8 results on '"Boston, A.J."'
Search Results
2. First experimental measurements with the Segmented Inverted-coaxial GerMAnium (SIGMA) detector
- Author
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Pearce, F.J., Harkness-Brennan, L.J., Alharbi, A., Boston, A.J., Griffiths, O., Holloway, F., Judson, D.S., Labiche, M., Nolan, P.J., Page, R.D., Radford, D.C., Rintoul, E., Simpson, J., Unsworth, C., and Wright, J.P.
- Published
- 2022
- Full Text
- View/download PDF
3. If not a transformative agreement, then what? Nine questions and answers about an alternative
- Author
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Boston, A.J., primary
- Published
- 2023
- Full Text
- View/download PDF
4. Monte Carlo simulation of a BEGe 6530 detector in GAMOS
- Author
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Woodroof, T.F., primary, Boston, A.J., additional, and Judson, D.S., additional
- Published
- 2022
- Full Text
- View/download PDF
5. νi13/2 structures in 155Sm and 159Gd: Supporting evidence of a Z=60 deformed subshell gap
- Author
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Hartley, D.J., Kondev, F.G., Janssens, R.V.F., Carpenter, M.P., Little, D., Lauritsen, T., Hoffman, C.R., Heery, J., Savard, G., Simpson, J., Auranen, K., Clark, J.A., Boston, A.J., Wilson, G.L., Stolze, S., Villafana, K., Riley, M.A., Li, J., Greene, J.P., Seweryniak, D., Paul, E.S., Zhu, S., Ayangeakaa, A.D., Baron, J.S., and Wu, J.
- Abstract
Maximal ground-state deformation should occur when both proton and neutron Fermi surfaces are located at midshell. However, subshell gaps that stabilize large deformation can exist at proton or neutron values other than midshell. One such gap may occur at Z=60 in the rare-earth region, as the energy of the first 2+ states in even-even nuclei are often lowest in an isotonic chain for neodymium (Z=60) rather than the midshell isotopes of dysprosium (Z=66). Further evidence of this deformed gap has now been observed by investigating the signature splitting systematics of the νi13/2 bands found in the odd-N, rare-earth nuclei. These were aided by the present observation of the νi13/2 band in Gd159 and the confirmation of the same structure in Sm155 via the transfer of a neutron from a Gd160 beam to a Sm154 target.
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- 2022
- Full Text
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6. New narrow resonances observed in the unbound nucleus <math><mmultiscripts><mi mathvariant='normal'>F</mi><mprescripts/><none/><mn>15</mn></mmultiscripts></math>
- Author
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Girard-Alcindor, V., Mercenne, A., Stefan, I., de Oliveira Santos, F., Michel, N., Płoszajczak, M., Assié, M., Lemasson, A., Clément, E., Flavigny, F., Matta, A., Ramos, D., Rejmund, M., Dudouet, J., Ackermann, D., Adsley, P., Assunção, M., Bastin, B., Beaumel, D., Benzoni, G., Borcea, R., Boston, A.J., Cáceres, L., Cederwall, B., Celikovic, I., Chudoba, V., Ciemala, M., Collado, J., Crespi, F.C.L., d'Agata, G., de France, G., Delaunay, F., Diget, C., Domingo-Pardo, C., Eberth, J., Fougères, C., Franchoo, S., Galtarossa, F., Georgiadou, A., Gibelin, J., Giraud, S., González, V., Goyal, N., Gottardo, A., Goupil, J., Grévy, S., Guimaraes, V., Hammache, F., Harkness-Brennan, L.J., Hess, H., Oliver, D.S. Judson, Kamalou, O., Kameneyero, A., Kiener, J., Korten, W., Koyama, S., Labiche, M., Lalanne, L., Lapoux, V., Leblond, S., Lefevre, A., Lenain, C., Leoni, S., Li, H., Lopez-Martens, A., Maj, A., Matea, I., Menegazzo, R., Mengoni, D., Meyer, A., Million, B., Monteagudo, B., Morfouace, P., Mrazek, J., Niikura, M., Piot, J., Podolyak, Zs., Portail, C., Pullia, A., Quintana, B., Recchia, F., Reiter, P., Rezynkina, K., Roger, T., Rojo, J.S., Rotaru, F., Salsac, M.D., Benitez, A.M. Sánchez, Sanchis, E., Şenyigit, M., de Séréville, N., Siciliano, M., Simpson, J., Sohler, D., Sorlin, O., Stanoiu, M., Stodel, C., Suzuki, D., Theisen, C., Thomas, J.C., Ujic, P., Valiente-Dobón, J.J., Zielińska, M., Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and ANR-17-CE31-0026,OASIS,Optimisation d'Agata pour la physique(2017)
