1,360 results on '"Clark C."'
Search Results
2. Comparison of peripheral leukocyte parameters in patients receiving conventionally and hypofractionated radiotherapy schemes for the treatment of newly diagnosed glioblastoma
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Lindsey Greenlund, Ryan Shanley, Kellen Mulford, Elizabeth C. Neil, Jessica Lawrence, Susan Arnold, Michael Olin, G. Elizabeth Pluhar, Andrew S. Venteicher, Clark C. Chen, Clara Ferreira, Margaret Reynolds, L. Chinsoo Cho, Christopher Wilke, B. Aika Shoo, Jianling Yuan, Kathryn Dusenbery, Lawrence R. Kleinberg, Stephanie A. Terezakis, and Lindsey Sloan
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fractionation ,leukocytes ,hypofractionated radiotherapy ,conventionally fractionated radiotherapy ,glioblastoma ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionTreatment for glioblastomas, aggressive and nearly uniformly fatal brain tumors, provide limited long-term success. Immunosuppression by myeloid cells in both the tumor microenvironment and systemic circulation are believed to contribute to this treatment resistance. Standard multi-modality therapy includes conventionally fractionated radiotherapy over 6 weeks; however, hypofractionated radiotherapy over 3 weeks or less may be appropriate for older patients or populations with poor performance status. Lymphocyte concentration changes have been reported in patients with glioblastoma; however, monocytes are likely a key cell type contributing to immunosuppression in glioblastoma. Peripheral monocyte concentration changes in patients receiving commonly employed radiation fractionation schemes are unknown.MethodsTo determine the effect of conventionally fractionated and hypofractionated radiotherapy on complete blood cell leukocyte parameters, retrospective longitudinal concentrations were compared prior to, during, and following standard chemoradiation treatment.ResultsThis study is the first to report increased monocyte concentrations and decreased lymphocyte concentrations in patients treated with conventionally fractionated radiotherapy compared to hypofractionated radiotherapy.DiscussionUnderstanding the impact of fractionation on peripheral blood leukocytes is important to inform selection of dose fractionation schemes for patients receiving radiotherapy.
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- 2023
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3. Pioneering models of pediatric brain tumors
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Florina-Nicoleta Grigore, Serena Johanna Yang, Clark C. Chen, and Tomoyuki Koga
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Genome engineering ,Models, Organoids ,Pediatric brain tumors ,Stem cells ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Among children and adolescents in the United States (0 to 19 years old), brain and other central nervous system tumors are the second most common types of cancers, surpassed in incidence only by leukemias. Despite significant progress in the diagnosis and treatment modalities, brain cancer remains the leading cause of death in the pediatric population. There is an obvious unfulfilled need to streamline the therapeutic strategies and improve survival for these patients. For that purpose, preclinical models play a pivotal role. Numerous models are currently used in pediatric brain tumor research, including genetically engineered mouse models, patient-derived xenografts and cell lines, and newer models that utilize novel technologies such as genome engineering and organoids. Furthermore, extensive studies by the Children's Brain Tumor Network (CBTN) researchers and others have revealed multiomic landscapes of variable pediatric brain tumors. Combined with such integrative data, these novel technologies have enabled numerous applicable models. Genome engineering, including CRISPR/Cas9, expanded the flexibility of modeling. Models generated through genome engineering enabled studying particular genetic alterations in clean isogenic backgrounds, facilitating the dissection of functional mechanisms of those mutations in tumor biology. Organoids have been applied to study tumor-to-tumor-microenvironment interactions and to address developmental aspects of tumorigenesis, which is essential in some pediatric brain tumors. Other modalities, such as humanized mouse models, could potentially be applied to pediatric brain tumors. In addition to current valuable models, such novel models are anticipated to expedite functional tumor biology study and establish effective therapeutics for pediatric brain tumors.
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- 2023
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4. Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse
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Samuel W. Cramer, Samuel P. Haley, Laurentiu S. Popa, Russell E. Carter, Earl Scott, Evelyn B. Flaherty, Judith Dominguez, Justin D. Aronson, Luke Sabal, Daniel Surinach, Clark C. Chen, Suhasa B. Kodandaramaiah, and Timothy J. Ebner
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Traumatic brain injury ,In vivo optical imaging ,Calcium imaging ,Network dynamics ,Spatial independent component analysis ,Functional connectivity ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
>2.5 million individuals in the United States suffer mild traumatic brain injuries (mTBI) annually. Mild TBI is characterized by a brief period of altered consciousness, without objective findings of anatomic injury on clinical imaging or physical deficit on examination. Nevertheless, a subset of mTBI patients experience persistent subjective symptoms and repeated mTBI can lead to quantifiable neurological deficits, suggesting that each mTBI alters neurophysiology in a deleterious manner not detected using current clinical methods. To better understand these effects, we performed mesoscopic Ca2+ imaging in mice to evaluate how mTBI alters patterns of neuronal interactions across the dorsal cerebral cortex. Spatial Independent Component Analysis (sICA) and Localized semi-Nonnegative Matrix Factorization (LocaNMF) were used to quantify changes in cerebral functional connectivity (FC). Repetitive, mild, controlled cortical impacts induce temporary neuroinflammatory responses, characterized by increased density of microglia exhibiting de-ramified morphology. These temporary neuro-inflammatory changes were not associated with compromised cognitive performance in the Barnes maze or motor function as assessed by rotarod. However, long-term alterations in functional connectivity (FC) were observed. Widespread, bilateral changes in FC occurred immediately following impact and persisted for up to 7 weeks, the duration of the experiment. Network alterations include decreases in global efficiency, clustering coefficient, and nodal strength, thereby disrupting functional interactions and information flow throughout the dorsal cerebral cortex. A subnetwork analysis shows the largest disruptions in FC were concentrated near the impact site. Therefore, mTBI induces a transient neuroinflammation, without alterations in cognitive or motor behavior, and a reorganized cortical network evidenced by the widespread, chronic alterations in cortical FC.
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- 2023
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5. TESS discovery of two super-Earths orbiting the M-dwarf stars TOI-6002 and TOI-5713 near the radius valley
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Ghachoui, M., Rackham, B. V., Dévora-Pajares, M., Chouqar, J., Timmermans, M., Kaltenegger, L., Sebastian, D., Pozuelos, F. J., Eastman, J. D., Burgasser, A. J., Murgas, F., Stassun, K. G., Gillon, M., Benkhaldoun, Z., Palle, E., Delrez, L., Jenkins, J. M., Barkaoui, K., Narita, N., de Leon, J. P., Mori, M., Shporer, A., Rowden, P., Kostov, V., Fűrész, G., Collins, K. A., Schwarz, R. P., Charbonneau, D., Guerrero, N. M., Ricker, G., Jehin, E., Fukui, A., Kawai, Y., Hayashi, Y., Esparza-Borges, E., Parviainen, H., Clark, C. A., Ciardi, D. R., Polanski, A. S., Schleider, J., Gilbert, E. A., Crossfield, I. J. M., Barclay, T., Dressing, C. D., Karpoor, P. R., Softich, E., Gerasimov, R., and Davoudi, F.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present the validation of two TESS super-Earth candidates transiting the mid-M dwarfs TOI-6002 and TOI-5713 every 10.90 and 10.44 days, respectively. The first star (TOI-6002) is located $32.038\pm0.019$ pc away, with a radius of $0.2409^{+0.0066}_{-0.0065}$ \rsun, a mass of $0.2105^{+0.0049}_{-0.0048}$ \msun, and an effective temperature of $3229^{+77}_{-57}$ K. The second star (TOI-5713) is located $40.946\pm0.032$ pc away, with a radius of $0.2985^{+0.0073}_{-0.0072}$ \rsun, a mass of $0.2653\pm0.0061$ \msun, and an effective temperature of $3225^{+41}_{-40}$ K. We validated the planets using TESS data, ground-based multi-wavelength photometry from many ground-based facilities, as well as high-resolution AO observations from Keck/NIRC2. TOI-6002 b has a radius of $1.65^{+0.22}_{-0.19}$ \re\ and receives $1.77^{+0.16}_{-0.11} S_\oplus$. TOI-5713 b has a radius of $1.77_{-0.11}^{+0.13} \re$ and receives $2.42\pm{0.11} S_\oplus$. Both planets are located near the radius valley and near the inner edge of the habitable zone of their host stars, which makes them intriguing targets for future studies to understand the formation and evolution of small planets around M-dwarf stars.
