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Background: There is wide variation in the problems prioritised by people with psychosis in cognitive behavioural therapy for psychosis (CBTp). While research trials and mental health services have often prioritised reduction in psychiatric symptoms, service users may prioritise issues not directly related to psychosis. This discrepancy suggests potential challenges in treatment outcome research. Aims: The present study aimed to examine the types of problems that were recorded on problem lists generated in CBTp trials. Method: Problem and goals lists for 110 participants were extracted from CBTp therapy notes. Subsequently, problems were coded into 23 distinct categories by pooling together items that appeared thematically related. Results: More than half of participants (59.62%) listed a non-psychosis-related priority problem, and 22.12% did not list any psychosis related problems. Chi-square tests indicated there was no difference between participants from early intervention (EI) and other services in terms of priority problem (χ2 = 0.06, p = .804), but that those from EI were more likely to include any psychosis-related problems in their lists (χ2 = 6.66, p = .010). Conclusions: The findings of this study suggest that psychiatric symptom reduction is not the primary goal of CBTp for most service users, particularly those who are not under the care of EI services. The implications for future research and clinical practice are discussed.

Swine production systems contribute to emission of greenhouse gases (CO2, N2O, and CH4) and ammonia (NH3) into the atmosphere. Therefore, the objective of this study was to evaluate methods for determining the emissions of ammonia and greenhouse gases (GHG) in a commercial swine production unit with natural ventilation during the finishing phase. The concentrations of gases in the air were measured using a gas analyzer (INNOVA 1412), and the flow emission was calculated by considering the ventilation rate and the differences in gas concentration between the interior and exterior of the installation. The results showed that the emission flow obtained via the simplified method in [g per swine h-1] was 2.689, 0.30, 4.39, 13.55, and 3.273 for CO2, N2O, CH4, NH3, and water vapor, respectively. The flow obtained using the continuous method in [g per swine h-1] was 574, 0.67, 19.50, 5.84, and 7.2 for CO2, N2O, CH4, NH3, and water vapor, respectively. The proposed simplified method was highly accurate for estimating GHG emissions from swine production systems with natural ventilation. RESUMO Os sistemas de produção de suínos contribuem com emissões de gases de efeito estufa (dióxido de carbono - CO2, óxido nitroso - N2O e metano - CH4) e amônia - NH3 para a atmosfera. Portanto, o objetivo deste estudo foi avaliar metodologias para determinação das emissões de amônia e gases de efeito estufa em uma unidade de produção comercial de suínos durante a fase de terminação, que possui ventilação natural. Foram medidas as concentrações de gases no ar pelo analisador de gases (INNOVA 1412) e foi calculada a vazão de emissões considerando a taxa de ventilação e as diferenças de concentração de gases entre o interior e o exterior da instalação. Os resultados mostraram que a vazão de emissão obtida pela metodologia simplificada em [g suíno por hora] foi: 2,689 para CO2, 0,30 para N2O, 4,39 para CH4, 13,55 para NH3 e 3,273 para vapor d’água. A vazão obtida para a metodologia contínua em [g suíno por hora] foi de 574 para CO2, 0,67 para N2O, 19,50 para CH4, 5,84 para NH3 e 7,2 para vapor d’água. A metodologia simplificada foi altamente precisa para estimar as emissões de GEE em sistemas de produção de suínos com ventilação natural.

Myofibroblastoma of the breast is a benign tumor originated from mesenquimal cells with a very low incidence in breast pathology. Only 80 cases were reported until 2018. Eight histological patterns were described and may mimic a number of other breast diseases. A 55-years old male was diagnosed with an incidental left breast nodule. An ultrasonography with biopsy showed a 27 mm nodule compatible with myofibroblastoma. We performed a lumpectomy via modified Benelli technique. Surgery was curative and the only necessary treatment. Myofibroblastoma could be misdiagnosed and clinical differential diagnosis includes other benign and malignant breast lesions. In the setting of a diagnosis, histology may be confusing as myofibroblastoma may exhibit a wide spectrum of histological features that defines 8 variants. These subgroups can mimic malignant lesions in their histological pattern. Definitive diagnosis depends on histopathological and immunochemical results. Physicians must be aware about heterogeneity in morphological and immunochemical aspects of myofibroblastoma and his variants, as they can lead to erroneous management of the lesion. Surgery is important for a definitive and accurate diagnosis, excluding malignancy and relieving the burden of a close image-based surveillance.

