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3. A new secondary metabolite from the marine-derived fungus Phomopsis lithocarpus FS508.

Author

Tan, Zi-Ling, Chen, Yu-Chan, Zhang, Jian-Peng, Liu, Hong-Xin, Zhang, Wei-Min, and Yan, Han-Jing

Subjects
*ANTI-inflammatory agents, *ANTINEOPLASTIC agents, *FUNGI, *IMMUNODIAGNOSIS, *BIOLOGICAL products, *METABOLITES, *CELL lines, *WATER, *MOLECULAR structure, *MASS spectrometry, *TRYPTOPHAN, *CELL surface antigens
Abstract

Based on the One Strain-Many Compounds (OSMAC) strategy, the secondary metabolites of Phomopsis lithocarpus FS508 were investigated. As a result, a new secondary metabolite, 4-methoxy-3-[4-(acetyloxy)-3-methyl-2-butenyl]benzoic acid (1) as well as eleven known compounds were isolated from the fermentation product of the strain FS508. Their structures were determined by NMR, IR, UV, and MS spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. Among them, compounds 3 and 9 displayed potent cytotoxicity against HepG-2 cell line, and compounds 2, 3 and 12 showed significant anti-inflammatory activities. [ABSTRACT FROM AUTHOR]

Published
2024
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