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Your search keyword '"Cantisan, Sara"' showing total 5 results
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5 results on '"Cantisan, Sara"'

1. Management of cytomegalovirus in adult solid organ transplant patients: GESITRA-IC-SEIMC, CIBERINFEC, and SET recommendations update

Author

Ruiz-Arabi, Elisa, Torre-Cisneros, Julian, Aguilera, Victoria, Alonso, Rodrigo, Berenguer, Marina, Bestard, Oriol, Bodro, Marta, Cantisán, Sara, Carratalà, Jordi, Castón, Juan José, Cordero, Elisa, Facundo, Carme, Fariñas, María Carmen, Fernández-Alonso, Mirian, Fernández-Ruiz, Mario, Fortún, Jesús, García-Cosío, Maria Dolores, Herrera, Sabina, Iturbe-Fernández, David, Len, Oscar, López-Medrano, Francisco, López-Oliva, María Ovidia, Los-Arcos, Ibai, Marcos, María Ángeles, Martín-Dávila, Pilar, Monforte, Víctor, Muñoz, Patricia, Navarro, David, Páez-Vega, Aurora, Pérez, Ana Belén, Redondo, Natalia, Álvarez R., Rodríguez, Rodríguez-Benot, Alberto, Rodríguez-Goncer, Isabel, San-Juan, Rafael, Sánchez-Céspedes, Javier, Valerio, Maricela, Vaquero, José Manuel, Viasus, Diego, Vidal, Elisa, and Aguado, José María

Published
2024
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3. Humoral/Cellular Immune Discordance in Stem Cell Donors: Impact on Cytomegalovirus-Specific Immune Reconstitution after Related Hematopoietic Transplantation

Author

Valle-Arroyo, Jorge, Páez-Vega, Aurora, Fernández-Moreno, Raquel, López-Jiménez, Javier, Luna, Alejandro, Duarte, Rafael, Serrano-Martínez, Francisco, Villar, Sara, Fernández-Alonso, Mirian, Reina, Gabriel, González-Rico, Claudia, Fariñas, María C, Rojas, Rafael, Herrera, Concha, Martín, Carmen, García-Torres, Estefanía, Torre-Cisneros, Julián, and Cantisán, Sara

Published
2022
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4. Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study

Author

Bodro, Marta, Cervera, Carlos, Linares, Laura, Suárez, Belén, Llopis, Jaume, Sanclemente, Gemma, Casadó-Llombart, Sergi, Fernández Ruiz, Mario, Fariñas, María Carmen, Cantisan, Sara, Montejo, Miguel, Cordero, Elisa, Oriol, Isabel, Marcos, Ma. Angeles, Lozano Soto, Francisco, Moreno, A. (Asunción), Gesitra-ic/seimc/reipi Investigators, Universidad de Cantabria, Instituto de Salud Carlos III, European Commission, Red Española de Investigación en Patología Infecciosa, Ministerio de Ciencia, Innovación y Universidades (España), and Agencia Estatal de Investigación (España)

Subjects
infectious disease, Immunology, Cytomegalovirus, Antiviral Agents, Mannose-Binding Lectin, Cytomegaloviruses, Solid organ transplantation, Immunology and Allergy, Humans, Prospective Studies, cytomegalovirus, innate immunity, solid organ transplantation, Ganciclovir, Innate immunity, Infectious disease, Transplantation of organs, Immunity, Immunity, Innate, Transplant Recipients, Multicenter study, Toll-Like Receptor 3, Toll-Like Receptor 4, Trasplantament d'òrgans, multicenter study, Immunitat, Toll-Like Receptor 7, Toll-Like Receptor 9, Cytomegalovirus Infections, Citomegalovirus
Abstract