O objetivo deste estudo foi avaliar as características dos usuários e dos atendimentos realizados nas Unidades Básicas de Saúde do município de Criciúma/SC. Foram avaliados todos atendimentos realizados no ano de 2018, através da coleta de dados secundários no sistema de informação em saúde (CELK Saúde) do município. As variáveis analisadas foram: idade, sexo, escolaridade, situação de moradia, encaminhamentos realizados à atenção secundária, classificação e tipos de atendimentos registrados durante as consultas e os principais procedimentos executados. Foram realizadas análises descritivas das variáveis estudadas, com a apresentação das frequências absolutas e relativas. Dentre os 452.605 atendimentos avaliados, observou-se que 64,57% dos atendimentos foram realizados pelo sexo feminino e pelos indivíduos com 60 anos ou mais. A maior prevalência de atendimentos foi na classificação saúde mental. Em relação aos tipos de atendimento, notou-se predominância de consulta médica em todos os distritos. Quanto aos encaminhados realizados à atenção secundária, os mais prevalentes foram a oftalmologia e a ortopedia. Os resultados encontrados neste estudo podem orientar os gestores em saúde no desenvolvimento de estratégias e alternativas de intervenções efetivas na atenção básica, melhorando a qualidade e otimizando os serviços públicos ofertados.

Essential oils from Amazonian species are gaining increasing interest worldwide due to their medicinal and cosmetic applications; however, the relation among the chemical constituents and their biological properties are not well explored. Therefore, the present research aims to obtain an understanding of the bioactivity of chemical compounds in the essential oils of plants from the Annonaceae family (Bocageopsis pleiosperma, Onychopetalum amazonicum, Unonopsis duckei, U. floribunda, U. rufescens, U.stipitata, U. guatterioides, Duguetia flagellaris and Xylopia benthamii). By means of gas chromatography coupled to mass spectrometry, in vitro cytotoxic and anti-lipase assays, principal component analysis and molecular docking, it was possible to establish the main compounds that may be responsible for the cytotoxic effect of O. amazonicum and B. pleiosperma. Moreover, the anti-lipase potential of D. flagellaris was also established, as well as its composition related to the activity. Thus, by the employed strategy, allo-aromadendrene, cryptomerione, δ-cadinene and β-bisabolene were suggested as plausible cytotoxic agents against cancer cell lines, and dehydroaromadendrene, spathulenol and elemol, against lipase. The present study provides significant information on the chemical profile and bioactivity studies of Amazon Annonaceae aromatic plants.

Objective: The clinical cases of patients with multisystem inflammatory syndrome (MIS-C) were analyzed via a systematic review and meta-analysis of the clinical findings, treatments, and possible outcomes of articles retrieved via database searches. Sources: The authors searched the PubMed, Scielo, Web of Science, Science Direct, EMBASA, EBSCO, and Scopus databases for articles containing the keywords “multisystem inflammatory syndrome in children” or “MIS-C” or “PIMS-TS” or “SIMP” and “COVID-19” or “SARS-CoV-2” published between December 1st, 2019 and July 10th, 2021. Patient characteristics, tissue and organ comorbidities, the incidence of symptoms after COVID-19 infection, treatment, and patient evolution in the articles found were evaluated. The data were abstracted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and Newcastle-Ottawa Scale (NOS). Findings: In total, 98 articles (2275 patients) were selected for demographics, clinical treatment, and outcomes of patients diagnosed with MIS-C. The average age of children with MIS-C, 56.8% of whom were male, was of nine years. Fever (100%), gastrointestinal (GI) (82%), and abdominal pain (68%) were the decisive symptoms for the diagnosis of MIS-C. Shock and/or hypotension were common in patients with MIS-C. Cardiac symptoms (66%) predominated over respiratory (39%) and neurological (28%) symptoms. MIS-C treatment followed the common guidelines for treating children with septic shock and Kawasaki disease (KD) and proved to be effective. Conclusions: This meta-analysis highlights the main clinical symptoms used for the diagnosis of MIS-C, the differences between MIS-C and KD, and the severity of the inflammatory process and urgency for hospital care.

Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and energy drinks, and is the most widely consumed substance worldwide. Therefore, it is extremely important to research the effects of this substance on the human body. With this in mind, caffeine and its derivatives have been extensively studied to evaluate its ability to prevent diseases and exert anti-aging and neuroprotective effects. This review is intended to provide an overview of the effects of caffeine on cancer, cardiovascular, immunological, inflammatory, and neurological diseases, among others. The heavily researched area of caffeine in sports will also be discussed. Finally, recent advances in the development of novel formulations, in the form of dietary supplements of caffeine and nanocarriers, to enhance the bioavailability of caffeine and its beneficial effects will be discussed. On the other hand, caffeine may contribute to elevated blood pressure, anemia, and migraine.