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- 2024
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6. Learning Curve Associated with ClearPoint Neuronavigation System: A Case Series
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Birra R. Taha, Christian R. Osswald, Matthew Rabon, Carolina Sandoval Garcia, Daniel J. Guillaume, Xiao Wong, Andrew S. Venteicher, David P. Darrow, Michael C. Park, Robert A. McGovern, Cornelius H. Lam, and Clark C. Chen
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ClearPoint ,IMRIS ,Intracranial biopsy ,Intracranial laser ablation ,Neurosurgery ,Targeted drug delivery ,Surgery ,RD1-811 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: The ClearPoint neuronavigation system affords real-time magnetic resonance imaging (MRI) guidance during stereotactic procedures. While such information confers potential clinical benefits, additional operative time may be needed. Methods: We conducted a retrospective analysis of procedural time associated with ClearPoint Stereotaxis, with hypothesis that this procedural time is comparable with that associated with frame-based biopsy. Results: Of the 52 patients evaluated, the total procedural time for ClearPoint stereotactic biopsy averaged 150.0 (±40.4) minutes, of which 111.5 (±16.5) minutes were dedicated to real-time MRI acquisition and trajectory adjustment. This procedural time is within the range of those reported for frame-based needle biopsies. Approximately 5 minutes of the procedural time is related to the mounting of the MRI-compatible stereotactic frame. Based on the procedural time, we estimate that four cases are required in the learning curve to achieve this efficiency. Efficient algorithms for distortion corrections and isocenter localization are keys to ClearPoint stereotaxis. Routine quality assurance/control after each MRI software update and institutional information technology maintenance also contribute to efficiency. Real-time MRI is essential for definitive diagnosis in select cases. Conclusions: ClearPoint stereotactic needle biopsy can be achieved in time frames comparable to frame-based stereotaxis. However, procedural efficiency requires 4 “learning curve” cases as well as vigilance in terms of MR distortion correction and information technology maintenance.
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- 2022
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7. The Discovery and Follow-up of Four Transiting Short-period Sub-Neptunes Orbiting M dwarfs
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Hori, Y., Fukui, A., Hirano, T., Narita, N., de Leon, J. P., Ishikawa, H. T., Hartman, J. D., Morello, G., García, N. Abreu, Hernández, L. Álvarez, Béjar, V. J. S., Calatayud-Borras, Y., Carleo, I., Enoc, G., Esparza-Borges, E., Fukuda, I., Galán, D., Geraldía-González, S., Hayashi, Y., Ikoma, M., Ikuta, K., Isogai, K., Kagetani, T., Kawai, Y., Kawauchi, K., Kimura, T., Kodama, T., Korth, J., Kusakabe, N., Laza-Ramos, A., Livingston, J. H., Luque, R., Miyakawa, K., Mori, M., Torres, S. Muñoz, Murgas, F., Orell-Miquel, J., Palle, E., Parviainen, H., Peláez-Torres, A., Puig-Subirá, M., Sánchez-Benavente, M., Sosa-Guillén, P., Stangret, M., Terada, Y., Watanabe, N., Bakos, G. Á., Barkaoui, K., Beichman, C., Benkhaldoun, Z., Boyle, A. W., Ciardi, D. R., Clark, C. A., Collins, K. A., Collins, K. I., Conti, D. M., Crossfield, I. J. M., Everett, M. E., Furlan, E., Ghachoui, M., Gillon, M., Gonzales, E. J., Higuera, J., Horne, K., Howell, S. B., Jehin, E., Lester, K. V., Lund, M. B., Matson, R., Matthews, E. C., Pozuelos, F. J., Safonov, B. S., Schlieder, J. E., Schwarz, R. P., Sefako, R., Srdoc, G., Strakhov, I. A., Waalkes, W. C., Ziegler, C., Charbonneau, D., Essack, Z., Timmermans, M., Guerrero, N. M., Harakawa, H., Hedges, C., Ishizuka, M., Jenkins, J. M., Konishi, M., Kotani, T., Kudo, T., Kurokawa, T., Kuzuhara, M., Nishikawa, J., Omiya, M., Ricker, G. R., Seager, S., Serizawa, T., Striegel, S., Tamura, M., Ueda, A., Vanderspek, R., Vievard, S., and Winn, J. N.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Sub-Neptunes with $2-3R_\oplus$ are intermediate in size between rocky planets and Neptune-sized planets. The orbital properties and bulk compositions of transiting sub-Neptunes provide clues to the formation and evolution of close-in small planets. In this paper, we present the discovery and follow-up of four sub-Neptunes orbiting M dwarfs (TOI-782, TOI-1448, TOI-2120, and TOI-2406), three of which were newly validated by ground-based follow-up observations and statistical analyses. TOI-782 b, TOI-1448 b, TOI-2120 b, and TOI-2406 b have radii of $R_\mathrm{p} = 2.740^{+0.082}_{-0.079}\,R_\oplus$, $2.769^{+0.073}_{-0.068}\,R_\oplus$, $2.120\pm0.067\,R_\oplus$, and $2.830^{+0.068}_{-0.066}\,R_\oplus$ and orbital periods of $P = 8.02$, $8.11$, $5.80$, and $3.08$\,days, respectively. Doppler monitoring with Subaru/InfraRed Doppler instrument led to 2$\sigma$ upper limits on the masses of $<19.1\ M_\oplus$, $<19.5\ M_\oplus$, $<6.8\ M_\oplus$, and $<15.6\ M_\oplus$ for TOI-782 b, TOI-1448 b, TOI-2120 b, and TOI-2406 b, respectively. The mass-radius relationship of these four sub-Neptunes testifies to the existence of volatile material in their interiors. These four sub-Neptunes, which are located above the so-called ``radius valley'', are likely to retain a significant atmosphere and/or an icy mantle on the core, such as a water world. We find that at least three of the four sub-Neptunes (TOI-782 b, TOI-2120 b, and TOI-2406 b) orbiting M dwarfs older than 1 Gyr, are likely to have eccentricities of $e \sim 0.2-0.3$. The fact that tidal circularization of their orbits is not achieved over 1 Gyr suggests inefficient tidal dissipation in their interiors., Comment: Accepted for publication in AJ, 32 pages, 17 figures, 6 tables
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- 2024
8. TRAPUM search for pulsars in supernova remnants and pulsar wind nebulae -- I. Survey description and initial discoveries
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Turner, J. D., Stappers, B. W., Carli, E., Barr, E. D., Becker, W., Behrend, J., Breton, R. P., Buchner, S., Burgay, M., Champion, D. J., Chen, W., Clark, C. J., Horn, D. M., Keane, E. F., Kramer, M., ünkel, L. K, Levin, L., Men, Y. P., Padmanabh, P. V., Ridolfi, A., and Krishnan, V. Venkatraman
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the description and initial results of the TRAPUM (TRAnsients And PUlsars with MeerKAT) search for pulsars associated with supernova remnants (SNRs), pulsar wind nebulae and unidentified TeV emission. The list of sources to be targeted includes a large number of well-known candidate pulsar locations but also new candidate SNRs identified using a range of criteria. Using the 64-dish MeerKAT radio telescope, we use an interferometric beamforming technique to tile the potential pulsar locations with coherent beams which we search for radio pulsations, above a signal-to-noise of 9, down to an average flux density upper limit of 30 $\mu$Jy. This limit is target-dependent due to the contribution of the sky and nebula to the system temperature. Coherent beams are arranged to overlap at their 50 per cent power radius, so the sensitivity to pulsars is not degraded by more than this amount, though realistically averages around 65 per cent if every location in the beam is considered. We report the discovery of two new pulsars; PSR J1831$-$0941 is an adolescent pulsar likely to be the plerionic engine of the candidate PWN G20.0+0.0, and PSR J1818$-$1502 appears to be an old and faint pulsar that we serendipitously discovered near the centre of a SNR already hosting a compact central object. The survey holds importance for better understanding of neutron star birth rates and the energetics of young pulsars., Comment: 17 pages, 6 figures, 3 tables. Accepted for publication in Monthly Notices of the Royal Astronomical Society
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- 2024
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9. Discovery and timing of ten new millisecond pulsars in the globular cluster Terzan 5
