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Various miRNAs have been shown to participate in the tumor progression and development of colorectal cancer (CRC). However, the role of miR-3913-5p in CRC are yet to be clearly defined. In the present study, we determine that miR-3913-5p is downregulated in CRC cell lines and CRC tissues. Exogenous miR-3913-5p expression weakens the CRC cells growth, migration and invasion. Mechanistically, miR-3913-5p directly targets the 3'UTR of CREB5. Overexpression of CREB5 reverses the suppression of CRC cells proliferation, migration and invasion induced by miR-3913-5p. Furthermore, ATF2 negatively regulates the transcription of miR-3913-5p by binding to its promoter. CREB5 can cooperate with ATF2. CREB5 is required for ATF2 in regulating miR-3913-5p. Finally, inverse correlations can be found between the expressions of miR-3913-5p and CREB5 or ATF2 in CRC tissues. Thus, a plausible mechanism of ATF2/miR-3913-5p/CREB5 axis regulating CRC progression is elucidated. Our findings suggest that miR-3913-5p functions as a tumor suppressor in CRC. ATF2/miR-3913-5p/CREB5 axis might be a potential therapeutic target against CRC progression. The miRNA miR-3913-5p inhibits colorectal cancer cell proliferation, migration and invasion, in concert with its regulation of and by CREB5 and ATF2. [ABSTRACT FROM AUTHOR]

Previous reports have shown that histone deacetylase inhibitors (HDACi) can alter miRNA expression in a range of cancers. Both the 5p-arm and 3p-arm of mature miRNAs can be expressed from the same precursor and involved in cancer progress. Nevertheless, the detailed mechanism by which vorinostat (SAHA), a HDACi, triggers miR-769-5p/miR-769-3p-mediated suppression of proliferation and induces apoptosis in gastric cancer (GC) cells remains elusive. Here, we showed that the miRNA-seq analysis of GC cells treated with SAHA identified seven differentially expressed miRNAs with both strands of the miRNA duplex. miR-769-5p/miR-769-3p expression was downregulated in GC tissues compared with normal tissues. Functionally, high expression of miR-769-5p/miR-769-3p blocked the malignant abilities of GC cells. Mechanistically, miR-769-5p/miR-769-3p targeted IGF1R and IGF1R overexpression rescued the effects of miR-769-5p/miR-769-3p on GC cells growth and metastasis. Moreover, STAT3 bound to the promoter of miR-769. Furthermore, miR-769-5p/miR-769-3p expression was negatively regulated by the STAT3-IGF1R-HDAC3 complex. Besides, miR-769-5p/miR-769-3p synergized with SAHA to promote GC cells apoptosis. Our studies suggest that miR-769-5p/miR-769-3p acts as a tumor suppressor by the STAT3-IGF1R-HDAC3 complex. Moreover, SAHA triggers miR-769-5p/miR-769-3p-mediated inhibition of proliferation and induces apoptosis in GC cells. [ABSTRACT FROM AUTHOR]

In this article, we have proposed and demonstrated a sensing interrogation scheme of microwave photonic filter (MPF) based on multi‐wavelength fiber laser (MWFL). A Mach‐Zehnder interferometer (FMZI) acts as the wavelength selective component in the laser cavity as well as the sensing element. An erbium doped fiber amplifier (EDFA) and a semiconductor optical amplifier (SOA) are employed as hybrid gain medium to suppress the homogeneous broadening of erbium doped fiber. The MWFL is employed as the optical source to implement the MPF together with a dispersive medium. The free spectrum range of interference pattern of the FMZI changes with the temperature variation, thus changing the central frequency of MPF's passbands. The sensitivities are −12.23 and 6.11 MHz/°C, respectively, when the sensing optical fiber with the length of 2.2 and 1.1 m are used. [ABSTRACT FROM AUTHOR]

