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43 results on '"D'Angelo, Fulvio"'

1. Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm

Author

Wang, Lujia, Wang, Hairong, D'Angelo, Fulvio, Curtin, Lee, Sereduk, Christopher P., De Leon, Gustavo, Singleton, Kyle W., Urcuyo, Javier, Hawkins-Daarud, Andrea, Jackson, Pamela R., Krishna, Chandan, Zimmerman, Richard S., Patra, Devi P., Bendok, Bernard R., Smith, Kris A., Nakaji, Peter, Donev, Kliment, Baxter, Leslie C., Mrugała, Maciej M., Ceccarelli, Michele, Iavarone, Antonio, Swanson, Kristin R., Tran, Nhan L., Hu, Leland S., and Li, Jing

Subjects
Computer Science - Machine Learning, Computer Science - Computer Vision and Pattern Recognition, Mathematics - Optimization and Control
Abstract

Glioblastoma (GBM) is one of the most aggressive and lethal human cancers. Intra-tumoral genetic heterogeneity poses a significant challenge for treatment. Biopsy is invasive, which motivates the development of non-invasive, MRI-based machine learning (ML) models to quantify intra-tumoral genetic heterogeneity for each patient. This capability holds great promise for enabling better therapeutic selection to improve patient outcomes. We proposed a novel Weakly Supervised Ordinal Support Vector Machine (WSO-SVM) to predict regional genetic alteration status within each GBM tumor using MRI. WSO-SVM was applied to a unique dataset of 318 image-localized biopsies with spatially matched multiparametric MRI from 74 GBM patients. The model was trained to predict the regional genetic alteration of three GBM driver genes (EGFR, PDGFRA, and PTEN) based on features extracted from the corresponding region of five MRI contrast images. For comparison, a variety of existing ML algorithms were also applied. The classification accuracy of each gene was compared between the different algorithms. The SHapley Additive exPlanations (SHAP) method was further applied to compute contribution scores of different contrast images. Finally, the trained WSO-SVM was used to generate prediction maps within the tumoral area of each patient to help visualize the intra-tumoral genetic heterogeneity. This study demonstrated the feasibility of using MRI and WSO-SVM to enable non-invasive prediction of intra-tumoral regional genetic alteration for each GBM patient, which can inform future adaptive therapies for individualized oncology., Comment: 36 pages, 8 figures, 3 tables

Published
2023

2. Glioma progression is shaped by genetic evolution and microenvironment interactions

Author

Varn, Frederick S, Johnson, Kevin C, Martinek, Jan, Huse, Jason T, Nasrallah, MacLean P, Wesseling, Pieter, Cooper, Lee AD, Malta, Tathiane M, Wade, Taylor E, Sabedot, Thais S, Brat, Daniel, Gould, Peter V, Wöehrer, Adelheid, Aldape, Kenneth, Ismail, Azzam, Sivajothi, Santhosh K, Barthel, Floris P, Kim, Hoon, Kocakavuk, Emre, Ahmed, Nazia, White, Kieron, Datta, Indrani, Moon, Hyo-Eun, Pollock, Steven, Goldfarb, Christine, Lee, Ga-Hyun, Garofano, Luciano, Anderson, Kevin J, Nehar-Belaid, Djamel, Barnholtz-Sloan, Jill S, Bakas, Spyridon, Byrne, Annette T, D’Angelo, Fulvio, Gan, Hui K, Khasraw, Mustafa, Migliozzi, Simona, Ormond, D Ryan, Paek, Sun Ha, Van Meir, Erwin G, Walenkamp, Annemiek ME, Watts, Colin, Weiss, Tobias, Weller, Michael, Palucka, Karolina, Stead, Lucy F, Poisson, Laila M, Noushmehr, Houtan, Iavarone, Antonio, Verhaak, Roel GW, Consortium, The GLASS, Alfaro, Kristin D, Amin, Samirkumar B, Ashley, David M, Bock, Christoph, Brodbelt, Andrew, Bulsara, Ketan R, and Castro, Ana Valeria

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Brain Disorders, Brain Cancer, Genetics, Cancer, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Adult, Brain Neoplasms, Evolution, Molecular, Genes, p16, Glioma, Humans, Isocitrate Dehydrogenase, Mutation, Neoplasm Recurrence, Local, Tumor Microenvironment, GLASS Consortium, genomics, glioblastoma, glioma, hypermutation, macrophages, microenvironment, neurons, single-cell, spatial imaging, treatment resistance, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.

