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29 results on '"Corradini, Roberto"'

2. Discovery of a Peptide Nucleic Acid (PNA) aptamer for cardiac troponin I: Substituting DNA with neutral PNA maintains picomolar affinity and improves performances for electronic sensing with graphene field-effect transistors (gFET)

Author

Rodrigues, Teresa, Curti, Federica, Leroux, Yann R., Barras, Alexandre, Pagneux, Quentin, Happy, Henri, Kleber, Christoph, Boukherroub, Rabah, Hasler, Roger, Volpi, Stefano, Careri, Maria, Corradini, Roberto, Szunerits, Sabine, and Knoll, Wolfgang

Published
2023
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4. Supramolecular Nucleic Acid-Based Organosilica Nanoparticles Responsive to Physical and Biological Inputs

Author

Picchetti, Pierre, primary, Volpi, Stefano, additional, Sancho-Albero, María, additional, Rossetti, Marianna, additional, Dore, Michael D., additional, Trinh, Tuan, additional, Biedermann, Frank, additional, Neri, Martina, additional, Bertucci, Alessandro, additional, Porchetta, Alessandro, additional, Corradini, Roberto, additional, Sleiman, Hanadi, additional, and De Cola, Luisa, additional

Published
2023
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5. Responsive Nucleic Acid-Based Organosilica Nanoparticles

Author

Picchetti, Pierre, primary, Volpi, Stefano, additional, Rossetti, Marianna, additional, Dore, Michael D., additional, Trinh, Tuan, additional, Biedermann, Frank, additional, Neri, Martina, additional, Bertucci, Alessandro, additional, Porchetta, Alessandro, additional, Corradini, Roberto, additional, Sleiman, Hanadi, additional, and De Cola, Luisa, additional

Published
2023
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7. Supplementary Figure 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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8. Supplementary Figure 2 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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9. CCR Translation for This Article from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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10. Supplementary Figure 3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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11. Supplementary Figure 6 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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12. Supplementary Tables 1-3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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13. Supplementary Tables 6-7 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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14. Supplementary Figure 4 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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15. Supplementary Materials and Methods from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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16. Supplementary Figure 1 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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17. Supplementary Table 4 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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18. Supplementary Table 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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19. MicroRNAs miR-584-5p and miR-425-3p Are Up-Regulated in Plasma of Colorectal Cancer (CRC) Patients: Targeting with Inhibitor Peptide Nucleic Acids Is Associated with Induction of Apoptosis in Colon Cancer Cell Lines

Author

Gasparello, Jessica, primary, Papi, Chiara, additional, Zurlo, Matteo, additional, Gambari, Laura, additional, Manicardi, Alex, additional, Rozzi, Andrea, additional, Ferrarini, Matteo, additional, Corradini, Roberto, additional, Gambari, Roberto, additional, and Finotti, Alessia, additional

Published
2022
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20. Combined Treatment of Bronchial Epithelial Calu-3 Cells with Peptide Nucleic Acids Targeting miR-145-5p and miR-101-3p: Synergistic Enhancement of the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene

Author

Papi, Chiara, primary, Gasparello, Jessica, additional, Zurlo, Matteo, additional, Manicardi, Alex, additional, Corradini, Roberto, additional, Cabrini, Giulio, additional, Gambari, Roberto, additional, and Finotti, Alessia, additional

Published
2022
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25. MicroRNAs miR-584-5p and miR-425-3p Are Up-Regulated in Plasma of Colorectal Cancer (CRC) Patients: Targeting with Inhibitor Peptide Nucleic Acids Is Associated with Induction of Apoptosis in Colon Cancer Cell Lines.

Author

Gasparello, Jessica, Papi, Chiara, Zurlo, Matteo, Gambari, Laura, Manicardi, Alex, Rozzi, Andrea, Ferrarini, Matteo, Corradini, Roberto, Gambari, Roberto, and Finotti, Alessia

Subjects
FUNCTIONAL foods, BIOPSY, SEQUENCE analysis, MICRORNA, APOPTOSIS, ANTINEOPLASTIC agents, COLORECTAL cancer, CELLULAR signal transduction, CELL lines, NUCLEIC acids
Abstract

Simple Summary: Starting from a list of nine miRNAs found to be dysregulated in the bloodstream of early-stage colon cancer (CRC) patients, the biological effects of the targeting of the most relevant up-regulated miRNAs with anti-miRNA peptide nucleic acids (PNAs) were verified. The down-regulation of these target miRNAs with PNAs is associated with apoptosis induction in CRC cellular models. Apoptosis induction, which is one of the most important anticancer mechanisms, reaches very high levels when anti-miRNAs PNAs are combined with other pro-apoptotic compounds such as sulforaphane. Liquid biopsy has dramatically changed cancer management in the last decade; however, despite the huge number of miRNA signatures available for diagnostic or prognostic purposes, it is still unclear if dysregulated miRNAs in the bloodstream could be used to develop miRNA-based therapeutic approaches. In one author's previous work, nine miRNAs were found to be dysregulated in early-stage colon cancer (CRC) patients by NGS analysis followed by RT-dd-PCR validation. In the present study, the biological effects of the targeting of the most relevant dysregulated miRNAs with anti-miRNA peptide nucleic acids (PNAs) were verified, and their anticancer activity in terms of apoptosis induction was evaluated. Our data demonstrate that targeting bloodstream up-regulated miRNAs using anti-miRNA PNAs leads to the down-regulation of target miRNAs associated with inhibition of the activation of the pro-apoptotic pathway in CRC cellular models. Moreover, very high percentages of apoptotic cells were found when the anti-miRNA PNAs were associated with other pro-apoptotic agents, such as sulforaphane (SFN). The presented data sustain the idea that the targeting of miRNAs up-regulated in the bloodstream with a known role in tumor pathology might be a tool for the design of protocols for anti-tumor therapy based on miRNA-targeting molecules. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Discovery of a Peptide Nucleic Acid (Pna) Aptamer for Cardiac Troponin I: Substituting DNA with Neutral Pna Maintains Picomolar Affinity and Improves Performances in Graphene Field-Effect Transistors (Gfet)

Author

Rodrigues, Teresa, primary, Curti, Federica, additional, Leroux, Yann R., additional, Barras, Alexandre, additional, Pagneux, Quentin, additional, Happy, Henri, additional, Kleber, Christoph, additional, Boukherroub, Rabah, additional, Volpi, Stefan, additional, Cereri, Maria, additional, Corradini, Roberto, additional, Szunerits, Sabine, additional, and Knoll, Wolfgang, additional

Published
2022
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