In this article, we have proposed and demonstrated a new approach to implementing microwave photonic filter (MPF) with switchable, tunable and reconfigurable passbands based on a multi-wavelength fiber laser (MWFL) cooperating with a fiber Mach–Zehnder interferometer (FMZI). An EDFA and an SOA have been employed as a hybrid gain medium in the laser cavity, to suppress the homogeneous broadening of EDF. By inserting the FMZI in the fiber laser cavity, MWFL with tunable and switchable wavelength spacing has been achieved, which can be used as the multi-wavelength optical source to implement switchable, tunable and reconfigurable MPF together with a dispersive medium. By tuning the length of variable optical delay line (VODL), the wavelength spacing of the MWFL can be changed, and thus the passband's central frequency of the MPF. By adjusting the polarization states, gain of EDFA or SOA of the laser cavity, the shape of the laser output can be adjustable, and as a result, shape-adjustable passbands of the MPF have been realized. By introducing the reflective FMZI structure as the wavelength selective component and carefully adjusting the polarization states, half number of the passband can be suppressed, which means the MPF can be switchable. The proposed MPF exhibits shape-adjustable and switchable passbands and enjoys more flexibility compared to previous methods. [ABSTRACT FROM AUTHOR]

• MFC signals with four switchable frequencies have been generated, which can be switched by simply rotating the PC. • By cascading a dual-loop structure, MFC signals with supermode noise suppression can be obtained. • By applying the longer length of the PMFs, the higher switchable central frequency of the MFC can be achieved. In this paper, we propose and experimentally demonstrate a flexibly frequency switchable active mode-locking optoelectronic oscillator (FSAML-OEO) in which a multi-passband microwave photonic filter (MPF) with two polarization-maintaining fibers (PMF) based Solc-Sagnac interferometer is used. Microwave frequency combs (MFCs) signals with four switchable central frequencies of 217 MHz, 453 MHz, 662 MHz and 1101 MHz are generated by controlling the polarization state of the Sagnac interferometer via rotating the polarization controller (PC). By cascading a dual-loop structure, MFCs signals with adjustable comb spacing of 1 MHz, 3 MHz, and 5 MHz are obtained with fundamental and harmonic FSAML-OEO, in which the supermode noise suppression ratios of the dominate modes and the super-modes are measured to be about 30 dB. [ABSTRACT FROM AUTHOR]

• A dual channel photonic crystal fiber is proposed for dual-parameter sensing. • The gold is coated on the outer surface of the sensor to measure the salinity. • The polydimethylsiloxane is coated on the half-side of the surface of the sensor. • The temperature sensitivity is −4.937 nm/°C in the sensing range from 25 °C to 50 °C. • The salinity sensitivity is 0.307 nm/‰ in the sensing range from 0‰ to 100‰. A novel half-side PDMS-coated photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) is proposed for simultaneous detection of seawater salinity and temperature. The plasmonic material gold is coated on the outer surface of the PCF to measure the seawater salinity by exciting SPR effect. Moreover, the polydimethylsiloxane (PDMS) layer is coated on the upper half-side of the surface of the sensor as an independent temperature sensing channel. The properties of modes coupling between surface plasmon polaritons (SPPs) mode and four different core modes are investigated. Meanwhile, the influence of various geometrical parameters on the sensing characteristics are theoretically simulated by using finite element method (FEM). The numerical results show that the salinity sensitivity of the designed sensor can reach 0.307 nm/‰ with a resolution of 0.3257‰. Additionally, the temperature sensitivity of −4.937 nm/°C with the resolution of 0.0203 °C in the sensing range from 25 °C to 50 °C has been obtained. The proposed sensor, possessing advantages such as ease of fabrication, excellent sensing performance and low cost, not only realizes the simultaneous measurement of two parameters, but also has potential in the field of seawater monitoring. [ABSTRACT FROM AUTHOR]