Published
2022

3. Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

Author

Hu, Leland S., D’Angelo, Fulvio, Weiskittel, Taylor M., Caruso, Francesca P., Fortin Ensign, Shannon P., Blomquist, Mylan R., Flick, Matthew J., Wang, Lujia, Sereduk, Christopher P., Meng-Lin, Kevin, De Leon, Gustavo, Nespodzany, Ashley, Urcuyo, Javier C., Gonzales, Ashlyn C, Curtin, Lee, Lewis, Erika M., Singleton, Kyle W., Dondlinger, Timothy, Anil, Aliya, Semmineh, Natenael B., Noviello, Teresa, Patel, Reyna A., Wang, Panwen, Wang, Junwen, Eschbacher, Jennifer M., Hawkins-Daarud, Andrea, Jackson, Pamela R., Grunfeld, Itamar S., Elrod, Christian, Mazza, Gina L., McGee, Sam C., Paulson, Lisa, Clark-Swanson, Kamala, Lassiter-Morris, Yvette, Smith, Kris A., Nakaji, Peter, Bendok, Bernard R., Zimmerman, Richard S., Krishna, Chandan, Patra, Devi P., Patel, Naresh P., Lyons, Mark, Neal, Matthew, Donev, Kliment, Mrugala, Maciej M., Porter, Alyx B., Beeman, Scott C., Jensen, Todd R., Schmainda, Kathleen M., Zhou, Yuxiang, Baxter, Leslie C., Plaisier, Christopher L., Li, Jing, Li, Hu, Lasorella, Anna, Quarles, C. Chad, Swanson, Kristin R., Ceccarelli, Michele, Iavarone, Antonio, and Tran, Nhan L.

Published
2023
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4. Integrated proteogenomic characterization of glioblastoma evolution

Author

Kim, Kyung-Hee, Migliozzi, Simona, Koo, Harim, Hong, Jun-Hee, Park, Seung Min, Kim, Sooheon, Kwon, Hyung Joon, Ha, Seokjun, Garofano, Luciano, Oh, Young Taek, D'Angelo, Fulvio, Kim, Chan Il, Kim, Seongsoo, Lee, Ji Yoon, Kim, Jiwon, Hong, Jisoo, Jang, Eun-Hae, Mathon, Bertrand, Di Stefano, Anna-Luisa, Bielle, Franck, Laurenge, Alice, Nesvizhskii, Alexey I., Hur, Eun-Mi, Yin, Jinlong, Shi, Bingyang, Kim, Youngwook, Moon, Kyung-Sub, Kwon, Jeong Taik, Lee, Shin Heon, Lee, Seung Hoon, Gwak, Ho Shin, Lasorella, Anna, Yoo, Heon, Sanson, Marc, Sa, Jason K., Park, Chul-Kee, Nam, Do-Hyun, Iavarone, Antonio, and Park, Jong Bae

Published
2024
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7. Quantifying intra-tumoral genetic heterogeneity of glioblastoma toward precision medicine using MRI and a data-inclusive machine learning algorithm

Author

Wang, Lujia, primary, Wang, Hairong, additional, D’Angelo, Fulvio, additional, Curtin, Lee, additional, Sereduk, Christopher P., additional, Leon, Gustavo De, additional, Singleton, Kyle W., additional, Urcuyo, Javier, additional, Hawkins-Daarud, Andrea, additional, Jackson, Pamela R., additional, Krishna, Chandan, additional, Zimmerman, Richard S., additional, Patra, Devi P., additional, Bendok, Bernard R., additional, Smith, Kris A., additional, Nakaji, Peter, additional, Donev, Kliment, additional, Baxter, Leslie C., additional, Mrugała, Maciej M., additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Swanson, Kristin R., additional, Tran, Nhan L., additional, Hu, Leland S., additional, and Li, Jing, additional

