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Your search keyword '"Coccia, Eliana Marina"' showing total 6 results
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6 results on '"Coccia, Eliana Marina"'

3. Functional diversification of innate and inflammatory immune responses mediated by antibody Fc activities against SARS-CoV-2

Author

Severa, Martina, primary, Etna, Marilena Paola, additional, Andreano, Emanuele, additional, Ricci, Daniela, additional, Cairo, Giada, additional, Fiore, Stefano, additional, Canitano, Andrea, additional, Cara, Andrea, additional, Stefanelli, Paola, additional, Rappuoli, Rino, additional, Palamara, Anna Teresa, additional, and Coccia, Eliana Marina, additional

Published
2024
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4. A specific anti‐COVID‐19 BNT162b2 vaccine‐induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients

Author

Severa, Martina, primary, Rizzo, Fabiana, additional, Sinigaglia, Alessandro, additional, Ricci, Daniela, additional, Etna, Marilena Paola, additional, Cola, Gaia, additional, Landi, Doriana, additional, Buscarinu, Maria Chiara, additional, Valdarchi, Catia, additional, Ristori, Giovanni, additional, Riccetti, Silvia, additional, Piubelli, Chiara, additional, Palmerini, Pierangela, additional, Rosato, Antonio, additional, Gobbi, Federico, additional, Balducci, Stefano, additional, Marfia, Girolama Alessandra, additional, Salvetti, Marco, additional, Barzon, Luisa, additional, and Coccia, Eliana Marina, additional

Published
2023
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6. A Serum Multi-Parametric Analysis Identifies an Early Innate Immune Signature Associated to Increased Vaccine-Specific Antibody Production and Seroconversion in Simultaneous COVID-19 mRNA and Cell-Based Quadrivalent Influenza Vaccination.

Author

Severa M, Ricci D, Etna MP, Facchini M, Puzelli S, Fedele G, Iorio E, Cairo G, Castrechini S, Ungari V, Iannetta M, Leone P, Chirico M, Pisanu ME, Bottazzi B, Benedetti L, Sali M, Bartolomucci R, Balducci S, Garlanda C, Stefanelli P, Spadea A, Palamara AT, and Coccia EM

Abstract

In this pilot study, a multi-parametric analysis comparing immune responses in sera of adult healthy subjects (HS) or people with type 2 diabetes mellitus (T2D) undergoing the single or simultaneous administration of mRNA-based COVID-19 and cellular quadrivalent inactivated influenza vaccines was conducted. While SARS-CoV-2 antibodies remains comparable, influenza antibody titers and seroconversion were significantly higher upon simultaneous vaccination. Magnitude of anti-influenza humoral response closely correlated with an early innate immune signature, previously described for the COVID-19 vaccine, composed of IL-15, IL-6, TNF-α, IFN-γ, CXCL-10 and here extended also to acute-phase protein Pentraxin 3. People with T2D receiving simultaneous vaccination showed a protective response comparable to HS correlating with the early induction of IFN-γ/CXCL10 and a significant reduction of the circulating glucose level due to increased oxidation of glucose digestion and consumption. These data, although preliminary and in-need of validation in larger cohorts, might be exploited to optimize future vaccination in people with chronic disorders, including diabetes.

Published
2024
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