chemotherapy Protocol ,business.industry ,Antineoplastic Combined Chemotherapy Protocols/adverse effects ,AL AMYLOIDOSIS ,Daratumumab ,Amyloid fibril ,medicine.disease ,Molecular biology ,Immunoglobulin Light-chain Amyloidosi ,biology.protein ,Bortezomib/administration & dosage ,business ,030215 immunology - Abstract
Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting antibody, may improve outcomes for this disease.We randomly assigned patients with newly diagnosed AL amyloidosis to receive six cycles of bortezomib, cyclophosphamide, and dexamethasone either alone (control group) or with subcutaneous daratumumab followed by single-agent daratumumab every 4 weeks for up to 24 cycles (daratumumab group). The primary end point was a hematologic complete response.A total of 388 patients underwent randomization. The median follow-up was 11.4 months. The percentage of patients who had a hematologic complete response was significantly higher in the daratumumab group than in the control group (53.3% vs. 18.1%) (relative risk ratio, 2.9; 95% confidence interval [CI], 2.1 to 4.1; P0.001). Survival free from major organ deterioration or hematologic progression favored the daratumumab group (hazard ratio for major organ deterioration, hematologic progression, or death, 0.58; 95% CI, 0.36 to 0.93; P = 0.02). At 6 months, more cardiac and renal responses occurred in the daratumumab group than in the control group (41.5% vs. 22.2% and 53.0% vs. 23.9%, respectively). The four most common grade 3 or 4 adverse events were lymphopenia (13.0% in the daratumumab group and 10.1% in the control group), pneumonia (7.8% and 4.3%, respectively), cardiac failure (6.2% and 4.8%), and diarrhea (5.7% and 3.7%). Systemic administration-related reactions to daratumumab occurred in 7.3% of the patients. A total of 56 patients died (27 in the daratumumab group and 29 in the control group), most due to amyloidosis-related cardiomyopathy.Among patients with newly diagnosed AL amyloidosis, the addition of daratumumab to bortezomib, cyclophosphamide, and dexamethasone was associated with higher frequencies of hematologic complete response and survival free from major organ deterioration or hematologic progression. (Funded by Janssen Research and Development; ANDROMEDA ClinicalTrials.gov number, NCT03201965.).
- Published
- 2021
26. Current applications of ex-vivo fluorescent confocal microscope in urological practice: a systematic review of literature.
- Author
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Eissa A, Puliatti S, Rodriguez Peñaranda N, Resca S, Di Bari S, Vella J, Maggiorelli S, Bertoni L, Azzoni P, Reggiani Bonetti L, Campobasso D, Ferretti S, Micali S, and Bianchi G
- Abstract
Background: Histopathological examination, a cornerstone in diagnosing cancer, faces challenges due to its time-consuming nature. This review explores the potential of ex-vivo fluorescent confocal microscopy (FCM) in urology, addressing the need for real-time pathological assessment, particularly in prostate cancer. This systematic review aims to assess the applications of FCM in urology, including its role in prostate cancer diagnosis, surgical margin assessment, and other urological fields., Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, a systematic search of PubMed and SCOPUS was conducted, focusing on English written original articles published after January 1, 2018, discussing the use of FCM in urological practice. The search included keywords related to FCM and urological terms. The risk of bias assessment was performed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool., Results: A total of 17 relevant studies were included in the review that focuses on three main urological issues: prostate cancer (15 articles), bladder cancer (1 article), and renal biopsy (1 article). FCM exhibited significant promise in diagnosing prostate cancer. These studies reported an accuracy range of 85.33% to 95.1% in distinguishing between cancerous and non-cancerous prostate tissues. Moreover, FCM proved valuable for assessing surgical margins in real-time during radical prostatectomy, reducing the need for frozen section analysis. In some investigations, researchers explored the integration of artificial intelligence (AI) with FCM to automate diagnostic processes. Concerning bladder cancer, FCM played a beneficial role in evaluating urethral and ureteral margins during radical cystectomy. Notably, it showed substantial agreement with conventional histopathology and frozen section examination. In the context of renal biopsy, FCM demonstrated the potential to differentiate normal renal parenchyma from cancerous tissue, although the available evidence is limited in this area. The main limitation of the current study is the scarcity of data regarding the topic of interest., Conclusions: Ex-vivo FCM holds promise in urology, particularly in prostate cancer diagnosis and surgical margin assessment. Its real-time capabilities may reduce diagnostic delays and patient stress. However, most studies remain experimental, requiring further research to validate clinical utility.