Published
2024
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8. First access to mental health services during COVID-19 pandemic: A multicenter study

Author

Eleonora Petri, Cristina Nardoni, Erika Fui, Elisa Gulino, Lachheb Abdelghani, Raffaele Barone, Paolo Angelo Fulvio Miragoli, Giuseppe Cardamone, and Agnese Ciberti

Subjects
Depression, Anxiety, post-traumatic, COVID-19, Pandemic, Mental health services, Mental healing, RZ400-408
Abstract

Background: The impact of the COVID-19 pandemic on mental health is complex and affects a broad segment of the population. Several studies indicate that depressive, anxious and post-traumatic symptoms are common in people exposed to SARS-Cov2.Methods: 458 subjects were recruited during their first consultation in outpatient psychiatric services between June 2020 and October 2021. Post-traumatic, depressive and anxious symptoms were assessed using the Impact of Event Scale-Revised (IES-R), the Beck Depression Inventory Scale-second edition (BDI-II), and the Self Rating Anxiety Scale (SAS). A specific set of questions was developed, with the aim of evaluating socio-demographic variables and work, environmental and personal characteristics related to the pandemic.Results: Prevalence rates of clinically significant depressive, anxious and post-traumatic symptoms were 57.6%, 63.5% and 54.8%, respectively. Female gender, worsening of relationship status and financial consequences due to the pandemic were the conditions most strongly associated with the presence of psychopathology.Limitation: The cross-sectional design of the study doesn't allow an evaluation over time of the sample. No assumption of causality can be made due to the lack of pre-pandemic assessments for the investigated variables.Conclusions: The impact of the pandemic involves depressive, anxious and post-traumatic dimensions. The investigated psychopathology correlates with several variables expressing the personal and environmental changes that occurred in the population due to the COVID-19 emergency. The study is multicentric and the recruitment of participants was held in a clinical setting, providing a realistic picture of the consequences of the pandemic in clinical practice within mental health services.

Published
2023
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10. Table S1 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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11. Supp Figures from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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12. Supplemental Figures Legends from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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13. Data from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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14. Supplementary Appendix from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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15. The epigenetic evolution of glioma is determined by the IDH1 mutation status and treatment regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., additional, Morosini, Natalia S., additional, Datta, Indrani, additional, Garofano, Luciano, additional, Vallentgoed, Wies R., additional, Varn, Frederick S., additional, Aldape, Kenneth, additional, D'Angelo, Fulvio, additional, Bakas, Spyridon, additional, Barnholtz-Sloan, Jill S., additional, Gan, Hui K., additional, Hasanain, Mohammad, additional, Hau, Ann-Christin, additional, Johnson, Kevin C., additional, Cazacu, Simona, additional, deCarvalho, Ana C., additional, Khasraw, Mustafa, additional, Kocakavuk, Emre, additional, Kouwenhoven, Mathilde C.M., additional, Migliozzi, Simona, additional, Niclou, Simone P., additional, Niers, Johanna M., additional, Ormond, D. Ryan., additional, Paek, Sun Ha, additional, Reifenberger, Guido, additional, Sillevis Smitt, Peter A., additional, Smits, Marion, additional, Stead, Lucy F., additional, van den Bent, Martin J., additional, Van Meir, Erwin G., additional, Walenkamp, Annemiek, additional, Weiss, Tobias, additional, Weller, Michael, additional, Westerman, Bart A., additional, Ylstra, Bauke, additional, Wesseling, Pieter, additional, Lasorella, Anna, additional, French, Pim J., additional, Poisson, Laila M., additional, Consortium, The GLASS, additional, Verhaak, Roel G.W., additional, Iavarone, Antonio, additional, and Noushmehr, Houtan, additional

Published
2023
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17. EPCO-27. RECONSTRUCTION OF THE SPATIAL ECOSYSTEM OF GLIOBLASTOMA REVEALS RECURRENT RELATIONSHIPS BETWEEN TUMOR CELL STATES AND TUMOR MICROENVIRONMENT

