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Your search keyword '"Corzo, Gerardo"' showing total 28 results
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28 results on '"Corzo, Gerardo"'

6. Indolealkylamines in the venom of the scorpion Thorellius intrepidus

Author

Ibarra-Vega, Rodrigo, Jiménez-Vargas, Juana María, Pineda-Contreras, Armando, Martínez-Martínez, Francisco Javier, Barajas-Saucedo, Carlos Eduardo, García-Ortega, Héctor, Magaña-Vergara, Nancy E., Possani, Lourival D., Corzo, Gerardo, Gaitan-Hinojosa, Mario Alberto, Vázquez-Vuelvas, Oscar Fernando, Zamudio, Fernando, and Valdez-Velazquez, Laura Leticia

Published
2023
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10. Proteomic Analysis of Heloderma horridum horridum Venom: Assessment to Its Transcriptome and Newfound Proteins.

Author

Lino-López, Gisela J., Ruiz-May, Eliel, Elizalde-Contreras, José M., Jiménez-Vargas, Juana M., Rodríguez-Vázquez, Armando, González-Carrillo, Gabino, Bojórquez-Velázquez, Esaú, García-Villalvazo, Patricia E., Bermúdez-Guzmán, Manuel de J., Zatarain-Palacios, Rocio, Vázquez-Vuelvas, Oscar F., Valdez-Velázquez, Laura L., and Corzo, Gerardo

Published
2024
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11. Immunological Cross-Reactivity and Preclinical Assessment of a Colombian Anticoral Antivenom against the Venoms of Three Micrurus Species

Author

Rodríguez-Vargas, Ariadna, primary, Franco-Vásquez, Adrián Marcelo, additional, Triana-Cerón, Miguel, additional, Alam-Rojas, Shaha Noor, additional, Escobar-Wilches, Derly C., additional, Corzo, Gerardo, additional, Lazcano-Pérez, Fernando, additional, Arreguín-Espinosa, Roberto, additional, and Ruiz-Gómez, Francisco, additional

Published
2024
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13. Structural, biochemical and immunochemical characterization of an acidic phospholipase A2 from Lachesis acrochorda (Viperidae: Crotalinae) venom

Author

Franco-Vásquez, Adrián Marcelo, primary, Lazcano-Pérez, Fernando, additional, Mejía-Sánchez, Miguel Angel, additional, Corzo, Gerardo, additional, Zamudio, Fernando, additional, Carbajal-Saucedo, Alejandro, additional, Román-González, Sergio Agustín, additional, Gómez-Manzo, Saúl, additional, and Arreguín-Espinosa, Roberto, additional

Published
2023
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15. Identification and Venom Characterization of Two Scorpions from the State of Chihuahua Mexico: Chihuahuanus coahuliae and Chihuahuanus crassimannus

Author

Alvarado-Gonzalez, Carolina, primary, Clement, Herlinda, additional, Ballinas-Casarrubias, Lourdes, additional, Escarcega-Avila, Angelica, additional, Arenas-Sosa, Ivan, additional, Lopez-Contreras, Karla Sofia, additional, Zamudio, Fernando, additional, Corzo, Gerardo, additional, and Espino-Solis, Gerardo Pavel, additional

Published
2023
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19. Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens

Author

Santana, Felix L., primary, Estrada, Karel, additional, Alford, Morgan A., additional, Wu, Bing C., additional, Dostert, Melanie, additional, Pedraz, Lucas, additional, Akhoundsadegh, Noushin, additional, Kalsi, Pavneet, additional, Haney, Evan F., additional, Straus, Suzana K., additional, Corzo, Gerardo, additional, and Hancock, Robert E. W., additional

Published
2022
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24. Discovery of human Hv1 channel peptide inhibitors

Author

Fehér, Ádám, primary, Borrego, Jesús, additional, Cardoso-Arenas, Samuel, additional, Arenas, Iván, additional, Clement, Herlinda, additional, Corzo, Gerardo, additional, Panyi, Gyorgy, additional, Varga, Zoltan, additional, and Papp, Ferenc, additional

Published
2022
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26. Proteomic Analysis of Heloderma horridum horridumVenom: Assessment to Its Transcriptome and Newfound Proteins

Author

Lino-López, Gisela J., Ruiz-May, Eliel, Elizalde-Contreras, José M., Jiménez-Vargas, Juana M., Rodríguez-Vázquez, Armando, González-Carrillo, Gabino, Bojórquez-Velázquez, Esaú, García-Villalvazo, Patricia E., Bermúdez-Guzmán, Manuel de J., Zatarain-Palacios, Rocio, Vázquez-Vuelvas, Oscar F., Valdez-Velázquez, Laura L., and Corzo, Gerardo

