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C17H13ClN2O2, monoclinic, P21/c (no. 14), a = 5.3601(4) Å, b = 10.6233(7) Å, c = 25.2125(16) Å, β = 92.920(5)°, V = 1433.96(17) Å3, Z = 4, Rgt(F) = 0.0495, wRref (F2) = 0.1143, T = 173(10) K.

Objective: Develop new natural characteristic plant tobacco flavor. Methods: The volatile oil from the seeds, leaves and stems of Pelargonium odoratissimum was extracted by simultaneous steam distillation solvent extraction （SDE）. The chemical components of volatile oil were analyzed by GC/MS, and the effects of volatile oil from different parts of Cardamom geranium in cigarette flavoring and conventional components of smoke were compared. Results: The volatile oil of Cardamom geranium seeds was mainly terpinen-4-ol（110.54 mg/g），myristicin（81.81 mg/g），β-phellandrene（58.33 mg/g）. The main components of leaf essential oil were linalool（90.04 mg/g），myristicin（59.09 mg/g）terpinen-4-ol（39.69 mg/g）. The stem essential oil was dominated by D-limonene （45.56 mg/g）， linalool（13.26 mg/g）， 3,7-dimethyl-1,5,7-octatrien-3-ol （12.11 mg/g）. Conclusion: Three kinds of volatile oils can give cigarettes unique flavor in varying degrees, improve aroma quality and aroma quantity, and reduce irritation.

Background: Inflammation plays a critical role in the prognosis of patients with pulmonary arterial hypertension (PAH). The lymphocyte-to-C-reactive protein ratio (LCR), as a novel inflammatory marker, has not been studied in patients with PAH. The objective of this study was to investigate the prognostic value of the LCR in patients with PAH. Methods: A retrospective cohort study was conducted on 116 patients with PAH diagnosed in Renji Hospital, School of Medicine, Shanghai Jiao Tong University, from January 2014 to December 2018. The primary outcome was a composite endpoint that included lung transplantation, rehospitalization for PAH, and all-cause death. The LCR is the ratio of the blood lymphocyte count to the C-reactive protein concentration. Results: A total of 116 patients with PAH were included in this study, with an average age of 41.53 years; 92.2% were female, and the event rate was 57.8%. Restricted cubic spline analysis confirmed a linear association between the LCR and the risk of clinical worsening events. Multivariate Cox proportional hazards analysis showed that the LCR was significantly negatively associated with clinical worsening events, with hazard ratios and 95% confidence intervals of 0.772 (0.614–0.970). The Kaplan–Meier curve showed that event-free survival decreased significantly when the LCR was less than 1.477. LASSO regression selected four potential predictors, including the LCR, to construct a nomogram. The nomogram had a high predictive strength, with an area under the ROC curve of 0.805 (0.713–0.896). The calibration curves and decision curve analysis indicated that the nomogram had good predictive performance and the ability to guide clinical management. Conclusions: The LCR is a valuable prognostic marker for predicting long-term clinical events in patients with PAH, and the nomogram incorporating the LCR could effectively stratify risk and guide clinical decision making. [ABSTRACT FROM AUTHOR]

Background: Hypertension is a chronic disease that consumes considerable medical resources. Aim: The aim of this study is to evaluate a model able to develop and assess the effectiveness of a mobile application disease self‐management programme regarding mental health and self‐management for patients with hypertension. Methods: A randomised controlled trial and single‐blind random assignment was employed to group the participants. A total of 100 patients were collected from the cardiology clinic of a teaching hospital in Taiwan. There were 50 participants in each group: the mobile application group (experimental group) and the routine care (control group). The primary outcome measures were mental health and self‐management. Results: This study discovered that the intervention improved the mental health and self‐management of the experimental group. The results for the experimental group revealed significantly improved effects and outcomes superior to those of the control group. Conclusions: The study results verified that a mobile application disease self‐management programme could improve the mental health and disease self‐management of patients with hypertension. Summary Statement: What is already known about this topic? Hypertension is a chronic disease that consumes considerable medical resources.Disease self‐management programmes have been successfully applied for many patients with chronic diseases and have been verified to provide benefits, such as effectively changing and maintaining the health behaviours of patients, reducing medical costs and increasing quality of life. What this paper adds? The mobile application disease self‐management programme is verified to improve the mental health of patients with hypertension.The mobile application disease self‐management programme can effectively improve the disease self‐management of patients with hypertension, and this improvement is superior to that achievable with usual care. The implications of this paper: This study may serve as a reference for nursing personnel for developing unconventional health education programmes.A mobile application disease self‐management programme improved the mental health and disease self‐management of patients with hypertension. [ABSTRACT FROM AUTHOR]