Author

Adabbo, Bruno, primary, Migliozzi, Simona, additional, Garofano, Luciano, additional, Oh, Young Taek, additional, Gultekin, Sakir H, additional, D'Angelo, Fulvio, additional, Roberts, Evan R, additional, Bilbao, Daniel C, additional, Davila, Pedro M, additional, Williams, Sion L, additional, Currall, Benjamin B, additional, Ceccarelli, Michele, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2023
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18. EPCO-37. DISSECTING GBM EVOLUTION FOLLOWING STANDARD-OF-CARE BY LARGE-SCALE LONGITUDINAL SINGLE NUCLEUS RNA-SEQUENCING

Author

Nomura, Masashi, primary, Spitzer, Avishay, additional, Johnson, Kevin, additional, Garofano, Luciano, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Alfred Yung, W K, additional, Lasorella, Anna, additional, Iavarone, Antonio, additional, Verhaak, Roel, additional, Suva, Mario, additional, and Tirosh, Itay, additional

Published
2023
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19. EPCO-09. CHARACTERIZING THE GBM CELLULAR LANDSCAPE BY LARGE-SCALE SINGLE-NUCLEUS RNA-SEQUENCING

Author

Spitzer, Avishay, primary, Nomura, Masashi, additional, Garofano, Luciano, additional, Johnson, Kevin, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Yung, W K Alfred, additional, Lasorella, Anna, additional, Verhaak, Roel, additional, Iavarone, Antonio, additional, Tirosh, Itay, additional, and Suva, Mario, additional

Published
2023
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20. Supplementary Tables S1-S3 from LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, primary, Oh, Young Taek, primary, D'Angelo, Fulvio, primary, Sommer, Danika, primary, Frangaj, Brulinda, primary, Tran, Suzanne, primary, Bielle, Franck, primary, Pollo, Bianca, primary, Paterra, Rosina, primary, Mokhtari, Karima, primary, Soni, Rajesh Kumar, primary, Peyre, Matthieu, primary, Eoli, Marica, primary, Papi, Laura, primary, Kalamarides, Michel, primary, Sanson, Marc, primary, Iavarone, Antonio, primary, and Lasorella, Anna, primary

Published
2023
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21. Supplementary Figure S1. from LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, primary, Oh, Young Taek, primary, D'Angelo, Fulvio, primary, Sommer, Danika, primary, Frangaj, Brulinda, primary, Tran, Suzanne, primary, Bielle, Franck, primary, Pollo, Bianca, primary, Paterra, Rosina, primary, Mokhtari, Karima, primary, Soni, Rajesh Kumar, primary, Peyre, Matthieu, primary, Eoli, Marica, primary, Papi, Laura, primary, Kalamarides, Michel, primary, Sanson, Marc, primary, Iavarone, Antonio, primary, and Lasorella, Anna, primary

Published
2023
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22. Abstract 5621: Multi-parametric MRI maps regional heterogeneity of high grade glioma phenotypes

Author

Flick, Matthew, primary, Weiskittel, Taylor, additional, Meng-Lin, Kevin, additional, D'Angelo, Fulvio, additional, Caruso, Francesca, additional, Ensign, Shannon, additional, Blomquist, Mylan, additional, Wang, Luija, additional, Sereduk, Christopher, additional, De Leon, Gustavo, additional, Nespodzany, Ashley, additional, Urcuyo, Javier, additional, Gonzalez, Ashlynn, additional, Curtin, Lee, additional, Singleton, Kyle, additional, Anil, Aliya, additional, Simmineh, Natenael, additional, Lewis, Erika, additional, Noviello, Teresa, additional, Patel, Reyna, additional, Wang, Panwen, additional, Wang, Junwen, additional, Eschbacher, Jennifer, additional, Hawkins-Daarud, Andrea, additional, Jackson, Pamela, additional, Smith, Kris, additional, Nakaji, Peter, additional, Bendok, Bernard, additional, Zimmerman, Richard, additional, Krishna, Chandan, additional, Patra, Devi, additional, Patel, Naresh, additional, Lyons, Mark, additional, Neal, Matthew, additional, Donev, Kliment, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Beeman, Scott, additional, Zhou, Yuxiang, additional, Baxter, Leslie, additional, Plaisier, Christopher, additional, Li, Jing, additional, Li, Hu, additional, Lasorella, Anna, additional, Quarles, Chad, additional, Swanson, Kristin, additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Tran, Nhan, additional, and Hu, Leland, additional