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Padmanabh, P. V., Ransom, S. M., Freire, P. C. C., Ridolfi, A., Taylor, J. D., Choza, C., Clark, C. J., Abbate, F., Bailes, M., Barr, E. D., Buchner, S., Burgay, M., DeCesar, M. E., Chen, W., Corongiu, A., Champion, D. J., Dutta, A., Geyer, M., Hessels, J. W. T., Kramer, M., Possenti, A., Stairs, I. H., Stappers, B. W., Krishnan, V. Venkatraman, Vleeschower, L., and Zhang, L.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report the discovery of ten new pulsars in the globular cluster Terzan 5 as part of the Transients and Pulsars with MeerKAT (TRAPUM) Large Survey Project. We observed Terzan 5 at L-band (856--1712 MHz) with the MeerKAT radio telescope for four hours on two epochs, and performed acceleration searches of 45 out of 288 tied-array beams covering the core of the cluster. We obtained phase-connected timing solutions for nine discoveries, covering nearly two decades of archival observations from the Green Bank Telescope for all but one. Highlights include PSR J1748$-$2446ao which is an eccentric ($e = 0.32$) wide-orbit (orbital period $P_{\rm b} = 57.55$ d) system. We were able to measure the rate of advance of periastron ($\dot{\omega}$) for this system allowing us to determine a total mass of $3.17 \pm \, 0.02\, \rm M_{\odot}$. With a minimum companion mass ($M_{\rm c}$) of $\sim 0.8\, \rm M_{\odot}$, PSR J1748$-$2446ao is a candidate double neutron star (DNS) system. If confirmed to be a DNS, it would be the fastest spinning pulsar ($P = 2.27$ ms) and the longest orbital period measured for any known DNS system. PSR J1748$-$2446ap has the second highest eccentricity for any recycled pulsar ($e \sim 0.905$) and for this system we can measure the total mass ($1.997 \pm 0.006\, \rm M_{\odot}$) and also estimate the individual pulsar and companion masses. PSR J1748$-$2446ar is an eclipsing redback (minimum $M_{\rm c} \sim 0.34\, \rm M_{\odot}$) system whose properties confirm it to be the counterpart to a previously published source identified in radio and X-ray imaging. With these discoveries, the total number of confirmed pulsars in Terzan 5 is 49, the highest for any globular cluster so far. These discoveries further enhance the rich set of pulsars known in Terzan 5 and provide scope for a deeper understanding of binary stellar evolution, cluster dynamics and ensemble population studies., Comment: 23 pages, 11 figures, 5 tables, published in A&A
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- 2024
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10. A targeted radio pulsar survey of redback candidates with MeerKAT
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Thongmeearkom, T., Clark, C. J., Breton, R. P., Burgay, M., Nieder, L., Freire, P. C. C., Barr, E. D., Stappers, B. W., Ransom, S. M., Buchner, S., Calore, F., Champion, D. J., Cognard, I., Grießmeier, J. -M., Kramer, M., Levin, L., Padmanabh, P. V., Possenti, A., Ridolfi, A., Krishnan, V. Venkatraman, and Vleeschower, L.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Redbacks are millisecond pulsar binaries with low mass, irradiated companions. These systems have a rich phenomenology that can be used to probe binary evolution models, pulsar wind physics, and the neutron star mass distribution. A number of high-confidence redback candidates have been identified through searches for variable optical and X-ray sources within the localisation regions of unidentified but pulsar-like Fermi-LAT gamma-ray sources. However, these candidates remain unconfirmed until pulsations are detected. As part of the TRAPUM project, we searched for radio pulsations from six of these redback candidates with MeerKAT. We discovered three new radio millisecond pulsars, PSRs J0838$-$2527, J0955$-$3947 and J2333$-$5526, confirming their redback nature. PSR J0838$-$2827 remained undetected for two years after our discovery despite repeated observations, likely due to evaporated material absorbing the radio emission for long periods of time. While, to our knowledge, this system has not undergone a transition to an accreting state, the disappearance, likely caused by extreme eclipses, illustrates the transient nature of spider pulsars and the heavy selection bias in uncovering their radio population. Radio timing enabled the detection of gamma-ray pulsations from all three pulsars, from which we obtained 15-year timing solutions. All of these sources exhibit complex orbital period variations consistent with gravitational quadrupole moment variations in the companion stars. These timing solutions also constrain the binary mass ratios, allowing us to narrow down the pulsar masses. We find that PSR J2333$-$5526 may have a neutron star mass in excess of 2 M$_{\odot}$., Comment: 19 pages, 7 figures, accepted for publication in MNRAS
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- 2024
11. Exosomal Carboxypeptidase E (CPE) and CPE-shRNA-Loaded Exosomes Regulate Metastatic Phenotype of Tumor Cells
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Sangeetha Hareendran, Bassam Albraidy, Xuyu Yang, Aiyi Liu, Anne Breggia, Clark C. Chen, and Y. Peng Loh
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cancer proliferation ,hepatocellular carcinoma ,metastasis ,engineered exosomes ,diagnostic biomarker ,cancer therapy ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Background: Exosomes promote tumor growth and metastasis through intercellular communication, although the mechanism remains elusive. Carboxypeptidase E (CPE) supports the progression of different cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether CPE is the bioactive cargo within exosomes, and whether it contributes to tumorigenesis, using HCC cell lines as a cancer model. Methods: Exosomes were isolated from supernatant media of cancer cells, or human sera. mRNA and protein expression were analyzed using PCR and Western blot. Low-metastatic HCC97L cells were incubated with exosomes derived from high-metastatic HCC97H cells. In other experiments, HCC97H cells were incubated with CPE-shRNA-loaded exosomes. Cell proliferation and invasion were assessed using MTT, colony formation, and matrigel invasion assays. Results: Exosomes released from cancer cells contain CPE mRNA and protein. CPE mRNA levels are enriched in exosomes secreted from high- versus low-metastastic cells, across various cancer types. In a pilot study, significantly higher CPE copy numbers were found in serum exosomes from cancer patients compared to healthy subjects. HCC97L cells, treated with exosomes derived from HCC97H cells, displayed enhanced proliferation and invasion; however, exosomes from HCC97H cells pre-treated with CPE-shRNA failed to promote proliferation. When HEK293T exosomes loaded with CPE-shRNA were incubated with HCC97H cells, the expression of CPE, Cyclin D1, a cell-cycle regulatory protein and c-myc, a proto-oncogene, were suppressed, resulting in the diminished proliferation of HCC97H cells. Conclusions: We identified CPE as an exosomal bioactive molecule driving the growth and invasion of low-metastatic HCC cells. CPE-shRNA loaded exosomes can inhibit malignant tumor cell proliferation via Cyclin D1 and c-MYC suppression. Thus, CPE is a key player in the exosome transmission of tumorigenesis, and the exosome-based delivery of CPE-shRNA offers a potential treatment for tumor progression. Notably, measuring CPE transcript levels in serum exosomes from cancer patients could have potential liquid biopsy applications.
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- 2022
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12. A 350-MHz Green Bank Telescope Survey of Unassociated Fermi LAT Sources: Discovery and Timing of Ten Millisecond Pulsars
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Bangale, P., Bhattacharyya, B., Camilo, F., Clark, C. J., Cognard, I., DeCesar, M. E., Ferrara, E. C., Gentile, P., Guillemot, L., Hessels, J. W. T., Johnson, T. J., Kerr, M., McLaughlin, M. A., Nieder, L., Ransom, S. M., Ray, P. S., Roberts, M. S. E., Roy, J., Sanpa-Arsa, S., Theureau, G., and Wolff, M. T.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We have searched for radio pulsations towards 49 Fermi Large Area Telescope (LAT) 1FGL Catalog $\gamma$-ray sources using the Green Bank Telescope at 350 MHz. We detected 18 millisecond pulsars (MSPs) in blind searches of the data; 10 of these were discoveries unique to our survey. Sixteen are binaries, with eight having short orbital periods $P_B < 1$ day. No radio pulsations from young pulsars were detected, although three targets are coincident with apparently radio-quiet $\gamma$-ray pulsars discovered in LAT data. Here, we give an overview of the survey and present radio and $\gamma$-ray timing results for the 10 MSPs discovered. These include the only isolated MSP discovered in our survey and six short-$P_B$ binary MSPs. Of these, three have very low-mass companions ($M_c$ $\ll$ 0.1M$_{\odot}$) and hence belong to the class of black widow pulsars. Two have more massive, non-degenerate companions with extensive radio eclipses and orbitally modulated X-ray emission consistent with the redback class. Significant $\gamma$-ray pulsations have been detected from nine of the discoveries. This survey and similar efforts suggest that the majority of Galactic $\gamma$-ray sources at high Galactic latitudes are either MSPs or relatively nearby non-recycled pulsars, with the latter having on average a much smaller radio/$\gamma$-ray beaming ratio as compared to MSPs. It also confirms that past surveys suffered from an observational bias against finding short-$P_B$ MSP systems., Comment: Accepted for publication in ApJ (25 pages, 15 figues, 4 tables)
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- 2024
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13. Dosimetric evaluation and treatment planning considerations for GammaTile permanent brain implants – a pilot, institutional experience
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Zhang, Shunqing, Patel, Krishnan, Dusenbery, Kathryn, Alshreef, Abdullah, Sterling, David, Sloan, Lindsey, Reynolds, Margaret, Chen, Clark C., and Ferreira, Clara
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- 2024
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14. Laser interstitial thermal therapy followed by consolidation stereotactic radiosurgery (LITT-cSRS) in patients with newly diagnosed brain metastasis
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Dharnipragada, Rajiv, Shah, Rena A., Reynolds, Margaret, Dusenbery, Kathryn, and Chen, Clark C.
