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Background: Bronchopneumonia (BP) in calves potentially causes systemic changes., Objectives: To describe metabolic, arterial blood gas, and acid-base disorders in calves with BP diagnosed by thoracic ultrasound (TUS), Wisconsin score (WISC), and combinations of WISC and TUS., Animals: Two hundred thirty-one dairy preweaned dairy calves from 13 dairy farms., Methods: Cross-sectional study. Each calf sequentially underwent arterial blood gas evaluation, WISC score, venous sampling, and TUS. Calves were grouped based on a single diagnostic method and combination of WISC and 2 TUS cutoffs (≥1 cm; ≥3 cm) as healthy, upper respiratory tract infection, subclinical BP, and clinical BP., Results: Oxygenation and acid-base variables were unaffected. Glucose concentration in TUS-affected calves was significantly lower (P < .001) than in healthy calves (median ≥TUS 1cm  = 5.2 mmol/L 25%-75% interquartile range [IQR] 4.5-6.1, 1cm  = 5.9 mmol/L IQR 5.5-6.6; ≥TUS 3cm  = 5.1 mmol/L IQR 4.4-6.2, 3cm  = 5.8 mmol/L IQR 5.3-6.4). Paraoxonase-1 was significantly lower (P < .001) in TUS-affected calves (≥TUS 1cm  = 64.1 U/mL IQR 40.8-78, 1cm  = 77.3 U/mL IQR 61.9-96.5; ≥TUS 3cm  = 59.2 U/mL IQR 37.7-72.4, 3cm  = 72.9 U/mL IQR 53.4-95.5). None of the variables highlighted clear distinctions in WISC-detected clinical and subclinical BP calves based on the combination of WISC and TUS., Conclusions and Clinical Importance: Clinical signs indicate minor systemic disorders compared to TUS. The abnormalities detected by ultrasonographic examination were moderate and did not deviate from normal reference ranges., (© 2024 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.)