Published
2023
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23. Data from LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, primary, Oh, Young Taek, primary, D'Angelo, Fulvio, primary, Sommer, Danika, primary, Frangaj, Brulinda, primary, Tran, Suzanne, primary, Bielle, Franck, primary, Pollo, Bianca, primary, Paterra, Rosina, primary, Mokhtari, Karima, primary, Soni, Rajesh Kumar, primary, Peyre, Matthieu, primary, Eoli, Marica, primary, Papi, Laura, primary, Kalamarides, Michel, primary, Sanson, Marc, primary, Iavarone, Antonio, primary, and Lasorella, Anna, primary

Published
2023
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24. Abstract 1507: Multiregional sampling of high grade glioma identifies regional biologic signatures

Author

Blomquist, Mylan R., primary, Hu, Leland S., additional, D'Angelo, Fulvio, additional, Weiskittel, Taylor M., additional, Caruso, Francesca P., additional, Ensign, Shannon P. Fortin, additional, Sereduk, Christopher, additional, De Leon, Gustavo, additional, Curtin, Lee, additional, Urcuyo, Javier, additional, Gonzalez, Ashlynn, additional, Nespodzany, Ashley, additional, Noviello, Teresa, additional, Eschbacher, Jennifer M., additional, Smith, Kris A., additional, Nakaji, Peter, additional, Bendok, Bernard R., additional, Zimmerman, Richard S., additional, Krishna, Chandan, additional, Patra, Devi, additional, Patel, Naresh, additional, Lyons, Mark, additional, Donev, Kliment, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Lasorella, Anna, additional, Swanson, Kristin R., additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, and Tran, Nhan L., additional

Published
2023
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25. Supplementary Figures 1-9 from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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26. Supplementary Tables 1-9 from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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27. Supplementary Materials and Methods from Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Author

Remo, Andrea, primary, Manfrin, Erminia, primary, Parcesepe, Pietro, primary, Ferrarini, Alberto, primary, Han, Hye Seung, primary, Mickys, Ugnius, primary, Laudanna, Carmelo, primary, Simbolo, Michele, primary, Malanga, Donatella, primary, Oliveira, Duarte Mendes, primary, Baritono, Elisabetta, primary, Colangelo, Tommaso, primary, Sabatino, Lina, primary, Giuliani, Jacopo, primary, Molinari, Enrico, primary, Garonzi, Marianna, primary, Xumerle, Luciano, primary, Delledonne, Massimo, primary, Giordano, Guido, primary, Ghimenton, Claudio, primary, Lonardo, Fortunato, primary, D'angelo, Fulvio, primary, Grillo, Federica, primary, Mastracci, Luca, primary, Viglietto, Giuseppe, primary, Ceccarelli, Michele, primary, Colantuoni, Vittorio, primary, Scarpa, Aldo, primary, and Pancione, Massimo, primary

Published
2023
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28. LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL

Author

Ko, Aram, primary, Hasanain, Mohammad, additional, Oh, Young Taek, additional, D'Angelo, Fulvio, additional, Sommer, Danika, additional, Frangaj, Brulinda, additional, Tran, Suzanne, additional, Bielle, Franck, additional, Pollo, Bianca, additional, Paterra, Rosina, additional, Mokhtari, Karima, additional, Soni, Rajesh Kumar., additional, Peyre, Matthieu, additional, Eoli, Marica, additional, Papi, Laura, additional, Kalamarides, Michel, additional, Sanson, Marc, additional, Iavarone, Antonio, additional, and Lasorella, Anna, additional

Published
2022
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30. EPCO-03. PATHWAY-BASED STRATIFICATION OF GLIOBLASTOMA BY MULTI-OMICS INFORMS SUBTYPE-SPECIFIC MASTER KINASES-PHOSPHOSITE SUBSTRATES