Abstract

Heloderma horridumhorridum, a venomous reptile native to America, has a venom with potential applications in treating type II diabetes. In this work, H. h. horridumvenom was extracted, lyophilized, and characterized using enzymatic assays for hyaluronidase, phospholipase, and protease. Proteomic analysis of the venom was conducted employing bottom-up/shotgun approaches, SDS-PAGE, high-pH reversed-phase chromatography, and fractionation of tryptic peptides using nano-LC-MS/MS. The proteins found in H. h. horridumvenom were reviewed according to the classification of the transcriptome previously reported. The proteomic approach identified 101 enzymes, 36 other proteins, 15 protein inhibitors, 11 host defense proteins, and 1 toxin, including novel venom components such as calcium-binding proteins, phospholipase A2 inhibitors, serpins, cathepsin, subtilases, carboxypeptidase-like, aminopeptidases, glycoside hydrolases, thioredoxin transferases, acid ceramidase-like, enolase, multicopper oxidases, phosphoglucose isomerase (PGI), fructose-1,6-bisphosphatase class 1, pentraxin-related, peptidylglycine α-hydroxylating monooxygenase/peptidyl-hydroxyglycine α-amidating lyase, carbonic anhydrase, acetylcholinesterase, dipeptidylpeptidase, and lysozymes. These findings contribute to understanding the venomous nature of H. h. horridumand highlight its potential as a source of bioactive compounds. Data are available via PRoteomeXchange with the identifier PXD052417.

Published
2024
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27. Cupiennius spiders (Trechaleidae) from southern Mexico: DNA barcoding, venomics, and biological effect.

Author

Padilla-Villavicencio M, Corzo G, Guillén-Navarro K, Ibarra-Núñez G, Arenas I, Zamudio F, and Diego-García E

Abstract

Background: Members of the genus Cupiennius Simon, 1891 are categorized as wandering spiders and are part of the family Trechaleidae. The genomics and proteomics of Cupiennius spiders from North America remain uncharacterized. The present study explores for the first time molecular data from the endemic species Cupiennius chiapanensis Medina, 2006, and also presents new data for Cupiennius salei (Keyserling, 1878), both collected in southern Mexico., Methods: In total, 88 Cupiennius specimens were collected from southern Mexico and morphologically identified. DNA was extracted and the mitochondrial COI fragment was amplified. COI sequences were analyzed, and a phylogenetic tree was inferred for species from the Americas. Genetic diversity was analyzed using haplotype networks and gene distances. Venom was obtained from C. chiapanensis and C. salei by electrostimulation. The venom was separated by HPLC, visualized using SDS-PAGE, and quantified for use in toxicity bioassays in mice and insects., Results: Analysis of COI sequences from C. chiapanensis showed 94% identity with C. salei , while C. salei exhibited 94-97% identity with sequences from Central and South American conspecifics. The venom from C. chiapanensis exhibited toxic activity against crickets. Venoms from C. chiapanensis and C. salei caused death in Anastrepha obliqua flies. Analysis of venom fractions from C. salei and C. chiapanensis revealed molecular masses of a similar size as some previously reported toxins and neurotoxic components. We determined the amino acid sequences of ChiaTx1 and ChiaTx2, toxins that are reported here for the first time and which showed toxicity against mice and insects., Conclusion: Our work is the first to report COI-based DNA barcoding sequences from southern Mexican Cupiennius spiders. Compounds with toxic activity were identified in venom from both species., Competing Interests: Competing interests: The authors declare that they have no competing interests.

Published
2024
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28. The Resilience of Pseudomonas aeruginosa to Antibiotics and the Designing of Antimicrobial Peptides to Overcome Microbial Resistance.

Author

Juárez-López D, Morales-Ruiz E, Herrera-Zúñiga LD, González-Carrera Z, Cuevas-Reyes E, Corzo G, Schcolnik-Cabrera A, and Villegas E

Subjects
Humans, Antimicrobial Peptides, Antimicrobial Cationic Peptides pharmacology, Bacteria, Microbial Sensitivity Tests, Anti-Bacterial Agents pharmacology, Pseudomonas aeruginosa
Abstract

Pseudomonas aeruginosa (P. aeruginosa) is a bacterium of medical concern known for its potential to persist in diverse environments due to its metabolic capacity. Its survival ability is linked to its relatively large genome of 5.5-7 Mbp, from which several genes are employed in overcoming conventional antibiotic treatments and promoting resistance. The worldwide prevalence of antibiotic-resistant clones of P. aeruginosa necessitates novel approaches to researching their multiple resistance mechanisms, such as the use of antimicrobial peptides (AMPs). In this review, we briefly discuss the epidemiology of the resistant strains of P. aeruginosa and then describe their resistance mechanisms. Next, we explain the biology of AMPs, enlist the present database platforms that describe AMPs, and discuss their usefulness and limitations in treating P. aeruginosa strains. Finally, we present 13 AMPs with theoretical action against P. aeruginosa, all of which we evaluated in silico in this work. Our results suggest that the AMPs we evaluated have a carpet-like mode of action with a membranolytic function in Gram-positive and Gramnegative bacteria, with a clear potential of synthesis for in vitro evaluation., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2022
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