Search

Your search keyword '"Cheng,Yan-Qiong"' showing total 8 results
Start Over Author "Cheng,Yan-Qiong" Publication Year Range Last 3 years
8 results on '"Cheng,Yan-Qiong"'

1. The Dopamine Transporter Is a New Target for Ischemic Stroke.

Author

Cheng, Yan‐Qiong, Zhang, Ruo‐Xi, Li, Xing‐Yuan, Zhou, Xiao‐Ting, Chen, Ming, and Liu, Ai‐Jun

Subjects
*NEUROLOGICAL disorders, *ISCHEMIC stroke, *DOPAMINE receptors, *ARTERIAL occlusions, *CEREBRAL arteries
Abstract

Aims: Dopamine transporter (DAT) can regulate DA homeostasis and has been implicated in many nervous system diseases. Whether DAT is involved in the protection against ischemic stroke is unclear. Methods: In vivo microdialysis measurements of DA were recorded in the ischemic penumbral area of mice with middle cerebral artery occlusion (MCAO). DAT coding gene, Slc6a3 mutation, and DAT overexpression animals were performed MCAO. Madopar (compound formulation of levodopa) and nomifensine (DA reuptake inhibitor) were administered in MCAO animals. Brain slices were prepared in Slc6a3 mutation or wild‐type (WT) animals with MCAO to record miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs). The effects of DA and its dopamine‐1 receptor (D1R) antagonists (SCH‐23390) on mEPSCs, mIPSCs, and neurons protection were recorded. Results: MCAO caused a prominent increase in DA. Slc6a3 mutation significantly attenuated the ischemic injury, whereas DAT overexpression aggravated this injury. Both nomifensine and madopar protected against brain injury. Slc6a3 mutation and DA restored the disturbance of mEPSCs and mIPSC, and protected against neuron death, which was abolished by SCH‐23390. Conclusion: DAT inhibition might be explored as a strategy for ischemic stroke prevention. DA and D1R involve in the restoration of synaptic dysfunction and neuron protection. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

2. Supplementary Figures and Figure Legends from Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer

Author

Huang, Hai, primary, Wang, Chao, primary, Liu, Fei, primary, Li, Hui-Zhen, primary, Peng, Guang, primary, Gao, Xu, primary, Dong, Ke-Qin, primary, Wang, Hong-Ru, primary, Kong, De-Pei, primary, Qu, Min, primary, Dai, Li-He, primary, Wang, Kai-Jian, primary, Zhou, Zhe, primary, Yang, Jun, primary, Yang, Ze-Yu, primary, Cheng, Yan-Qiong, primary, Tian, Qin-Qin, primary, Liu, Dan, primary, Xu, Chuan-Liang, primary, Xu, Dan-Feng, primary, Cui, Xin-Gang, primary, and Sun, Ying-Hao, primary

Published
2023
Full Text
View/download PDF

3. Supplementary Tables S1-18 from Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer

Author

Wang, Kai-Jian, primary, Wang, Chao, primary, Dai, Li-He, primary, Yang, Jun, primary, Huang, Hai, primary, Ma, Xiao-Jing, primary, Zhou, Zhe, primary, Yang, Ze-Yu, primary, Xu, Wei-Dong, primary, Hua, Mei-Mian, primary, Lu, Xin, primary, Zeng, Shu-Xiong, primary, Wang, Hui-Qing, primary, Zhang, Zhen-Sheng, primary, Cheng, Yan-Qiong, primary, Liu, Dan, primary, Tian, Qin-Qin, primary, Sun, Ying-Hao, primary, and Xu, Chuan-Liang, primary

Published
2023
Full Text
View/download PDF

4. Supplementary Tables (S1-S8) from Blocking the Feedback Loop between Neuroendocrine Differentiation and Macrophages Improves the Therapeutic Effects of Enzalutamide (MDV3100) on Prostate Cancer

Author

Wang, Chao, primary, Peng, Guang, primary, Huang, Hai, primary, Liu, Fei, primary, Kong, De-Pei, primary, Dong, Ke-Qin, primary, Dai, Li-He, primary, Zhou, Zhe, primary, Wang, Kai-Jian, primary, Yang, Jun, primary, Cheng, Yan-Qiong, primary, Gao, Xu, primary, Qu, Min, primary, Wang, Hong-Ru, primary, Zhu, Feng, primary, Tian, Qin-Qin, primary, Liu, Dan, primary, Cao, Li, primary, Cui, Xin-Gang, primary, Xu, Chuan-Liang, primary, Xu, Dan-Feng, primary, and Sun, Ying-Hao, primary

Published
2023
Full Text
View/download PDF

5. Supplementary Tables from Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer

Author

Huang, Hai, primary, Wang, Chao, primary, Liu, Fei, primary, Li, Hui-Zhen, primary, Peng, Guang, primary, Gao, Xu, primary, Dong, Ke-Qin, primary, Wang, Hong-Ru, primary, Kong, De-Pei, primary, Qu, Min, primary, Dai, Li-He, primary, Wang, Kai-Jian, primary, Zhou, Zhe, primary, Yang, Jun, primary, Yang, Ze-Yu, primary, Cheng, Yan-Qiong, primary, Tian, Qin-Qin, primary, Liu, Dan, primary, Xu, Chuan-Liang, primary, Xu, Dan-Feng, primary, Cui, Xin-Gang, primary, and Sun, Ying-Hao, primary

Published
2023
Full Text
View/download PDF

6. Supplementary Data from Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer

Author

Wang, Kai-Jian, primary, Wang, Chao, primary, Dai, Li-He, primary, Yang, Jun, primary, Huang, Hai, primary, Ma, Xiao-Jing, primary, Zhou, Zhe, primary, Yang, Ze-Yu, primary, Xu, Wei-Dong, primary, Hua, Mei-Mian, primary, Lu, Xin, primary, Zeng, Shu-Xiong, primary, Wang, Hui-Qing, primary, Zhang, Zhen-Sheng, primary, Cheng, Yan-Qiong, primary, Liu, Dan, primary, Tian, Qin-Qin, primary, Sun, Ying-Hao, primary, and Xu, Chuan-Liang, primary

Published
2023
Full Text
View/download PDF

7. Supplementary Figures and Legends (S1-S6) from Blocking the Feedback Loop between Neuroendocrine Differentiation and Macrophages Improves the Therapeutic Effects of Enzalutamide (MDV3100) on Prostate Cancer

Author

Wang, Chao, primary, Peng, Guang, primary, Huang, Hai, primary, Liu, Fei, primary, Kong, De-Pei, primary, Dong, Ke-Qin, primary, Dai, Li-He, primary, Zhou, Zhe, primary, Wang, Kai-Jian, primary, Yang, Jun, primary, Cheng, Yan-Qiong, primary, Gao, Xu, primary, Qu, Min, primary, Wang, Hong-Ru, primary, Zhu, Feng, primary, Tian, Qin-Qin, primary, Liu, Dan, primary, Cao, Li, primary, Cui, Xin-Gang, primary, Xu, Chuan-Liang, primary, Xu, Dan-Feng, primary, and Sun, Ying-Hao, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results