- Subjects
[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th] ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] - Abstract
International audience; The structure of the unbound F15 nucleus is investigated using the inverse kinematics resonant scattering of a radioactive O14 beam impinging on a CH2 target. The analysis of H1(O14,p)O14 and H1(O14,2p)N13 reactions allowed the confirmation of the previously observed narrow 1/2− resonance, near the two-proton decay threshold, and the identification of two new narrow 5/2− and 3/2− resonances. The newly observed levels decay by 1p emission to the ground of O14, and by sequential 2p emission to the ground state of N13 via the 1− resonance of O14. Gamow shell model (GSM) analysis of the experimental data suggests that the wave functions of the 5/2− and 3/2− resonances may be collectivized by the continuum coupling to nearby 2p- and 1p-decay channels. The observed excitation function H1(O14,p)O14 and resonance spectrum in F15 are well reproduced in the unified framework of the GSM.
- Published
- 2022
7. Narrow resonances in the continuum of the unbound nucleus $^{15}$F
- Author
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Girard-Alcindor, V., Mercenne, A., Stefan, I., de Oliveira Santos, F., Michel, N., Płoszajczak, M., Assié, M., Lemasson, A., Clément, E., Flavigny, F., Matta, A., Ramos, D., Rejmund, M., Dudouet, J., Ackermann, D., Adsley, P., Assunção, M., Bastin, B., Beaumel, D., Benzoni, G., Borcea, R., Boston, A.J., Cáceres, L., Cederwall, B., Celikovic, I., Chudoba, V., Ciemala, M., Collado, J., Crespi, F.C.L., D'Agata, G., De France, G., Delaunay, F., Diget, C., Domingo-Pardo, C., Eberth, J., Fougères, C., Franchoo, S., Galtarossa, F., Georgiadou, A., Gibelin, J., Giraud, S., González, V., Goyal, N., Gottardo, A., Goupil, J., Grévy, S., Guimaraes, V., Hammache, F., Harkness-Brennan, L.J., Hess, H., Oliver, D.S. Judson, Kamalou, O., Kameneyero, A., Kiener, J., Korten, W., Koyama, S., Labiche, M., Lalanne, L., Lapoux, V., Leblond, S., Lefevre, A., Lenain, C., Leoni, S., Li, H., Lopez-Martens, A., Maj, A., Matea, I., Menegazzo, R., Mengoni, D., Meyer, A., Million, B., Monteagudo, B., Morfouace, P., Mrazek, J., Niikura, M., Piot, J., Podolyak, Zs., Portail, C., Pullia, A., Quintana, B., Recchia, F., Reiter, P., Rezynkina, K., Roger, T., Rojo, J.S., Rotaru, F., Salsac, M.D., Benitez, A.M. Sánchez, Sanchis, E., Şenyigit, M., De Séréville, N., Siciliano, M., Simpson, J., Sohler, D., Sorlin, O., Stanoiu, M., Stodel, C., Suzuki, D., Theisen, C., Thomas, J.C., Ujic, P., Valiente-Dobón, J.J., Zielińska, M., Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Nuclear Theory (nucl-th) ,Nuclear Theory ,[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th] ,FOS: Physical sciences ,Nuclear Experiment (nucl-ex) ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Nuclear Experiment - Abstract
The structure of the unbound $^{15}$F nucleus is investigated using the inverse kinematics resonant scattering of a radioactive $^{14}$O beam impinging on a CH$_2$ target. The analysis of $^{1}$H($^{14}$O,p)$^{14}$O and $^{1}$H($^{14}$O,2p)$^{13}$N reactions allowed the confirmation of the previously observed narrow $1/2^{-}$ resonance, near the two-proton decay threshold, and the identification of two new narrow 5/2$^{-}$ and 3/2$^{-}$ resonances. The newly observed levels decay by 1p emission to the ground of $^{14}$O, and by sequential 2p emission to the ground state (g.s.) of $^{13}$N via the $1^-$ resonance of $^{14}$O. Gamow shell model (GSM) analysis of the experimental data suggests that the wave functions of the 5/2$^{-}$ and 3/2$^{-}$ resonances may be collectivized by the continuum coupling to nearby 2p- and 1p- decay channels. The observed excitation function $^{1}$H($^{14}$O,p)$^{14}$O and resonance spectrum in $^{15}$F are well reproduced in the unified framework of the GSM., Comment: 7 pages, 4 figures
