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The treatment outcomes of nanomedicines against colorectal cancer are severely restricted by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and weak immunometabolic modulation. To address these issues, flying‐saucer‐shaped nanoheterojunctions by coating copper oxide (CuxO) onto the surface of PEGylated zinc oxide (ZnO) nanoparticles are constructed. When exposed to ultrasound, the resultant CuxO@ZnO nanoheterojunctions exhibit increased locomotor activities, facilitating colorectal mucus infiltration, deep tumor penetration, and tumor cell internalization. The decoration of CuxO suppresses the rapid recombination of electrons and holes in CuxO@ZnO exposed to ultrasound, promoting the production of singlet oxygen and hydroxyl radical, which are generated by CuxO through a Fenton‐like chemodynamic reaction and CuxO@ZnO through sonodynamic reaction. After rectal administration, the sono‐chemodynamic CuxO@ZnO plus PD‐L1 antibodies effectively inhibit the growth of orthotopic and distant tumors. It elicits immunometabolic responses by inducing immunogenic cell death, activating the interferon genes signaling pathway stimulator, and inhibiting glucose transport and the glycolytic signaling pathways. This combined modality also increases the proportion of beneficial microbes (e.g., Bifidobacterium) and decreases the abundance of harmful microorganisms (e.g., Romboutsia) in the intestine. This treatment modality (CuxO@ZnO plus ultrasound and PD‐L1 antibodies) is a promising strategy for the synergistic treatment of colorectal cancer. [ABSTRACT FROM AUTHOR]

The clinical application of regenerated silk fibroin (RSF) films for wound treatment is restricted by its undesirable mechanical properties and lack of antibacterial activity. Herein, different pluronic polymers were introduced to optimize their mechanical properties and the RSF film with 2.5% pluronic F127 (RSFPF127) stood out to address the above issues owing to its satisfactory mechanical properties, hydrophilicity, and transmittance. Diverse antibacterial agents (curcumin, Ag nanoparticles, and antimicrobial peptide KR-12) were separately encapsulated in RSFPF127 to endow it with antibacterial activity. In vitro experiments revealed that the medicated RSFPF127 could persistently release drugs and had desirable bioactivities toward killing bacteria, promoting fibroblast adhesion, and modulating macrophage polarization. In vivo experiments revealed that medicated RSFPF127 not only eradicated methicillin-resistant Staphylococcus aureus in the wound area and inhibited inflammatory responses, but also facilitated angiogenesis and re-epithelialization, regardless of the types of antibacterial agents, thus accelerating the recovery of infected wounds. These results demonstrate that RSFPF127 is an ideal matrix platform to load different types of drugs for application as wound dressings. [ABSTRACT FROM AUTHOR]

Beijing–Tianjin–Hebei, the main economic area in northern China, has seen significant changes in its regional economic and physical landscape as a result of the coordinated development strategy. Assessing the link between land use and land cover (LULC) change and carbon emissions in the Chaobai River region, which represents the growth of the Beijing–Tianjin–Hebei urban agglomeration, is crucial to achieve coordinated low-carbon development in this area. This study uses statistics from statistical yearbooks of Chinese provinces and cities along with land use change data to analyze the relationship between land use changes and carbon emissions in the Chaobai River region from 2001 to 2017 using dynamic land use attitudes and land use transfer matrices, combined with carbon emission factors based on the IPCC inventory method and carbon emission models for energy consumption. In addition, this study makes use of the LMDI model and geographical detectors to identify and assess the factors that influence changes in land use carbon emissions and the driving forces behind the regional differentiation of land use changes. The results show that: (1) The Chaobai River region's predominant land use classes during the past 17 years have been agricultural land and construction land. In addition to the decrease in cropland and the increase in urban land, the land use patterns of other land classes also changed to a certain extent. (2) Carbon emissions from land use showed an increasing trend, from 6.1 × 106 tons in 2001 to 1.1 × 107 tons in 2017. (3) Carbon emission intensity, economic development level, land use efficiency, and construction land scale have a certain regularity in the evolution of carbon emissions, and economic development level has become the most important driving factor controlling the growth of land use carbon emissions. (4) Driving factors in different periods have different degrees of influence on land use change, among which socio-economic factors such as population density and GDP have the strongest explanatory power. In addition, the interactions of each factor mainly present a double factor enhancement. In the future, the Chaobai River region should be based on the coordinated development strategy and take the "double carbon" target as its guiding principle to promote the innovation of the regional development system and further achieve the optimization of the regional land use patterns. [ABSTRACT FROM AUTHOR]