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Acknowledgements This study was funded by the European Commission, under the LIFE Nature and Biodiversity program, as part of the project LIFE-DIVAQUA (Proyecto LIFE18 NAT/ES/000121). We also like to thank all the Spanish government agencies and research institutions who provided information, answered the questionnaires and participated in the workshop “Synthesis of the monitoring programs of global change in aquatic ecosystems SMNP: Autonomous Organism of National Parks, MAPAMA-Dir. Gral. Agua, Universidad de Granada, Instituto Universitario de Investigación del Agua, (IdeA-UGR), Universidad Politécnica de Madrid, CISE-P.N. Sierra de Guadarrama, Fundación Biodiversidad, CEAB-CSIC, IGME, MNCN-CSIC, Universidad de Córdoba, Universidad de Barcelona and ICTA-UAB. We also like to thank the 28 European Nation Parks who responded our query. The authors finally thank the support provided by Christoph Wohner in the use of the DEIMS-SDR., Electronic supplementary material The online version contains supplementary material available at https://doi.org/10.1007/s10531-022-02466-x., Data Availability The datasets used to review the monitoring programs at the Global scale conducted in the ILTER nodes that are included in Rivers (ILTER-Rivers) or Lakes (ILTER-Lakes) are available at the DEIMS dataset registry (DEIMS-SDR) (for more details see: Wohner et al. 2019; https://deims.org/). The datasets used to review the monitoring programs at the European scale conducted in the EMNP are available by requesting them via email to the corresponding EMNP. The datasets used to review the monitoring programs at the National scale conducted in the five SMNP are mostly included in this article and it supplementary information file. In addition, meteorological data recorded by the Spanish Global Change Monitoring Network in available at the Meteorological data download web application (https://www.miteco.gob.es/es/redparques- nacionales/red-seguimiento/acceso-datos.aspx). Further and more detailed information is available from the corresponding author on reasonable request., Funding This study was carried out with the financial support of the EU LIFE programme, as part of the project LIFE-DIVAQUA (Proyecto LIFE18 NAT/ES/000121). The information showed in this publication only reflects the point of view of the authors. The European Comission and CINEA cannot be held responsible for any use which be made of the information contained here. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature., Identifying and quantifying global change impacts on biotic and abiotic components of ecosystems is critical to promote an effective adaptation that increases the success of conservation strategies. To achieve this goal, global and regional assessment efforts require certain degree of harmonization on local monitoring programs to establish relevant comparisons at different spatio-temporal scales. Otherwise, the lack of harmonization might hinder the detection and assessment on the effects of human impacts. In this work we have compiled information on freshwater monitoring programs located in areas of intensive research and conservation interest: International Long Term Ecological Research (ILTER) nodes and mountain National Parks. We aimed at evaluating the quality and robustness of these programs to assess the impact of global change, addressing from the worldwide to the European and Spanish national scale. Results highlighted that freshwater monitoring programs lack a common strategy to monitor these ecosystems. Even at the continental and national scales, contrasting strategies and level of detail have been historically applied. Water quality, habitat and biodiversity are more commonly monitored than community structure and ecosystem functioning. Monitoring efforts on the Spanish Mountain National parks indicated differences on the targeted aquatic ecosystems. Rivers and lakes received a higher attention, while mires were rarely considered. Our results provide evidence that greater efforts should be directed towards constructing a coordinated strategy to monitor freshwater ecosystems at national, continental, and global scales. This strategy should involve a shared backbone of biophysical and biogeochemical variables for each habitat type on agreed protocols that are implemented across regions and administrative borders. Achieving this will support a substantial advance on the ecological research to further delineate proper conservation strategies to face the challenges imposed by global change., European Commission LIFE18 NAT/ES/000121

A high cobalamin level has been related to non-malignant diseases (mainly liver diseases, alcoholism, and renal diseases) and cancer (haematological malignancies and solid cancers such as liver and stomach cancer). However, a previous high level of cobalamin and the implications in the possible development of cancer is still unclear. The main objective of this study was to describe if a previous high cobalamin level is a determinant in the future development of cancer in five years of follow-up. The secondary objective was to determine any differences between cancer groups.A retrospective study was performed. Two databases were employed. The first one included all patients who had a determination of cobalamin in a routine blood test during the year 2010 (a total of 44,166 patients). The second one showed every patient who was admitted to the reference hospital, Hospital Clinico Universitario de Valladolid, during the following five years. Finally, a number of 6,710 patients was included. Both databases belong to the medical records of the Hospital Data Surveillance System, and are completely validated. Multivariate logistic regression analyses were employed to evaluate the association between cobalamin levels and the appearance of cancer (total and in each subgroup). All analyses were performed using IBM SPSS 24 software.The sample studied showed a clear association between the risk of haematological cancer and a previous high Cbl level. This relationship was higher among patients with the highest levels (over 779 pmol/L), showing almost two times more risk for development of haematological malignance within 5 years in the multivariate analysis [OR: 1.975, 95% CI: 1.056-3.697, p=0.033]. Haematological malignancies were mostly diagnosed within the first three years (86.6%), showing a similar percentage in those three years. There was no association between this previous level and the development of any other type of cancer.Our study shows that a high cobalamin plasma level (hypervitaminosis) is associated with the development of haematologic cancer within five years after the measurement. The clinical implication of these findings, together with the clinical suspicion, reinforces the necessity of carrying out specific screening haematological tests in patients with not justified elevated plasma cobalamin levels. New prospective and multicentre studies are necessary in order to validate these results.

Mountain regions are areas characterized by great spatial variability in climate variables, due to the great differences in altitude, orientation and the abrupt topography that characterizes them. These features of the territory, together with a relative lower density of meteorological stations, make it difficult to characterize climate change in these areas.This work describes the Spanish High Mountain Climate Database (SHMCDv1) consisting of daily quality controlled and homogenised records of maximum temperature, minimum temperature and precipitation for the territories that include the two highest altitude national parks in mainland Spain, the Sierra Nevada National Park (PNSN) and the Aigüestortes i Sant Maurici National Park (PNASM), and its area of ​​influence.To build this database, 129 climatic series corresponding to the PPNASM area and 166 series in the PNSN area have been used, for the period between 1893 and 2020, obtained from various sources (AEMET, SMC, Climanevada database, LOOP Project). A systematic quality control has been applied to the series using the RClimdex-extraqc (see http://www.c3.urv.cat/data/manual/Manual_rclimdex_extraQC.r.pdf). This procedure has allowed the identification of 857 values considered erroneous, of which 10% has been recovered with the correct value. Its homogeneity has been tested and adjusted with a CLIMATOL homogenization method developed by J. Guijarro (2016) (see http://www.climatol.eu/index.html). 205 inhomogeneities have been detected and adjusted in the temperature series, which represents an average of 2 inhomogeneities for each series.In total, thermo-pluviometric series have been composed for a set of 98 meteorological stations, 27 of them located above 1500 meters of altitude.Sen’s estimator of the slope have been used to estimate the temperature and precipitation trends corresponding to low mountain areas ( 1500 m altitude) are calculated and analyzed to determine if there are differences in the evolution of recent temperature or precipitation due to altitude and between both mountain areas.This work has been done thanks to funding from MINECO and MITECO, through the projects LACEN-CLI (ref: 2476-S/2017), MEROMONT (ref: CGL2017-85682-R) and Smart EcoMountains (LifeWatch-2019-10-UGR-01).