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- 2024
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27. Applicability and feasibility of robot-assisted cystectomy and intracorporeal urinary diversion in a patient with right renal pelvic ectopia.
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Puliatti S, Ferretti S, Peñaranda NR, Eissa A, Ticonosco M, De Faveri A, De Carne C, Wisz P, Ferrari R, Tosi G, Annino F, Bianchi G, and Micali S
- Subjects
- Humans, Aged, Cystectomy, Feasibility Studies, Neoplasm Recurrence, Local, Kidney surgery, Carcinoma, Transitional Cell, Robotics, Urinary Bladder Neoplasms surgery, Urinary Diversion
- Abstract
Background: The ectopic pelvic kidney, a common renal anomaly, is often smaller and malformed, with a shorter and sometimes tortuous ureter (1). Muscle-invasive bladder cancer (MIBC), constituting 15-25% of bladder cancer cases (2), mandates radical cystectomy with a 50% 5-year survival rate (2). Despite the growing use of robot-assisted radical cystectomy (RARC) (3, 4), there is limited data on its application in ectopic kidneys. Only one RARC case has been reported (5), in contrast to numerous open radical cystectomies (1, 6) involving an ectopic kidney., Patient and Methods: After being diagnosed with T2 high-grade urothelial carcinoma, the 66-year-old patient, previously treated with multiple transurethral resections and adjuvant BCG therapy, received neoadjuvant chemotherapy. Preoperative staging CT revealed a 2.6 x 2.2 cm bladder neoformation and an ectopic right pelvic kidney., Results: Using the da Vinci Surgical System, radical cystectomy with ileal conduit (sec Wallace II) and lymphadenectomy were performed. During the demolition phase, the shorter right ureter was dissected with care to avoid damage to the renal pedicle. The reconstructive phase included intracorporeal urinary diversion (ICUD) and uretero-ileal anastomosis, facilitated by the favorable position of the kidney. The 8-hour console surgery resulted in minimal blood loss. Discharged on day 16 due to COVID-19, the patient exhibited positive outcomes. A 2-month CT follow-up revealed no cancer recurrence, metastasis, hydronephrosis, and complete regression of the lymphocele. Imaging follow-up continues without postoperative adjuvant chemotherapy., Conclusion: Robotic surgery with intracorporeal urinary diversion holds potential for right-sided pelvic kidney cases, but additional studies are necessary for validation., Competing Interests: None declared., (Copyright® by the International Brazilian Journal of Urology.)
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- 2024
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28. Endovascular repair of isolated post-traumatic subclavian artery false-aneurysm (FA) using gore viabahn vbx-balloon-expandable (BE) stent-graft: case report and literature review.
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Perri M, Timpani C, Capoccia L, Bianchi G, Balzano RF, Popolizio T, Pennelli AM, Guglielmi G, D'Elia M, and Filauri P
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- Blood Vessel Prosthesis, Humans, Prosthesis Design, Stents, Subclavian Artery diagnostic imaging, Subclavian Artery surgery, Treatment Outcome, Aneurysm diagnostic imaging, Aneurysm etiology, Aneurysm surgery, Aneurysm, False diagnostic imaging, Aneurysm, False etiology, Aneurysm, False surgery, Blood Vessel Prosthesis Implantation, Endovascular Procedures
- Abstract
True and false aneurysms (FA) of the subclavian artery are at high risk of rupture due to their localization and proximity/closeness to the articular bone structures of the upper thoracic outlet and shoulders. Surgical and endovascular treatments are good options to avoid complications such as aneurysms rupture, thrombosis and distal embolism alone or in combination. Self-expandable (SE) covered stents are the most used devices for the treatment of subclavian artery aneurysms. We report on a case of post traumatic left intra-thoracic subclavian artery FA treated using endovascular technique, highlighting the usefulness of the new covered Gore Viabahn VBX-BE stent-graft that combines the advantages of a high radial strength of a BE stent with the deliverability and conformability of a SE stent.
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- 2022
- Full Text
- View/download PDF
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