Search

Your search keyword '"Chris Richter"' showing total 4 results
Start Over Author "Chris Richter" Publication Year Range Last 3 years
4 results on '"Chris Richter"'

1. Endotoxin Tolerance Acquisition and Altered Hepatic Fatty Acid Profile in Aged Mice

Author

Amanda A. Wiesenthal, Thierry M. Legroux, Chris Richter, Björn H. Junker, Anne Hecksteden, Sonja M. Kessler, Jessica Hoppstädter, and Alexandra K. Kiemer

Subjects
LPS tolerance, hepatic fatty acids, immune response, immunosuppression, inflammation, fatty acid elongation, Biology (General), QH301-705.5
Abstract

(1) Background: Aging is linked to an altered immune response and metabolism. Inflammatory conditions, such as sepsis, COVID-19, and steatohepatitis are more prevalent in the elderly and steatosis is linked both to severe COVID-19 and sepsis. We hypothesized that aging is linked to a loss of endotoxin tolerance, which normally protects the host from excessive inflammation, and that this is accompanied by elevated levels of hepatic lipids. (2) Methods: An in vivo lipopolysaccharide (LPS) tolerance model in young and old mice was used and the cytokine serum levels were measured by ELISA. Cytokine and toll-like receptor gene expression was determined by qPCR in the lungs and the liver; hepatic fatty acid composition was assessed by GC–MS. (3) Results: The old mice showed a distinct potential for endotoxin tolerance as suggested by the serum cytokine levels and gene expression in the lung tissue. Endotoxin tolerance was less pronounced in the livers of the aged mice. However, the fatty acid composition strongly differed in the liver tissues of the young and old mice with a distinct change in the ratio of C18 to C16 fatty acids. (4) Conclusions: Endotoxin tolerance is maintained in advanced age, but changes in the metabolic tissue homeostasis may lead to an altered immune response in old individuals.

Published
2023
Full Text
View/download PDF

2. Interchangeability of optical tracking technologies: potential overestimation of the sprint running load demands in the English Premier League

Author

Matt Taberner, Tom Allen, Jason O’Keefe, Chris Richter, Daniel Cohen, Damian Harper, and Martin Buchheit

Subjects
Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine
Abstract

The purpose of this study was to assess the agreement between match-derived running load outputs; total distance (TD), high-speed running (HSR) and sprint distance (SPR) obtained by two optical tracking systems.Data were collected from 31 elite footballers from the first team and under-21 squads of an English Premier League (EPL) football club across three competitive matches. One EPL game (game 2) and one under-21 Premier League game (game 3) were played at the team's home stadium and one EPL game (game 1) at an away venue. All matches were tracked concomitantly using eight colour cameras sampling at 10 Hz (PROZONE®) and six high-definition motion cameras sampling at 25 Hz (TRACAB®).TD displayed a perfect (TD and HSR can be interchanged between PROZONE® and TRACAB®, to allow accurate interpretation between the two optical systems. PROZONE® overestimated SPR compared to the TRACAB®, with the magnitude of difference considered meaningful, altering interpretation of historical match outputs, sprint volume trends in the EPL and forecasts of the modern game.

Published
2022

3. Hip and groin pain prevalence and prediction in Elite Gaelic Games: 2703 male athletes across two seasons

Author

David Carolan, Chris Richter, Kristian Thorborg, Andrew Franklyn‐Miller, James O’ Donovan, Ciaran McDonald, and Enda King

Subjects
Male, Hip, Gaelic Athletic Association, hurling, FOOTBALL PLAYERS, Pain, Physical Therapy, Sports Therapy and Rehabilitation, prediction, Groin, Gaelic Football, Hip and groin pain, Hip and Groin Outcome Score, COPENHAGEN HIP, OUTCOME SCORE HAGOS, INJURY, Prevalence, Humans, Orthopedics and Sports Medicine, COHORT, Seasons
Abstract

Objective Hip and groin pain is highly prevalent in sub-elite Gaelic Athletic Association (GAA) athletes, but its prevalence at the elite level is unknown. The aims of this study were to report hip and groin pain prevalence in elite male athletes, to report changes in Copenhagen Hip and Groin Outcome Score (HAGOS) across two seasons and to assess if previous hip and groin pain or pre-season HAGOS could predict future hip and groin pain. Methods During the 2017 and 2018 pre-season male Gaelic Players Association (GPA) playing members were invited to complete two questionnaires. The first questionnaire collected demographic information including age, GAA code played (Gaelic football or Hurling) and prevalence of hip and groin pain in the previous season. The second questionnaire was the HAGOS. Step-wise logistic regression models were fitted to HAGOS subscales, to examine if pre-season HAGOS subscale scores could predict future hip and groin pain. Results The prevalence of hip and groin pain across the elite GAA cohort was 38%. Hip and groin pain in the previous season was the strongest predictor of future hip and groin pain (r(2)=0.19, AUC=0.73, 95% CI 1.76-2.27) whereas pre-season HAGOS subscale scores had limited and no additional predictive ability (AUC 0.05-0.18). Conclusions Hip and groin pain prevalence is high in elite male GAA, with one in three athletes reporting pain. Previous season hip and groin pain is the strongest predictor of future hip and groin pain, while pre-season HAGOS scores have limited ability to predict future hip and groin pain.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results