This study applied a cross-sectional design to examine the relationship between self-management, psychological well-being, and quality of life in patients with hypertension and evaluated the mediation effect of psychological well-being on self-management and quality of life. Through purposive sampling, this study enrolled 255 patients with hypertension from the cardiology department of a teaching hospital in Taiwan. Mediation effects were estimated using linear regression and the Sobel test. Age, number of chronic diseases, waist circumference, self-management, and psychological well-being explained 18.7% of the total variance in quality of life. Psychological well-being partially mediated the effects of self-management on quality of life, with a total effect of 19.2%. Psychological well-being is an important factor correlated with self-management and quality of life in patients with hypertension. [ABSTRACT FROM AUTHOR]

C17H13ClN2O2, monoclinic, P21/c (no. 14), a = 5.3601(4) Å, b = 10.6233(7) Å, c = 25.2125(16) Å, β = 92.920(5)°, V = 1433.96(17) Å3, Z = 4, Rgt(F) = 0.0495, wRref (F2) = 0.1143, T = 173(10) K. [ABSTRACT FROM AUTHOR]

Currently, the treatment of septic myopathy presents significant challenges with implications for increased mortality rates and prolonged hospitalizations. Effective therapeutic strategies for septic myopathy remain elusive, highlighting an urgent need for novel therapeutic approaches. High-mobility group box 1 (HMGB1) is a conserved nonhistone nuclear protein that is released passively from deceased cells or actively secreted by activated immune cells, influencing both infectious and noninfectious inflammatory responses. Studies have indicated that HMGB1 likely plays a pivotal role in the pathogenesis of septic myopathy by crucial pathways associated with muscle atrophy and contributing to muscle regeneration under certain conditions. This review aims to summarize the possible mechanisms of HMGB1 in muscle atrophy and its potential in muscle regeneration, providing a theoretical basis for HMGB1 treatment of septic myopathy. Research shows that the dual role of HMGB1 is related to its specific forms, which are influenced to varying degrees by environmental factors. HMGB1 is a key participant in septic muscle atrophy, whereas HMGB1 shows therapeutic potential in muscle regeneration. One key mechanism by which HMGB1 contributes to septic muscle atrophy is through the exacerbation of inflammation. HMGB1 can amplify the inflammatory response by promoting the release of pro-inflammatory cytokines, which further damages muscle tissue. HMGB1 is also involved in promoting cell death in sepsis, which contributes to muscle degradation. Another important mechanism is the regulation of protein degradation systems. HMGB1 can activate the ubiquitin-proteasome system and autophagy-lysosome pathway, both of which are crucial for the breakdown of muscle proteins during atrophy. Conversely, targeting HMGB1 has shown the potential to ameliorate muscle atrophy in various diseases. For instance, HMGB1 has been shown to promote muscle vascular regeneration, modify stem cell status and enhance stem cell migration and differentiation, all of which are beneficial for muscle repair and recovery. Pharmacological inhibition of HMGB1 has been explored, with several drugs demonstrating efficacy in reducing inflammation and muscle degradation in sepsis models. These findings suggest that HMGB1 inhibition could be a viable therapeutic approach for septic myopathy. However, the function of promoting muscle regeneration in septic myopathy needs further research. HMGB1 emerges as a promising therapeutic target for the treatment of muscle atrophy in sepsis. This review focuses on identifying the correlation between HMGB1 and septic myopathy, analysing the possible role of HMGB1 in disease development and examining the feasibility of HMGB1 as a therapeutic target., (© 2025 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC.)