Author

Migliozzi, Simona, primary, Oh, Young Taek, additional, Hasanain, Mohammad, additional, Garofano, Luciano, additional, D'Angelo, Fulvio, additional, Picca, Alberto, additional, Bielle, Franck, additional, Sarkaria, Jann, additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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31. EXTH-21. DEVELOPMENT OF THERAPEUTIC STRATEGIES BY PATHWAY-BASED MULTI-OMICS APPROACH AND MASTER KINASE ANALYSIS IN GLIOBLASTOMA MULTIFORME

Author

Oh, Michael, primary, Hasanain, Mohammad, additional, Migliozzi, Simona, additional, Garofano, Luciano, additional, D'Angelo, Fulvio, additional, Stefano, Anna Luisa Di, additional, Lerond, Julie, additional, Sarkaria, Jann, additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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33. CSIG-01. EGFR AND AXL RECEPTOR TYROSINE KINASES DRIVE ONCOGENESIS BY LZTR1 MUTATION

Author

Ko, Aram, primary, Hasanain, Mohammad, additional, Oh, Young Taek, additional, D'Angelo, Fulvio, additional, Sommer, Danika, additional, Frangaj, Brulinda, additional, Tran, Suzanne, additional, Bielle, Franck, additional, Pollo, Bianca, additional, Paterra, Rosina, additional, Mokhtari, Karima, additional, Soni, Rajesh, additional, Peyre, Matthieu, additional, Eoli, Marica, additional, Kalamarides, Michel, additional, Sanson, Marc, additional, Iavarone, Antonio, additional, and Lasorella, Anna, additional

Published
2022
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34. Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification

Author

Migliozzi, Simona, primary, Oh, Young Taek, additional, Garofano, Luciano, additional, Mohammad, Hasanain, additional, D'Angelo, Fulvio, additional, Najac, Ryan D., additional, Bielle, Franck, additional, Mokhtari, Karima, additional, Sarkaria, Jann N., additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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35. Abstract 770: Multiregional imaging and genomic analysis in high-grade IDH-mutant astrocytoma identifies intratumor subclones with aggressive features

Author

Ensign, Shannon P. Fortin, primary, D'Angelo, Fulvio, additional, Caruso, Francesca P., additional, Sereduk, Christopher, additional, Singleton, Kyle, additional, Eschbacher, Jennifer, additional, Mazza, Gina, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Bendok, Bernard, additional, Zimmerman, Richard, additional, Smith, Kris, additional, Nakaji, Peter, additional, Swanson, Kamala, additional, Wang, Junwen, additional, Semmineh, Nathenael, additional, Quarles, Christopher, additional, Lasorella, Anna, additional, Swanson, Kristin, additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Hu, Leland, additional, and Tran, Nhan L., additional

Published
2022
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36. Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification

Author

Oh, Young Taek, primary, Migliozzi, Simona, additional, Garofano, Luciano, additional, Mohammad, Hasanain, additional, D’Angelo, Fulvio, additional, Najac, Ryan D., additional, Bielle, Franck, additional, Mokhtari, Karima, additional, Sarkaria, Jann N., additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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37. CSIG-08. ABT-414 RESISTANT GBM TUMORS HARBOR THE TEK S466I MUTATION AND EXHIBIT INCREASED STEMNESS

Author

Blomquist, Mylan, primary, Noviello, Teresa, additional, D'Angelo, Fulvio, additional, Sereduk, Christopher, additional, Rabichow, Benjamin, additional, Miller, Aunay, additional, Marin, Bianca-Maria, additional, White, Forest, additional, Sarkaria, Jann, additional, Lasorella, Anna, additional, Iavarone, Antonio, additional, Ceccarelli, Michele, additional, and Tran, Nhan, additional

Published
2021
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38. EPCO-09. LONGITUDINAL ANALYSIS OF DIFFUSE GLIOMA REVEALS CELL STATE DYNAMICS AT RECURRENCE ASSOCIATED WITH CHANGES IN GENETICS AND THE MICROENVIRONMENT