Aim The primary aim of the study is to determine the efficacy of the placement of an onlay mesh for prevention of incisional hernia after loop ileostomy closure Material & Methods This is a multicentric, prospective, randomized controlled trial including patients operated on for loop ileostomy closure after a prior rectal resection for rectal cancer. In the control group (C), after the digestive tract is reconstructed, the closure of the abdominal wall is performed by a 4:1 ratio running suture of polydioxanone. Patients in the study group (M) had the same closure procedure performed, and a light polypropilene mesh is placed onlay. The presence of incisional hernia was evaluated by physical examination at scheduled clinical visits and radiologically by an abdominal CT scan performed at the end of follow-up (6 month after surgery) Results 58 patients were included (27 in control group and 31 in mesh group) . Both groups had similar characteristics, except for a higher rate of smokers in the control group (48% vs 6%). During the follow-up, 5% of patients developed an incisional hernia (Group M 0 vs Group C 11%). At 30 days of follow-up 5 (16%) surgical site occurrences were detected in Group M for 4 (15%) in Group C. Conclusions A low incidence of IH after ileostomy closure is detected. All the IH were presented in the control group with no stadistically significant differences between groups. Larger trials with longer follow-up are needed to confirm the results.

In the present study, a numerical model was developed to predict the flow pattern inside a broiler building. The model intends to predict the velocities fields inside the domain and ammonia (NH3) emitted or released by litter from poultry housing. The numerical model developed in Computational Fluid Dynamics (CFD) commercial code, intends to represent a commercial broiler building, and intends to simulate the 3D and heat transfer, in steady state flow. The evaporative cooling pads were also included in the model. The validation of the model was based in experimental measurements obtained in previous studies. The simulations were focused on Summer, Winter and also Mid-Season situation. The numerical results of NH3 concentration were compared with the experimental measurements, and a quite good agreement was verified. The numerical results allowed the characterization of: the inside flow pattern developed for the summer and winter situation; the inside NH3 distribution, and the velocity field distribution inside the broiler building. It was found that NH3 concentration increases along the tunnel, especially in low flow rate imposed from the exhaust fan. Also, it was verified that the low velocities inside domain are no sufficient to remove the gaseous pollutants.

Made available in DSpace on 2022-05-01T16:48:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Sugarcane mosaic disease (SMD) caused by sugarcane mosaic virus, is one of the main diseases in sugarcane production areas in Brazil. Thus, the identification of new sources of resistance for use in future introgression crosses is key for reliable economic gains. Here, we aimed to screen a diversity panel of 98 sugarcane genotypes for SMD under natural infection conditions, to investigate virus-specific amplicons from SCMV coat protein gene (CP), and identify marker-trait associations via association mapping using Amplified Fragment Length Polymorphism (AFLP) and Simple Sequence Repeats (SSR). The highest SMD incidence (26.53%) was observed eight months after planting, with significant differences (p

Endothelial dysfunction has been suggested as a potential mechanism contributing to the development and progression of heart failure (HF). Levels of circulating endothelial cells (CECs), endothelial progenitor cells (EPCs), and hematopoietic stem and progenitor cells (HSPCs) have been recognized as useful markers of vascular damage and endothelial repair in response to tissue injury.To evaluate the circulating levels of EPCs, CECs, and HSPCs among patients with HF with reduced ejection fraction (HFrEF).In 82 individuals (42 patients with HFrEF and 42 age-matched subjects without established cardiovascular disease), peripheral blood was drawn and levels of EPCs, CECs, and HSPCs were quantified by flow cytometry.Patients with HFrEF showed lower levels of circulating EPCs (5.28 × 10Circulating levels of EPCs and CECs were significantly decreased in patients with HFrEF in comparison to age-matched subjects without established cardiovascular disease, suggesting that the levels of CECs and EPCs may be potential biomarkers of the cellular response to vascular injury in patients with HFrEF.

This paper aims to present a new method for obtaining an analytical solution for the Kaniadakis Doppler broadening (KDB) function. Also, in this work, we report the computational efficiencies of this solution compared with the numerical one. The solution of the differential equation achieved in this paper is free of approximations and is, consequently, a more robust methodology for obtaining an analytical representation of ψ k . Moreover, the results show an improvement in efficiency using the analytical approximation, indicating that it may be helpful in different applications that require the calculation of the deformed Doppler broadening function.

This study aimed to verify the effects of congested fixture and matches’ participation on internal and external workload indexes in professional Brazilian soccer players. Rate of perceived exertion-based training load (sRPE), distance- and accelerometry-based measures were daily monitored over 119 training sessions and 33 matches performed by 29 male outfield players. Weeks were classified as congested (n = 11, two or more matches within a 7-day period) and regular (n = 10, one match or less within a 7-day period). The players were divided based on the matches’ participation: (1) players who played ≥ 60 min (G1); (2) players who played