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- 2024
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15. Exploring the interstellar medium of NGC 891 at millimeter wavelengths using the NIKA2 camera
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Katsioli, S., Adam, R., Ade, P., Ajeddig, H., André, P., Artis, E., Aussel, H., Baes, M., Beelen, A., Benoît, A., Berta, S., Bing, L., Bourrion, O., Calvo, M., Catalano, A., Clark, C. J. R., De Looze, I., De Petris, M., Désert, F. -X., Doyle, S., Driessen, E. F. C., Ejlali, G., Galametz, M., Galliano, F., Gomez, A., Goupy, J., Hanser, C., Hughes, A., Kéruzoré, F., Kramer, C., Jones, A. P., Ladjelate, B., Lagache, G., Leclercq, S., Lestrade, J. -F., Macías-Pérez, J. F., Madden, S. C., Maury, A., Mauskopf, P., Mayet, F., Monfardini, A., Moyer-Anin, A., Muñoz-Echeverría, M., Nersesian, A., Pantoni, L., Paradis, D., Perotto, L., Pisano, G., Ponthieu, N., Revéret, V., Rigby, A. J., Ritacco, A., Romero, C., Roussel, H., Ruppin, F., Schuster, K., Sievers, A., Smith, M. W. L., Tedros, J., Tabatabaei, F., Tucker, C., Xilouris, E. M., Ysard, N., and Zylka, R.
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Astrophysics - Astrophysics of Galaxies - Abstract
In the framework of the IMEGIN Large Program, we used the NIKA2 camera on the IRAM 30-m telescope to observe the edge-on galaxy NGC 891 at 1.15 mm and 2 mm and at a FWHM of 11.1" and 17.6", respectively. Multiwavelength data enriched with the new NIKA2 observations fitted by the HerBIE SED code (coupled with the THEMIS dust model) were used to constrain the physical properties of the ISM. Emission originating from the diffuse dust disk is detected at all wavelengths from mid-IR to mm, while mid-IR observations reveal warm dust emission from compact HII regions. Indications of mm excess emission have also been found in the outer parts of the galactic disk. Furthermore, our SED fitting analysis constrained the mass fraction of the small (< 15 Angstrom) dust grains. We found that small grains constitute 9.5% of the total dust mass in the galactic plane, but this fraction increases up to ~ 20% at large distances (|z| > 3 kpc) from the galactic plane., Comment: To appear in Proc. of the mm Universe 2023 conference, Grenoble (France), June 2023, published by F. Mayet et al. (Eds), EPJ Web of conferences, EDP Sciences
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- 2023
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16. The stratification of ISM properties in the edge-on galaxy NGC 891 revealed by NIKA2
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Katsioli, S., Xilouris, E. M., Kramer, C., Adam, R., Ade, P., Ajeddig, H., André, P., Artis, E., Aussel, H., Baes, M., Beelen, A., Benoît, A., Berta, S., Bing, L., Bourrion, O., Calvo, M., Catalano, A., Clark, C. J. R., De Looze, I., De Petris, M., Désert, F. -X., Doyle, S., Driessen, E. F. C., Ejlali, G., Galametz, M., Galliano, F., Gomez, A., Goupy, J., Hanser, C., Hughes, A., Jones, A. P., Kéruzoré, F., Ladjelate, B., Lagache, G., Leclercq, S., Lestrade, J. -F., Macías-Pérez, J. -F., Madden, S. C., Maury, A., Mauskopf, P., Mayet, F., Monfardini, A., Muñoz-Echeverría, M., Nersesian, A., Pantoni, L., Paradis, D., Perotto, L., Pisano, G., Ponthieu, N., Revéret, V., Rigby, A. J., Ritacco, A., Romero, C., Roussel, H., Ruppin, F., Schuster, K., Sievers, A., Smith, M. W. L., Tedros, J., Tabatabaei, F., Tucker, C., Ysard, N., and Zylka, R.
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Astrophysics - Astrophysics of Galaxies - Abstract
As the millimeter wavelength range remains a largely unexplored spectral region for galaxies, the IMEGIN large program aims to map the millimeter continuum emission of 22 nearby galaxies at 1.15 and 2 mm. Using the high-resolution maps produced by the NIKA2 camera, we explore the existence of very cold dust and take possible contamination by free-free and synchrotron emission into account. We study the IR-to-radio emission coming from different regions along the galactic plane and at large vertical distances. New observations of NGC 891, using the NIKA2 camera on the IRAM 30m telescope, along with a suite of observations at other wavelengths were used to perform a multiwavelength study of the spectral energy distribution in the interstellar medium in this galaxy. This analysis was performed globally and locally, using the advanced hierarchical Bayesian fitting code, HerBIE, coupled with the THEMIS dust model. Our dust modeling is able to reproduce the near-IR to millimeter emission of NGC 891, with the exception of an excess at a level of 25% obtained by the NIKA2 observations in the outermost parts of the disk. The radio continuum and thermal dust emission are distributed differently in the disk and galaxy halo. Different dusty environments are also revealed by a multiwavelength investigation of the emission features. Our detailed decomposition at millimeter and centimeter wavelengths shows that emission at 1 mm is purely originated by dust. Radio components become progressively important with increasing wavelengths. Finally, we find that emission arising from small dust grains accounts for ~ 9.5% of the total dust mass, reaching up to 20% at large galactic latitudes. Shock waves in the outflows that shatter the dust grains might explain this higher fraction of small grains in the halo., Comment: 15 pages, 10 figures, Accepted for publication in A&A
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- 2023
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17. PulsarX: a new pulsar searching package -I. A high performance folding program for pulsar surveys
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Men, Yunpeng, Barr, Ewan, Clark, C. J., Carli, Emma, and Desvignes, Gregory
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Pulsar surveys with modern radio telescopes are becoming increasingly computationally demanding. This is particularly true for wide field-of-view pulsar surveys with radio interferometers, and those conducted in real or quasi-real time. These demands result in data analysis bottlenecks that can limit the parameter space covered by the surveys and diminish their scientific return. In this paper, we address the computational challenge of `candidate folding' in pulsar searching, presenting a novel, efficient approach designed to optimise the simultaneous folding of large numbers of pulsar candidates. We provide a complete folding pipeline appropriate for large-scale pulsar surveys including radio frequency interference (RFI) mitigation, dedispersion, folding and parameter optimization. By leveraging the Fast Discrete Dispersion Measure Transform (FDMT) algorithm proposed by Zackay et al. (2017), we have developed an optimized, and cache-friendly implementation that we term the pruned FDMT (pFDMT). The pFDMT approach efficiently reuses intermediate processing results and prunes the unused computation paths, resulting in a significant reduction in arithmetic operations. In addition, we propose a novel folding algorithm based on the Tikhonov-regularised least squares method (TLSM) that can improve the time resolution of the pulsar profile. We present the performance of its real-world application as an integral part of two major pulsar search projects conducted with the MeerKAT telescope: the MPIfR-MeerKAT Galactic Plane Survey (MMGPS) and the Transients and Pulsars with MeerKAT (TRAPUM) project. In our processing, for approximately 500 candidates, the theoretical number of dedispersion operations can be reduced by a factor of around 50 when compared to brute-force dedispersion, which scales with the number of candidates., Comment: Accepted for publication in A&A
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- 2023
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18. Open Access: Enacting Treaty Rights through Restoring Shoshone Ancestral Foods on the Wind River Indian Reservation
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Keith, J.F., primary, Olsen, L., additional, Barney, N., additional, Clark, C., additional, LeBeau, J.L., additional, Meyers, D., additional, Mills, C., additional, Mionczynski, J., additional, Panzetanga, V., additional, and Wechsler, A., additional
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- 2024
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19. Spigelian hernia: a multi-site review of operative outcomes of surgical repair in the adult population
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Clark, C. R., Kelly, M. L., and Palamuthusingam, P.