Background: In the post-pandemic era, a wide range of COVID-19 sequelae is of growing health concern. However, the risks of digestive diseases in long COVID have not been comprehensively understood. To investigate the long-term risk of digestive diseases among COVID patients. Methods: In this large-scale retrospective cohort study with up to 2.6 years follow-up (median follow-up: 0.7 years), the COVID-19 group (n = 112,311), the contemporary comparison group (n = 359,671) and the historical comparison group (n = 370,979) predated the COVID-19 outbreak were built using UK Biobank database. Each digestive outcome was defined as the diagnosis 30 days or more after the onset of COVID-19 infection or the index date. Hazard ratios (HRs) and corresponding 95% confidence intervals (CI) were computed utilizing the Cox regression models after inverse probability weighting. Results: Compared with the contemporary comparison group, patients with previous COVID-19 infection had higher risks of digestive diseases, including gastrointestinal (GI) dysfunction (HR 1.38 (95% CI 1.26 to 1.51)); peptic ulcer disease (HR 1.23 (1.00 to 1.52)); gastroesophageal reflux disease (GERD) (HR 1.41 (1.30 to 1.53)); gallbladder disease (HR 1.21 (1.06 to 1.38)); severe liver disease (HR 1.35 (1.03 to 1.76)); non-alcoholic liver disease (HR 1.27 (1.09 to 1.47)); and pancreatic disease (HR 1.36 (1.11 to 1.66)). The risks of GERD were increased stepwise with the severity of the acute phase of COVID-19 infection. Even after 1-year follow-up, GERD (HR 1.64 (1.30 to 2.07)) and GI dysfunction (HR 1.35 (1.04 to 1.75)) continued to pose risks to COVID-19 patients. Compared to those with one SARS-CoV-2 infection, reinfected patients were at a higher risk of pancreatic diseases (HR 2.57 (1.23 to 5.38)). The results were consistent when the historical cohort was used as the comparison group. Conclusions: Our study provides insights into the association between COVID-19 and the long-term risk of digestive system disorders. COVID-19 patients are at a higher risk of developing digestive diseases. The risks exhibited a stepwise escalation with the severity of COVID-19, were noted in cases of reinfection, and persisted even after 1-year follow-up. This highlights the need to understand the varying risks of digestive outcomes in COVID-19 patients over time, particularly those who experienced reinfection, and develop appropriate follow-up strategies. [ABSTRACT FROM AUTHOR]

In this paper, a structured light vision measurement method using a scanning laser line and a positioning laser line is proposed. The novel method enables the scanning laser plane to slide along a slide rail while maintaining intersection with the positioning laser plane, eliminating the need to determine the scanning direction and moving step. During the measurement process, the laser plane equations need to be recalibrated for each new position, so a real-time calibration method is given. Initially, the geometric barycenter method is employed to detect the subpixel coordinates of the light stripe intersection point. Subsequently, these coordinates are projected into the camera coordinate system using the initial equations of the positioning laser plane. Finally, leveraging the normal information of the initial equation of the scanning laser plane and the three-dimensional coordinates of the light stripe intersection point, the real-time calibration of the scanning laser plane equations can be accomplished. The proposed method enables the three-dimensional reconstruction of objects, and its accuracy is verified through measurements on gauge blocks. Experimental results demonstrate that this method achieves precise and stable three-dimensional reconstruction of object surface shape. [ABSTRACT FROM AUTHOR]

A multi-line structured light measurement method that combines a single-line and a three-line laser, in which precision sliding rails and displacement measurement equipment are not required, is proposed in this paper. During the measurement, the single-line structured light projects onto the surface of an object and the three-line structured light remains fixed. The single-line laser is moved and intersects with the three-line laser to form three intersection points. The single-line light plane can be solved using the camera coordinates of three intersection points, thus completing the real-time calibration of the scanned light plane. The single-line laser can be scanned at any angle to determine the overall complete three-dimensional (3D) shape of the object during the process. Experimental results show that this method overcomes the difficulty of obtaining information about certain angles and locations and can effectively recover the 3D shape of the object. The measurement system's repetition error is under 0.16 mm, which is sufficient to measure the 3D shapes of complicated workpieces. [ABSTRACT FROM AUTHOR]

• A dual-parameter sensor based on four-core fiber (FCF) with a hybrid sensing mechanism is proposed. • The surface of FCF is covered with gold film to excite the SPR and MZI for measuring refractive index (RI) and temperature. • The proposed sensor exhibits a high RI sensitivity of 2091 nm/RIU and a temperature sensitivity of 0.0398 nm/°C. A dual-parameter sensor based on a hybrid sensing mechanism of surface plasmon resonance (SPR) and Mach–Zehnder interference (MZI) using a four-core fiber (FCF), is proposed and implemented. The designed sensor is fabricated by cascading a sandwich structure of the FCF, multimode fiber and lead-in/out single-mode fiber. The gold-coated FCF as the critical component, enabling the excitation of the SPR and MZI for measuring refractive index (RI) and temperature. The proposed sensor exhibits a high RI sensitivity of 2091 nm/RIU and a temperature sensitivity of 0.0398 nm/°C. The proposed dual-parameter sensor based on FCF provides a new insight for the design of fiber SPR sensor, which can be used to measure multiple physical parameters in various fields such as biochemistry, gene diagnosis, environmental monitoring, and so on. [ABSTRACT FROM AUTHOR]