Several genetic polymorphisms of the innate immune system have been described to increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this study was to assess the impact of a polygenic score to predict CMV infection and disease in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively included for this purpose during a 2-year period. All recipients received 100-day prophylaxis with valganciclovir. CMV infection occurred in 61 patients (53%) at 163 median days from transplant, 33 asymptomatic replication (28%) and 28 CMV disease (24%). Eleven patients (9%) had recurrent CMV infection. Clinically and/or functionally relevant single nucleotide polymorphisms (SNPs) from TLR2, TLR3, TLR4, TLR7, TLR9, AIM2, MBL2, IL28, IFI16, MYD88, IRAK2 and IRAK4 were assessed by real time polymerase chain reaction (RT-PCR) or sequence-based typing (PCR-SBT). A polygenic score including the TLR4 (rs4986790/rs4986791), TLR9 (rs3775291), TLR3 (rs3775296), AIM2 (rs855873), TLR7 (rs179008), MBL (OO/OA/XAO), IFNL3/IL28B (rs12979860) and IFI16 (rs6940) SNPs was built based on the risk of CMV infection and disease. The CMV score predicted the risk of CMV disease with an AUC of the model of 0.68, with sensitivity and specificity of 64.3 and 71.6%, respectively. Even though further studies are needed to validate this score, its use would represent an effective model to develop more robust scores predicting the risk of CMV disease in donor/recipient mismatch (D+/R-) transplant recipients., This work was supported by Spanish Ministerio de Sanidad y Consumo (FIS PI12/01743), Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional (FEDER). Unión Europea. “Una manera de hacer Europa”; Network for the Research in Infectious Diseases (REIPI) from the Instituto de Salud Carlos III, Madrid, Spain; and Ministerio de Ciencia e Innovación (PID2019-106658RB-I00, funded by MCIN/AEI/10.13039/501100011033). MF-R holds a research contract “Miguel Servet” (CP18/00073) from the Instituto de Salud Carlos III, Spanish Ministerio de Ciencia e Innovación.

Published
2022

5. Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study.

Author

Bodro M, Cervera C, Linares L, Suárez B, Llopis J, Sanclemente G, Casadó-Llombart S, Fernández-Ruiz M, Fariñas MC, Cantisan S, Montejo M, Cordero E, Oriol I, Marcos MA, Lozano F, and Moreno A

Subjects
Antiviral Agents therapeutic use, Ganciclovir therapeutic use, Humans, Immunity, Innate, Prospective Studies, Toll-Like Receptor 3, Toll-Like Receptor 4, Toll-Like Receptor 7, Toll-Like Receptor 9, Transplant Recipients, Cytomegalovirus Infections prevention & control, Mannose-Binding Lectin
Abstract

Several genetic polymorphisms of the innate immune system have been described to increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this study was to assess the impact of a polygenic score to predict CMV infection and disease in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively included for this purpose during a 2-year period. All recipients received 100-day prophylaxis with valganciclovir. CMV infection occurred in 61 patients (53%) at 163 median days from transplant, 33 asymptomatic replication (28%) and 28 CMV disease (24%). Eleven patients (9%) had recurrent CMV infection. Clinically and/or functionally relevant single nucleotide polymorphisms (SNPs) from TLR2 , TLR3 , TLR4 , TLR7 , TLR9 , AIM2 , MBL2 , IL28 , IFI16, MYD88 , IRAK2 and IRAK4 were assessed by real time polymerase chain reaction (RT-PCR) or sequence-based typing (PCR-SBT). A polygenic score including the TLR4 (rs4986790/rs4986791), TLR9 (rs3775291), TLR3 (rs3775296), AIM2 (rs855873), TLR7 (rs179008), MBL (OO/OA/XAO), IFNL3/IL28B (rs12979860) and IFI16 (rs6940) SNPs was built based on the risk of CMV infection and disease. The CMV score predicted the risk of CMV disease with an AUC of the model of 0.68, with sensitivity and specificity of 64.3 and 71.6%, respectively. Even though further studies are needed to validate this score, its use would represent an effective model to develop more robust scores predicting the risk of CMV disease in donor/recipient mismatch (D+/R-) transplant recipients., Competing Interests: FL is founder and ad honorem scientific advisor or Sepsia Therapeutics S.L. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Bodro, Cervera, Linares, Suárez, Llopis, Sanclemente, Casadó-Llombart, Fernández-Ruiz, Fariñas, Cantisan, Montejo, Cordero, Oriol, Marcos, Lozano, Moreno and GESITRA-IC/SEIMC/REIPI investigators.)

Published
2022
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