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- 2024
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20. The MPIfR-MeerKAT Galactic Plane survey I -- System setup and early results
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Padmanabh, P. V., Barr, E. D., Sridhar, S. S., Rugel, M. R., Damas-Segovia, A., Jacob, A. M., Balakrishnan, V., Berezina, M., Bernadich, M. C. i, Brunthaler, A., Champion, D. J., Freire, P. C. C., Khan, S., Klöckner, H. -R., Kramer, M., Ma, Y. K., Mao, S. A., Men, Y. P., Menten, K. M., Sengupta, S., Krishnan, V. Venkatraman, Wucknitz, O., Wyrowski, F., Bezuidenhout, M. C., Buchner, S., Burgay, M., Chen, W., Clark, C. J., Künkel, L., Nieder, L., Stappers, B., Legodi, L. S., and Nyamai, M. M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Galactic plane radio surveys play a key role in improving our understanding of a wide range of astrophysical phenomena. Performing such a survey using the latest interferometric telescopes produces large data rates necessitating a shift towards fully or quasi-real-time data analysis with data being stored for only the time required to process them. We present here the overview and setup for the 3000 hour Max-Planck-Institut fuer Radioastronomie (MPIfR) MeerKAT Galactic Plane survey (MMGPS). The survey is unique by operating in a commensal mode, addressing key science objectives of the survey including the discovery of new pulsars and transients as well as studies of Galactic magnetism, the interstellar medium and star formation rates. We explain the strategy coupled with the necessary hardware and software infrastructure needed for data reduction in the imaging, spectral and time domains. We have so far discovered 78 new pulsars including 17 confirmed binary systems of which two are potential double neutron star systems. We have also developed an imaging pipeline sensitive to the order of a few tens of micro-Jansky with a spatial resolution of a few arcseconds. Further science operations with an in-house built S-Band receiver operating between 1.7-3.5 GHz are about to commence. Early spectral line commissioning observations conducted at S-Band, targeting transitions of the key molecular gas tracer CH at 3.3 GHz already illustrate the spectroscopic capabilities of this instrument. These results lay a strong foundation for future surveys with telescopes like the Square Kilometre Array (SKA)., Comment: 25 pages, 10 figures, Accepted in MNRAS
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- 2023
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21. Tied-Array Beam Localisation of Radio Transients and Pulsars
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Bezuidenhout, M. C., Clark, C. J., Breton, R. P., Stappers, B. W., Barr, E. D., Caleb, M., Chen, W., Jankowski, F., Kramer, M., Rajwade, K., and Surnis, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Multi-element interferometers such as MeerKAT, which observe with high time resolution and have a wide field-of-view, provide an ideal opportunity to perform real-time, untargeted transient and pulsar searches. However, because of data storage limitations, it is not always feasible to store the baseband data required to image the field of a discovered transient or pulsar. This limits the ability of surveys to effectively localise their discoveries and may restrict opportunities for follow-up science, especially of one-off events like some Fast Radio Bursts (FRBs). Here we present a novel maximum-likelihood estimation approach to localising transients and pulsars detected in multiple MeerKAT tied-array beams at once, which we call Tied Array Beam Localisation (TABLo), as well as a Python implementation of the method named SeeKAT. We provide real-world examples of SeeKAT's use as well as a Monte Carlo analysis to show that it is capable of localising single pulses detected in beamformed MeerKAT data to (sub-)arcsecond precision., Comment: 15 pages, 13 figures
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- 2023
22. Neutron star mass estimates from gamma-ray eclipses in spider millisecond pulsar binaries
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Clark, C. J., Kerr, M., Barr, E. D., Bhattacharyya, B., Breton, R. P., Bruel, P., Camilo, F., Chen, W., Cognard, I., Cromartie, H. T., Deneva, J., Dhillon, V. S., Guillemot, L., Kennedy, M. R., Kramer, M., Lyne, A. G., Sánchez, D. Mata, Nieder, L., Phillips, C., Ransom, S. M., Ray, P. S., Roberts, M. S. E., Roy, J., Smith, D. A., Spiewak, R., Stappers, B. W., Tabassum, S., Theureau, G., and Voisin, G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Reliable neutron star mass measurements are key to determining the equation-of-state of cold nuclear matter, but these are rare. "Black Widows" and "Redbacks" are compact binaries consisting of millisecond pulsars and semi-degenerate companion stars. Spectroscopy of the optically bright companions can determine their radial velocities, providing inclination-dependent pulsar mass estimates. While inclinations can be inferred from subtle features in optical light curves, such estimates may be systematically biased due to incomplete heating models and poorly-understood variability. Using data from the Fermi Large Area Telescope, we have searched for gamma-ray eclipses from 49 spider systems, discovering significant eclipses in 7 systems, including the prototypical black widow PSR B1957$+$20. Gamma-ray eclipses require direct occultation of the pulsar by the companion, and so the detection, or significant exclusion, of a gamma-ray eclipse strictly limits the binary inclination angle, providing new robust, model-independent pulsar mass constraints. For PSR B1957$+$20, the eclipse implies a much lighter pulsar ($M_{\rm psr} = 1.81 \pm 0.07\,M_{\odot}$) than inferred from optical light curve modelling., Comment: 31 pages, 4 figures, includes supplementary tables; published in Nature Astronomy
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- 2023
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23. A black widow population dissection through HiPERCAM multi-band light curve modelling
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Sánchez, D. Mata, Kennedy, M. R., Clark, C. J., Breton, R. P., Dhillon, V. S., Voisin, G., Camilo, F., Littlefair, S., Marsh, T. R., and Stringer, J.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Black widows are extreme millisecond pulsar binaries where the pulsar wind ablates their low-mass companion stars. Their optical light curves vary periodically due to the high irradiation and tidal distortion of the companion, which allows us to infer the binary parameters. We present simultaneous multi-band observations obtained with the HIPERCAM instrument at the 10.4-m GTC telescope for six of these systems. The combination of this five-band fast photometer with the world's largest optical telescope enables us to inspect the light curve range near minima. We present the first light curve for PSR J1641+8049, as well as attain a significant increase in signal-to-noise and cadence compared with previous publications for the remaining 5 targets: PSR J0023+0923, PSR J0251+2606, PSR J0636+5129, PSR J0952-0607 and PSR J1544+4937. We report on the results of the light curve modelling with the Icarus code for all six systems, which reveals some of the hottest and densest companion stars known. We compare the parameters derived with the limited but steadily growing black widow population for which optical modelling is available. We find some expected correlations, such as that between the companion star mean density and the orbital period of the system, but also a puzzling positive correlation between the orbital inclination and the irradiation temperature of the companion. We propose such a correlation would arise if pulsars with magnetic axis orthogonal to their spin axis are capable of irradiating their companions to a higher degree., Comment: 18 pages (+12 pages for appendix), 12 figures (+13 in the appendix), 3 tables (1 in the appendix). Accepted for publication in MNRAS on 2023 January 17th
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- 2023
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24. A rapid optical and X-ray timing study of the neutron star X-ray binary Swift J1858.6-0814
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Shahbaz, T., Paice, J. A., Rajwade, K. M., Veledina, A., Gandhi., P., Dhillon, V. S., Marsh, T. R., Littlefair, S., Kennedy, M. R., Breton, R. P., and Clark, C. J.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present a rapid timing analysis of optical (HiPERCAM and ULTRACAM) and X-ray (NICER) observations of the X-ray transient Swift J1858.6-0814 during 2018 and 2019. The optical light curves show relatively slow, large amplitude (~1 mags in g$_s$) `blue' flares (i.e. stronger at shorter wavelengths) on time-scales of ~minutes as well as fast, small amplitude (~0.1 mag in g$_s$) `red' flares (i.e. stronger at longer wavelengths) on time-scales of ~seconds. The `blue' and `red' flares are consistent with X-ray reprocessing and optically thin synchrotron emission, respectively, similar to what is observed in other X-ray binaries. The simultaneous optical versus soft- and hard-band X-ray light curves show time- and energy dependent correlations. The 2019 March 4 and parts of the June data show a nearly symmetric positive cross correlations (CCFs) at positive lags consistent with simple X-ray disc reprocessing. The soft- and hard-band CCFs are similar and can be reproduced if disc reprocessing dominates in the optical and one component (disc or synchrotron Comptonization) dominates both the soft and hard X-rays. A part of the 2019 June data shows a very different CCFs. The observed positive correlation at negative lag in the soft-band can be reproduced if the optical synchrotron emission is correlated with the hot flow X-ray emission. The observed timing properties are in qualitative agreement with the hybrid inner hot accretion flow model, where the relative role of the different X-ray and optical components that vary during the course of the outburst, as well as on shorter time-scales, govern the shape of the optical/X-ray CCFs., Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society. 18 pages, 14 figures
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- 2023
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25. The TRAPUM L-band survey for pulsars in Fermi-LAT gamma-ray sources
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Clark, C. J., Breton, R. P., Barr, E. D., Burgay, M., Thongmeearkom, T., Nieder, L., Buchner, S., Stappers, B., Kramer, M., Becker, W., Mayer, M., Phosrisom, A., Ashok, A., Bezuidenhout, M. C., Calore, F., Cognard, I., Freire, P. C. C., Geyer, M., Grießmeier, J. -M., Karuppusamy, R., Levin, L., Padmanabh, P. V., Possenti, A., Ransom, S., Serylak, M., Krishnan, V. Venkatraman, Vleeschower, L., Behrend, J., Champion, D. J., Chen, W., Horn, D., Keane, E. F., Künkel, L., Men, Y., Ridolfi, A., Dhillon, V. S., Marsh, T. R., and Papa, M. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
More than 100 millisecond pulsars (MSPs) have been discovered in radio observations of gamma-ray sources detected by the Fermi Large Area Telescope (LAT), but hundreds of pulsar-like sources remain unidentified. Here we present the first results from the targeted survey of Fermi-LAT sources being performed by the Transients and Pulsars with MeerKAT (TRAPUM) Large Survey Project. We observed 79 sources identified as possible gamma-ray pulsar candidates by a Random Forest classification of unassociated sources from the 4FGL catalogue. Each source was observed for 10 minutes on two separate epochs using MeerKAT's L-band receiver (856-1712 MHz), with typical pulsed flux density sensitivities of $\sim$100$\,\mu$Jy. Nine new MSPs were discovered, eight of which are in binary systems, including two eclipsing redbacks and one system, PSR J1526$-$2744, that appears to have a white dwarf companion in an unusually compact 5 hr orbit. We obtained phase-connected timing solutions for two of these MSPs, enabling the detection of gamma-ray pulsations in the Fermi-LAT data. A follow-up search for continuous gravitational waves from PSR J1526$-$2744 in Advanced LIGO data using the resulting Fermi-LAT timing ephemeris yielded no detection, but sets an upper limit on the neutron star ellipticity of $2.45\times10^{-8}$. We also detected X-ray emission from the redback PSR J1803$-$6707 in data from the first eROSITA all-sky survey, likely due to emission from an intra-binary shock., Comment: 17 pages, 8 figures, accepted for publication in MNRAS
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- 2022
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26. Non-Cooperative Full-Envelope Calibration of a Supersonic Air Data System.