• Balloon-like and waist-enlarged structures are proposed for RI and temperature measurement. • The sensor is constructed using single-mode optical fiber, which is simple and inexpensive. • The RI and temperature sensitivity of the proposed sensor can be up to 340.9 nm/RIU and −0.162 nm/°C, respectively. A balloon-like composite optical fiber interferometer, integrated with a waist-enlarged structure, is presented for measuring refractive index (RI) and temperature. The waist-enlarged fusion tapers (WEFTs) are spliced to the single-mode fiber (SMF) to form a Mach-Zehnder interferometer (MZI). Meanwhile, the WEFTs structure is curved into a balloon-like structure. When the two structures are integrated, a larger evanescent field is formed, which can interact with the external environment better. The experiment results indicate that the best sensitivity of RI and temperature can achieve 340.9 nm/RIU and −0.162 nm/℃, respectively. In addition, the interferometer is small, easy to manufacture, and can be widely applied in various measurement applications. [ABSTRACT FROM AUTHOR]

• A highly sensitive surface plasmon resonance (SPR) sensor based on seven-core photonic crystal fiber (SCPCF) is proposed. • The surface of SCPCF is covered with gold film as the sensing region for refractive index (RI) and temperature measurement. • Gold film covers SCPCF surface for RI sensing, with polydimethylsiloxane (PDMS) coating for temperature sensing on one part of the gold film. • The experiment results show that the RI sensitivity and temperature sensitivity of the proposed sensor reach 1644 nm/RIU and −2.59 nm/°C, respectively. A highly sensitive surface plasmon resonance (SPR) sensor based on seven-core photonic crystal fiber (SCPCF) is proposed and experimentally demonstrated for refractive index (RI) and temperature measurement. The dual-parameter sensor is fabricated by inserting an SCPCF between two multimode fibers (MMFs). The surface of SCPCF is covered with gold film as the sensing region. One part of the gold film is additionally coated with polydimethylsiloxane (PDMS) to enable temperature sensing, while the rest is used for RI sensing. The experiment results show that the RI sensitivity and temperature sensitivity of the proposed sensor reach 1644 nm/RIU and −2.59 nm/°C, respectively. Additionally, the SPR dual-parameter sensor based on SCPCF has good stability and repeatability, which has great application potential in the field of environmental monitoring, disease diagnosis, and biochemical sensing. [ABSTRACT FROM AUTHOR]

The Editors-in-Chief therefore consider the data reported in this the article to be unreliable. Figure 4f: the AGS and BGC-823 panels for miR-4490/USP22 appear to partially overlap. [Extracted from the article]

The coiled-coil domain-containing protein 43 (CCDC43) is essential to promote gastric cancer (GC) proliferation and invasion, while four and a half LIM domains 1 (FHL1) involves GC cells apoptosis. We attempted to address inter-relationship between CCDC43 and FHL1 in modulating GC cells growth and apoptosis. Levels of protein expression were assessed by western blot, immunofluorescence. Using EdU, plate colony formation, Matrigel invasion and animal models, we evaluated the function in vitro and in vivo. Apoptosis was evaluated by flow cytometry and Hoechst 33258 staining. Reciprocal co-immunoprecipitation (co-IP) analyses indicated that CCDC43 physically interacted with FHL1. The expression of CCDC43 was negatively correlated with FHL1. Moreover, up-regulation of CCDC43 resulted in FHL1 level decline, and the reverse is also true. CCDC43 expressed jointly with FHL1 group significantly decreases the ability of the growth, metastasis and invasion of GC cells compared with that of the CCDC43 group. Furthermore, siRNA-mediated repression of CCDC43 results in dissociation from FHL1 and causes suppression of GC cell proliferation and metastasis. CCDC43 repression mediates the stability of FHL1 protein. In addition, CCDC43 interacts with FHL1. Knockdown of CCDC43 plus FHL1 overexpression inhibits proliferation and migration and induces apoptosis of GC cells in vitro and vivo. • CCDC43 interacts and colocates with FHL1 in GC. • The decrease of FHL1 by CCDC43 promotes the growth and migration of GC cells. • CCDC43 inhibits the stability of FHL1 protein and promotes apoptosis in GC cells. [ABSTRACT FROM AUTHOR]