- Published
- 2021
8. Human Macrophage Long Intergenic Noncoding RNA, SIMALR , Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1).
- Author
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Cynn E, Li DY, O'Reilly ME, Wang Y, Bashore AC, Jha A, Foulkes AS, Zhang H, Winter H, Maegdefessel L, Yan H, Li M, Ross L, Xue C, and Reilly MP
- Subjects
- Humans, Lipopolysaccharides, Netrin-1, HEK293 Cells, Macrophages metabolism, Apoptosis, Hypoxia-Inducible Factor 1, RNA, Long Noncoding metabolism, Plaque, Atherosclerotic metabolism, Atherosclerosis metabolism
- Abstract
Background: Long noncoding RNAs (lncRNAs) have emerged as novel regulators of macrophage biology and inflammatory cardiovascular diseases. However, studies focused on lncRNAs in human macrophage subtypes, particularly human lncRNAs that are not conserved in rodents, are limited., Methods: Through RNA-sequencing of human monocyte-derived macrophages, we identified suppressor of inflammatory macrophage apoptosis lncRNA ( SIMALR ). Lipopolysaccharide/IFNγ (interferon γ) stimulated human macrophages were treated with SIMALR antisense oligonucleotides and subjected to RNA-sequencing to investigate the function of SIMALR . Western blots, luciferase assay, and RNA immunoprecipitation were performed to validate function and potential mechanism of SIMALR. RNAscope was performed to identify SIMALR expression in human carotid atherosclerotic plaques., Results: RNA-sequencing of human monocyte-derived macrophages identified SIMALR , a human macrophage-specific long intergenic noncoding RNA that is highly induced in lipopolysaccharide/IFNγ-stimulated macrophages. SIMALR knockdown in lipopolysaccharide/IFNγ stimulated THP1 human macrophages induced apoptosis of inflammatory macrophages, as shown by increased protein expression of cleaved PARP (poly[ADP-ribose] polymerase), caspase 9, caspase 3, and Annexin V+. RNA-sequencing of control versus SIMALR knockdown in lipopolysaccharide/IFNγ-stimulated macrophages showed Netrin-1 ( NTN1 ) to be significantly decreased upon SIMALR knockdown. We confirmed that NTN1 knockdown in lipopolysaccharide/IFNγ-stimulated macrophages induced apoptosis. The SIMALR knockdown-induced apoptotic phenotype was rescued by adding recombinant NTN1. NTN1 promoter-luciferase reporter activity was increased in HEK293T (human embryonic kidney 293) cells treated with lentiviral overexpression of SIMALR . NTN1 promoter activity is known to require HIF1α (hypoxia-inducible factor 1 subunit alpha), and our studies suggest that SIMALR may interact with HIF1α to regulate NTN1 transcription, thereby regulating macrophages apoptosis. SIMALR was found to be expressed in macrophages in human carotid atherosclerotic plaques of symptomatic patients., Conclusions: SIMALR is a nonconserved, human macrophage lncRNA expressed in atherosclerosis that suppresses macrophage apoptosis. SIMALR partners with HIF1α (hypoxia-inducible factor 1 subunit alpha) to regulate NTN1, which is a known macrophage survival factor. This work illustrates the importance of interrogating the functions of human lncRNAs and exploring their translational and therapeutic potential in human atherosclerosis.
- Published
- 2023
- Full Text
- View/download PDF
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