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Juan D. Jurado and Clark C. McGehee
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- 2024
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27. Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity
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Raviram, Ramya, Raman, Anugraha, Preissl, Sebastian, Ning, Jiangfang, Wu, Shaoping, Koga, Tomoyuki, Zhang, Kai, Brennan, Cameron W, Zhu, Chenxu, Luebeck, Jens, Van Deynze, Kinsey, Han, Jee Yun, Hou, Xiaomeng, Ye, Zhen, Mischel, Anna K, Li, Yang Eric, Fang, Rongxin, Baback, Tomas, Mugford, Joshua, Han, Claudia Z, Glass, Christopher K, Barr, Cathy L, Mischel, Paul S, Bafna, Vineet, Escoubet, Laure, Ren, Bing, and Chen, Clark C
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Biological Sciences ,Biotechnology ,Brain Cancer ,Brain Disorders ,Neurosciences ,Rare Diseases ,Cancer ,Human Genome ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Generic health relevance ,Adult ,Humans ,Glioblastoma ,Chromatin ,Transcriptome ,Astrocytoma ,Brain Neoplasms ,Mutation ,Isocitrate Dehydrogenase ,single cell ,glioblastoma ,extrachromosomal DNA ,amplicons - Abstract
In 2021, the World Health Organization reclassified glioblastoma, the most common form of adult brain cancer, into isocitrate dehydrogenase (IDH)-wild-type glioblastomas and grade IV IDH mutant (G4 IDHm) astrocytomas. For both tumor types, intratumoral heterogeneity is a key contributor to therapeutic failure. To better define this heterogeneity, genome-wide chromatin accessibility and transcription profiles of clinical samples of glioblastomas and G4 IDHm astrocytomas were analyzed at single-cell resolution. These profiles afforded resolution of intratumoral genetic heterogeneity, including delineation of cell-to-cell variations in distinct cell states, focal gene amplifications, as well as extrachromosomal circular DNAs. Despite differences in IDH mutation status and significant intratumoral heterogeneity, the profiled tumor cells shared a common chromatin structure defined by open regions enriched for nuclear factor 1 transcription factors (NFIA and NFIB). Silencing of NFIA or NFIB suppressed in vitro and in vivo growths of patient-derived glioblastomas and G4 IDHm astrocytoma models. These findings suggest that despite distinct genotypes and cell states, glioblastoma/G4 astrocytoma cells share dependency on core transcriptional programs, yielding an attractive platform for addressing therapeutic challenges associated with intratumoral heterogeneity.
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- 2023
28. TFAW survey II: 6 Newly Validated Planets and 13 Planet Candidates from K2
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del Ser, D., Fors, O., del Alcázar, M., Dyachenko, V., Horch, E. P., Tokovinin, A., Ziegler, C., van Belle, G. T., Clark, C. A., and Hartman, Z. D.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Searching for Earth-sized planets in data from Kepler's extended mission (K2) is a niche that still remains to be fully exploited. The TFAW survey is an ongoing project that aims to re-analyze all light curves in K2 C1-C8 and C12-C18 campaigns with a wavelet-based detrending and denoising method, and the period search algorithm TLS to search for new transit candidates not detected in previous works. We have analyzed a first subset of 24 candidate planetary systems around relatively faint host stars (10.9 < $K_{p}$ < 15.4) to allow for follow-up speckle imaging observations. Using VESPA and TRICERATOPS, we statistically validate six candidates orbiting four unique host stars by obtaining false-positive probabilities smaller than 1% with both methods. We also present 13 vetted planet candidates that might benefit from other, more precise follow-up observations. All of these planets are sub-Neptune-sized, with two validated planets and three candidates with sub-Earth sizes, and have orbital periods between 0.81 and 23.98 days. Some interesting systems include two ultra-short-period planets, three multi-planetary systems, three sub-Neptunes that appear to be within the small planet Radius Gap, and two validated and one candidate sub-Earths (EPIC 210706310, EPIC 210768568, and EPIC 246078343) orbiting metal-poor stars., Comment: Submitted to Monthly Notices of the Royal Astronomical Society. 25 pages, 14 figures
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- 2022
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29. GammaTile® (GT) as a brachytherapy platform for rapidly proliferating glioblastomas: from case series to clinical trials
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Yekula, Anudeep, Gessler, Dominic J., Ferreira, Clara, Shah, Rena, Reynolds, Margaret, Dusenbery, Kathryn, and Chen, Clark C.
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- 2024
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30. Comparison of Gamma Knife (GK) and Linear Accelerator (LINAC) radiosurgery of brain metastasis resection cavity: a systematic review and proportional meta-analysis
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Dharnipragada, Rajiv, Dusenbery, Kathryn, Watanabe, Yoichi, Ferreira, Clara, and Chen, Clark C.
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- 2024
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31. Multi-colour optical light curves of the companion star to the millisecond pulsar PSR J2051-0827
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Dhillon, V. S., Kennedy, M. R., Breton, R. P., Clark, C. J., Sánchez, D. Mata, Voisin, G., Breedt, E., Brown, A. J., Dyer, M. J., Green, M. J., Kerry, P., Littlefair, S. P., Marsh, T. R., Parsons, S. G., Pelisoli, I., Sahman, D. I., Wild, J. F., van Kerkwijk, M. H., and Stappers, B. W.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present simultaneous, multi-colour optical light curves of the companion star to the black-widow pulsar PSR J2051-0827, obtained approximately 10 years apart using ULTRACAM and HiPERCAM, respectively. The ULTRACAM light curves confirm the previously reported asymmetry in which the leading hemisphere of the companion star appears to be brighter than the trailing hemisphere. The HiPERCAM light curves, however, do not show this asymmetry, demonstrating that whatever mechanism is responsible for it varies on timescales of a decade or less. We fit the symmetrical HiPERCAM light curves with a direct-heating model to derive the system parameters, finding an orbital inclination of $55.9^{+4.8}_{-4.1}$ degrees, in good agreement with radio-eclipse constraints. We find that approximately half of the pulsar's spin-down energy is converted to optical luminosity, resulting in temperatures ranging from approximately $5150^{+190}_{-190}$ K on the day side to $2750^{+130}_{-150}$ K on the night side of the companion star. The companion star is close to filling its Roche lobe ($f_{\rm RL} =0.88^{+0.02}_{-0.02}$) and has a mass of $0.039^{+0.010}_{-0.011}$ M$_{\odot}$, giving a mean density of $20.24^{+0.59}_{-0.44}$ g cm$^{-3}$ and an apsidal motion constant in the range $0.0036 < k_2 < 0.0047$. The companion mass and mean density values are consistent with those of brown dwarfs, but the apsidal motion constant implies a significantly more centrally-condensed internal structure than is typical for such objects., Comment: 10 pages, 4 figures, 3 tables, accepted for publication in Monthly Notices of the Royal Astronomical Society
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- 2022
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32. Dust emissivity in resolved spiral galaxies
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Bianchi, S., Casasola, V., Corbelli, E., Galliano, F., Magrini, L., Nersesian, A., Salvestrini, F., Baes, M., Cassara, L. P., Clark, C. J. R., De Looze, I., Jones, A. P., Madden, S. C., Mosenkov, A., and Ysard, N.