Author

Varn, Frederick, primary, Johnson, Kevin, additional, Wade, Taylor, additional, Malta, Tathiane, additional, Sabedot, Thais, additional, Barthel, Floris, additional, Kim, Hoon, additional, Ahmed, Nazia, additional, Datta, Indrani, additional, Barnholtz-Sloan, Jill, additional, Bakas, Spyridon, additional, D'Angelo, Fulvio, additional, Gan, Hui, additional, Garofano, Luciano, additional, Huse, Jason, additional, Khasraw, Mustafa, additional, Kocakavuk, Emre, additional, Migliozzi, Simona, additional, Ormond, David, additional, Paek, Sun Ha, additional, Van Meir, Erwin, additional, Walenkamp, Annemiek, additional, Watts, Colin, additional, Weller, Michael, additional, Weiss, Tobias, additional, Wesseling, Pieter, additional, Stead, Lucy, additional, Poisson, Laila, additional, Noushmehr, Houtan, additional, Iavarone, Antonio, additional, and Verhaak, Roel, additional

Published
2021
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40. Inhibition of ERK/MAPK signaling as potential therapy to prevent optic pathway glioma in infants with neurofibromatosis type 1.

Author

D'Angelo, Fulvio and Lasorella, Anna

Subjects
*NEUROFIBROMATOSIS 1, *MITOGEN-activated protein kinases, *GLIOMAS, *PROGENITOR cells
Abstract

Pediatric low-grade gliomas (pLGGs) arise primarily at early stages of development. The molecular mechanisms of pLGG gliomagenesis are unclear, as is the progenitor cell of origin. In this issue of Developmental Cell , Jecrois et al. show that NF1-associated optic pathway gliomas originate from migrating glial progenitors that have distinct MEK/ERK dependency. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy

Author

Simona Migliozzi, Young Taek Oh, Mohammad Hasanain, Luciano Garofano, Fulvio D’Angelo, Ryan D. Najac, Alberto Picca, Franck Bielle, Anna Luisa Di Stefano, Julie Lerond, Jann N. Sarkaria, Michele Ceccarelli, Marc Sanson, Anna Lasorella, Antonio Iavarone, Migliozzi, Simona, Oh, Young Taek, Hasanain, Mohammad, Garofano, Luciano, D'Angelo, Fulvio, Najac, Ryan D, Picca, Alberto, Bielle, Franck, Di Stefano, Anna Luisa, Lerond, Julie, Sarkaria, Jann N, Ceccarelli, Michele, Sanson, Marc, Lasorella, Anna, and Iavarone, Antonio

Subjects
Cancer Research, Oncology
Abstract

Despite producing a panoply of potential cancer-specific targets, the proteogenomic characterization of human tumors has yet to demonstrate value for precision cancer medicine. Integrative multi-omics using a machine-learning network identified master kinases responsible for effecting phenotypic hallmarks of functional glioblastoma subtypes. In subtype-matched patient-derived models, we validated PKCδ and DNA-PK as master kinases of glycolytic/plurimetabolic and proliferative/progenitor subtypes, respectively, and qualified the kinases as potent and actionable glioblastoma subtype-specific therapeutic targets. Glioblastoma subtypes were associated with clinical and radiomics features, orthogonally validated by proteomics, phospho-proteomics, metabolomics, lipidomics and acetylomics analyses, and recapitulated in pediatric glioma, breast and lung squamous cell carcinoma, including subtype specificity of PKCδ and DNA-PK activity. We developed a probabilistic classification tool that performs optimally with RNA from frozen and paraffin-embedded tissues, which can be used to evaluate the association of therapeutic response with glioblastoma subtypes and to inform patient selection in prospective clinical trials.

