1. Both HFpEF and HFmrEF should be included in calculating CHA 2 DS 2 -VASc score: A Taiwanese longitudinal cohort.
- Author
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Cheng CC, Huang PS, Chen JJ, Chiu FC, Chang SN, Wang YC, Wu CK, Hwang JJ, and Tsai CT
- Subjects
- Humans, Male, Female, Taiwan epidemiology, Aged, Risk Assessment methods, Risk Factors, Longitudinal Studies, Follow-Up Studies, Middle Aged, Stroke epidemiology, Stroke etiology, Stroke physiopathology, Incidence, Ventricular Function, Left physiology, Retrospective Studies, Prognosis, Stroke Volume physiology, Heart Failure physiopathology, Heart Failure epidemiology, Heart Failure complications, Atrial Fibrillation physiopathology, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology
- Abstract
Background: Congestive heart failure (CHF) as a risk of stroke in patients with atrial fibrillation (AF) mainly referred to patients with left ventricular systolic dysfunction. Whether this should include patients with preserved ejection fraction is debatable., Objective: The study aimed to investigate the variation in stroke risk of AF patients with heart failure with preserved ejection fraction (HFpEF), heart failure with mid-range ejection fraction (HFmrEF), and heart failure with reduced ejection fraction (HFrEF) for enhancing risk assessment and subsequent management strategies., Methods: In a longitudinal study using the National Taiwan University Hospital integrated Medical Database, 8358 patients with AF were observed for 10 years (mean follow-up, 3.76 years). The study evaluated the risk of ischemic stroke in patients with differing ejection fractions and CHA
2 DS2 -VASc score, further using Cox models adjusted for risk factors of AF-related stroke., Results: Patients with HFpEF and HFmrEF had a higher mean CHA2 DS2 -VASc score compared with patients with HFrEF (4.30 ± 1.729 vs 4.15 ± 1.736 vs 3.73 ± 1.712; P < .001) and higher risk of stroke during follow-up (hazard ratio [HR], 1.40 [1.161-1.688; P < .001] for HFmrEF; HR, 1.184 [1.075-1.303; P = .001] for HFpEF vs no CHF) after multivariate adjustment). In patients with lower CHA2 DS2 -VASc score (0-4), presence of any type of CHF increased ischemic stroke risk (HFrEF HR, 1.568 [1.189-2.068; P = .001]; HFmrEF HR, 1.890 [1.372-2.603; P < .001]; HFpEF HR, 1.800 [1.526-2.123; P < .001] vs no CHF)., Conclusion: After multivariate adjustment, HFpEF and HFmrEF showed a similar risk of stroke in AF patients. Therefore, it is important to extend the criteria for C in the CHA2 DS2 -VASc score to include patients with HFpEF and HFmrEF. In patients with fewer concomitant stroke risk factors, the presence of any subtype of CHF increases risk for ischemic stroke., Competing Interests: Disclosures The authors have no conflicts of interest to disclose., (Copyright © 2024 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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