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Astrophysics - Astrophysics of Galaxies - Abstract
Context: The far-infrared (FIR) and sub-millimeter (submm) emissivity of the Milky Way (MW) cirrus is an important benchmark for dust grain models. Dust masses in other galaxies are generally derived from the FIR/submm using the emission properties of these MW-calibrated models. Aims: We seek to derive the FIR/submm emissivity in nine nearby spiral galaxies to check its compatibility with MW cirrus measurements. Methods: We obtained values of the emissivity at 70 to 500 um, using maps of dust emission from the Herschel satellite and of gas surface density from the THINGS and HERACLES surveys on a scale generally corresponding to 440 pc. We studied the variation of the emissivity with the surface brightness ratio I(250um)/I(500um), a proxy for the intensity of the interstellar radiation field heating the dust. Results: We find that the average value of the emissivity agrees with MW estimates for pixels sharing the same color as the cirrus, namely, for I(250um)/I(500um) = 4.5. For I(250um)/I(500um) > 5, the measured emissivity is instead up to a factor ~2 lower than predicted from MW dust models heated by stronger radiation fields. Regions with higher I(250um)/I(500um) are preferentially closer to the galactic center and have a higher overall (stellar+gas) surface density and molecular fraction. The results do not depend strongly on the adopted CO-to-molecular conversion factor and do not appear to be affected by the mixing of heating conditions. Conclusions: Our results confirm the validity of MW dust models at low density, but are at odds with predictions for grain evolution in higher density environments. If the lower-than-expected emissivity at high I(250um)/I(500um) is the result of intrinsic variations in the dust properties, it would imply an underestimation of the dust mass surface density of up to a factor ~2 when using current dust models., Comment: 16 pages, 11 figures, A&A accepted
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- 2022
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33. A Gamma-ray Pulsar Timing Array Constrains the Nanohertz Gravitational Wave Background
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Ajello, M., Atwood, W. B., Baldini, L., Ballet, J., Barbiellini, G., Bastieri, D., Bellazzini, R., Berretta, A., Bhattacharyya, B., Bissaldi, E., Blandford, R. D., Bloom, E., Bonino, R., Bruel, P., Buehler, R., Burns, E., Buson, S., Cameron, R. A., Caraveo, P. A., Cavazzuti, E., Cibrario, N., Ciprini, S., Clark, C. J., Cognard, I., Coronado-Blázquez, J., Crnogorcevic, M., Cromartie, H., Crowter, K., Cutini, S., D'Ammando, F., Gaetano, S. D., Palma, F. d., Digel, S. W., Lalla, N. D., Dirirsa, F. Fan., Venere, L. D., Domínguez, A., Ferrara, E. C., Fiori, A., Franckowiak, A., Fukazawa, Y., Funk, S., Fusco, P., Gammaldi, V., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Giroletti, M., Green, D., Grenier, I. A., Guillemot, L., Guiriec, S., Gustafsson, M., Harding, A. K., Hays, E., Hewitt, J. W., Horan, D., Hou, X., Jóhannesson, G., Keith, M. J., Kerr, M., Kramer, M., Kuss, M., Larsson, S., Latronico, L., Li, J., Longo, F., Loparco, F., Lovellette, M. N., Lubrano, P., Maldera, S., Manfreda, A., Martí-Devesa, G., Mazziotta, M. N., Mereu, I., Michelson, P. F., Mirabal, N., Mitthumsiri, W., Mizuno, T., Monzani, M. E., Morselli, A., Negro, M., Nieder, L., Ojha, R., Omodei, N., Orienti, M., Orlando, E., Ormes, J. F., Paneque, D., Parthasarathy, A., Pei, Z., Persic, M., Pesce-Rollins, M., Pillera, R., Poon, H., Porter, T. A., Principe, G., Racusin, J. L., Rainò, S., Rando, R., Rani, B., Ransom, S. M., Ray, P. S., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Roy, J., Sánchez-Conde, M., Parkinson, P. M. Sa., Scargle, J., Scotton, L., Serini, D., Sgrò, C., Siskind, E. J., Smith, D. A., Spandre, G., Spiewak, R., Spinelli, P., Stairs, I., Suson, D. J., Swihart, S. J., Tabassum, S., Thayer, J. B., Theureau, G., Torres, D. F., Troja, E., Valverde, J., Wadiasingh, Z., Wood, K., and Zaharijas, G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
After large galaxies merge, their central supermassive black holes are expected to form binary systems whose orbital motion generates a gravitational wave background (GWB) at nanohertz frequencies. Searches for this background utilize pulsar timing arrays, which perform long-term monitoring of millisecond pulsars (MSPs) at radio wavelengths. We use 12.5 years of Fermi Large Area Telescope data to form a gamma-ray pulsar timing array. Results from 35 bright gamma-ray pulsars place a 95\% credible limit on the GWB characteristic strain of $1.0\times10^{-14}$ at 1 yr$^{-1}$, which scales as the observing time span $t_{\mathrm{obs}}^{-13/6}$. This direct measurement provides an independent probe of the GWB while offering a check on radio noise models., Comment: 3 figures in the main text. 3 figures and 8 tables are in the supplementary material
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- 2022
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34. Irradiated but not eclipsed, the case of PSR J0610-2100
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van der Wateren, E., Bassa, C. G., Clark, C. J., Breton, R. P., Cognard, I., Guillemot, L., Janssen, G. H., Lyne, A. G., Stappers, B. W., and Theureau, G.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report on radio timing observations of the black widow binary pulsar J0610$-$2100 and optical observations of its binary companion. The radio timing observations extend the timing baseline to 16yr and reveal a marginal detection of the orbital period derivative, but they show no significant evidence of orbital variations such as those seen in other black widow pulsars. Furthermore, no eclipses are seen in the observations at observing frequencies ranging from 310 to 2700MHz. The optical VRI light curves were modulated with the orbital period, reaching maximum brightness of $V=26.8$, $R=25.4$, and $I=23.8$ at superior conjunction of the companion, confirming irradiation of the companion by the pulsar. Modelling the light curves indicates that the companion is likely not filling its Roche lobe, while having a moderate inclination ($i > 54\degr$). We find an unusually low temperature and a low irradiation for the irradiated hemisphere of the companion. We investigate the absence of radio eclipses in PSR J0610-2100 and in other black widow systems in relation to their binary, pulsar, and companion properties. We also discuss the suitability of PSR J0610-2100 for pulsar timing array observations aimed at detecting nano-Hertz gravitational waves., Comment: 9 pages, 5 figures, accepted for publication by A&A
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- 2022
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35. “Doctor, What Would You do if You Were Me?” - A Survey of Physician Perspectives Toward Glioblastoma Resection
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Wilson, Bayard, Peterson, Crina M., Wei, Hua, Ying, Mao, Bartek, Jiri, and Chen, Clark C.
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- 2024
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36. FACTFINDERS FOR PATIENT SAFETY: Minimizing risks with cervical epidural injections
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Holder, Eric K., Lee, Haewon, Raghunandan, Aditya, Marshall, Benjamin, Michalik, Adam, Nguyen, Minh, Saffarian, Mathew, Schneider, Byron J., Smith, Clark C., Tiegs-Heiden, Christin A., Zheng, Patricia, Patel, Jaymin, and Levi, David
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- 2024
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37. Is the black-widow pulsar PSR J1555-2908 in a hierarchical triple system?
