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In this paper, for the first time to the best of our knowledge, organic electrochemical transistors are employed to investigate the electrical response of human blood, plasma and alternative buffer solutions that inhibit red blood cell (RBC) aggregation. Our focus is on selecting a suitable electrolytic platform and the related operating conditions, where the RBC effect on the OECT response can be observed separately from the strong ionic environment of plasma in whole blood. The transient response of whole blood to pulse experiments is characterized by two time constants, which can be related to blood viscosity and to the capacitive coupling between the ionic and electronic components of the overall system. The role of capacitive effects, likely due to enhanced double-layer formation by negatively charged RBCs, is also confirmed by the increase of transconductance which was found in RBC suspensions as compared to the suspending buffer. Overall, the complex behavior found in these experiments provides new insights for the development of innovative blood-based sensing devices for biomedical applications.

Transglutaminase 2 (TG2) is a ubiquitously expressed member of the transglutaminase family with Ca2+-dependent protein crosslinking activity. Its subcellular localization is crucial in determining its function, and indeed, TG2 is found in the extracellular matrix, mitochondria, recycling endosomes, plasma membrane, cytosol, and nucleus because it is associated with cell growth, differentiation, and apoptosis. It is involved in several pathologies, such as celiac disease, cardiovascular, hepatic, renal, and fibrosis diseases, carrying out opposite functions of up and down regulation in the progression of the same pathology. Therefore, this fine regulation requires a very sensitive and specific method of identification of TG2, which is to be detected in very small quantities in a deregulated condition. Here, we demonstrate the possibility of detecting TG2 down to attomolar concentration by using organic electrochemical transistors driven by gold electrodes functionalized with anti-TG2 antibodies. In particular, a direct correlation between the TG2 concentration and the transistor transconductance values, as extracted from typical transfer curves, was found. Overall, our findings highlight the potentialities of this new biosensing approach for the detection of TG2 in the context of pathological diseases, offering a rapid and cost-effective alternative to traditional methods.

Researchers have found various families of two-dimensional (2D) materials and associated heterostructures through detailed theoretical work and experimental efforts. Such primitive studies provide a framework to investigate novel physical/chemical characteristics and technological aspects from micro to nano and pico scale. Two-dimensional van der Waals (vdW) materials and their heterostructures can be obtained to enable high-frequency broadband through a sophisticated combination of stacking order, orientation, and interlayer interactions. These heterostructures have been the focus of much recent research due to their potential applications in optoelectronics. Growing the layers of one kind of 2D material over the other, controlling absorption spectra via external bias, and external doping proposes an additional degree of freedom to modulate the properties of such materials. This mini review focuses on current state-of-the-art material design, manufacturing techniques, and strategies to design novel heterostructures. In addition to a discussion of fabrication techniques, it includes a comprehensive analysis of the electrical and optical properties of vdW heterostructures (vdWHs), particularly emphasizing the energy-band alignment. In the following sections, we discuss specific optoelectronic devices, such as light-emitting diodes (LEDs), photovoltaics, acoustic cavities, and biomedical photodetectors. Furthermore, this also includes a discussion of four different 2D-based photodetector configurations according to their stacking order. Moreover, we discuss the challenges that remain to be addressed in order to realize the full potential of these materials for optoelectronics applications. Finally, as future perspectives, we present some key directions and express our subjective assessment of upcoming trends in the field.

Three novel diketopyrrolopyrrole (DPP) based small molecules have been synthesized and characterized in terms of their chemical-physical, electrochemical and electrical properties. All the molecules consist of a central DPP electron acceptor core symmetrically functionalized with donor bi-thienyl moieties and flanked in the terminal positions by three different auxiliary electron-acceptor groups. This kind of molecular structure, characterized by an alternation of electron acceptor and donor groups, was purposely designed to provide a significant absorption at the longer wavelengths of the visible spectrum: when analysed as thin films, in fact, the dyes absorb well over 800 nm and exhibit a narrow optical bandgap down to 1.28 eV. A detailed DFT analysis provides useful information on the electronic structure of the dyes and on the features of the main optical transitions. Organic field-effect transistors (OFETs) have been fabricated by depositing the DPP dyes as active layers from solution: the different end-functionalization of the dyes had an effect on the charge transport properties with two of the dyes acting as n-type semiconductors (electron mobility up to 4.4∙10 -2 cm 2 /V∙s) and the third one as a p-type semiconductor (hole mobility up to 2.3∙10 -3 cm 2 /V∙s). Interestingly, well-balanced ambipolar transistors were achieved by blending the most performant n-type and p-type dyes with hole and electron mobility in the order of 10 -3 cm 2 /V∙s.

The inclusion of functional molecules as substitutional dopants in single crystals of organic hosts with complementary optical properties provides a versatile strategy to tune optical and magnetic properties in view of their applications in opto-electronics and spintronics. Here, by combining electron spin resonance and optical spectroscopy, isolated triplet exciton states with distinct emission and absorptive resonance modes from two magnetically inequivalent sites of pentacene within the picene crystal are detected at room temperature. This is possible due to the incorporation of a low-doping, 1% mol/mol of pentacene into the monoclinic polymorph of picene high-quality single crystals. In addition, delayed fluorescence—optically detected magnetic resonance (ODMR) studies demonstrate efficient spin-dependent optical activities that are tuned by crystallographically oriented magnetic fields. These properties are particularly appealing for the exploitation of pentacene in room-temperature spin-driven opto-electronics, quantum sensing and in microwave amplification by stimulated emission of radiation (MASER). Graphical abstract: Triplet excitons of pentacene molecules doped into a picene single crystal provide microwave emission and absorptive resonance modes as well as large optically detected magnetic resonance contrast which can be tuned by magnetic field strength and direction. These properties make pentacene-doped picene single crystals promising materials for spin-driven opto-electronics and, in particular, in microwave amplification by stimulated emission of radiation (MASER). [Figure not available: see fulltext.].

Modern-day society requires advanced technologies based on renewable and sustainable energy resources to meet environmental remediation challenges. Solar-inspired photocatalytic applications such as water splitting, hydrogen evolution reaction (HER), and carbon dioxide reduction reaction (CO2RR) are unique solutions based on green and efficient technologies. Considering the special electronic features and larger surface area, two-dimensional (2D) materials, especially metal oxides (MOs), have been broadly explored for the abovementioned applications in the past few years. However, their photocatalytic potential has not been optimized yet to the level required for practical and commercial applications. Among many strategies available, defect engineering, including cation and anion vacancy creations, can potentially boost the photocatalytic performance of 2D MOs. This mini-review covers recent advancements in 2D engineered materials for various photocatalysis applications such as H2O2 oxidation, HER, and CO2RR for environmental remediation from theoretical perspectives. By thoroughly addressing the fundamental aspects, recent developments, and associated challenges—the author’s recommendations in compliance with future challenges and prospects will pave the way for readers.