Published
2023

42. The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.

Author

Malta TM, Sabedot TS, Morosini NS, Datta I, Garofano L, Vallentgoed W, Varn FS, Aldape K, D'Angelo F, Bakas S, Barnholtz-Sloan JS, Gan HK, Hasanain M, Hau AC, Johnson KC, Cazacu S, deCarvalho AC, Khasraw M, Kocakavuk E, Kouwenhoven MCM, Migliozzi S, Niclou SP, Niers JM, Ormond DR, Paek SH, Reifenberger G, Sillevis Smitt PA, Smits M, Stead LF, van den Bent MJ, Van Meir EG, Walenkamp A, Weiss T, Weller M, Westerman BA, Ylstra B, Wesseling P, Lasorella A, French PJ, Poisson LM, Verhaak RGW, Iavarone A, and Noushmehr H

Subjects
Humans, Epigenesis, Genetic, Epigenomics, Mutation, Neoplasm Recurrence, Local genetics, Tumor Microenvironment, Brain Neoplasms pathology, Glioma pathology, Isocitrate Dehydrogenase genetics, Isocitrate Dehydrogenase metabolism
Abstract

Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) glioma. IDHwt gliomas showed a stable epigenome over time with relatively low levels of global methylation. The epigenome of IDHmut gliomas showed initial high levels of genome-wide DNA methylation that was progressively reduced to levels similar to those of IDHwt tumors. Integration of epigenomics, gene expression, and functional genomics identified HOXD13 as a master regulator of IDHmut astrocytoma evolution. Furthermore, relapse of IDHmut tumors was accompanied by histologic progression that was associated with survival, as validated in an independent cohort. Finally, the initial cell composition of the tumor microenvironment varied between IDHwt and IDHmut tumors and changed differentially following treatment, suggesting increased neoangiogenesis and T-cell infiltration upon treatment of IDHmut gliomas. This study provides one of the largest cohorts of paired longitudinal glioma samples with epigenomic, transcriptomic, and genomic profiling and suggests that treatment of IDHmut glioma is associated with epigenomic evolution toward an IDHwt-like phenotype., Significance: Standard treatments are related to loss of DNA methylation in IDHmut glioma, resulting in epigenetic activation of genes associated with tumor progression and alterations in the microenvironment that resemble treatment-naïve IDHwt glioma., (©2023 The Authors; Published by the American Association for Cancer Research.)

Published
2024
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43. LZTR1 Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL.

Author

Ko A, Hasanain M, Oh YT, D'Angelo F, Sommer D, Frangaj B, Tran S, Bielle F, Pollo B, Paterra R, Mokhtari K, Soni RK, Peyre M, Eoli M, Papi L, Kalamarides M, Sanson M, Iavarone A, and Lasorella A

Subjects
Animals, Humans, Mice, Carcinogenesis, Cell Transformation, Neoplastic, ErbB Receptors genetics, Mutation, Ubiquitins genetics, Neurilemmoma genetics, Neurilemmoma metabolism, Neurilemmoma pathology, Transcription Factors genetics, Transcription Factors metabolism
Abstract

LZTR1 is the substrate-specific adaptor of a CUL3-dependent ubiquitin ligase frequently mutated in sporadic and syndromic cancer. We combined biochemical and genetic studies to identify LZTR1 substrates and interrogated their tumor-driving function in the context of LZTR1 loss-of-function mutations. Unbiased screens converged on EGFR and AXL receptor tyrosine kinases as LZTR1 interactors targeted for ubiquitin-dependent degradation in the lysosome. Pathogenic cancer-associated mutations of LZTR1 failed to promote EGFR and AXL degradation, resulting in dysregulated growth factor signaling. Conditional inactivation of Lztr1 and Cdkn2a in the mouse nervous system caused tumors in the peripheral nervous system including schwannoma-like tumors, thus recapitulating aspects of schwannomatosis, the prototype tumor predisposition syndrome sustained by LZTR1 germline mutations. Lztr1- and Cdkn2a-deleted tumors aberrantly accumulated EGFR and AXL and exhibited specific vulnerability to EGFR and AXL coinhibition. These findings explain tumorigenesis by LZTR1 inactivation and offer therapeutic opportunities to patients with LZTR1-mutant cancer., Significance: EGFR and AXL are substrates of LZTR1-CUL3 ubiquitin ligase. The frequent somatic and germline mutations of LZTR1 in human cancer cause EGFR and AXL accumulation and deregulated signaling. LZTR1-mutant tumors show vulnerability to concurrent inhibition of EGFR and AXL, thus providing precision targeting to patients affected by LZTR1-mutant cancer. This article is highlighted in the In This Issue feature, p. 517., (©2022 American Association for Cancer Research.)

Published
2023
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