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Nieder, L., Kerr, M., Clark, C. J., Bruel, P., Cromartie, H. T., Ransom, S. M., and Ray, P. S.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The 559 Hz black-widow pulsar PSR J1555-2908, originally discovered in radio, is also a bright gamma-ray pulsar. Timing its pulsations using 12 yr of Fermi-LAT gamma-ray data reveals long-term variations in its spin frequency that are much larger than is observed from other millisecond pulsars. While this variability in the pulsar rotation rate could be intrinsic "timing noise", here we consider an alternative explanation: the variations arise from the presence of a very-low-mass third object in a wide multi-year orbit around the neutron star and its low-mass companion. With current data, this hierarchical-triple-system model describes the pulsar's rotation slightly more accurately than the best-fitting timing-noise model. Future observations will show if this alternative explanation is correct., Comment: 6 pages, 2 figures, submitted to ApJL
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- 2022
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38. METAL: The Metal Evolution, Transport, and Abundance in the Large Magellanic Cloud Hubble program. III. Interstellar Depletions, Dust-to-Metal, and Dust-to-Gas Ratios Versus Metallicity
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Roman-Duval, J., Jenkins, E. B., Tchernyshyov, K., Clark, C. J. R., De Cia, A., Gordon, K. D., Hamanowicz, A., Lebouteiller, V., Rafelski, M., Sandstrom, K., Werk, J., and Merica-Jones, P. Yanchulova
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Astrophysics - Astrophysics of Galaxies - Abstract
The metallicity and gas density dependence of interstellar depletions, the dust-to-gas (D/G), and dust-to-metal (D/M) ratios have important implications for how accurately we can trace the chemical enrichment of the universe; either by using FIR dust emission as a tracer of the ISM; or by using spectroscopy of damped Lyman-alpha systems (DLAs) to measure chemical abundances over a wide range of redshifts. We collect and compare large samples of depletion measurements in the Milky Way (MW), LMC (Z=0.5 Zsun), and SMC (Z=0.2 Zsun). The relation between the depletions of different elements do not strongly vary between the three galaxies, implying that abundance ratios should trace depletions accurately down to 20% solar metallicity. From the depletions, we derive D/G and D/M. The D/G increases with density, consistent with the more efficient accretion of gas-phase metals onto dust grains in the denser ISM. For log N(H) > 21 cm^-2, the depletion of metallicity tracers (S, Zn) exceeds -0.5 dex, even at 20% solar metallicity. The gas fraction of metals increases from the MW to the LMC (factor 3) and SMC (factor 6), compensating the reduction in total heavy element abundances and resulting in those three galaxies having the same neutral gas-phase metallicities. The D/G derived from depletions are a factor of 2 (LMC) and 5 (SMC) higher than the D/G derived from FIR, 21 cm, and CO emission, likely due to the combined uncertainties on the dust FIR opacity and on the depletion of carbon and oxygen., Comment: 26 pages, 12 figures
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- 2022
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39. Measuring the mass of the black widow PSR J1555-2908
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Kennedy, M. R., Breton, R. P., Clark, C. J., Mata-Sanchez, D., Voisin, G., Dhillon, V. S., Halpern, J. P., Marsh, T. R., Nieder, L., Ray, P. S., and van Kerkwijk, M. H.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Accurate measurements of the masses of neutron stars are necessary to test binary evolution models, and to constrain the neutron star equation of state. In pulsar binaries with no measurable post-Keplerian parameters, this requires an accurate estimate of the binary system's inclination and the radial velocity of the companion star by other means than pulsar timing. In this paper, we present the results of a new method for measuring this radial velocity using the binary synthesis code Icarus. This method relies on constructing a model spectrum of a tidally distorted, irradiated star as viewed for a given binary configuration. This method is applied to optical spectra of the newly discovered black widow PSR J1555-2908. By modelling the optical spectroscopy alongside optical photometry, we find that the radial velocity of the companion star is $397\pm4$ km s$^{-1}$ (errors quoted at 95\% confidence interval), as well as a binary inclination of $>75^{\rm o}$. Combined with $\gamma$-ray pulsation timing information, this gives a neutron star mass of 1.67$^{+0.15}_{-0.09}$ M$_\odot$ and a companion mass of 0.060$^{+0.005}_{-0.003}$ M$_\odot$, placing PSR J1555-2908 at the observed upper limit of what is considered a black widow system., Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society. 15 pages, 7 Figures. Underlying data available at https://zenodo.org/record/5653061
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- 2022
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40. The effect of Mediterranean diet on inflammatory biomarkers and components of metabolic syndrome in adolescent girls
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Asoudeh, F., Fallah, M., Aminianfar, A., Djafarian, K., Shirzad, N., Clark, C. C. T., Larijani, B., and Esmaillzadeh, A.
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- 2023
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41. Modeling atom interferometry experiments with Bose-Einstein condensates in power-law potentials
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Thomas, S., Sapp, C., Henry, C., Smith, A., Sackett, C. A., Clark, C. W., and Edwards, M.
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Condensed Matter - Quantum Gases ,Quantum Physics - Abstract
Recent atom interferometry (AI) experiments involving Bose--Einstein condensates (BECs) have been conducted under extreme conditions of volume and interrogation time. Numerical solution of the standard mean-field theory applied to these experiments presents a nearly intractable challenge. We present an approximate variational model that provides rapid approximate solutions of the rotating-frame Gross--Pitaevskii equation for a power-law potential. This model is well-suited to the design and analysis of AI experiments involving BECs that are split and later recombined to form an interference pattern. We derive the equations of motion of the variational parameters for this model and illustrate how the model can be applied to the sequence of steps in a recent AI experiment where BECs were used to implement a dual-Sagnac atom interferometer rotation sensor. We use this model to investigate the impact of finite-size and interaction effects on the single-Sagnac-interferometer phase shift., Comment: 22 pages, 3 figures
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- 2021
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42. Population trends in an endemic dwarf succulent over two decades: rainfall, elevation, microsite and landuse effects
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Milton, S.J., Clark, C., Hundermark, C.R., Hurt, C., and Van der Merwe, H.
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- 2024
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43. Differentiation of regioisomeric N-substituted meta-chlorophenylpiperazine derivatives
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Randall Clark, C., Almaghrabi, Mohammed, Dhanasakaran, Murali, DeRuiter, Jack, and Abiedalla, Younis
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- 2024
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44. FACTFINDERS for PATIENT SAFETY: Preventing procedure-related complications: Epidural lipomatosis and postpartum steroid exposure
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D'Souza, Ryan S., Zheng, Patricia, Christolias, George, Holder, Eric K., Lee, Haewon, Miller, David C., Raghunandan, Aditya, Smith, Clark C., and Patel, Jaymin
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- 2024
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45. Revealing the diversity of internal body temperature and panting response for feedlot cattle under environmental thermal stress
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Islam, M. A., Lomax, S., Doughty, A. K., Islam, M. R., Thomson, P. C., and Clark, C. E. F.
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- 2023
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46. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial
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Nassiri, Farshad, Patil, Vikas, Yefet, Leeor S., Singh, Olivia, Liu, Jeff, Dang, Rachel M. A., Yamaguchi, Takafumi N., Daras, Mariza, Cloughesy, Timothy F., Colman, Howard, Kumthekar, Priya U., Chen, Clark C., Aiken, Robert, Groves, Morris D., Ong, Shirley S., Ramakrishna, Rohan, Vogelbaum, Michael A., Khagi, Simon, Kaley, Thomas, Melear, Jason M., Peereboom, David M., Rodriguez, Analiz, Yankelevich, Maxim, Nair, Suresh G., Puduvalli, Vinay K., Aldape, Kenneth, Gao, Andrew, López-Janeiro, Álvaro, de Andrea, Carlos E., Alonso, Marta M., Boutros, Paul, Robbins, Joan, Mason, Warren P., Sonabend, Adam M., Stupp, Roger, Fueyo, Juan, Gomez-Manzano, Candelaria, Lang, Frederick F., and Zadeh, Gelareh
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- 2023
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47. The ClearPoint Array Frame: An MRI Compatible System that Supports Non-craniotomy, Multi-trajectory (NCMT) Stereotactic Procedures
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Hamade, Youssef J., Dharnipragada, Rajiv, and Chen, Clark C.
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- 2024
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48. Identifying critical quality metrics in Mohs Surgery: A national expert consensus process
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Dodson, Joseph A., Ibrahim, Sarah A., Rogers, Howard, Council, M. Laurin, Nehal, Kishwer S., Tung, Rebecca, Leffell, David J., Zeitouni, Nathalie C., Totonchy, Mariam B., Fosko, Scott W., Lee Soon, Seaver, Blalock, Travis W., Brodland, David G., Billingsley, Elizabeth M., Scott, Jeffrey F., Leach, Brian C., Ratner, Desiree, Washington, Carl, Hanke, C. William, Otley, Clark C., Golda, Nicholas, Nijhawan, Rajiv I., Brewer, Jerry, Demer, Addison, Fish, Frederick, Harmon, Christopher B., Zitelli, John, Knackstedt, Thomas, Singh, Gaurav, Mollet, Todd, Carr, David R., Albertini, John G., Moody, Brent R., McDonald, Michel, Bordeaux, Jeremy S., Massey, Paul R., MacCormack, Mollie A., Vidimos, Allison, Arpey, Christopher J., Arron, Sarah T., Ibrahimi, Omar A., Jiang, S. Brian, Miller, Christopher J., Maher, Ian A., Wysong, Ashley, Leshin, Barry, Goldman, Glenn D., Kibbi, Nour, Feng, Hao, and Collins, Lindsey
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- 2024
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49. Using a birth ball to reduce pain perception in the latent phase of labour: a randomised controlled trial
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Mylod, D.C.M., Hundley, V., Way, S., and Clark, C.
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- 2024
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50. FactFinders for patient safety: Delaying epidural steroid injections: Infection and safe platelet cutoff
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Zheng, Patricia, Hao, David, Christolias, George, Marshall, Ben, Smith, Clark C., Sudhakaran, Shaan, Patel, Jaymin, and McCormick, Zachary L.
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- 2024
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